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Drosophila melanogaster histone deacetylase 4, transcript variant F


LOCUS       NM_001258722            5487 bp    mRNA    linear   INV 26-DEC-2023
            (HDAC4), mRNA.
ACCESSION   NM_001258722
VERSION     NM_001258722.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5487)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5487)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5487)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5487)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5487)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5487)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5487)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5487)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5487)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5487)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5487)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5487)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5487)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5487)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5487)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5487)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5487)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5487)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5487)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5487)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5487)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5487)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5487)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258722.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5487
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5487
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylase 4"
                     /map="11E8-11E9"
                     /db_xref="FLYBASE:FBgn0041210"
                     /db_xref="GeneID:32278"
     CDS             532..4260
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /EC_number="3.5.1.98"
                     /note="CG1770 gene product from transcript CG1770-RF;
                     CG1770-PF; HDAC4-PF; histone deacetylase 4"
                     /codon_start=1
                     /product="histone deacetylase 4, isoform F"
                     /protein_id="NP_001245651.1"
                     /db_xref="FLYBASE:FBpp0300800"
                     /db_xref="GeneID:32278"
                     /db_xref="FLYBASE:FBgn0041210"
                     /translation="MSSPDDRIPIHDLPSEAGSDERLLHITPATLTLDFKPHPAVDID
                     QQIMELKKSQELQKQRLINSFQEQSKQMELEHKLQLEHKYQELRNESMVTAAAAAVAQ
                     EQHRQQLHQQQQQHQQQQQQQQHQQQQQQQQARGRDGMKLKQNCSANASPEVKQILNC
                     FILSRKSQAAASNGTTTTSPYRNRGVVKSSSGESLPAGTVTSAHPYKIPQPPPSLLKY
                     ESDFPLRKTASEPNLLKIRLKQSVIERKARIGGPAGARRHERLLQAAQRRQQKNSVLT
                     NCNSTPDSGPNSPPSAAALAVGVVGSRGSPTSAPIQEENEEGSQYQPGQRSSINDLPL
                     FSSPSLPNISLGRPHLPNSAQAHAQVNAQVAAQAQAQAQAQAQAHAMFAALAAAQGGC
