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LOCUS NM_001272228 8417 bp mRNA linear INV 26-DEC-2023 (Hr4), mRNA. ACCESSION NM_001272228 VERSION NM_001272228.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 8417) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 8417) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 8417) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 8417) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 8417) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 8417) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 8417) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 8417) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 8417) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 8417) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 8417) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 8417) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 8417) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 8417) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 8417) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 8417) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 8417) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 8417) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 8417) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 8417) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 8417) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 8417) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 8417) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..8417 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..8417 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /exception="dicistronic gene" /note="Hormone receptor 4" /map="2B16-2C1" /db_xref="FLYBASE:FBgn0264562" /db_xref="GeneID:31162" CDS 660..5495 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="CG43934 gene product from transcript CG43934-RF; CG43934-PF; Hr4-PF" /codon_start=1 /product="hormone receptor 4, isoform F" /protein_id="NP_001259157.1" /db_xref="FLYBASE:FBpp0305530" /db_xref="GeneID:31162" /db_xref="FLYBASE:FBgn0264562" /translation="MLPERVTIIPKIQTNTSTKSKFNEKSRTPHANSKNTHKSKCKLK SKIGKKRKPPTIKTTTTTTIGKQENFLFLSKFEQSAKTRKNEIMTSIGIMTLSRGPYS ELDKMSLFQDLKLKRRKIDSRCSSDGESIADTSTSSPDLLAPMSPKLCDSGSAGASLG ASLPLPLALPLPMALPLPMSLPLPLTAASSAVTVSLAAVVAAVAETGGAGAGGAGTAV TASGAGPCVSTSSTTAAAATSSTSSLSSSSSSSSSTSSSTSSASPTAGASSTATCPAS SSSSSGNGSGGKSGSIKQEHTEIHSSSSAISAAAASTVMSPPPAEATRSSPATPEGGG PAGDGSGATGGGNTSGGSTAGVAINEHQNNGNGSGGSSRASPDSLEEKPSTTTTTGRP TLTPTNGVLSSASAGTGISTGSSAKLSEAGMSVIRSVKEERLLNVSSKMLVFHQQREQ ETKAVAAAAAAAAAGHVTVLVTPSRIKSEPPPPASPSSTSSTQRERERERDRERDRER ERERDRDREREREQSISSSQQHLSRVSASPPTQLSHGSLGPNIVQTHHLHQQLTQPLT LRKSSPPTEHLLSQSMQHLTQQQAIHLHHLLGQQQQQQQASHPQQQQQQQHSPHSLVR VKKEPNVGQRHLSPHHQQQSPLLQHHQQQQQQQQQQQQHLHQQQQQQQHHQQQPQALA LMHPASLALRNSNRDAAILFRVKSEVHQQVAAGLPHLMQSAGGAAAAAAAAVAAQRMV CFSNARINGVKPEVIGGPLGNLRPVGVGGGNGSGSVQCPSPHPSSSSSSSQLSPQTPS QTPPRGTPTVIMGESCGVRTMVWGYEPPPPSAGQSHGQHPQQQQQSPHHQPQQQQQQQ QQQSQQQQQQQQQQSLGQQQHCLSSPSAGSLTPSSSSGGGSVSGGGVGGPLTPSSVAP