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LOCUS NM_001272229 9374 bp mRNA linear INV 26-DEC-2023 (Hr4), mRNA. ACCESSION NM_001272229 VERSION NM_001272229.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 9374) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 9374) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 9374) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 9374) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 9374) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 9374) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 9374) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 9374) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 9374) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 9374) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 9374) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 9374) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 9374) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 9374) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 9374) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 9374) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 9374) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 9374) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 9374) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 9374) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 9374) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 9374) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 9374) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..9374 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..9374 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /exception="dicistronic gene" /note="Hormone receptor 4" /map="2B16-2C1" /db_xref="FLYBASE:FBgn0264562" /db_xref="GeneID:31162" CDS 924..6452 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="CG43934 gene product from transcript CG43934-RE; CG43934-PE; Hr4-PE" /codon_start=1 /product="hormone receptor 4, isoform E" /protein_id="NP_001259158.1" /db_xref="FLYBASE:FBpp0305531" /db_xref="GeneID:31162" /db_xref="FLYBASE:FBgn0264562" /translation="MNAQQPLILEPGSKASSVVAAAAELEAATTTAALATSSATEASA ADSYPAVQQNGGHEEQRLNGNHGCRREQPDDRTDQPEQLDQQDEPEPVKDVANKLTII KTPLNKTLLKKCNSNGSLQMPHANNGSSININNRNNTNNTNNNNSNNNNNAASNDVCD SGLQSGNSNEQEPFANNDRHHHIYHHHHHHYHHHHGGDKSEASGDVASSSSADPNSQV KDEPTAQDSQDNQAAGAAEAGGATAVAATCSPSKCNKCNSHNNNSNCNNNNNTISNNN NNTSSNTNTNSNSNNNANNNNNNNNNNHYNNYNNYYKKKSRMPPICRIMTLSRGPYSE LDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTSSPDLLAPMSPKLCDSGSAGASLGA SLPLPLALPLPMALPLPMSLPLPLTAASSAVTVSLAAVVAAVAETGGAGAGGAGTAVT ASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSSTSSSTSSASPTAGASSTATCPASS SSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAASTVMSPPPAEATRSSPATPEGGGP AGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSGGSSRASPDSLEEKPSTTTTTGRPT LTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIRSVKEERLLNVSSKMLVFHQQREQE TKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRERE RERDRDREREREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQLTQPLTL RKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQQQQQASHPQQQQQQQHSPHSLVRV KKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALAL MHPASLALRNSNRDAAILFRVKSEVHQQVAAGLPHLMQSAGGAAAAAAAAVAAQRMVC FSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPSQ TPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQQ QQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAPQ NNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLSA QQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIITC EGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDRM PGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQHQ QQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQQ QQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASPH LSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEIV HLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISEK LCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRRG EGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLTT LMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKEVELESIQ ERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASIR " misc_feature 4632..4901 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers; Region: NR_DBD_DHR4_like; cd07168" /db_xref="CDD:143542" misc_feature order(4656..4658,4665..4667,4707..4709,4716..4718, 4764..4766,4782..4784,4812..4814,4821..4823) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="zinc binding site [ion binding]; other site" /db_xref="CDD:143542" misc_feature order(4686..4694,4710..4715,4719..4721,4725..4727, 4734..4736,4743..4745,4803..4808,4815..4817,4824..4826, 4857..4859,4866..4868) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:143542" misc_feature 5661..6437 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; Region: NR_LBD_DHR4_like; cd06953" /db_xref="CDD:132751" misc_feature order(5751..5756,5766..5768,5868..5870,5880..5882, 5889..5891,6087..6089,6156..6158) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:132751" misc_feature order(5781..5783,5790..5792,5802..5804,5817..5819, 5832..5837,5841..5846,5853..5858) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative coactivator recognition site [active]" /db_xref="CDD:132751" ORIGIN 1 tttcacttta tttcgttcgc atgcacgcac gttggccgcg gagcaacatc tccagcaaac 61 agaaatcgaa acctaaacag aaacagaaac agaagcaaaa aataaaacat aaaaaaaaaa 121 caaaaaaaaa taaaaaacaa aacgaaacta caaatacaaa taacaaaaaa caaataacac 181 ggcagcagcc gtcgctgaga cgcgaaactt ggctcgaact ttagtttagt ttttctcagt 241 ttcagtggcc agtggctaaa gtgcggcgat atcgggcgaa acggttaacg gctcacggct 301 catggctaac ggttgacagc cagcggttca tcacgcgcca aatccttttt tttcaagttt 361 gtcaatgttt ttagtggtac taaagaaaac acatcattat atgtaaacta taggcaagaa 421 tctaaagcca agagtggtat gtgcccttag ttttgaccca agacctacaa gtccctagaa 481 gacccctgac agccagaacc acccacccac acaccacgca taaacacacg cacacacaca 541 aacacactca ttcgccaccc acccacacag tctcatatct cagtctcagt ctcagtttca 601 atctcagttc caatctcagt tccaatccaa tctcaatctc atttcgagga tcaaaaacgg 661 agcagcaaca tcaatcgatt cattatgttt acatattttt ttcgagtgat ttaagttttg 721 gcaatggacg cagacttctt ctccatctaa tcgaaccgag tgacttcgca tcatgctgta 781 gaagaagaag ttgactaaca aatggttgtt gtgatcgaaa gtgtcttttg agatgtgttt 841 aaaactcggt gtttgcccag ccaaaatggc ccagcatcgt tcgcttgtcc gtctctacct 901 gcccacctag aagagctgcc cagatgaatg cccagcagcc gctgatcctg gagcctggat 961 ccaaggccag cagtgttgtt gcggcagctg ccgagctaga ggcagcaaca accacggcag 1021 cgctggccac gtcctccgcc acggaggctt ctgcagcgga cagctatcct gccgtacagc 1081 