                     GQPGYYNPLGMAFVGRQPAPLAMIPATGIAPQQPSPVVRSASATSTSSSQASLVGDVA
                     PPQAHAASTILPSSSSYMQQLGSVAGSGVNLHAAAVAAAAAAAAAAGSLPPTNSHGHG
                     HGSHAHPHPHAHGHGHGHGHGIYAGHQHNVPITDAQVAQVHLHKQGHRPLGRTQSAPL
                     PLGHPMLTGAVQLNVVQTHYENSEAERQAYEHQVVNQKVRQTVLTRSGAAAAAAAAAG
                     VSVVREAQLKEEDDDSAAEVMDLTDKKKPPKTVLTSTIATSTSQNLPEALAAAAAAAA
                     YRAPHNASSNSASATKSGIKLRDQEYLQQQREQLLLLQQEEELAKSLMRPLSRTLSSP
                     LVPLGPHGLSQIPDTGQQPAPIATSSSADHIPPVNLSLPHRQHRQLMSTLYASQLRNH
                     QPSASGSPPHKVTTGLAYDPLMLKHSCICGDNAQHPEHSGRLQSVWARLNETDLVKRC
                     DRLRARKATQEELQTVHTEAHAMLFGSNQCQLSRPKLENTLSASFVRLSCGGLGVDLD
                     TTWNEHHTATAARMAAGCVIDLALKTAKGDLRNGFAVVRPPGHHAEANLAMGFCFFNS
                     IAIAAKLLRQRMPEVRRILIVDWDVHHGNGTQQAFYQSPDILYLSIHRHDDGNFFPGT
                     GGPTECGSGAGLGFNVNISWSGALNPPLGDAEYIAAFRTVVMPIARSFNPDIVLVSSG
                     FDAATGHPAPLGGYHVSPACFGFMTRELLQLANGKVVLALEGGYDLAAICDSAQECVR
                     ALLGDPAAPIAKAELERPPCQNAINTLQKTIAIQQTHWPCVRMLEHTVGLSALETLKV
                     EHDESETINAMAGLSMQSMHRTLSRDDSEEPMDQDETK"
     misc_feature    658..>789
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Glutamine-rich N-terminal helical domain of various
                     Class IIa histone deacetylases (HDAC4, HDAC5 and HDCA9);
                     Region: ClassIIa_HDAC_Gln-rich-N; cl25407"
                     /db_xref="CDD:421006"
     misc_feature    order(670..672,682..684,694..696,703..705,715..717,
                     724..726,736..741,748..753,760..762,778..780)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="dimer interface A, D [polypeptide binding]; other
                     site"
                     /db_xref="CDD:197398"
     misc_feature    2959..4083
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="Histone deacetylases, class IIa; Region:
                     HDAC_classIIa; cd11681"
                     /db_xref="CDD:212544"
     misc_feature    order(3400..3405,3427..3432,3517..3519,3523..3525,
                     3799..3801,3919..3921)
                     /gene="HDAC4"
                     /locus_tag="Dmel_CG1770"
                     /gene_synonym="CG1770; dHDAC4; DHDAC4; Dmel\CG1770;
                     dmHDA405; GC1770; HDAC; hdac4; Hdac4; HDAC4a"
                     /note="active site"
                     /db_xref="CDD:212544"
ORIGIN      
        1 agatatcgat gtggttccag ctctaatagt cgtggatttc ggaacattaa tttgtatttt
       61 ttgcgtcgcg tcgccccaga aagtccaatc caacagcaaa tcgcgcgttt tccaaagaac
      121 aacaaccccg aaaaattcga aaataataat tttcttgttt tttttttctg ttttcctgcg
      181 gcaaaaattc caattttttt cgtaacatct aaacaacaac aacaaaaaaa gtgcgtgcgc
      241 gtgcagaagc gaaaaaaacc gaataaattg tgggcgaatc aacaagcaaa agagaatgag
      301 cgatgatgag gagaagaggc aaaaaaagca gaggcagttg tcgtagtact agtaccaaaa
      361 agaaactgcg aaaactgcta aagtgacaaa aacaacaaca gcaagtaacg aaagagaaaa
      421 gcaaaagaag ttggaaaagc gacaatacaa aatacagcaa caacaatagc agcagtaagc
      481 agtttgcacc acttggaaga ggttccgccc tcccccaatt ccatatgcaa aatgtctagt
