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Drosophila melanogaster found in neurons (fne), transcript variant


LOCUS       NM_001258718            8626 bp    mRNA    linear   INV 26-DEC-2023
            D, mRNA.
ACCESSION   NM_001258718
VERSION     NM_001258718.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8626)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8626)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8626)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8626)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8626)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8626)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8626)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8626)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8626)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8626)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8626)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8626)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8626)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8626)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8626)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8626)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8626)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8626)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8626)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8626)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8626)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8626)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8626)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258718.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8626
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8626
                     /gene="fne"
                     /locus_tag="Dmel_CG4396"
                     /old_locus_tag="CR32646"
                     /old_locus_tag="Dmel_CR32646"
                     /gene_synonym="BcDNA:HL02010; BcDNA:RE25290; BEST:HL02010;
                     cg4396; CG4396; CR32646; Dmel\CG4396; Fne; FNE;
                     lincRNA.985; MRE28"
                     /note="found in neurons"
                     /map="11D3-11D4"
                     /db_xref="FLYBASE:FBgn0086675"
                     /db_xref="GeneID:32245"
     CDS             2638..3699
                     /gene="fne"
                     /locus_tag="Dmel_CG4396"
                     /old_locus_tag="CR32646"
                     /old_locus_tag="Dmel_CR32646"
                     /gene_synonym="BcDNA:HL02010; BcDNA:RE25290; BEST:HL02010;
                     cg4396; CG4396; CR32646; Dmel\CG4396; Fne; FNE;
                     lincRNA.985; MRE28"
                     /note="CG4396 gene product from transcript CG4396-RD;
                     CG4396-PD; fne-PD; CR32646; found in neurons"
                     /codon_start=1
                     /product="found in neurons, isoform D"
                     /protein_id="NP_001245647.1"