agaacggcgg ccacgaggag cagcggctca atggcaacca cggatgtcgc cgcgagcagc 1141 cggatgatcg gacggaccag ccggagcagt tggatcagca ggatgagccc gagccagtca 1201 aggacgtggc caacaagctg accattatca agacgccgtt gaacaagact ctgctgaaga 1261 agtgcaacag caacgggagc ctgcagatgc cgcacgccaa caatggcagc agcatcaaca 1321 tcaataatcg caacaacaca aacaacacca acaacaacaa tagcaacaat aacaacaatg 1381 cggccagcaa cgacgtctgc gattccggtt tgcaaagcgg aaatagcaat gaacaagaac 1441 catttgccaa caacgatcgc catcaccaca tctaccacca ccaccaccat cactatcatc 1501 atcaccatgg cggcgataag agcgaggcga gcggcgacgt tgcatcctcg tcctccgcgg 1561 accccaactc gcaggtcaag gacgagccca cagcgcagga tagccaggac aatcaagcgg 1621 ccggagctgc agaggctgga ggagctactg cggttgcagc cacgtgcagc cccagcaagt 1681 gcaacaagtg caactcgcac aataacaaca gcaactgcaa caataacaat aataccatca 1741 gcaacaacaa caataataca agcagtaata ccaatacgaa cagcaacagc aacaacaatg 1801 ccaacaacaa taataataat aacaataata accattacaa caactacaat aactattata 1861 agaaaaagtc tcgtatgccg cccatttgcc gaattatgac actgagccgt ggcccgtaca 1921 gcgagctcga taaaatgagc ctttttcaag acctcaaact caaacggcgc aaaatcgatt 1981 cgcgatgcag cagtgacggc gagtccatag cggacacgtc cacctcgtcg ccggacctgc 2041 tggcgcccat gtcgccgaag ctctgcgaca gcggctcggc gggggcgtcg ctgggggcat 2101 cgctgcccct gccgctggcc ctgcccctgc caatggccct gccactgccc atgtcgctgc 2161 ccctgcccct cacggcggca tcttcggcgg tcaccgtttc gctggcagcg gtcgtggccg 2221 cggtggccga gacgggtggc gcgggcgcgg gaggagctgg gacagcagta acagcgtcgg 2281 gagcaggacc atgcgtctcc acgtcgtcta cgacggcagc ggcagccaca tcctcgacct 2341 cctcgctctc gtcctcctcc tcttcgtcat cctccacgtc ctccagcact tcctccgcct 2401 cgccgacagc tggagcctcc tccacggcca cctgccccgc cagcagcagc agcagcagtg 2461 gaaacggaag tgggggcaaa agtggtagca tcaagcagga gcacacggag atacactcgt 2521 cgagcagtgc gatttcggcg gccgccgcct caacggtgat gtcaccgccg cccgctgagg 2581 cgacgagatc cagtccagcc acgcccgagg gaggcggacc agctggcgac ggaagtggag 2641 caacgggagg cggaaacacg agcggcggat caacggctgg agtggccatt aatgaacacc 2701 aaaacaatgg caatggcagc ggcgggagca gtcgagcctc tcccgattcg ctggaagaga 2761 agccctctac cacaacgacc acaggtcgtc caacgctcac gcccacgaat ggggtgctgt 2821 cctccgcctc ggcgggcacg gggatttcca caggaagcag cgccaagctg agcgaggctg 2881 gtatgagtgt gatacggtcc gtgaaggagg agcgcttgct caacgtatcc agcaagatgc 2941 tggtgttcca tcagcagcgg gagcaagaga ccaaagcagt ggcggctgca gcagcagcag 3001 cagcggcggg ccatgtgacg gttctagtga cgccatcgcg catcaaatcg gagccaccgc 3061 cgccggcttc accctcctct acatccagca cacaaaggga aagggaacgg gaacgcgatc 3121 gagagaggga tcgcgaaagg gaacgcgagc gggaccggga ccgggaacgg gaacgggaac 3181 agtccatcag ctcctcgcag cagcacctaa gtcgggtctc cgccagtcca cccactcagc 3241 tgtcccacgg cagcctggga cccaacattg tgcagacgca ccatcttcac cagcaactca 3301 cacagccgct gacgctgcgc aagagcagcc cgcccacaga gcacctgctc agtcagtcca 3361 tgcaacatct cacacagcag caggcgatcc acctgcatca cctacttggc cagcagcagc 3421 agcagcagca ggcgtcgcat ccccagcagc aacagcagca gcaacactcg ccccactccc 3481 tggtgcgggt gaaaaaggaa ccgaatgttg gtcagcggca cttatcgccg catcaccaac 3541 aacagtcgcc actcctgcag caccaccaac agcagcagca gcagcaacaa caacagcaac 3601 agcatctgca tcagcaacag caacagcagc agcatcacca gcagcagccc caggcactgg 3661 ccctgatgca tccggcttcc ctggcgctaa ggaacagcaa tcgggatgcg gccattctgt 3721 ttcgggtgaa gagcgaagtg caccagcagg tggccgccgg gctgccgcat ctgatgcagt 3781 ccgctggtgg ggcagcggcc gccgccgcag cagctgtggc cgctcagcga atggtatgct 3841 tcagcaatgc