      541 cccgacgata gaataccaat acacgatctg ccatcagaag ccggaagcga tgagcgattg
      601 ctgcacataa cgccggccac tctgacattg gacttcaagc cccatcccgc cgtggatatc
      661 gatcagcaga tcatggagct caagaagagc caggagctgc aaaagcagcg gcttatcaac
      721 tcgtttcagg agcaatcgaa gcaaatggaa ttggagcata aacttcaatt ggagcacaag
      781 tatcaagaat tgcgaaacga gagcatggtg acagccgccg ctgctgcggt ggctcaggag
      841 caacatcgcc aacagttgca tcaacagcag cagcaacatc agcagcagca gcagcagcag
      901 caacatcaac agcagcagca gcagcaacag gcacgcggca gggatggcat gaaactcaag
      961 cagaactgta gtgccaatgc cagtcccgag gtcaaacaga ttctcaactg cttcatcctg
     1021 agcagaaagt cccaggcggc ggcatcgaat ggcacaacga caacgtcgcc ctacaggaat
     1081 cgcggcgtgg tgaagagctc ctcgggcgaa tccctcccag ctggaaccgt gaccagtgcg
     1141 catccgtaca aaatacctca gccgccaccc tcactgctca aatatgaatc tgattttccg
     1201 ctgaggaaga cagcatccga accgaacctg ctgaagatcc ggctgaagca gagcgtcatc
     1261 gagcgcaagg cccgcatcgg aggaccggcg ggagcccggc gccacgaacg actcctccag
     1321 gcggcgcagc gtaggcagca aaagaactcg gttctcacaa actgcaacag tacaccggat
     1381 tctggaccca attcaccgcc ctcggcagct gcgttggcgg tgggcgtggt cggtagccgt
     1441 ggatcaccga caagtgcacc cattcaggag gaaaacgagg agggcagcca atatcagccg
     1501 ggccagagga gcagcatcaa cgatttgcca ttgttcagtt caccatcgct gccgaatatt
     1561 tcgctcgggc gaccgcattt acccaactcg gcgcaggcgc atgcccaggt gaatgcccag
     1621 gttgctgccc aggctcaggc acaggcccag gcacaggcac aggcgcatgc catgttcgcg
     1681 gcactggctg ccgcccaggg tggctgcgga cagccgggct actataatcc actgggcatg
     1741 gcattcgttg gccggcaacc agcaccgctg gccatgattc cggccacggg gatagcaccg
     1801 cagcaaccgt cgccggtggt gcgcagtgca tcggccactt cgacatcgtc gtcgcaggcc
     1861 tcgctggtgg gcgatgtggc gccaccgcag gctcatgccg cctccaccat tctgccctcg
     1921 tcatcgtcct acatgcagca actgggcagt gtggccggtt cgggtgttaa tctccatgcc
     1981 gccgccgttg ctgcagcggc agcagcagca gccgccgccg gttcactgcc accgaccaat
     2041 agccatggtc acggacacgg ttcccacgca catccacatc cacatgccca tggacacggg
     2101 catggccatg gccatggtat ctacgctggc caccagcaca atgtgcccat aacggacgcc
     2161 caggtggcgc aggtgcatct gcacaaacag ggccatcggc cgctgggacg aacgcagtcg
     2221 gcaccactgc cccttggaca tccgatgcta accggagctg tgcaactgaa tgtggtccaa
     2281 acgcactacg agaatagtga ggcggagcgc caggcgtacg agcaccaggt ggtgaaccag
     2341 aaagtccgcc agaccgtcct gactcgcagc ggagctgctg cagcagccgc tgctgccgcc
     2401 ggcgtgagcg tggtgcgtga ggcacagttg aaggaggagg atgacgactc ggccgccgag
     2461 gtgatggacc tcacagataa gaaaaaaccg ccgaagacgg tgctaaccag cacgatagcc
     2521 accagtacgt cccagaatct gcccgaagct ttggcggcgg cggcggcggc agccgcctac
     2581 cgtgccccgc acaacgcgtc cagtaactcc gcctccgcca caaagtccgg tattaagctg
     2641 cgggaccagg agtatttgca acagcagcgg gagcaactat tgctccttca gcaggaggag
     2701 gaactggcga agagcctaat gcgtccgcta tcgcgaacgc ttagcagtcc gctggtgccg
     2761 ctggggccac atggtcttag tcagattccc gacactggac aacagccggc accgatagcc
     2821 acatcctcgt cggccgatca tataccgccc gttaacctct cgctgccgca tcgccagcac
     2881 cgccagctaa tgagcacact atacgccagc caattgcgta accaccagcc atcggcgagt
     2941 ggttcaccgc cgcacaaggt caccaccggt ttggcctacg atccgcttat gctgaagcat