                     /db_xref="FLYBASE:FBpp0297665"
                     /db_xref="GeneID:32245"
                     /db_xref="FLYBASE:FBgn0086675"
                     /translation="MTNAMDIVKNGSANGSVDGSNDESRTNLIVNYLPQTMTQEEMRS
                     LFSSIGELESCKLVRDKVSVLPASLTALNPALQQGQSLGYGFVNYVRAEDAEKAVNTL
                     NGLRLQNKVIKVSYARPSSESIKGANLYVSGLPKNLSQPDLEGMFASFGKIITSRILC
                     DNISGLSKGVGFIRFDQRNEAERAIQELNGKTPKGYAEPITVKFANNPSNSAKAQIAP
                     PLTAYLTPQAAAATRRLAGALPSAGRIRYSPLAGDLLANSILPGNAMTGSGWCIFVYN
                     LAPETEENVLWQLFGPFGAVQSVKVIRDLQTSKCKGFGFVTMTNYDEAVVAIQSLNGY
                     TLGNRVLQVSFKTNKTKTT"
     misc_feature    2704..3690
                     /gene="fne"
                     /locus_tag="Dmel_CG4396"
                     /old_locus_tag="CR32646"
                     /old_locus_tag="Dmel_CR32646"
                     /gene_synonym="BcDNA:HL02010; BcDNA:RE25290; BEST:HL02010;
                     cg4396; CG4396; CR32646; Dmel\CG4396; Fne; FNE;
                     lincRNA.985; MRE28"
                     /note="ELAV/HuD family splicing factor; Region:
                     ELAV_HUD_SF; TIGR01661"
                     /db_xref="CDD:273741"
ORIGIN      
        1 gtcaagcagt cttcggcgca tccagcaaac gcggttcttt tttaagcgcg ttttcgtatt
       61 attctactca tatgatttat catttgcgtc gctatatgat ttctccttgt ttccgtagta
      121 tgacaagcca ctactactaa acaacaacaa caacaacaac aacaacaaca acaacaacaa
      181 caacaaaaaa agaaaacaca accaaataaa aaacaacaac aacaaccaat atcaagcgga
      241 agacgtggga gatggcccag gtgctctaaa cacatccttg ctggccgaac gagcgaaaaa
      301 ttcctgggga ataccggcaa acaaccttca ctcagtcacc aattgagagc gttttaacac
      361 aaaagtctgc tggcagcaat caactttagg ccgaaattat ctaaaatcca cgatcgaaat
      421 cgttaataaa acgaacagaa attgcataca actatcatca ggatttttca ctgtttcaat
      481 tttgtgttgt tgactgatac gaagatcaaa gataaaagag accaaattcg ataaggaaaa
      541 gcaattctcc cacacaacag agtatataat aaaaataata ataataataa taataatata
      601 gtatacaatt tgattaaaac atacatttga tttcaatcag tgtgcgctag atagaatcac
      661 acatatatat atatatatac gtatatacgg ataacatttg attaccttcg tcggtgagtg
      721 tctagccaat caatctatag cttataggaa ccataccata tataccacaa ggttttatac
      781 tgaatttata aaattttggg taagcgcgca gtgcgcatcg aaaggcccca tcaaagcatc
      841 aacaccaaac tcaatataaa ctaaaaaaaa aaaaaacgaa aaaaaaaaca aaaaacaaaa
      901 taccataagc aagtgttttt ttgtcgcata taaataaaat ttacatattt acaacatacg
      961 agacggaagt taagcaaaag taatattaat ataaagactt gaatttctca aagaaataaa
     1021 tatttataca agaacaagcg aagaaataag aagaacaagc aaaaaaaaaa aacggacttc
     1081 caacgatttc aaaatacgac gaaaaatacg aattacgaaa tattttttaa agcaaggacc
     1141 cagcaaaaaa agatatgata tgactaaatc tacgcaaatc ggttaacaaa aatatttgcc
     1201 aaatctatgt attgaatcaa aaacaaataa aacggaaaga aacccgcata cttaatgaaa
     1261 aattgaacgt cgagctacaa gaatttatac ggaaaacaga ggcatcgcag aaaataaaaa
     1321 gaaaaaaaga ataaaaaaca gcgaagcagg aaaagtgcaa aagcggattt attggaaaag
     1381 ctgagtggaa aaatcgagat caacggcgat cagcgttaaa gtgatatttt ataaaaaccg
