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Drosophila melanogaster no circadian temperature entrainment


LOCUS       NM_001258685            7901 bp    mRNA    linear   INV 26-DEC-2023
            (nocte), transcript variant C, mRNA.
ACCESSION   NM_001258685
VERSION     NM_001258685.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7901)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7901)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7901)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7901)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7901)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7901)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7901)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7901)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7901)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7901)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7901)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7901)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7901)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7901)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7901)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7901)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7901)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7901)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7901)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7901)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7901)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7901)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7901)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258685.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7901
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7901
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="no circadian temperature entrainment"
                     /map="9C5-9D1"
                     /db_xref="FLYBASE:FBgn0261710"
                     /db_xref="GeneID:31976"
     CDS             337..7266
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="CG17255 gene product from transcript CG17255-RC;
                     CG17255-PC; nocte-PC"
                     /codon_start=1
                     /product="no circadian temperature entrainment, isoform C"
                     /protein_id="NP_001245614.1"
                     /db_xref="FLYBASE:FBpp0298823"
                     /db_xref="GeneID:31976"
                     /db_xref="FLYBASE:FBgn0261710"
                     /translation="MSTLGGSRGERNAKPKFTALDINRMYKNSRGESSEPSAQKNQVP
                     RKHGMQILGKVPSARRPPANLPSLKAETHTSSNNNLLVSVEGATSGGAGAGGAAGSGA
                     AGTNTSHNNTTAHSGSSGTSGGAGSGGGGTASSSAGGHLSQQLTHSQHQHNNNVALGP
                     NAGKFVNSNNGSSNNNAGSSGSGNKNFKLINNSVGSSGGGGQGGSGGGGSSGVGGGSG
                     SGSGGHSVNSPKTWSAITTGHERGSGGQNYGRQQQQVVPHYQSPQFQYEFPTLDGTVG
                     SGAGGGSGAGVGSGSGAGKSHYQNQVHHAGHQNHHQHQQHHQQHQQHHHQQQQHHRDY
                     HHGHGRQYGHHSHRDYRDGSDDVGGGSADLGELSLRPQNDTAAWLQQQEKAAKVAAAA
                     AADQGLNLQGPGHHQMGGNGGAGGGSGGAVPLPILSLMPSFMRSGAPMPASGATAASI