QNNEEAAQLLLSLGQTRIQDMRSRPHPFRTPHALNMERLWAGDYSQLPPGQLQALNLS AQQQQWGSSNSTGLGGVGGGMGGRNLEAPHEPTDEDEQPLVCMICEDKATGLHYGIIT CEGCKGFFKRTVQNRRVYTCVADGTCEITKAQRNRCQYCRFKKCIEQGMVLQAVREDR MPGGRNSGAVYNLYKVKYKKHKKTNQKQQQQAAQQQQQQAAAQQQHQQQQQHQQHQQH QQQQLHSPLHHHHHQGHQSHHAQQQHHPQLSPHHLLSPQQQQLAAAVAAAAQHQQQQQ QQQQQQQQAKLMGGVVDMKPMFLGPALKPELLQAPPMHSPAQQQQQQQQQQQQQQASP HLSLSSPHQQQQQQQGQHQNHHQQQGGGGGGAGGGAQLPPHLVNGTILKTALTNPSEI VHLRHRLDSAVSSSKDRQISYEHALGMIQTLIDCDAMEDIATLPHFSEFLEDKSEISE KLCNIGDSIVHKLVSWTKKLPFYLEIPVEIHTKLLTDKWHEILILTTAAYQALHGKRR GEGGGSRHGSPASTPLSTPTGTPLSTPIPSPAQPLHKDDPEFVSEVNSHLSTLQTCLT TLMGQPIAMEQLKLDVGHMVDKMTQITIMFRRIKLKMEEYVCLKVYILLNKEVELESI QERYVQVLRSYLQNSSPQNPQARLSELLSHIPEIQAAASLLLESKMFYVPFVLNSASI R" misc_feature 3675..3944 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="DNA-binding domain of ecdysone-induced DHR4 orphan nuclear receptor is composed of two C4-type zinc fingers; Region: NR_DBD_DHR4_like; cd07168" /db_xref="CDD:143542" misc_feature order(3699..3701,3708..3710,3750..3752,3759..3761, 3807..3809,3825..3827,3855..3857,3864..3866) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="zinc binding site [ion binding]; other site" /db_xref="CDD:143542" misc_feature order(3729..3737,3753..3758,3762..3764,3768..3770, 3777..3779,3786..3788,3846..3851,3858..3860,3867..3869, 3900..3902,3909..3911) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative DNA binding site [nucleotide binding]; other site" /db_xref="CDD:143542" misc_feature 4704..5480 /gene="Hr4" /locus_tag="Dmel_CG43934" /old_locus_tag="Dmel_CG16902" /old_locus_tag="Dmel_CG3600" /old_locus_tag="Dmel_CG42527" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="The ligand binding domain of orphan nuclear receptor Ecdysone-induced receptor DHR4; Region: NR_LBD_DHR4_like; cd06953" /db_xref="CDD:132751" misc_feature order(4794..4799,4809..4811,4911..4913,4923..4925, 4932..4934,5130..5132,5199..5201) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative ligand binding site [chemical binding]; other site" /db_xref="CDD:132751" misc_feature order(4824..4826,4833..4835,4845..4847,4860..4862, 4875..4880,4884..4889,4896..4901) /gene="Hr4" /locus_tag="Dmel_CG43934" /gene_synonym="CG16902; CG3600; CG42527; CG43692; CG43934; DHR4; Dmel\CG43934; EG:133E12.2; EG:BACH61I5.1; EP(X)1232; EP1232; GRF; hr4; HR4; NR6A2; null" /note="putative coactivator recognition site [active]" /db_xref="CDD:132751" ORIGIN 1 tttcacttta tttcgttcgc atgcacgcac gttggccgcg gagcaacatc tccagcaaac 61 agaaatcgaa acctaaacag aaacagaaac agaagcaaaa aataaaacat aaaaaaaaaa 121 caaaaaaaaa taaaaaacaa aacgaaacta caaatacaaa taacaaaaaa caaataacac 181 ggcagcagcc gtcgctgaga cgcgaaactt ggctcgaact ttagtttagt ttttctcagt 241 ttcagtggcc agtggctaaa gtgcggcgat atcgggcgaa acggttaacg gctcacggct 301 catggctaac ggttgacagc cagcggttca tcacgcgcca aatccttttt tttcaagttt 361 gtcaatgttt ttagtggtac taaagaaaac acatcattat atgtaaacta taggcaagaa 421 tctaaagcca agagtgaatt gcagtcatcg aaaagcaacc ccaccccagt gcactaaact 481 ggagcaacca acaattggcc aagaaaacaa acaagaacag aactcaccca gaaccaccca 541 accaccaacc accaaccacc acccaccaaa aaccaaaaac cacccactgg