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LOCUS NM_001272230 8596 bp mRNA linear INV 26-DEC-2023 (Hr4), mRNA. ACCESSION NM_001272230 VERSION NM_001272230.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 8596) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 8596) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 8596) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 8596) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 8596) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 8596) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 8596) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 8596) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 8596) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 8596) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 8596) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 8596) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 8596) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 8596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 8596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 8596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 8596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 8596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 8596) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 8596) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 8596) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 8596) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 8596) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..8596 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..8596 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /exception="dicistronic gene" /note="Hormone receptor 4" /map="2B16-2C1" /db_xref="FLYBASE:FBgn0264562" /db_xref="GeneID:31162" CDS 1085..5674 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="CG43934 gene product from transcript CG43934-RD; CG43934-PD; Hr4-PD" /codon_start=1 /product="hormone receptor 4, isoform D" /protein_id="NP_001259159.1" /db_xref="FLYBASE:FBpp0305532" /db_xref="GeneID:31162" /db_xref="FLYBASE:FBgn0264562" /translation="MPGPALWSGIMTLSRGPYSELDKMSLFQDLKLKRRKIDSRCSSD GESIADTSTSSPDLLAPMSPKLCDSGSAGASLGASLPLPLALPLPMALPLPMSLPLPL TAASSAVTVSLAAVVAAVAETGGAGAGGAGTAVTASGAGPCVSTSSTTAAAATSSTSS LSSSSSSSSSTSSSTSSASPTAGASSTATCPASSSSSSGNGSGGKSGSIKQEHTEIHS SSSAISAAAASTVMSPPPAEATRSSPATPEGGGPAGDGSGATGGGNTSGGSTAGVAIN EHQNNGNGSGGSSRASPDSLEEKPSTTTTTGRPTLTPTNGVLSSASAGTGISTGSSAK LSEAGMSVIRSVKEERLLNVSSKMLVFHQQREQETKAVAAAAAAAAAGHVTVLVTPSR IKSEPPPPASPSSTSSTQRERERERDRERDRERERERDRDREREREQSISSSQQHLSR VSASPPTQLSHGSLGPNIVQTHHLHQQLTQPLTLRKSSPPTEHLLSQSMQHLTQQQAI HLHHLLGQQQQQQQASHPQQQQQQQHSPHSLVRVKKEPNVGQRHLSPHHQQQSPLLQH HQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALALMHPASLALRNSNRDAAILFRVKSE VHQQVAAGLPHLMQSAGGAAAAAAAAVAAQRMVCFSNARINGVKPEVIGGPLGNLRPV GVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQTPPRGTPTVIMGESCGVRTMVWGY EPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQQQSQQQQQQQQQQSLGQQQHCLSS PSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAPQNNEEAAQLLLSLGQTRIQDMRSRP HPFRTPHALNMERLWAGDYSQLPPGQLQALNLSAQQQQWGSSNSTGLGGVGGGMGGRN LEAPHEPTDEDEQPLVCMICEDKATGLHYGIITCEGCKGFFKRTVQNRRVYTCVADGT CEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRMPGGRNSGAVYNLYKVKYKKHKKTN QKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQQQQLHSPLHHHHHQGHQSHHAQQQ HHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQQQQQQQQAKLMGGVVDMKPMFLGP ALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPHLSLSSPHQQQQQQQGQHQNHHQQQ GGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIVHLRHRLDSAVSSSKDRQISYEHAL GMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEKLCNIGDSIVHKLVSWTKKLPFYLE IPVEIHTKLLTDKWHEILILTTAAYQALHGKRRGEGGGSRHGSPASTPLSTPTGTPLS TPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTTLMGQPIAMEQLKLDVGHMVDKMTQ ITIMFRRIKLKMEEYVCLKVYILLNKAEVELESIQERYVQVLRSYLQNSSPQNPQARL SELLSHIPEIQAAASLLLESKMFYVPFVLNSASIR" misc_feature 3851..4120 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers; Region: NR_DBD_DHR4_like; cd07168" /db_xref="CDD:143542" misc_feature order(3875..3877,3884..3886,3926..3928,3935..3937, 3983..3985,4001..4003,4031..4033,4040..4042) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="zinc binding site [ion binding]; other site" /db_xref="CDD:143542" misc_feature order(3905..3913,3929..3934,3938..3940,3944..3946, 3953..3955,3962..3964,4022..4027,4034..4036,4043..4045, 4076..4078,4085..4087) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:143542" misc_feature 4880..5659 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; Region: NR_LBD_DHR4_like; cd06953" /db_xref="CDD:132751" misc_feature order(4970..4975,4985..4987,5087..5089,5099..5101, 5108..5110,5306..5308,5375..5377) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:132751" misc_feature order(5000..5002,5009..5011,5021..5023,5036..5038, 5051..5056,5060..5065,5072..5077) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative coactivator recognition site [active]" /db_xref="CDD:132751" ORIGIN 1 gtgtatccca cgagctagtc gcgcgcggaa agcaaacgct tcgaaaatca aacgatattt 61 ccgttttgac gtttaacccc cacccaccca aataaagcaa atctaactaa agagtcctgc 121 aaaaaaatca acagctgctt gatcttgaag cctccatatc ttgaaatcct gcatcagcca 181 acagccccaa aacaaaacaa aacaaaacga atgcaaatac actaatgtga acaacaacta 241 aattgctagt gaaatgtttt aagccaaatg ctgtgagtgt gtaacaaaaa aaaaaaaaaa 301 aaaaaaaaaa aaagaagagt gattcaaagc aaccgcaagc aatcaacttg taacggtagt 361 cggatactcg cttgcccgcg gagcatggat atcgccccag ttccgccacc accattatcg 421 atatccgtat cgctttcggc tccaggatca acggtattcg caaacgctgg ccactagaga 481 agcgtcagcc gaatgcctca aagatgacac cgctgcaacg ggaccaattg aaccaccaac 541 aatttgtgca ccactatttg caaagtcaac ctgtcaataa caaaattgac agctttgata 601 ttaaacatat acgtaaaacc caaaacccga ccacaaaccc aaagtttcga actgaagacc 661 gtttcaagac aagcagcaag agcaagatta ccaacccgga gagcggaaat acccaactcc 721 attttcattt gagtgaaacg ccagacttat ccgcctcaac ttcgctgttg ccgtcagcat 781 ttgttgcatc ctccgccgcc ttggtgaatg tgacatgcca ggcggaggaa ggacaaagtt 841 cagcaggatc acactacaca gttcatagag ggaatgacgc aggcatttct