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Drosophila melanogaster ER degradation enhancer, mannosidase


LOCUS       NM_001272223            3883 bp    mRNA    linear   INV 26-DEC-2023
            alpha-like 1 (Edem1), transcript variant E, mRNA.
ACCESSION   NM_001272223
VERSION     NM_001272223.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3883)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3883)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3883)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3883)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3883)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3883)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3883)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3883)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3883)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3883)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3883)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3883)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3883)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3883)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3883)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3883)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3883)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3883)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3883)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3883)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3883)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3883)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3883)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001272223.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3883
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3883
                     /gene="Edem1"
                     /locus_tag="Dmel_CG3810"
                     /gene_synonym="CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1;
                     EDEM1; EG.86E4.2; EG:86E4.2"
                     /note="ER degradation enhancer, mannosidase alpha-like 1"
                     /map="2B15-2B15"
                     /db_xref="FLYBASE:FBgn0023511"
                     /db_xref="GeneID:31154"
     CDS             361..3375
                     /gene="Edem1"
                     /locus_tag="Dmel_CG3810"
                     /gene_synonym="CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1;
                     EDEM1; EG.86E4.2; EG:86E4.2"
                     /EC_number="3.2.1.113"
                     /note="CG3810 gene product from transcript CG3810-RE;
                     CG3810-PE; Edem1-PE"
                     /codon_start=1
                     /product="ER degradation enhancer, mannosidase alpha-like
                     1, isoform E"
                     /protein_id="NP_001259152.1"
                     /db_xref="FLYBASE:FBpp0304832"
                     /db_xref="GeneID:31154"
                     /db_xref="FLYBASE:FBgn0023511"
                     /translation="MQQKPRNNGYPGTLICAVLLVLLSTGVSGQKQYSKARKLELRED
                     VRRMFQHAYDGYLRHASNYDELRPLTCDGHDTWGSYSLTLIDALDTLATMGNFTEFRR
                     AARLLEEKMDFDRDINVSVFETNIRIVGGLLSAHLLSKRAGVELEPGWPCKGPLLRLA
