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LOCUS NM_001272231 8406 bp mRNA linear INV 26-DEC-2023 (Hr4), mRNA. ACCESSION NM_001272231 VERSION NM_001272231.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 8406) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 8406) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 8406) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 8406) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 8406) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 8406) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 8406) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 8406) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 8406) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 8406) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 8406) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 8406) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 8406) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 8406) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 8406) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 8406) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 8406) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 8406) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 8406) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 8406) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 8406) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 8406) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 8406) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..8406 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..8406 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /exception="dicistronic gene" /note="Hormone receptor 4" /map="2B16-2C1" /db_xref="FLYBASE:FBgn0264562" /db_xref="GeneID:31162" CDS 925..6516 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="CG43934 gene product from transcript CG43934-RH; CG43934-PH; Hr4-PH" /codon_start=1 /transl_except=(pos:5482..5484,aa:OTHER) /product="hormone receptor 4, isoform H" /protein_id="NP_001259160.1" /db_xref="FLYBASE:FBpp0305534" /db_xref="GeneID:31162" /db_xref="FLYBASE:FBgn0264562" /translation="MTLSRGPYSELDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTS SPDLLAPMSPKLCDSGSAGASLGASLPLPLALPLPMALPLPMSLPLPLTAASSAVTVS LAAVVAAVAETGGAGAGGAGTAVTASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSS TSSSTSSASPTAGASSTATCPASSSSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAA STVMSPPPAEATRSSPATPEGGGPAGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSG GSSRASPDSLEEKPSTTTTTGRPTLTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIR SVKEERLLNVSSKMLVFHQQREQETKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPAS PSSTSSTQRERERERDRERDRERERERDRDREREREQSISSSQQHLSRVSASPPTQLS HGSLGPNIVQTHHLHQQLTQPLTLRKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQ QQQQASHPQQQQQQQHSPHSLVRVKKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQ QQQHLHQQQQQQQHHQQQPQALALMHPASLALRNSNRDAAILFRVKSEVHQQVAAGLP HLMQSAGGAAAAAAAAVAAQRMVCFSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGS VQCPSPHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQS HGQHPQQQQQSPHHQPQQQQQQQQQQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSS SSGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALN MERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDE DEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNR CQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQ QQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHL LSPQQQQLAAAVAAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAP PMHSPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGG AQLPPHLVNGTILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCD AMEDIATLPHFSEFLEDKSEISEKLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLL TDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPL HKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKL KMEEYVCLKVYILLNKAEVELESIQERYVQVLRSYLQNSSPQNPQARLSELLSHIPEI QAAASLLLESKMFYVPFVLNSASIRXQMLEHGLLPTANHQSAPPPGPDTIPERQQQQQ QERRRSRQQQHQLLRNLPKIKIEIGSQRDPEEEESEQELEQEPEQEQDVQSRPSAAST SILKTSLLSGAAATLATLTAAAEQIARSSASCDTARDYSQSSNSSSNSNAATGATGTM ASGRTGSSNSLEESKRLEHQQQQQQQQQQPQQHQQQQYTSILHTALMSQRSMPPATSA TSAAAAVTSTPTTAATTSPTPAHVLKTAVTLASLSEIATARQQQQEQQQQQQQQQQQQ QLLAMQQQQQQLTKLPRRIINFGSNHTANTATKALGAGSEAGAGAGVGMATATATATV GRNRQLGLSQGQVVNGKQKEL" misc_feature 3661..3930 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers; Region: NR_DBD_DHR4_like; cd07168" /db_xref="CDD:143542" misc_feature order(3685..3687,3694..3696,3736..3738,3745..3747, 3793..3795,3811..3813,3841..3843,3850..3852) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="zinc binding site [ion binding]; other site" /db_xref="CDD:143542" misc_feature order(3715..3723,3739..3744,3748..3750,3754..3756, 3763..3765,3772..3774,3832..3837,3844..3846,3853..3855, 3886..3888,3895..3897) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:143542" misc_feature 4690..5469 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; Region: NR_LBD_DHR4_like; cd06953" /db_xref="CDD:132751" misc_feature order(4780..4785,4795..4797,4897..4899,4909..4911, 4918..4920,5116..5118,5185..5187) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:132751" misc_feature order(4810..4812,4819..4821,4831..4833,4846..4848, 4861..4866,4870..4875,4882..4887) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative coactivator recognition site [active]" /db_xref="CDD:132751" ORIGIN 1 gtgtatccca cgagctagtc gcgcgcggaa agcaaacgct tcgaaaatca aacgatattt 61 ccgttttgac gtttaacccc cacccaccca aataaagcaa atctaactaa agagtcctgc 121 aaaaaaatca acagctgctt gatcttgaag cctccatatc ttgaaatcct gcatcagcca 181 acagccccaa aacaaaacaa aacaaaacga atgcaaatac actaatgtga acaacaacta 241 aattgctagt gaaatgtttt aagccaaatg ctgtgagtgt gtaacaaaaa aaaaaaaaaa 301 aaaaaaaaaa aaagaagagt gattcaaagc aaccgcaagc aatcaacttg taacggtagt 361 cggatactcg cttgcccgcg gagcatggat atcgccccag ttccgccacc accattatcg 421 atatccgtat cgctttcggc tccaggatca acggtattcg caaacgctgg ccactagaga 481 agcgtcagcc gaatgcctca aagatgacac cgctgcaacg ggaccaattg aaccaccaac 541 aatttgtgca ccactatttg caaagtcaac ctgtcaataa caaaattgac agctttgata 601 