tttgcagcgt 901 tggactttcg ttttataagt gagttctaga cttgagtgct tgcatactat gtggcagcca 961 ctggcgcccg cactggccca ctgaaaagga aagagtgcga aaccaggccg aaataaaagt 1021 ttgcgagcaa acaacagcag cccccaagac gtcaggcaaa cgacaacaac aacaacaacc 1081 agctatgcct ggcccggctt tgtggtccgg aattatgaca ctgagccgtg gcccgtacag 1141 cgagctcgat aaaatgagcc tttttcaaga cctcaaactc aaacggcgca aaatcgattc 1201 gcgatgcagc agtgacggcg agtccatagc ggacacgtcc acctcgtcgc cggacctgct 1261 ggcgcccatg tcgccgaagc tctgcgacag cggctcggcg ggggcgtcgc tgggggcatc 1321 gctgcccctg ccgctggccc tgcccctgcc aatggccctg ccactgccca tgtcgctgcc 1381 cctgcccctc acggcggcat cttcggcggt caccgtttcg ctggcagcgg tcgtggccgc 1441 ggtggccgag acgggtggcg cgggcgcggg aggagctggg acagcagtaa cagcgtcggg 1501 agcaggacca tgcgtctcca cgtcgtctac gacggcagcg gcagccacat cctcgacctc 1561 ctcgctctcg tcctcctcct cttcgtcatc ctccacgtcc tccagcactt cctccgcctc 1621 gccgacagct ggagcctcct ccacggccac ctgccccgcc agcagcagca gcagcagtgg 1681 aaacggaagt gggggcaaaa gtggtagcat caagcaggag cacacggaga tacactcgtc 1741 gagcagtgcg atttcggcgg ccgccgcctc aacggtgatg tcaccgccgc ccgctgaggc 1801 gacgagatcc agtccagcca cgcccgaggg aggcggacca gctggcgacg gaagtggagc 1861 aacgggaggc ggaaacacga gcggcggatc aacggctgga gtggccatta atgaacacca 1921 aaacaatggc aatggcagcg gcgggagcag tcgagcctct cccgattcgc tggaagagaa 1981 gccctctacc acaacgacca caggtcgtcc aacgctcacg cccacgaatg gggtgctgtc 2041 ctccgcctcg gcgggcacgg ggatttccac aggaagcagc gccaagctga gcgaggctgg 2101 tatgagtgtg atacggtccg tgaaggagga gcgcttgctc aacgtatcca gcaagatgct 2161 ggtgttccat cagcagcggg agcaagagac caaagcagtg gcggctgcag cagcagcagc 2221 agcggcgggc catgtgacgg ttctagtgac gccatcgcgc atcaaatcgg agccaccgcc 2281 gccggcttca ccctcctcta catccagcac acaaagggaa agggaacggg aacgcgatcg 2341 agagagggat cgcgaaaggg aacgcgagcg ggaccgggac cgggaacggg aacgggaaca 2401 gtccatcagc tcctcgcagc agcacctaag tcgggtctcc gccagtccac ccactcagct 2461 gtcccacggc agcctgggac ccaacattgt gcagacgcac catcttcacc agcaactcac 2521 acagccgctg acgctgcgca agagcagccc gcccacagag cacctgctca gtcagtccat 2581 gcaacatctc acacagcagc aggcgatcca cctgcatcac ctacttggcc agcagcagca 2641 gcagcagcag gcgtcgcatc cccagcagca acagcagcag caacactcgc cccactccct 2701 ggtgcgggtg aaaaaggaac cgaatgttgg tcagcggcac ttatcgccgc atcaccaaca 2761 acagtcgcca ctcctgcagc accaccaaca gcagcagcag cagcaacaac aacagcaaca 2821 gcatctgcat cagcaacagc aacagcagca gcatcaccag cagcagcccc aggcactggc 2881 cctgatgcat ccggcttccc tggcgctaag gaacagcaat cgggatgcgg ccattctgtt 2941 tcgggtgaag agcgaagtgc accagcaggt ggccgccggg ctgccgcatc tgatgcagtc 3001 cgctggtggg gcagcggccg ccgccgcagc agctgtggcc gctcagcgaa tggtatgctt 3061 cagcaatgcc aggatcaatg gcgttaagcc ggaggtgatt ggaggaccgc tgggcaacct 3121 gcggcccgtg ggcgtcggtg gcggaaacgg aagtggctcc gtgcagtgcc cctcgccgca 3181 tccatcctcc tcgtcgtcat cctcgcagct gtcgccgcag acgccctccc agacgccgcc 3241 ccgaggcacg cccaccgtca taatgggcga gagctgcggg gtgcgcacca tggtctgggg 3301 ctacgagcct ccgccaccct cggcgggcca gtcccacggc cagcacccgc aacagcaaca 3361 gcagtcgccc caccaccagc cgcaacaaca acagcagcag caacaacagc agtcgcagca 3421 gcaacagcaa cagcagcagc aacagtcgct gggccagcag