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Drosophila melanogaster secretory 22, transcript variant B (Sec22),


LOCUS       NM_001272174            1749 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001272174
VERSION     NM_001272174.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 1749)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1749)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1749)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 1749)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 1749)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 1749)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 1749)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 1749)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 1749)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 1749)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 1749)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 1749)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 1749)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 1749)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 1749)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 1749)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 1749)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 1749)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 1749)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 1749)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 1749)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 1749)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 1749)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..1749
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..1749
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="Secretory 22"
                     /map="1C5-1C5"
                     /db_xref="FLYBASE:FBgn0260855"
                     /db_xref="GeneID:31030"
     CDS             410..1051
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="CG7359 gene product from transcript CG7359-RB;
                     CG7359-PB; Sec22-PB; Sec22 ortholog"
                     /codon_start=1
                     /product="secretory 22, isoform B"
                     /protein_id="NP_001259103.1"
                     /db_xref="FLYBASE:FBpp0301847"
                     /db_xref="GeneID:31030"
                     /db_xref="FLYBASE:FBgn0260855"
                     /translation="MALLTMIARVIDGLPLVGTMQDDEQVPSGRSILDYQNQAKMLFR
                     KLGTHSPARCSIETGPYLFHYLIENDVCYLVMVDKMYSKRLAFNYLEDLAQEFHANYG
                     RRVNSVTRPYAFIEFDVYIQKAKKQLTDRRRNISNINTQLQDVQRIMVQNIDDVLQRG
                     TVLAELDTKTQNLSMMSQKYKKDAKLLNRKSMYVKAMALGMILLVFIMYFWVL"
     misc_feature    416..790
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="longin domain; Region: Longin; cd14824"
                     /db_xref="CDD:341428"
     misc_feature    order(416..418,512..514,521..523,581..583,590..592,
                     596..598)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="lipid binding site [chemical binding];
                     lipid-binding site"
                     /db_xref="CDD:341428"
     misc_feature    order(452..454,461..463,467..469,515..517,527..529,
                     764..766,776..778,785..787)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="Sec22 interface [polypeptide binding]; other site"
                     /db_xref="CDD:341428"
     misc_feature    order(578..580,587..589,647..649,659..661)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="VARP interface [polypeptide binding]; other site"
                     /db_xref="CDD:341428"
     misc_feature    803..994
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="SNARE motif of SEC22; Region: R-SNARE_SEC22;
                     cd15866"
                     /db_xref="CDD:277219"
     misc_feature    order(809..817,821..826,830..847,851..859,863..865,
                     872..877,881..889,893..910,914..931,935..952,956..973,
                     977..985)
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="heterotetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:277219"
     misc_feature    884..886
                     /gene="Sec22"
                     /locus_tag="Dmel_CG7359"
                     /gene_synonym="34F3.8; CG7359; Dmel\CG7359; EG:34F3.8;
                     sec22; SEC22; Sec22p"
                     /note="zero layer; other site"
                     /db_xref="CDD:277219"
ORIGIN      
        1 cggtatattt acacggacat accggtgacg tggttacatt gcaacaaaca tccacagaaa
       61 cctccaatcc actccaatcc cagacacccg cccgccgcga cgttgcaaca cagttttcat
      121 ggtagcagcg aacgttcccg attcgaggca gagtccattt ggaagtcccg ggcatcgcag
      181 gagcactgcg gcaagcaccg accgatcggc tgagttgtga aatccaagaa gtggaagagg
      241 acgaccggac acaaacttca cacactggtg actggactgc agcggatcca catcggaata
      301 agtagcagcc agtggaagga ggcgacggca gagtgcagcc gtggccaaga agacttgaga
      361 cgcagccccg tagttccgcg agcaatcgta accaggaaca gcagaagcca tggcgctgct
      421 gaccatgata gccagggtca tcgatggcct tcctctggtg gggaccatgc aggatgacga
      481 gcaggtaccc agcggacgca gcatactgga ctaccaaaac caggctaaga tgctcttccg
      541 caagctgggt acccactccc cggctcgatg cagtatcgag accggaccct acctattcca
      601 ctacctaatc gagaacgacg tctgctacct ggtgatggtg gacaagatgt actcaaagcg
      661 actggccttc aattacctgg aggacctggc ccaggagttc catgctaact acggccggcg
      721 agtaaactca gtgactcgcc catacgcatt catcgagttt gacgtgtaca tacagaaggc
      781 gaaaaaacag ttgacggacc gcagacgcaa catcagcaac atcaacacac agctgcagga
      841 tgtgcagcgc atcatggtgc aaaacattga cgacgtgctc caacgtggca cagtgctggc
      901 ggaactcgac accaagaccc agaacctatc gatgatgtca cagaagtaca agaaggacgc
      961 caagctgctc aaccgaaagt ccatgtacgt gaaggcgatg gccttgggca tgatacttct
     1021 agtgttcatc atgtatttct gggttctgta atatcaagca gttccatggc cactcggagc
     1081 ggcgcgttct ttgttggagt caagcgtcaa ggacgcaaga ccaaaagaca tttagattac
     1141 gcgtgcacct gtactccacg ccaccaacca caccatattc attcatatct atgaatcata
     1201 ggcaagcgaa aagtgaatag cgaaaccccc taccagcata cgcatcgctc ccgaggattg
     1261 ttttacttct aatattaact tacctttgcg ttatttacgg tctgggattc cattaattat
     1321 taactcccat ttcatttcgc ctcgcgcttc cgttgcgcag gttttctaaa tatttgatta
     1381 cgaatcgggt ttagtttaga cgacctttga gccaagtcgg ttgactacga cccaaatctg
     1441 taaattatga gcgtcgatcc gtgtgtgtgt gtataaatgt ctagattgta gatggatcgc
     1501 tgcatagcga atccgaatcc ggcggagtgc ttgatacaag ctgcaaaaac accgcaaaaa
     1561 acaaaagaaa aagaaaagat aacaagcgaa ccgaaagaaa agaaaagaag agaaagggaa
     1621 ataaacaata acagttttag gcaatttata tgtgtaaaat taaggcaaat aaataaattt
     1681 atattgttta ataaagagaa ggcaaaactg tgttcgatgc actacccaag cccgaaagat
     1741 agaaactgc