     1441 aaaatatcag ttaaggacaa cgacttataa gccaggaaat cgttggacaa aggagcgtgc
     1501 agaccaaaaa gagagcgaac gagtgagaga gcgagtcgac gcgaaagaaa gtcctttttg
     1561 tgcaatcaat atacatctat tatatagtca gtcggactca attccccgct ccccattaga
     1621 acacactgta tgacagtgta acttcttaaa cgcacctcgc tcccacaact ttttcgattt
     1681 cgtctcgcca gcgaagcaca ttgagtgaaa acgagcgagc aatcgaacag ccatcattta
     1741 tcagaggaaa taaacggatc accgagaaag agggaaattt tttaaccgca gagggaaaag
     1801 caaacagacg agtcgaaagg aaatacgaag gaaaagtcaa caaaaaacca aacaccacca
     1861 aataaaacca actactatta atttaacgca aacattaacg aataatcata ttcaagcggt
     1921 atatatatat atatatacac aagaggataa cggataacac aactaactaa atatatatat
     1981 atatacgata tatgaatgta tatttgaaaa ccaaagctaa gttccagtca aagaaaaaaa
     2041 ccaaataaac cagcgcaaat ttagtaaaag tataataaaa cgaaaaaaac caaaacaaat
     2101 tattgctatc tttttgcatt tttgcaattt tataaaaaaa taacaaagaa aacgaaaaac
     2161 aaacaaaacc aaaaacccac aactaaagat cataataatc tttaaaattc ggagaagcaa
     2221 aaagaaaata agaagtaaac acatttagca aaatttactc ttttatctaa acgaaaacaa
     2281 aagaaagaca taagaacaaa aaacacacaa atcaaattaa gacctaattc aagcataaat
     2341 taaattttaa acgttttaga cagagagaga gagcgctcta aacttaactt aaaaagcaaa
     2401 tacatttttt tcgcgatcgt agttgatcta aaacccccca gaaaaaagcc caaataaaat
     2461 ctgcggaaaa aaaacctaac tttaggcggg acttgtgcaa agcgctgaaa ataccgcccc
     2521 cccccaaaaa aaaaaaacga gcagctctaa cttgtaagcg aataccaacc gagcagtgag
     2581 attaactact aaccaaaaag gacgaaatca ggaccggatt tcagaaccac aatcacaatg
     2641 accaacgcca tggatattgt gaagaacggc agtgccaacg gatccgtgga tggcagcaat
     2701 gatgagtcgc gcaccaattt gattgtcaac tatctgccgc aaaccatgac gcaggaggag
     2761 atgcgatcgc tcttctccag catcggtgag ctcgagagtt gcaaactggt gcgtgataaa
     2821 gtctcagtct tgccagcatc gttgaccgct ctcaatccgg cattgcagca aggtcagagt
     2881 ctgggctatg gatttgttaa ttacgtcagg gccgaggatg ctgagaaggc tgtgaacacc
     2941 ctgaacggtc tgcgtttgca gaataaggtt attaaagtat catatgcccg tccaagctca
     3001 gaatctatta agggtgctaa tttatatgta tcgggtcttc cgaaaaatct atcacaacca
     3061 gacttggagg ggatgtttgc ttcgtttggc aaaataatta catctcgtat actctgtgat
     3121 aatatttctg gtctatcgaa gggtgtcggt tttattcgct tcgatcagcg caacgaagcc
     3181 gagcgagcca tccaggagtt gaatggcaag accccgaaag gatatgccga accgatcacc
     3241 gtcaagttcg ccaacaatcc gagcaatagc gccaaggctc aaattgcccc gccccttacc
     3301 gcctacttga caccacaggc ggcagcggcc actcgccgtt tggccggagc tctgccctcc
     3361 gccggtcgca ttaggtactc accgctggct ggcgatctat tggccaattc gattttaccg
     3421 ggaaatgcca tgactggatc gggatggtgc atattcgtct ataacctggc cccggagacc
     3481 gaggagaacg tgctgtggca gctattcggg ccattcggtg ccgttcaatc ggtgaaggtg
     3541 atccgggatc tgcagaccag caagtgcaag ggattcggat tcgtgaccat gaccaactac
     3601 gatgaggccg tggtggccat tcagtcgctg aatggttata ccctgggcaa tcgggtgctg
     3661 caggtcagct ttaagactaa caagaccaaa accacttagg cgaaccagcc aatctggact
     3721 agacctttcc aatactccac gatctgtttg atttaacaac aacctagact atagattgat
     3781 ctgatctgat aagatatgat gatatgatac gatgatatga tgtgacaaag acagtgtagt