ttaaacatat acgtaaaacc caaaacccga ccacaaaccc aaagtttcga actgaagacc 661 gtttcaagac aagcagcaag agcaagatta ccaacccgga gagcggaaat acccaactcc 721 attttcattt gagtgaaacg ccagacttat ccgcctcaac ttcgctgttg ccgtcagcat 781 ttgttgcatc ctccgccgcc ttggtgaatg tgacatgcca ggcggaggaa ggacaaagtt 841 cagcaggatc acactacaca gttcatagag ggaatgacgc aggcatttct tttgcagcgt 901 tggactttcg ttttataagg aattatgaca ctgagccgtg gcccgtacag cgagctcgat 961 aaaatgagcc tttttcaaga cctcaaactc aaacggcgca aaatcgattc gcgatgcagc 1021 agtgacggcg agtccatagc ggacacgtcc acctcgtcgc cggacctgct ggcgcccatg 1081 tcgccgaagc tctgcgacag cggctcggcg ggggcgtcgc tgggggcatc gctgcccctg 1141 ccgctggccc tgcccctgcc aatggccctg ccactgccca tgtcgctgcc cctgcccctc 1201 acggcggcat cttcggcggt caccgtttcg ctggcagcgg tcgtggccgc ggtggccgag 1261 acgggtggcg cgggcgcggg aggagctggg acagcagtaa cagcgtcggg agcaggacca 1321 tgcgtctcca cgtcgtctac gacggcagcg gcagccacat cctcgacctc ctcgctctcg 1381 tcctcctcct cttcgtcatc ctccacgtcc tccagcactt cctccgcctc gccgacagct 1441 ggagcctcct ccacggccac ctgccccgcc agcagcagca gcagcagtgg aaacggaagt 1501 gggggcaaaa gtggtagcat caagcaggag cacacggaga tacactcgtc gagcagtgcg 1561 atttcggcgg ccgccgcctc aacggtgatg tcaccgccgc ccgctgaggc gacgagatcc 1621 agtccagcca cgcccgaggg aggcggacca gctggcgacg gaagtggagc aacgggaggc 1681 ggaaacacga gcggcggatc aacggctgga gtggccatta atgaacacca aaacaatggc 1741 aatggcagcg gcgggagcag tcgagcctct cccgattcgc tggaagagaa gccctctacc 1801 acaacgacca caggtcgtcc aacgctcacg cccacgaatg gggtgctgtc ctccgcctcg 1861 gcgggcacgg ggatttccac aggaagcagc gccaagctga gcgaggctgg tatgagtgtg 1921 atacggtccg tgaaggagga gcgcttgctc aacgtatcca gcaagatgct ggtgttccat 1981 cagcagcggg agcaagagac caaagcagtg gcggctgcag cagcagcagc agcggcgggc 2041 catgtgacgg ttctagtgac gccatcgcgc atcaaatcgg agccaccgcc gccggcttca 2101 ccctcctcta catccagcac acaaagggaa agggaacggg aacgcgatcg agagagggat 2161 cgcgaaaggg aacgcgagcg ggaccgggac cgggaacggg aacgggaaca gtccatcagc 2221 tcctcgcagc agcacctaag tcgggtctcc gccagtccac ccactcagct gtcccacggc 2281 agcctgggac ccaacattgt gcagacgcac catcttcacc agcaactcac acagccgctg 2341 acgctgcgca agagcagccc gcccacagag cacctgctca gtcagtccat gcaacatctc 2401 acacagcagc aggcgatcca cctgcatcac ctacttggcc agcagcagca gcagcagcag 2461 gcgtcgcatc cccagcagca acagcagcag caacactcgc cccactccct ggtgcgggtg 2521 aaaaaggaac cgaatgttgg tcagcggcac ttatcgccgc atcaccaaca acagtcgcca 2581 ctcctgcagc accaccaaca gcagcagcag cagcaacaac aacagcaaca gcatctgcat 2641 cagcaacagc aacagcagca gcatcaccag cagcagcccc aggcactggc cctgatgcat 2701 ccggcttccc tggcgctaag gaacagcaat cgggatgcgg ccattctgtt tcgggtgaag 2761 agcgaagtgc accagcaggt ggccgccggg ctgccgcatc tgatgcagtc cgctggtggg 2821 gcagcggccg ccgccgcagc agctgtggcc gctcagcgaa tggtatgctt cagcaatgcc 2881 aggatcaatg gcgttaagcc ggaggtgatt ggaggaccgc tgggcaacct gcggcccgtg 2941 ggcgtcggtg gcggaaacgg aagtggctcc gtgcagtgcc cctcgccgca tccatcctcc 3001 tcgtcgtcat cctcgcagct gtcgccgcag acgccctccc agacgccgcc ccgaggcacg 3061 cccaccgtca taatgggcga gagctgcggg gtgcgcacca tggtctgggg ctacgagcct 3121 ccgccaccct cggcgggcca gtcccacggc cagcacccgc aacagcaaca gcagtcgccc 3181 caccaccagc cgcaacaaca acagcagcag