     3001 tcgtgtattt gcggagacaa tgcccagcat ccggagcaca gtggtcgact gcagagcgtg
     3061 tgggcacggt taaatgaaac ggatctggtg aagcgttgcg atcgcctgcg cgctcgcaag
     3121 gcgacacagg aggagctgca gactgtgcac accgaagcgc atgccatgct cttcggttcg
     3181 aatcagtgcc agctcagcag gcccaagttg gaaaacacgt tgtcggccag ctttgtgcgt
     3241 ttgtcgtgcg gcggcttggg tgtggatctg gataccacgt ggaatgagca ccatacggca
     3301 accgctgcac gaatggcagc cggttgtgtt atcgatttgg cactgaagac ggccaagggt
     3361 gacctgcgga atggctttgc cgttgtccgg ccgccgggcc atcatgcgga ggccaatttg
     3421 gccatgggct tttgtttctt caattcgata gccattgcgg ccaagctgct gcgtcagcgg
     3481 atgcccgagg tgcggcgcat cctgatcgtc gattgggatg tgcatcacgg caatggcaca
     3541 cagcaagcat tctaccaaag tcccgacatt ctatatcttt ccatacatcg acacgatgac
     3601 ggtaacttct ttcccggcac aggtggaccc acagagtgcg gctccggtgc tggtctcggc
     3661 tttaacgtga acatctcatg gtctggggca cttaatccgc cactgggcga cgccgagtat
     3721 atcgctgcat tccgtaccgt tgtgatgccc atcgcgcgga gctttaatcc ggacattgtg
     3781 ctggtatcct ccggcttcga tgcggccacc ggccatccgg caccgctggg tggctaccat
     3841 gtctctccgg cctgctttgg gttcatgacc cgcgaactcc ttcagttggc caacggcaaa
     3901 gtggtgctgg ccctcgaggg cggctacgat ctggccgcca tctgtgattc cgcccaggag
     3961 tgtgtgcggg cgctgctcgg cgatcccgct gctcccattg ccaaggccga gctggagcgc
     4021 ccgccttgcc agaatgccat caatacgctc cagaagacga tagccataca gcaaacgcat
     4081 tggccctgcg tgaggatgct ggagcacacg gttggcttgt ctgcgctgga gacgctcaag
     4141 gtggagcacg acgagtccga gacgatcaac gccatggctg gcctctcgat gcagtcgatg
     4201 cacagaactc tatcccgcga tgattccgag gagccgatgg atcaggatga aaccaaatag
     4261 aaggcgatgc agacgtatat tgcggaagag gaggcggtgg gcgtggcgag gtttttgtgg
     4321 acctggtaga gtgggaatgg caggaggggg cgtggccgca agctgctcaa tgcacattta
     4381 gttatttgtt gtagttgaat tgattgttgt tgctgttgtt gttgtggcgc tcgcttgcaa
     4441 ttgttgtcgt tgtcattgat cgtctatagc cacatctatc tctctcactc gatcgattat
     4501 agcatcccaa ttccccgccc cgccaaaaaa aacaaaaaga agagaaacat cgaaaatata
     4561 ggggaacatg tctaaaagaa gcagaacagg gcctaaagtt caaaatggtg gctgtgcctc
     4621 caaaagaaga aataattata ataattagaa aagaatcctt tcaaaaaaaa aggagatttt
     4681 atatgaatat atatatatat gaatatatat gtagcttaag ctcagaattt agttgtagaa
     4741 gtcatcgaga tttttttttt ttgttttaag gtgagagcag aggtatttta acgcacacac
     4801 aaacacacgc aactcaatgt atcttattat tattatttaa gtaagtgtgt caaaaggata
     4861 tagaaccact aacgtactgg tgaacatcat cagtaagcta taaagataat gtttaaagag
     4921 gtcgggtgca agaagcatgt gttttttttt ataaggtaag gttcaacctc aaagttccca
     4981 agtctagacc ccaccacgcc cacttatccg ccatcgctta cagagatcga gtggggagtt
     5041 gattacatgt tatgtagaat gctttagttg ataataagat atgagaaaaa aaaaacttaa
     5101 caactaacta gttggatgaa aagcgaaaaa actgagaaat ctttttgtac aatttatagt
     5161 ttagtgcaag tttcaagtac aacatgctat tatttaaaga attctatata tatacatata
     5221 tatatatata tatacaaaaa aaatatatat tgtgcaataa atgtgagaaa atgaaaatcg
     5281 ccacacaaaa cagaaactaa aacgaataag agaaaatttg ttgttaaatg ttgccgagat
     5341 cttatatacg tatgtatacc taataactgt tacaataata accctttata tatataacta
     5401 tataaatgca catgtgtatt caccatgtgt gtaacgataa cgatgttcaa caaatgtctg
     5461 aaatgaagta aaactattat tatatgt