                     EDVARRLLPAFVTNTGMPYGTVNLRYGVPKGETSITCTAGVGTFLIEFGTLSRLTGKT
                     IYEDVAMKAVHALWAYRSPIGLFGNHIDVQSGRWTALDSGIGAGVDSLFEYLVKASVL
                     LNRPELLELFHEARAAIDKYMRKEDWYVWVGMNKGRVTLPVFQSLEAFWPGILSIIGD
                     TEPALRTISRYIGVWKKYGFLPEFYNIAAGEASPNREVYPLRPELIESAMYLYRATGN
                     EYLLEFGEHMLETLEFSAKTKCGYATIRNVVTHEKENRMESFFLAETSKYLYLLFDEE
                     NFLHNDGSGGELLSTEDDVCVVQAGAYIFNTEAHPMDMSALHCCHAHNEDIYTSLDLQ
                     RFSPRAILERSKKRQVAVQEQWVPQCHPENNEFFNKEDESVQAQDSEKEQEREQSGTS
                     TTMAVDIEVFDEFQQPAGDLLVSNFEQIREERELNESLHRNVVARNQLTVSDLDEFFA
                     QRRESFASASEALNYVKTFMGNYTMDVAFIRGLQLYDTNMSSVLGTGAQKEYESRMRT
                     LWQLYELQQQYVANIRVIQGLGLLTFPADGDRIPSHLTEVLDSLDKSAHLEHMDLQDL
                     ETRVSNTSSPQLAHIREVILKARNAYAIAMVNTSAMQEFAIRIYLSGTSEAGVRIHPL
                     LEDGELSEEARKRPLKLAEERALFSYARRIVDFRKRMAETVDRLQTLMQDIPPPKRKE
                     ATTDSQAADASTVYTQTKAQMAAPAQQPEPSQEEKQSTQIQKGKLAENGSGLGEEESG
                     CVWSQLVQTILRKTTVQRVKFDEAVLQENTRKALEKYARKELPHHLFACHRPEYIEGF
                     AYRDFYPEALKVRRRCAHDNERLNCRAKRTER"
     misc_feature    502..1818
                     /gene="Edem1"
                     /locus_tag="Dmel_CG3810"
                     /gene_synonym="CG3810; dEDEM1; DM-pI; Dmel\CG3810; edem1;
                     EDEM1; EG.86E4.2; EG:86E4.2"
                     /note="Glycosyl hydrolase family 47; Region:
                     Glyco_hydro_47; pfam01532"
                     /db_xref="CDD:460241"
ORIGIN      
        1 caccctacgg aatgacatat cctattgcta gggattttgt tgggtaaaat taacgtactt
       61 cagaattggc ggagaataca gtgtttgcta gcctatagtg tttggttgtt accttaaaaa
      121 agctctttgg cttgtgttct ttcccccgtt tgctactcta agcgctctat aaaaaaacac
      181 tcaccgaacg gaattagtag ggcattcggc ggtcgatgcc accgccgaat cagcccttgt
      241 tgtgattttg cgtcaacgta gccgcatttg acttccacac atcccacatc cacgctggct
      301 atggaacact gaccatgccc ataattgaat tagcggccct gattgattga ctgtcccacg
      361 atgcagcaaa aaccccgaaa caacggctat ccgggcaccc tcatctgcgc ggtcctcctc
      421 gtcctgctgt ccaccggtgt cagcggccag aagcagtatt ccaaggcaag aaagttggaa
      481 ctgagggagg atgtgcggcg catgttccag cacgcctacg atggttacct gcgccacgcc
      541 tccaactacg atgaactgcg tccgctgacc tgcgatggcc acgacacctg gggcagctac
      601 tccttgacac tgatcgacgc tctggacacg ctggccacca tgggcaactt cacggaattc
      661 cgccgcgcgg caagactgct cgaggagaag atggattttg acagggacat caacgtgtcc
      721 gtgttcgaga caaacatccg catcgtgggc gggctgctgt ccgcgcatct gctctccaag
      781 cgtgctggcg tagagctaga gccaggatgg ccctgcaagg gacctctgct gcgactggcg
      841 gaggatgtgg cccgacgatt attgccagcc ttcgtcacga acacgggtat gccttatggc
      901 acggtgaacc tgcgctatgg cgtgcccaag ggcgagacct ctataacctg tacggcgggc
      961 gtggggacat tcctcatcga atttggtacc cttagccggt tgaccgggaa aaccatctac
     1021 gaggatgttg ctatgaaggc ggtacatgct ctatgggcat atcgctcgcc cattggactt
     1081 tttggcaatc acatcgacgt gcagagcggt cgttggaccg ccctcgactc tggtatcgga
     1141 gcaggagtgg attccctttt tgaataccta gttaaggcat ctgtcctgct caatcgccca
     1201 gaactcttgg agttattcca tgaggctcgc gcggccattg ataagtacat gcggaaggag
     1261 gactggtacg tgtgggtagg catgaacaaa ggccgcgtca cccttcccgt ctttcagtcc