aatgcgtact 601 gccactgcca ctctgctctg cagctcaatg ggcagcgggc agggacgaac gcagtctaga 661 tgcttcccga acgagtcaca ataataccaa aaatccaaac aaacacaagt acaaaatcca 721 aattcaatga aaaatcaaga accccacatg caaactcaaa aaacacacac aaaagcaaat 781 gcaaactgaa aagtaaaatc ggcaagaaaa gaaaaccccc aacaataaaa acaacaacaa 841 caacaacgat cggcaagcaa gagaattttt tgtttttatc caaatttgaa caatcggcaa 901 agacaagaaa aaacgaaatt atgacatcca taggaattat gacactgagc cgtggcccgt 961 acagcgagct cgataaaatg agcctttttc aagacctcaa actcaaacgg cgcaaaatcg 1021 attcgcgatg cagcagtgac ggcgagtcca tagcggacac gtccacctcg tcgccggacc 1081 tgctggcgcc catgtcgccg aagctctgcg acagcggctc ggcgggggcg tcgctggggg 1141 catcgctgcc cctgccgctg gccctgcccc tgccaatggc cctgccactg cccatgtcgc 1201 tgcccctgcc cctcacggcg gcatcttcgg cggtcaccgt ttcgctggca gcggtcgtgg 1261 ccgcggtggc cgagacgggt ggcgcgggcg cgggaggagc tgggacagca gtaacagcgt 1321 cgggagcagg accatgcgtc tccacgtcgt ctacgacggc agcggcagcc acatcctcga 1381 cctcctcgct ctcgtcctcc tcctcttcgt catcctccac gtcctccagc acttcctccg 1441 cctcgccgac agctggagcc tcctccacgg ccacctgccc cgccagcagc agcagcagca 1501 gtggaaacgg aagtgggggc aaaagtggta gcatcaagca ggagcacacg gagatacact 1561 cgtcgagcag tgcgatttcg gcggccgccg cctcaacggt gatgtcaccg ccgcccgctg 1621 aggcgacgag atccagtcca gccacgcccg agggaggcgg accagctggc gacggaagtg 1681 gagcaacggg aggcggaaac acgagcggcg gatcaacggc tggagtggcc attaatgaac 1741 accaaaacaa tggcaatggc agcggcggga gcagtcgagc ctctcccgat tcgctggaag 1801 agaagccctc taccacaacg accacaggtc gtccaacgct cacgcccacg aatggggtgc 1861 tgtcctccgc ctcggcgggc acggggattt ccacaggaag cagcgccaag ctgagcgagg 1921 ctggtatgag tgtgatacgg tccgtgaagg aggagcgctt gctcaacgta tccagcaaga 1981 tgctggtgtt ccatcagcag cgggagcaag agaccaaagc agtggcggct gcagcagcag 2041 cagcagcggc gggccatgtg acggttctag tgacgccatc gcgcatcaaa tcggagccac 2101 cgccgccggc ttcaccctcc tctacatcca gcacacaaag ggaaagggaa cgggaacgcg 2161 atcgagagag ggatcgcgaa agggaacgcg agcgggaccg ggaccgggaa cgggaacggg 2221 aacagtccat cagctcctcg cagcagcacc taagtcgggt ctccgccagt ccacccactc 2281 agctgtccca cggcagcctg ggacccaaca ttgtgcagac gcaccatctt caccagcaac 2341 tcacacagcc gctgacgctg cgcaagagca gcccgcccac agagcacctg ctcagtcagt 2401 ccatgcaaca tctcacacag cagcaggcga tccacctgca tcacctactt ggccagcagc 2461 agcagcagca gcaggcgtcg catccccagc agcaacagca gcagcaacac tcgccccact 2521 ccctggtgcg ggtgaaaaag gaaccgaatg ttggtcagcg gcacttatcg ccgcatcacc 2581 aacaacagtc gccactcctg cagcaccacc aacagcagca gcagcagcaa caacaacagc 2641 aacagcatct gcatcagcaa cagcaacagc agcagcatca ccagcagcag ccccaggcac 2701 tggccctgat gcatccggct tccctggcgc taaggaacag caatcgggat gcggccattc 2761 tgtttcgggt gaagagcgaa gtgcaccagc aggtggccgc cgggctgccg catctgatgc 2821 agtccgctgg tggggcagcg gccgccgccg cagcagctgt ggccgctcag cgaatggtat 2881 gcttcagcaa tgccaggatc aatggcgtta agccggaggt gattggagga ccgctgggca 2941 acctgcggcc cgtgggcgtc ggtggcggaa acggaagtgg ctccgtgcag tgcccctcgc 3001 cgcatccatc ctcctcgtcg tcatcctcgc agctgtcgcc gcagacgccc tcccagacgc 3061 cgccccgagg cacgcccacc gtcataatgg gcgagagctg cggggtgcgc accatggtct 3121 ggggctacga gcctccgcca ccctcggcgg gccagtccca cggccagcac ccgcaacagc 3181 aacagcagtc gccccaccac