caacaacagc agtcgcagca gcaacagcaa 3241 cagcagcagc aacagtcgct gggccagcag cagcactgcc tctcctcgcc gtcggcggga 3301 tcgctgacgc cctcctcttc gtccggcggt ggttcggtat ctggcggcgg agtgggcgga 3361 ccactcacac cctcctcggt ggcgccgcag aataacgagg aggccgccca actcctgctc 3421 tccctgggac agacacgcat ccaggacatg agatcacggc cacacccctt ccgcacaccg 3481 cacgccctta atatggagcg gctgtgggcg ggagactact cgcaattgcc gcccggccag 3541 ctgcaggctc tgaatctcag tgcccaacag cagcagtggg gcagcagcaa ctccacgggt 3601 cttggtggcg taggcggcgg catgggcgga cgcaacctgg aggcgccgca cgagccgacc 3661 gacgaggacg aacagccgct cgtttgcatg atctgcgagg acaaggccac cggcctgcac 3721 tacggcatca tcacctgcga ggggtgcaag ggcttcttca agcggacggt gcagaaccga 3781 cgagtctaca cctgcgtggc ggacggcacc tgcgagataa ccaaagcaca gcgcaaccgt 3841 tgtcagtatt gtcgatttaa gaagtgcatc gagcagggca tggtgctgca agccgttcgc 3901 gaggatcgca tgccgggcgg tcgcaacagt ggcgccgtct acaatttgta caaggtgaag 3961 tacaagaagc acaagaagac caatcagaag cagcagcagc aggccgccca gcagcagcag 4021 cagcaggcgg cggcgcagca gcagcaccag caacagcagc agcatcaaca gcaccagcaa 4081 catcagcaac agcagttgca ctcgccgctc caccatcacc accaccaggg ccaccagtcg 4141 caccacgcgc agcagcagca ccacccacag ctgtcgccgc accacctgct gtcgccgcag 4201 cagcagcaac ttgccgccgc ggtggcagca gctgcgcagc accaacagca acagcaacaa 4261 cagcagcaac agcagcagca ggccaagctg atgggcggcg tggtggacat gaagcccatg 4321 ttcctcggcc ccgctttgaa gccggagttg ctgcaagcac cccccatgca cagtccggcc 4381 cagcaacaac aacagcagca gcagcagcag cagcaacagc aggcctcgcc gcatctctcg 4441 cttagctcac cgcaccagca gcagcagcag cagcagggac agcaccaaaa ccaccaccag 4501 caacaaggtg ggggtggcgg aggagctggt ggaggagctc aactgccgcc gcacctggtg 4561 aacggaacga tactgaagac ggccctaacc aatcccagcg agattgtaca tctgcgccac 4621 cgcctcgact cggcggtcag ttcgtccaag gaccgacaga tctcgtacga gcacgcctta 4681 ggcatgatcc agacactgat cgactgcgac gcgatggagg acatagccac actgccgcac 4741 ttcagcgagt tccttgagga caagtcggag attagcgaga aactgtgcaa catcggcgat 4801 tccatagtcc acaagctggt gtcgtggaca aaaaagttgc ccttctacct ggagatcccg 4861 gtggagatac ataccaaact actgacggac aagtggcacg agatccttat cctgaccacg 4921 gccgcctacc aggcgttgca tggcaagcgg cgtggcgagg gaggaggcag caggcatggt 4981 tcgccggcgt caacgccact gagcacgccc actggtacgc cgttgagcac accgataccc 5041 tcgcccgccc agccactgca caaggacgac ccggagtttg tcagcgaggt gaactcgcac 5101 ctgagcacac tgcaaacctg cttgaccacg ctaatgggcc agccgatagc gatggagcag 5161 ctgaagctgg acgtcgggca catggtggac aagatgaccc agatcaccat catgttccgg 5221 cgaatcaagc tcaagatgga ggagtacgtc tgcctgaagg tttacatact gctaaacaaa 5281 gcagaagtgg aactggagag catccaggag cggtacgtcc aggtgctgcg ctcctacctg 5341 caaaactcct cgccgcagaa tccgcaggcg aggctcagtg aactgctctc ccacatacca 5401 gagatccagg ctgcggctag cctgctgctc gagagcaaga tgttctatgt gcccttcgtg 5461 ctcaactcgg cgagcataag gtagcagatg cttgagcacg gactgctgcc caccgccaac 5521 catcagtcgg cgccaccacc tggtcctgat acgatcccgg agcggcagca gcaacagcaa 5581 caggagcggc gtcgaagcag gcagcagcag caccagttgc tgcgcaacct gcccaagatc 5641 aagatcgaga tcggttccca gcgcgatccg gaggaagagg agtcggagca agagctagag 5701 caggagccgg agcaagagca ggatgtgcag tcccgaccct cagccgcatc cacgtccatt 5761 ttgaagactt cactgctgag cggagcggcg gcgacgttgg ccaccttgac