     1321 ctggaggcgt tttggcccgg catcctgagc attattggcg acacggagcc ggccttgcgc
     1381 accatatcac ggtacattgg ggtctggaag aagtacggct ttctgccaga gttttataac
     1441 attgctgctg gagaggcatc gccgaatcgg gaggtgtacc ccctgcgacc ggagctaatc
     1501 gagtcagcta tgtatctcta tcgagccaca ggaaacgagt atcttctgga gtttggtgag
     1561 cacatgctgg agaccttgga gttcagtgcc aaaaccaaat gcggatatgc aacgattcgc
     1621 aatgttgtca cccacgaaaa ggagaatcgc atggagtcat tcttcctggc ggaaacaagc
     1681 aagtaccttt atctgctgtt tgacgaggaa aacttcctgc acaacgatgg gtccggaggc
     1741 gagctgctgt caaccgagga tgatgtatgc gtggtacagg ccggtgcgta catcttcaac
     1801 acagaggctc atcccatgga catgtcagcc ctccactgtt gccacgccca caacgaggac
     1861 atctacacct ctctggatct acagcggttt agtccacggg cgatattaga gaggagcaaa
     1921 aagcggcagg tagctgttca ggaacagtgg gtgccgcagt gtcacccaga gaacaacgag
     1981 ttctttaata aagaggatga gagtgtgcag gcgcaggact ctgaaaaaga gcaggaacgc
     2041 gagcaatccg gcacaagcac taccatggcc gtagatattg aggtgttcga cgaatttcaa
     2101 cagcccgccg gcgatctgtt agtaagcaac ttcgagcaga tacgcgagga gcgggagcta
     2161 aacgagagcc tgcacagaaa cgtggtggca cgaaaccagt tgacagtcag cgatttggat
     2221 gaattctttg ctcagcgacg ggagagtttc gcaagcgcct ccgaggctct taactatgta
     2281 aagaccttca tgggcaacta taccatggat gtagccttta tacggggctt gcaactgtac
     2341 gatactaata tgagtagtgt attgggcaca ggcgcccaga aagagtatga gtctcgaatg
     2401 aggacccttt ggcagctgta cgaactgcag cagcaatatg tggccaacat ccgagtgatt
     2461 caaggattag gtttgctaac ctttccggcg gacggtgacc ggatacctag ccatttgaca
     2521 gaggtgttgg acagcctgga taagtcggct cacttggagc atatggatct acaagatctc
     2581 gaaacaagag tgtccaatac ctcctcgccc cagttggctc atataagaga agttattcta
     2641 aaagcacgta atgcctatgc catagccatg gtcaatactt cggccatgca ggaatttgct
     2701 atccgaatct acctcagtgg cacttcggag gccggtgttc gcattcaccc acttttggaa
     2761 gacggagaac taagtgagga agcacgtaaa aggccattaa agttggcgga ggagcgagcc
     2821 ctcttcagct acgcccgtcg aatagtggac tttcggaaac gaatggcgga gacagttgat
     2881 cgattgcaga cgctcatgca ggacattccg ccacccaaaa ggaaagaggc cactaccgac
     2941 tctcaggccg cagatgcgtc cacagtctac actcaaacca aagcccagat ggcggcgcct
     3001 gcacagcagc cggagccgag ccaggaagag aagcagtcga cacaaattca aaaaggaaag
     3061 cttgccgaaa acggctccgg attgggtgaa gaggagtccg gctgcgtgtg gtcgcagttg
     3121 gtgcagacca tccttcggaa gaccacggtg cagcgggtca aatttgacga ggccgtgctc
     3181 caggaaaata cgcgcaaggc actggagaag tacgcccgca aggagttacc ccaccatctg
     3241 ttcgcctgcc accggccgga gtacattgag ggattcgcct atcgggactt ttatccggaa
     3301 gcgctcaaag ttcggcgtcg atgcgcgcat gacaatgagc gactcaattg cagagcgaaa
     3361 aggacagagc gctaagccaa agcggcaagc gcgaaagtac aagatgaaga cagcgcgaga
     3421 ggaggggaac ttagataacg aaagagaacc atcacctcta acggttttct gatatgttgc
     3481 cgatcatgat atttgcagtg ctgtactttg tacttttcta tcgtttaaat tgtaagctat
     3541 gtacatatat gtacgtacat atgtatgcaa ttaccaaacc atttccagga atttcaactt
     3601 cttgtacaat catgtttacc agcgattttt taaagctcag ttaagatatg ataatagaac
     3661 ttccaaaaat atgtatagct aaagaacctt aagtggtcct acttgtgccg acaattaatt
     3721 taattagcat atgaacccgc aactcttgag gttttctcaa taccttacca aggcttaaac
     3781 aaatttatat ctgtaataat aatggttcga gtgcttgtgt gcgtgtaaac tatttgcgat
     3841 gactgttgtt ggctgtattg taattaaatt gatttatttc cgt