cagccgcaac aacaacagca gcagcaacaa cagcagtcgc 3241 agcagcaaca gcaacagcag cagcaacagt cgctgggcca gcagcagcac tgcctctcct 3301 cgccgtcggc gggatcgctg acgccctcct cttcgtccgg cggtggttcg gtatctggcg 3361 gcggagtggg cggaccactc acaccctcct cggtggcgcc gcagaataac gaggaggccg 3421 cccaactcct gctctccctg ggacagacac gcatccagga catgagatca cggccacacc 3481 ccttccgcac accgcacgcc cttaatatgg agcggctgtg ggcgggagac tactcgcaat 3541 tgccgcccgg ccagctgcag gctctgaatc tcagtgccca acagcagcag tggggcagca 3601 gcaactccac gggtcttggt ggcgtaggcg gcggcatggg cggacgcaac ctggaggcgc 3661 cgcacgagcc gaccgacgag gacgaacagc cgctcgtttg catgatctgc gaggacaagg 3721 ccaccggcct gcactacggc atcatcacct gcgaggggtg caagggcttc ttcaagcgga 3781 cggtgcagaa ccgacgagtc tacacctgcg tggcggacgg cacctgcgag ataaccaaag 3841 cacagcgcaa ccgttgtcag tattgtcgat ttaagaagtg catcgagcag ggcatggtgc 3901 tgcaagccgt tcgcgaggat cgcatgccgg gcggtcgcaa cagtggcgcc gtctacaatt 3961 tgtacaaggt gaagtacaag aagcacaaga agaccaatca gaagcagcag cagcaggccg 4021 cccagcagca gcagcagcag gcggcggcgc agcagcagca ccagcaacag cagcagcatc 4081 aacagcacca gcaacatcag caacagcagt tgcactcgcc gctccaccat caccaccacc 4141 agggccacca gtcgcaccac gcgcagcagc agcaccaccc acagctgtcg ccgcaccacc 4201 tgctgtcgcc gcagcagcag caacttgccg ccgcggtggc agcagctgcg cagcaccaac 4261 agcaacagca acaacagcag caacagcagc agcaggccaa gctgatgggc ggcgtggtgg 4321 acatgaagcc catgttcctc ggccccgctt tgaagccgga gttgctgcaa gcacccccca 4381 tgcacagtcc ggcccagcaa caacaacagc agcagcagca gcagcagcaa cagcaggcct 4441 cgccgcatct ctcgcttagc tcaccgcacc agcagcagca gcagcagcag ggacagcacc 4501 aaaaccacca ccagcaacaa ggtgggggtg gcggaggagc tggtggagga gctcaactgc 4561 cgccgcacct ggtgaacgga acgatactga agacggccct aaccaatccc agcgagattg 4621 tacatctgcg ccaccgcctc gactcggcgg tcagttcgtc caaggaccga cagatctcgt 4681 acgagcacgc cttaggcatg atccagacac tgatcgactg cgacgcgatg gaggacatag 4741 ccacactgcc gcacttcagc gagttccttg aggacaagtc ggagattagc gagaaactgt 4801 gcaacatcgg cgattccata gtccacaagc tggtgtcgtg gacaaaaaag ttgcccttct 4861 acctggagat cccggtggag atacatacca aactactgac ggacaagtgg cacgagatcc 4921 ttatcctgac cacggccgcc taccaggcgt tgcatggcaa gcggcgtggc gagggaggag 4981 gcagcaggca tggttcgccg gcgtcaacgc cactgagcac gcccactggt acgccgttga 5041 gcacaccgat accctcgccc gcccagccac tgcacaagga cgacccggag tttgtcagcg 5101 aggtgaactc gcacctgagc acactgcaaa cctgcttgac cacgctaatg ggccagccga 5161 tagcgatgga gcagctgaag ctggacgtcg ggcacatggt ggacaagatg acccagatca 5221 ccatcatgtt ccggcgaatc aagctcaaga tggaggagta cgtctgcctg aaggtttaca 5281 tactgctaaa caaagaagtg gaactggaga gcatccagga gcggtacgtc caggtgctgc 5341 gctcctacct gcaaaactcc tcgccgcaga atccgcaggc gaggctcagt gaactgctct 5401 cccacatacc agagatccag gctgcggcta gcctgctgct cgagagcaag atgttctatg 5461 tgcccttcgt gctcaactcg gcgagcataa ggtagcagat gcttgagcac ggactgctgc 5521 ccaccgccaa ccatcagtcg gcgccaccac ctggtcctga tacgatcccg gagcggcagc 5581 agcaacagca acaggagcgg cgtcgaagca ggcagcagca gcaccagttg ctgcgcaacc 5641 tgcccaagat caagatcgag atcggttccc agcgcgatcc ggaggaagag gagtcggagc 5701 aagagctaga gcaggagccg gagcaagagc aggatgtgca gtcccgaccc tcagccgcat 5761 ccacgtccat tttgaagact tcactgctga gcggagcggc ggcgacgttg