caggatcaat ggcgttaagc cggaggtgat tggaggaccg ctgggcaacc 3901 tgcggcccgt gggcgtcggt ggcggaaacg gaagtggctc cgtgcagtgc ccctcgccgc 3961 atccatcctc ctcgtcgtca tcctcgcagc tgtcgccgca gacgccctcc cagacgccgc 4021 cccgaggcac gcccaccgtc ataatgggcg agagctgcgg ggtgcgcacc atggtctggg 4081 gctacgagcc tccgccaccc tcggcgggcc agtcccacgg ccagcacccg caacagcaac 4141 agcagtcgcc ccaccaccag ccgcaacaac aacagcagca gcaacaacag cagtcgcagc 4201 agcaacagca acagcagcag caacagtcgc tgggccagca gcagcactgc ctctcctcgc 4261 cgtcggcggg atcgctgacg ccctcctctt cgtccggcgg tggttcggta tctggcggcg 4321 gagtgggcgg accactcaca ccctcctcgg tggcgccgca gaataacgag gaggccgccc 4381 aactcctgct ctccctggga cagacacgca tccaggacat gagatcacgg ccacacccct 4441 tccgcacacc gcacgccctt aatatggagc ggctgtgggc gggagactac tcgcaattgc 4501 cgcccggcca gctgcaggct ctgaatctca gtgcccaaca gcagcagtgg ggcagcagca 4561 actccacggg tcttggtggc gtaggcggcg gcatgggcgg acgcaacctg gaggcgccgc 4621 acgagccgac cgacgaggac gaacagccgc tcgtttgcat gatctgcgag gacaaggcca 4681 ccggcctgca ctacggcatc atcacctgcg aggggtgcaa gggcttcttc aagcggacgg 4741 tgcagaaccg acgagtctac acctgcgtgg cggacggcac ctgcgagata accaaagcac 4801 agcgcaaccg ttgtcagtat tgtcgattta agaagtgcat cgagcagggc atggtgctgc 4861 aagccgttcg cgaggatcgc atgccgggcg gtcgcaacag tggcgccgtc tacaatttgt 4921 acaaggtgaa gtacaagaag cacaagaaga ccaatcagaa gcagcagcag caggccgccc 4981 agcagcagca gcagcaggcg gcggcgcagc agcagcacca gcaacagcag cagcatcaac 5041 agcaccagca acatcagcaa cagcagttgc actcgccgct ccaccatcac caccaccagg 5101 gccaccagtc gcaccacgcg cagcagcagc accacccaca gctgtcgccg caccacctgc 5161 tgtcgccgca gcagcagcaa cttgccgccg cggtggcagc agctgcgcag caccaacagc 5221 aacagcaaca acagcagcaa cagcagcagc aggccaagct gatgggcggc gtggtggaca 5281 tgaagcccat gttcctcggc cccgctttga agccggagtt gctgcaagca ccccccatgc 5341 acagtccggc ccagcaacaa caacagcagc agcagcagca gcagcaacag caggcctcgc 5401 cgcatctctc gcttagctca ccgcaccagc agcagcagca gcagcaggga cagcaccaaa 5461 accaccacca gcaacaaggt gggggtggcg gaggagctgg tggaggagct caactgccgc 5521 cgcacctggt gaacggaacg atactgaaga cggccctaac caatcccagc gagattgtac 5581 atctgcgcca ccgcctcgac tcggcggtca gttcgtccaa ggaccgacag atctcgtacg 5641 agcacgcctt aggcatgatc cagacactga tcgactgcga cgcgatggag gacatagcca 5701 cactgccgca cttcagcgag ttccttgagg acaagtcgga gattagcgag aaactgtgca 5761 acatcggcga ttccatagtc cacaagctgg tgtcgtggac aaaaaagttg cccttctacc 5821 tggagatccc ggtggagata cataccaaac tactgacgga caagtggcac gagatcctta 5881 tcctgaccac ggccgcctac caggcgttgc atggcaagcg gcgtggcgag ggaggaggca 5941 gcaggcatgg ttcgccggcg tcaacgccac tgagcacgcc cactggtacg ccgttgagca 6001 caccgatacc ctcgcccgcc cagccactgc acaaggacga cccggagttt gtcagcgagg 6061 tgaactcgca cctgagcaca ctgcaaacct gcttgaccac gctaatgggc cagccgatag 6121 cgatggagca gctgaagctg gacgtcgggc acatggtgga caagatgacc cagatcacca 6181 tcatgttccg gcgaatcaag ctcaagatgg aggagtacgt ctgcctgaag gtttacatac 6241 tgctaaacaa agaagtggaa ctggagagca tccaggagcg gtacgtccag gtgctgcgct 6301 cctacctgca aaactcctcg ccgcagaatc cgcaggcgag gctcagtgaa ctgctctccc 6361 acataccaga gatccaggct gcggctagcc tgctgctcga gagcaagatg ttctatgtgc 6421 ccttcgtgct caactcggcg agcataaggt agcagatgct tgagcacgga ctgctgccca 6481 ccgccaacca tcagtcggcg ccaccacctg gtcctgatac gatcccggag cggcagcagc 6541 aacagcaaca ggagcggcgt cgaagcaggc agcagcagca ccagttgctg cgcaacctgc 6601 ccaagatcaa