                     LAGGSLDTSALPNAPYQNGILGARSASPAVVGSGSFRAATAIPKRPPTSSSPPQSGLG
                     IGGSPTPPQSQQQANGGAGGAGRKDKDYVVEPEVAQMQRPIIREEDLERLNAIAKDDS
                     WTKQDDIDFTKKLAFSDDESTPEEHQGQGKQHSSAQLQAQGSSSSTDQRKLSASTTSW
                     QRGKESTDRDQPSEGIQDQQQQLQQQQQQQEVRQQNGHRGSSGNVGAPVAGGIALDAS
                     VYERVKQRKEEEERREMERKQAAAKKLQELEMKMNSKKAAAAALAGAEGGVSSASVPL
                     SNEVPPTSAPLGNASEDEGGGQGGGGGLNRRPRGSISSLGSGVTPTGGAGGGGGGVSS
                     SSSAGGDYGQKNFLTHFQSNLPPRFQRQQQQQQQQLPRLEKSASASSAFDSNSRYLQK
                     GGVSGGGGGVSGGAQANAGQGRSISGGYVQRGASVGGSSGYGRNRHDSSSAREDQDLD
                     QQRFTRGQDYRQAQALPRSISENSHRKTSVSSAGDDVLGGSCSSWAEQTDAEQKVHHR
                     HREESFSSSHSHDSAVQIKILQRPARQPSLSEESSTQQKQLPASPQQQKTLTTDPMPT
                     QILRRSVDIDKSGDERAEDKSALESDDKAKSAGKVEEDKSGNKRVSPRSGAACGGRGG
                     RGYAGSSGGSSVGSGSSYRGQRNASDWGSSRGSGGAGGRRYYGSGGEQSEHSEDVDEE
                     CYSSGGGGAARRSPKESGNGAPNSGASANKAGFSPRGEPSRRGRGGLSSGGGASASCY
                     RRQPVGTGSAGGSGSGGSGRSYGRLGYEEYGKQQRTSESETDLDKTKQNQLALSAGLH
                     KPSKDDKDLPALGGEEKDKTAALAPAHNTALLAKDELQKDAAGRLPLPPGLAAPGSAV
                     GSVTATSSSVVVPGAADKKKIESCAVVGGEKVTGSKLPAIGEKTSLGAVGSGPSTSLL
                     LDAGAPVNTIIFENSTYKQQAAAASVVTKPGTLSVSSSGATMTVDSLSSALSQMSFGG
                     KATAAGSGDDSQDMKLGFSFGDDPTTPLKVVDNIDKTASQQQQQQQQQHSQQQQQQQQ
                     QQNNSTADLNMKIASVKKVWESATPMSDGPSPAQVQQQQQQQPQQQQQSQVQVAAQQQ
                     QQQVVGPQQAGDDGSGHMSAASFVAAVAASQHQQQHQQMPHYAVSAVHMQSHHHQQQQ
                     QQQQAAVAAAQAQHHQQQQAQAHHQHHALSSPGPVPGSHGHGYSHGSPFDAGSLEQQF
                     QQEDYPSPQQQQQAHQKTKQLQQQQHLGMSPPPSQQQQQQHSQQQQQAQHQQQQQQAH
                     QQQQQQQQPSFYQASPQFGVGGIPTIPSPPAVVYNSSQMPPPSQGGNLYAPFHSLDHS
                     SRSPAYSAAAAAHSYPNPYAAAAAAAAAAAAGGGPFNVNVNAYAMQTPHGGSLPPTAP
                     TPDMYSNLSSQFRLGGGPGPGPGPFGQPSSQQLSNPSNHAAVAIISSSSNSMMSSGAA
                     KPPQSQQTIGAIGSKSAGSGGGPGPGPGPYATTQTYMNLYAAPPPQHPGQGGPPPGAH
                     QLQSNSFYSNSAPGGPSGPQFYGGPPPQGNGGAQSYGLATAAGMYGGHQGGPPGSNGP
                     PGPPQSQHTMGTFNTPFMNSQLLTAASINQYRGGPTPGAAYLKGNQGQTHMQDSMGRQ
                     LKSPLSADMSLGLAKQVQSQPSPPHHKNYGAWDLQNQVLQQQQQQSQQQQQQQQRQVG
                     GGNGPSMNALGGRGSGAVGSGSGNGGGGGGGAGGSQVGGNGGGNGVGSVGQSGGGGQG
                     RYPTPIQRPNNYPQHPQQQQQQQQQQQQQREQAAAAAVAAQRAQNMRQVTGAGGGVAG
                     SAGGGGSQTPVGPAGGNGGPGGAGGGGGAGGAAGSGPGKPYYANNASGAAVAANRGEW
                     HAN"
     misc_feature    337..825
                     /gene="nocte"
                     /locus_tag="Dmel_CG17255"
                     /gene_synonym="CG17255; Dmel\CG17255"
                     /note="BAT2 N-terminus; Region: BAT2_N; pfam07001"
                     /db_xref="CDD:462063"
ORIGIN      
        1 tgagaagtgg tagaggaaga actcgaggaa gaagaattag cggcaaactt tatgttggac
       61 ggtgaaaagc agaatcaaaa gatatcaatt tccgcgaagt taacagttaa ataaccaaca
      121 tacaggcggc caagtgtgcc agcagaccgc gaaacattcg aacccaccag aaagactgaa
      181 acaaggagct tcggcccaaa agcgatccca gctccttaaa ctcattctcg tcaagaacca