gccaccttga 5821 cggcggcagc cgagcaaata gcccgctcct cggccagctg cgacactgcc agggattatt 5881 cccaaagcag caacagcagc agcaatagca acgctgccac aggagcaaca ggaactatgg 5941 ccagcggcag gacaggcagc agcaacagtt tagaagagag caaaagactt gagcatcaac 6001 aacaacaaca acaacagcag caacaaccac aacagcatca gcagcaacaa tatacatcaa 6061 tactacacac ggccttaatg tcacagcgtt ccatgccacc agcgacatca gctacatcag 6121 cagcagcggc ggtcacatcg acgccgacaa cggcagcaac aacatcgcct acgcctgcgc 6181 atgtgctgaa aacagcggtg accttagcca gtctaagtga gatagccaca gcacgtcagc 6241 agcagcagga gcagcagcag caacagcagc agcagcagca gcagcaacaa ttgctggcga 6301 tgcaacagca acagcaacag ctaacgaaac tgcccagaag gataatcaac tttggcagca 6361 atcacactgc caacactgcc accaaagcat tgggagcggg atcagaagca ggagcaggag 6421 caggagtggg catggccaca gcaacggcaa cagcaacagt tggacgcaat cgccaactgg 6481 gcctgagtca gggtcaagtg gtgaatggta agcagaaaga attgtgagcc ttgtgtttgc 6541 gataacgttt gtgtacccct cgttaacgct gccagtcagg acagcacgcc tgctcaatgg 6601 caactgttgc ggccgattgc aggcgacagc aggaacaggg gccagcaggg gcaccaacac 6661 tgccggcagc aacacggtca acatgcagac ccagaccgac gatgagttgc tgccgctgtt 6721 agccatgctc ccacaagacg ctcccacaac aacaggagca gcagcaggag cagcagtatc 6781 attatcatta ttagccacag ccacagccac aaccacatct tcatcatcat catcatcatc 6841 atcattatca tcatcatcga cgatttcatt agcaacacgt gcagcagcag taatgcagca 6901 gcagcaacaa tggactgccg tgtcgacgac gccagcaaca ggagtgatga tgacgacgac 6961 gacgacacaa tcacaatcac aagcaacatt agcaccacaa caacagcaac tatcactgcc 7021 acaacaaaag caacaattta atacgagaat aaacagaaaa acaacaatta caacagccac 7081 cacaacagca ccaacagcaa caacagcaac aacaacaaca acacgaaaca gcaacatcaa 7141 cttcaacagc aacaataact atatgaataa caataatata aacgccgcca ctgccagagc 7201 ctctgccttc gcctccgcct ctgccatggc cacggccacg cccacaggca cacccactgc 7261 cacgggcccg cgccagagac cggccccgca accgcccccg cccccgcgca cgcccacagc 7321 cacctcagct tctgttactg tagttgtgtt caaaacaatg ttacctgatg actgaattat 7381 tttagaatcg tacacataga gcatgtttta ttatgattac cactatgatt accacttacg 7441 atttacgatt acgattatga ttacgattat gagtatgtct ggatatcatt acctattaac 7501 tattcattag ttatggatta tcgattatta ctatttttac tattactatt gctacatgca 7561 taatgtagag cctaattgat ctatcgtgta ttttagtttg tctaattgtt ggatccctgt 7621 actatatccc acacacatac acacactctc acccatattt gatcctcacc cccaaacaat 7681 ccataagcac acactcatac acacacacac acacacacac acattgccgt tactaaggaa 7741 gggtatgcgc atatgcgaag ttgaaacatt ttaatcatgt attttttttt tttgtgtttt 7801 tgctgaacgg agatgaaagt taaggaggtc gagcaacagc aattagaagt gttaattgag 7861 taggattatg agtacgtagc gagtatgtaa cgagtatgta atgactaagt aaagtttacg 7921 tagacacaat gccacacaca gctatagcaa gcatttagga tgcgtgcata tgtcagttat 7981 ctattttttt tttttaaact aaaatctata taaagtaacg agagaggaag gaagagcgaa 8041 gcagggcggg agattcaacc acataaagta taaatagtag agcttgagcc aagtagctag 8101 tttagtgtac atccgttttg gggcagggaa gtagagcaat ttgttgacga gtcggggtgg 8161 tggggtgagc ggtaacgaag atcggtaacg gaagtggaga caaagcggaa ccggaaacgg 8221 gagctggact gccagatcgg aatcacacat caaccattat gagaacttcg ctcgcaactc 8281 ttgcagaatt atactgttag atcctgttag ttatccaacc caaaactccc aacccacaca 8341 cactatacct aagttaagaa cgcataatca catactacac ataaattacg catagtacat 8401 acaaaaaaga tgaagag