     3841 cgaaattgcg aaatttagcg cgagtttatg atatgtctat catttgattt gtacgctaaa
     3901 cgaaattatt atgattgtaa ttctaatgaa atcttagtga aaattgattt atttccatct
     3961 ctataattta attttattaa ctaatccaag aaatgaaaaa atgcaaaaaa aaaaaaacaa
     4021 acaaacaaca aacaaacaaa gcttgaatga ggcaaccaaa aaacacaaca cagaaactaa
     4081 ggaaaacttt agacaaaaag gagatgagcc agacgacaac tgtctataaa ttgacaaatg
     4141 agaaaaatga gaaggtaata gggtcaaagg aaaaacaaaa caaaacaaaa taaaaaacaa
     4201 aaagcgaaaa acgataaata aaaaaccgca aaaatatgaa tgaaaatgat ctaagtcgca
     4261 atatatagta actatttttt tttttttaaa cttatgtata tgtaattcaa ttcgattata
     4321 ttcaattaaa caaagtattt aaacaagcta accaaatgat ttaatgtcta ttgatttagg
     4381 aactaccagc ataactctct cagcttacct aagtacttat tataatggat atgcataaaa
     4441 aatattgtat tgtattgtat tgtatcttgt gttcgttttg caaccctaac ttacattaca
     4501 ttacattaat tctagtgcta ttcagctctt atatttaatt cgattcgcct tgatttacac
     4561 tcgaagacga aacgaaaatc gaagatatag ccgcgatata tcctccaaac gtaacaaaca
     4621 aaaccccaag cacccaaaca cacacactca cttgtaatca ttattatata tatatgtaac
     4681 cagatttaaa tatctttttt tcgtcgtcta agattcgtat tcgtattcgt caagtgcaaa
     4741 ccaaagtaaa tgaaaccaag aaaacttatt atattatatt acattatata ttattacgcc
     4801 tacttattat tccattttta taattattat aacttattga atgcaaccaa gcgaaaccaa
     4861 acaaaagcaa acaaaaaaaa aaaaaaaaca taactacaac taaaaatata tatttattat
     4921 taaataaatg tgtgacttat tccaaaaact atgcaaaaaa aaaaaatgaa aaaacacaaa
     4981 aaactaaaac acaaaatttg ttttcttttc tccccaaata actaacacca cacacacgca
     5041 cacctaaact agagctggca cgacttcgat cgatagaatc gattgggtta ttttattcga
     5101 ctccatcttt ttcgaaatag aaatgcctat agaatatatt cgcgattcat ttcaatatta
     5161 tcattactaa cgatggcttg ccagctctaa tctgtaccca cctgaaaatt ggcaatattg
     5221 caggcaaaac gctttcgcag ttgaagtgat catttaataa ttggatcgga ttgaagatga
     5281 atcgaaatat ggccagctaa aatcggaact tcagccgtga aaatcgctcc acacaacaaa
     5341 tacacaacaa cagcactcgc atttatacag atataattaa aatacagatt aagtttcaac
     5401 gctctctaac gtataactaa gttttaacta agttttacgc ctatataaat aaatatataa
     5461 tcaaacacga actatatgta cgcgcatcta tattaattca attaaagatt gtttattcga
     5521 ttttccactt caatagtcta gttttcaagt ccgagatcat ttcgtagagt ctaccaacaa
     5581 tcaatgtgtg tgtctgtagt ttaacttaag acatttttag gaagcaaaca tttttttttg
     5641 tgtgtactta gggctgaaag gtcaggccac atctacatgg cgattggcca taaaaaataa
     5701 taaacacaag aaaaaaaaca aacaaacctt aaactaggca aaccaagaaa aaccaaacaa
     5761 aagaactcaa gaaaagagga agttgcgaaa gcaaattgaa aacaccaaat ttttaagtat
     5821 ataacataaa tgatgtaaaa ttttttaaac aaagatttat agtaaaattt attaaggtat
     5881 taagtatgta tgtataacga tatatacaaa ttacacaagg ataagagaat caagagaaac
     5941 cactgcgaaa acgcgaaatt caatggaata tgagcaatgt gaaatacatt aaaaaaatac
     6001 ctaaaattac ctagaaacgc gaaatcagca aatagaccgg aagtcctcga aaggcgactg
     6061 cttgcaagca gtggcctctc atatccggtc tgccctatgc aagcagtttg ccatcgagac
     6121 taaagacaaa gacacaaaaa aaaatgaaca ggtctccact tgctgattcg ttttccactt
     6181 cccggcgact agttaaccta ctcaatactc aatacgacat atggaataat caagtaatca