cagcactgcc tctcctcgcc 3481 gtcggcggga tcgctgacgc cctcctcttc gtccggcggt ggttcggtat ctggcggcgg 3541 agtgggcgga ccactcacac cctcctcggt ggcgccgcag aataacgagg aggccgccca 3601 actcctgctc tccctgggac agacacgcat ccaggacatg agatcacggc cacacccctt 3661 ccgcacaccg cacgccctta atatggagcg gctgtgggcg ggagactact cgcaattgcc 3721 gcccggccag ctgcaggctc tgaatctcag tgcccaacag cagcagtggg gcagcagcaa 3781 ctccacgggt cttggtggcg taggcggcgg catgggcgga cgcaacctgg aggcgccgca 3841 cgagccgacc gacgaggacg aacagccgct cgtttgcatg atctgcgagg acaaggccac 3901 cggcctgcac tacggcatca tcacctgcga ggggtgcaag ggcttcttca agcggacggt 3961 gcagaaccga cgagtctaca cctgcgtggc ggacggcacc tgcgagataa ccaaagcaca 4021 gcgcaaccgt tgtcagtatt gtcgatttaa gaagtgcatc gagcagggca tggtgctgca 4081 agccgttcgc gaggatcgca tgccgggcgg tcgcaacagt ggcgccgtct acaatttgta 4141 caaggtgaag tacaagaagc acaagaagac caatcagaag cagcagcagc aggccgccca 4201 gcagcagcag cagcaggcgg cggcgcagca gcagcaccag caacagcagc agcatcaaca 4261 gcaccagcaa catcagcaac agcagttgca ctcgccgctc caccatcacc accaccaggg 4321 ccaccagtcg caccacgcgc agcagcagca ccacccacag ctgtcgccgc accacctgct 4381 gtcgccgcag cagcagcaac ttgccgccgc ggtggcagca gctgcgcagc accaacagca 4441 acagcaacaa cagcagcaac agcagcagca ggccaagctg atgggcggcg tggtggacat 4501 gaagcccatg ttcctcggcc ccgctttgaa gccggagttg ctgcaagcac cccccatgca 4561 cagtccggcc cagcaacaac aacagcagca gcagcagcag cagcaacagc aggcctcgcc 4621 gcatctctcg cttagctcac cgcaccagca gcagcagcag cagcagggac agcaccaaaa 4681 ccaccaccag caacaaggtg ggggtggcgg aggagctggt ggaggagctc aactgccgcc 4741 gcacctggtg aacggaacga tactgaagac ggccctaacc aatcccagcg agattgtaca 4801 tctgcgccac cgcctcgact cggcggtcag ttcgtccaag gaccgacaga tctcgtacga 4861 gcacgcctta ggcatgatcc agacactgat cgactgcgac gcgatggagg acatagccac 4921 actgccgcac ttcagcgagt tccttgagga caagtcggag attagcgaga aactgtgcaa 4981 catcggcgat tccatagtcc acaagctggt gtcgtggaca aaaaagttgc ccttctacct 5041 ggagatcccg gtggagatac ataccaaact actgacggac aagtggcacg agatccttat 5101 cctgaccacg gccgcctacc aggcgttgca tggcaagcgg cgtggcgagg gaggaggcag 5161 caggcatggt tcgccggcgt caacgccact gagcacgccc actggtacgc cgttgagcac 5221 accgataccc tcgcccgccc agccactgca caaggacgac ccggagtttg tcagcgaggt 5281 gaactcgcac ctgagcacac tgcaaacctg cttgaccacg ctaatgggcc agccgatagc 5341 gatggagcag ctgaagctgg acgtcgggca catggtggac aagatgaccc agatcaccat 5401 catgttccgg cgaatcaagc tcaagatgga ggagtacgtc tgcctgaagg tttacatact 5461 gctaaacaaa gcagaagtgg aactggagag catccaggag cggtacgtcc aggtgctgcg 5521 ctcctacctg caaaactcct cgccgcagaa tccgcaggcg aggctcagtg aactgctctc 5581 ccacatacca gagatccagg ctgcggctag cctgctgctc gagagcaaga tgttctatgt 5641 gcccttcgtg ctcaactcgg cgagcataag gtagcagatg cttgagcacg gactgctgcc 5701 caccgccaac catcagtcgg cgccaccacc tggtcctgat acgatcccgg agcggcagca 5761 gcaacagcaa caggagcggc gtcgaagcag gcagcagcag caccagttgc tgcgcaacct 5821 gcccaagatc aagatcgaga tcggttccca gcgcgatccg gaggaagagg agtcggagca 5881 agagctagag caggagccgg agcaagagca ggatgtgcag tcccgaccct cagccgcatc 5941 cacgtccatt ttgaagactt cactgctgag cggagcggcg gcgacgttgg ccaccttgac 6001 ggcggcagcc gagcaaatag cccgctcctc