ggcggcagcc 5821 gagcaaatag cccgctcctc ggccagctgc gacactgcca gggattattc ccaaagcagc 5881 aacagcagca gcaatagcaa cgctgccaca ggagcaacag gaactatggc cagcggcagg 5941 acaggcagca gcaacagttt agaagagagc aaaagacttg agcatcaaca acaacaacaa 6001 caacagcagc aacaaccaca acagcatcag cagcaacaat atacatcaat actacacacg 6061 gccttaatgt cacagcgttc catgccacca gcgacatcag ctacatcagc agcagcggcg 6121 gtcacatcga cgccgacaac ggcagcaaca acatcgccta cgcctgcgca tgtgctgaaa 6181 acagcggtga ccttagccag tctaagtgag atagccacag cacgtcagca gcagcaggag 6241 cagcagcagc aacagcagca gcagcagcag cagcaacaat tgctggcgat gcaacagcaa 6301 cagcaacagc taacgaaact gcccagaagg ataatcaact ttggcagcaa tcacactgcc 6361 aacactgcca ccaaagcatt gggagcggga tcagaagcag gagcaggagc aggagtgggc 6421 atggccacag caacggcaac agcaacagtt ggacgcaatc gccaactggg cctgagtcag 6481 ggtcaagtgg tgaatggtaa gcagaaagaa ttgtgagcct tgtgtttgcg ataacgtttg 6541 tgtacccctc gttaacgctg ccagtcagga cagcacgcct gctcaatggc aactgttgcg 6601 gccgattgca ggcgacagca ggaacagggg ccagcagggg caccaacact gccggcagca 6661 acacggtcaa catgcagacc cagaccgacg atgagttgct gccgctgtta gccatgctcc 6721 cacaagacgc tcccacaaca acaggagcag cagcaggagc agcagtatca ttatcattat 6781 tagccacagc cacagccaca accacatctt catcatcatc atcatcatca tcattatcat 6841 catcatcgac gatttcatta gcaacacgtg cagcagcagt aatgcagcag cagcaacaat 6901 ggactgccgt gtcgacgacg ccagcaacag gagtgatgat gacgacgacg acgacacaat 6961 cacaatcaca agcaacatta gcaccacaac aacagcaact atcactgcca caacaaaagc 7021 aacaatttaa tacgagaata aacagaaaaa caacaattac aacagccacc acaacagcac 7081 caacagcaac aacagcaaca acaacaacaa cacgaaacag caacatcaac ttcaacagca 7141 acaataacta tatgaataac aataatataa acgccgccac tgccagagcc tctgccttcg 7201 cctccgcctc tgccatggcc acggccacgc ccacaggcac acccactgcc acgggcccgc 7261 gccagagacc ggccccgcaa ccgcccccgc ccccgcgcac gcccacagcc acctcagctt 7321 ctgttactgt agttgtgttc aaaacaatgt tacctgatga ctgaattatt ttagaatcgt 7381 acacatagag catgttttat tatgattacc actatgatta ccacttacga tttacgatta 7441 cgattatgat tacgattatg agtatgtctg gatatcatta cctattaact attcattagt 7501 tatggattat cgattattac tatttttact attactattg ctacatgcat aatgtagagc 7561 ctaattgatc tatcgtgtat tttagtttgt ctaattgttg gatccctgta ctatatccca 7621 cacacataca cacactctca cccatatttg atcctcaccc ccaaacaatc cataagcaca 7681 cactcataca cacacacaca cacacacaca cattgccgtt actaaggaag ggtatgcgca 7741 tatgcgaagt tgaaacattt taatcatgta tttttttttt ttgtgttttt gctgaacgga 7801 gatgaaagtt aaggaggtcg agcaacagca attagaagtg ttaattgagt aggattatga 7861 gtacgtagcg agtatgtaac gagtatgtaa tgactaagta aagtttacgt agacacaatg 7921 ccacacacag ctatagcaag catttaggat gcgtgcatat gtcagttatc tatttttttt 7981 ttttaaacta aaatctatat aaagtaacga gagaggaagg aagagcgaag cagggcggga 8041 gattcaacca cataaagtat aaatagtaga gcttgagcca agtagctagt ttagtgtaca 8101 tccgttttgg ggcagggaag tagagcaatt tgttgacgag tcggggtggt ggggtgagcg 8161 gtaacgaaga tcggtaacgg aagtggagac aaagcggaac cggaaacggg agctggactg 8221 ccagatcgga atcacacatc aaccattatg agaacttcgc tcgcaactct tgcagaatta 8281 tactgttaga tcctgttagt tatccaaccc aaaactccca acccacacac actataccta 8341 agttaagaac gcataatcac atactacaca taaattacgc atagtacata caaaaaagat 8401 gaagag