gatcgagatc ggttcccagc gcgatccgga ggaagaggag tcggagcaag 6661 agctagagca ggagccggag caagagcagg atgtgcagtc ccgaccctca gccgcatcca 6721 cgtccatttt gaagacttca ctgctgagcg gagcggcggc gacgttggcc accttgacgg 6781 cggcagccga gcaaatagcc cgctcctcgg ccagctgcga cactgccagg gattattccc 6841 aaagcagcaa cagcagcagc aatagcaacg ctgccacagg agcaacagga actatggcca 6901 gcggcaggac aggcagcagc aacagtttag aagagagcaa aagacttgag catcaacaac 6961 aacaacaaca acagcagcaa caaccacaac agcatcagca gcaacaatat acatcaatac 7021 tacacacggc cttaatgtca cagcgttcca tgccaccagc gacatcagct acatcagcag 7081 cagcggcggt cacatcgacg ccgacaacgg cagcaacaac atcgcctacg cctgcgcatg 7141 tgctgaaaac agcggtgacc ttagccagtc taagtgagat agccacagca cgtcagcagc 7201 agcaggagca gcagcagcaa cagcagcagc agcagcagca gcaacaattg ctggcgatgc 7261 aacagcaaca gcaacagcta acgaaactgc ccagaaggat aatcaacttt ggcagcaatc 7321 acactgccaa cactgccacc aaagcattgg gagcgggatc agaagcagga gcaggagcag 7381 gagtgggcat ggccacagca acggcaacag caacagttgg acgcaatcgc caactgggcc 7441 tgagtcaggg tcaagtggtg aatggtaagc agaaagaatt gtgagccttg tgtttgcgat 7501 aacgtttgtg tacccctcgt taacgctgcc agtcaggaca gcacgcctgc tcaatggcaa 7561 ctgttgcggc cgattgcagg cgacagcagg aacaggggcc agcaggggca ccaacactgc 7621 cggcagcaac acggtcaaca tgcagaccca gaccgacgat gagttgctgc cgctgttagc 7681 catgctccca caagacgctc ccacaacaac aggagcagca gcaggagcag cagtatcatt 7741 atcattatta gccacagcca cagccacaac cacatcttca tcatcatcat catcatcatc 7801 attatcatca tcatcgacga tttcattagc aacacgtgca gcagcagtaa tgcagcagca 7861 gcaacaatgg actgccgtgt cgacgacgcc agcaacagga gtgatgatga cgacgacgac 7921 gacacaatca caatcacaag caacattagc accacaacaa cagcaactat cactgccaca 7981 acaaaagcaa caatttaata cgagaataaa cagaaaaaca acaattacaa cagccaccac 8041 aacagcacca acagcaacaa cagcaacaac aacaacaaca cgaaacagca acatcaactt 8101 caacagcaac aataactata tgaataacaa taatataaac gccgccactg ccagagcctc 8161 tgccttcgcc tccgcctctg ccatggccac ggccacgccc acaggcacac ccactgccac 8221 gggcccgcgc cagagaccgg ccccgcaacc gcccccgccc ccgcgcacgc ccacagccac 8281 ctcagcttct gttactgtag ttgtgttcaa aacaatgtta cctgatgact gaattatttt 8341 agaatcgtac acatagagca tgttttatta tgattaccac tatgattacc acttacgatt 8401 tacgattacg attatgatta cgattatgag tatgtctgga tatcattacc tattaactat 8461 tcattagtta tggattatcg attattacta tttttactat tactattgct acatgcataa 8521 tgtagagcct aattgatcta tcgtgtattt tagtttgtct aattgttgga tccctgtact 8581 atatcccaca cacatacaca cactctcacc catatttgat cctcaccccc aaacaatcca 8641 taagcacaca ctcatacaca cacacacaca cacacacaca ttgccgttac taaggaaggg 8701 tatgcgcata tgcgaagttg aaacatttta atcatgtatt tttttttttt gtgtttttgc 8761 tgaacggaga tgaaagttaa ggaggtcgag caacagcaat tagaagtgtt aattgagtag 8821 gattatgagt acgtagcgag tatgtaacga gtatgtaatg actaagtaaa gtttacgtag 8881 acacaatgcc acacacagct atagcaagca tttaggatgc gtgcatatgt cagttatcta 8941 tttttttttt ttaaactaaa atctatataa agtaacgaga gaggaaggaa gagcgaagca 9001 gggcgggaga ttcaaccaca taaagtataa atagtagagc ttgagccaag tagctagttt 9061 agtgtacatc cgttttgggg cagggaagta gagcaatttg ttgacgagtc ggggtggtgg 9121 ggtgagcggt aacgaagatc ggtaacggaa gtggagacaa agcggaaccg gaaacgggag 9181 ctggactgcc agatcggaat cacacatcaa ccattatgag aacttcgctc gcaactcttg 9241 cagaattata ctgttagatc ctgttagtta tccaacccaa aactcccaac ccacacacac 9301 tatacctaag ttaagaacgc ataatcacat actacacata aattacgcat agtacataca 9361 aaaaagatga agag