ggccagctgc gacactgcca gggattattc 6061 ccaaagcagc aacagcagca gcaatagcaa cgctgccaca ggagcaacag gaactatggc 6121 cagcggcagg acaggcagca gcaacagttt agaagagagc aaaagacttg agcatcaaca 6181 acaacaacaa caacagcagc aacaaccaca acagcatcag cagcaacaat atacatcaat 6241 actacacacg gccttaatgt cacagcgttc catgccacca gcgacatcag ctacatcagc 6301 agcagcggcg gtcacatcga cgccgacaac ggcagcaaca acatcgccta cgcctgcgca 6361 tgtgctgaaa acagcggtga ccttagccag tctaagtgag atagccacag cacgtcagca 6421 gcagcaggag cagcagcagc aacagcagca gcagcagcag cagcaacaat tgctggcgat 6481 gcaacagcaa cagcaacagc taacgaaact gcccagaagg ataatcaact ttggcagcaa 6541 tcacactgcc aacactgcca ccaaagcatt gggagcggga tcagaagcag gagcaggagc 6601 aggagtgggc atggccacag caacggcaac agcaacagtt ggacgcaatc gccaactggg 6661 cctgagtcag ggtcaagtgg tgaatggtaa gcagaaagaa ttgtgagcct tgtgtttgcg 6721 ataacgtttg tgtacccctc gttaacgctg ccagtcagga cagcacgcct gctcaatggc 6781 aactgttgcg gccgattgca ggcgacagca ggaacagggg ccagcagggg caccaacact 6841 gccggcagca acacggtcaa catgcagacc cagaccgacg atgagttgct gccgctgtta 6901 gccatgctcc cacaagacgc tcccacaaca acaggagcag cagcaggagc agcagtatca 6961 ttatcattat tagccacagc cacagccaca accacatctt catcatcatc atcatcatca 7021 tcattatcat catcatcgac gatttcatta gcaacacgtg cagcagcagt aatgcagcag 7081 cagcaacaat ggactgccgt gtcgacgacg ccagcaacag gagtgatgat gacgacgacg 7141 acgacacaat cacaatcaca agcaacatta gcaccacaac aacagcaact atcactgcca 7201 caacaaaagc aacaatttaa tacgagaata aacagaaaaa caacaattac aacagccacc 7261 acaacagcac caacagcaac aacagcaaca acaacaacaa cacgaaacag caacatcaac 7321 ttcaacagca acaataacta tatgaataac aataatataa acgccgccac tgccagagcc 7381 tctgccttcg cctccgcctc tgccatggcc acggccacgc ccacaggcac acccactgcc 7441 acgggcccgc gccagagacc ggccccgcaa ccgcccccgc ccccgcgcac gcccacagcc 7501 acctcagctt ctgttactgt agttgtgttc aaaacaatgt tacctgatga ctgaattatt 7561 ttagaatcgt acacatagag catgttttat tatgattacc actatgatta ccacttacga 7621 tttacgatta cgattatgat tacgattatg agtatgtctg gatatcatta cctattaact 7681 attcattagt tatggattat cgattattac tatttttact attactattg ctacatgcat 7741 aatgtagagc ctaattgatc tatcgtgtat tttagtttgt ctaattgttg gatccctgta 7801 ctatatccca cacacataca cacactctca cccatatttg atcctcaccc ccaaacaatc 7861 cataagcaca cactcataca cacacacaca cacacacaca cattgccgtt actaaggaag 7921 ggtatgcgca tatgcgaagt tgaaacattt taatcatgta tttttttttt ttgtgttttt 7981 gctgaacgga gatgaaagtt aaggaggtcg agcaacagca attagaagtg ttaattgagt 8041 aggattatga gtacgtagcg agtatgtaac gagtatgtaa tgactaagta aagtttacgt 8101 agacacaatg ccacacacag ctatagcaag catttaggat gcgtgcatat gtcagttatc 8161 tatttttttt ttttaaacta aaatctatat aaagtaacga gagaggaagg aagagcgaag 8221 cagggcggga gattcaacca cataaagtat aaatagtaga gcttgagcca agtagctagt 8281 ttagtgtaca tccgttttgg ggcagggaag tagagcaatt tgttgacgag tcggggtggt 8341 ggggtgagcg gtaacgaaga tcggtaacgg aagtggagac aaagcggaac cggaaacggg 8401 agctggactg ccagatcgga atcacacatc aaccattatg agaacttcgc tcgcaactct 8461 tgcagaatta tactgttaga tcctgttagt tatccaaccc aaaactccca acccacacac 8521 actataccta agttaagaac gcataatcac atactacaca taaattacgc atagtacata 8581 caaaaaagat gaagag