     6241 agtaatatcc gcaaaataac cgccgcaacg ctgctgcgca ggcgcgtgtg tcattcacaa
     6301 aagcaatatg aagatgtggc gcgagttggc tgttttggcc cacgctgact tactatatat
     6361 atactatatg tatgtatatg tatatgtatg ggaaaggcga ctatatgacg cagttgtaca
     6421 aatcgcaact cagcgactcg gtcacattca ttaacggcac ctacgccgcc acttacaatt
     6481 tacccgaaaa aaaaaaaaac aaaaatgaaa aaaaatcacc catattaacc gaagcgtata
     6541 agtttaaaat tcagctaaat aaaagccgaa gatgagaaat acacgcaaaa tccatacacc
     6601 gatcagttgg cgaaagttct tcgatattca ttttagcaaa agaaaacaaa acaaaaaaac
     6661 caaataaata agaacagcag aatgcaaaaa ctataactga acccaacaat gaaaatcatc
     6721 aactaagcat gaaatgcatt taaaaattaa acacaacaaa tacatattta tttatatata
     6781 tatatagatg tacatgtcta cttgtatggc caggatagcg aaaatatgaa atatagcccc
     6841 cgatgacaga atccagaatt gaaaatcgaa aacagagcaa caccaaaaac ggaaatgaat
     6901 ttgagctgag aaaatcgtct agaacggaaa ccccaaaaaa accaaaaaaa aaaaaaaccc
     6961 aaaaataccc gaaagtgaaa gtgaagcgat tttgcgacgc ctcccgaagc tacacccgaa
     7021 aatcaacttc caacattttt attgatatac actaaaatct agacacttaa ggcgatttca
     7081 tcgataccaa aatctaatct aagacgagat tgcatgcaag ttagcgaata tgaaacttca
     7141 atttagtgtg taagcatcga taaaacgtgc gacagattat gcaaatctac agaattaagc
     7201 cattaaaagc caaagagcgt tagaatgcca gaaatttcaa taaaattaaa tggtcgcctg
     7261 aggcagaaaa cacggtaatc agtgttgaat gttaaattac ttgctaaatt caagcagata
     7321 gtttaaacaa ataacaaaaa aaaaaaaaaa aaaaaaatag ggagaagaca agaaaatata
     7381 cgtagccgct ttgtcagacg gaacgcgccc aaaccaaact aagtaactaa gtaaacagaa
     7441 ataaattaaa ataaattaaa tgaaaaaaaa aaaatcgcaa gaatatttaa atcaattttg
     7501 tgcataagaa aactcgataa ccgttatata catatgtatg tatatgtaag ccaactacat
     7561 atgtgtgtgt gagcaagaac aagatcacaa atcaaaataa atataaaaaa atgcaaaaaa
     7621 taaaaatcat aactcaactt caaacttaat taattattat ccatttgatt gtgtatgcta
     7681 attattattg tctatagcgt atcgtacaca tattaatata cttttcgtgc aaatccaagg
     7741 gcagcaccta tttaccagca ttaccctacg atcgtactta tccaattagt taaccatata
     7801 ccgcataccc atgtacttac cttactttta aatatgctta cttaatcaca tttcgatatt
     7861 gtattcgtag cccctgagta gaactatttc aattgatttt gtacacactc caagtcacac
     7921 aatccaaacc cgaaaaaccg cccagcagct aatgaaatga tctaacttaa tgtaatacat
     7981 acaacaacgt aaaatatatt ggaggcctgt atgaatatga atatgttttc gatcacagga
     8041 cattgcagct caaggatgca caaaggaaat gcgaattctt cagttcgaaa aatattcgaa
     8101 attgtttcac aattttctaa aattttcggt catttctgca ggcctctaat acatctaaat
     8161 ggatatatgc atatttgtat gtatttacca gcaaaatata tctaactaac acagacacaa
     8221 acagttcaca cttacacacc cacacacaca cactcacaca gtaaaggaaa tgataccaag
     8281 gtgacacaaa atttagatgc atattattat ataacttata ttgaaaaacc aaaagcgata
     8341 agatgaaaac gtaaatttta ctatactcgt acatataaat tatatgaatg tatgtaaatt
     8401 attattatat ttgtatttta ttgtatgtat tagttttgtt ctacgctctt ttgctctttc
     8461 ataaacaaaa aacaaaaatt ttaaaacgaa atccaaacga aacttgataa cacaaaaact
     8521 aaaacaacaa aaagccggca agcaatggta tacaaaataa ataaaaaaaa atatgacaag
     8581 agaaaatcca caaaaaaatg aaataaaatt gaatgaaaaa tttacc