      241 cagccacatc ctagcccatc ctccagcgca gcgggaagac gaggagcgcg gcggtggcga
      301 gaaggaagct aacgctaatg aggatctatt ggcagcatga gtacactggg gggaagtagg
      361 ggagagcgaa atgccaagcc caaattcaca gcgttagata taaatcgcat gtacaagaat
      421 agccgcggcg agtcaagtga accatctgca caaaagaatc aagtgccacg taaacatgga
      481 atgcaaatct tgggcaaagt gccgtccgct aggcgaccac cagccaattt gccatccctg
      541 aaggccgaga cccacaccag cagcaacaac aatctcttag tctcagtcga aggagccaca
      601 tctggtgggg cgggcgcagg cggagcagcg ggatctggcg cggcaggaac caacactagc
      661 cacaacaaca ccactgccca cagcggaagt tcaggaacga gcggcggagc gggatcaggc
      721 ggcggaggaa ctgcgtcttc atctgctggt ggccatctat cccagcagct gactcacagc
      781 cagcatcagc acaataataa cgtcgctctc ggccctaacg ccggaaagtt tgtcaacagc
      841 aacaacggca gcagcaacaa caacgccggc agctcaggca gcggcaacaa gaacttcaaa
      901 ttaatcaaca actccgtggg cagttccggc ggaggcggac aaggagggtc gggcggcggc
      961 ggatcgtcag gagtaggagg tggatcaggg tcaggatcgg gcggacactc agtcaactca
     1021 cccaagacat ggtctgcaat taccacagga cacgagcggg gctcgggcgg tcagaactat
     1081 ggacgccagc aacagcaggt ggtcccccat tatcagagtc cacagttcca gtacgaattt
     1141 cccacgctgg acggcacagt tggcagcggc gccggcggag gatcgggagc gggtgtgggt
     1201 tcaggatctg gagcgggcaa gagccattac cagaatcagg tgcaccatgc cggccaccaa
     1261 aaccatcacc agcatcagca gcaccaccag cagcatcaac agcaccacca ccagcagcaa
     1321 cagcaccatc gggactacca ccatggccac gggcgccagt atggacacca ctcgcatcgc
     1381 gactacagag atggcagcga cgacgtcggc ggcgggtccg cggatctggg cgagctcagc
     1441 cttcggccac agaacgacac ggccgcctgg ttgcagcagc aggagaaggc ggccaaggtg
     1501 gcagcagctg cggcagcgga ccagggcctc aacctacagg gcccgggcca ccatcagatg
     1561 ggcggtaatg gcggagcagg aggagggtcg ggcggagctg tgcccctgcc catactatcg
     1621 ctgatgccct cgttcatgcg tagcggagct ccgatgcccg ccagtggagc gacagcggcc
     1681 agcatcttgg ccggcggatc gttggacact tctgcgttgc ccaacgctcc ctaccagaac
     1741 ggaatcctgg gtgctcggtc tgcctcgcca gctgtggtgg gcagtggaag cttcagggcg
     1801 gccactgcca ttcccaagcg accaccgacc tcctcgtcgc ccccacaatc tggcctaggc
     1861 attggaggat cacccactcc cccacaatcc cagcagcagg ccaacggagg cgctggcgga
     1921 gccgggcgca aggataagga ctacgtggtg gagccggagg tggcccaaat gcagcgtcct
     1981 atcatacgcg aagaggactt ggagcgcctc aacgccatcg ccaaggacga tagctggacc
     2041 aagcaggacg acattgactt cacgaagaaa ctagcattct cggacgatga gtccactccg
     2101 gaagagcacc aaggccaggg caagcagcac agctccgccc aactgcaggc gcaaggatcc
     2161 tcctcctcaa ccgatcaacg aaagctgtcc gcttccacaa ccagttggca gcgcggcaag
     2221 gagagcaccg atcgcgacca gccatcggaa ggcattcagg atcagcagca gcagcttcag
     2281 cagcaacagc agcagcaaga ggttcgccaa cagaatggcc accgcggtag ctctggcaac
     2341 gttggagcac cagtggccgg tggaattgcc ttggatgcca gcgtgtacga gcgagtaaag
     2401 cagcgcaagg aggaggaaga gcgtcgcgag atggaacgca agcaggcggc tgctaagaag
     2461 ttgcaagaac tggaaatgaa gatgaatagc aaaaaggcag cggctgcggc tctggctgga
     2521 gccgagggcg gcgtgtcctc tgcctcagtc ccgttgagca atgaggtgcc acccacgtcc
     2581 gcaccgctag gcaatgccag cgaagatgag ggcggaggcc aaggcggcgg cggagggttg
     2641 aatcgtcgac cccggggaag catctctagc ttgggaagcg gcgtaacacc cacgggagga
     2701 gctggcggcg gcggcggagg agtttcgtca tcctcgtcag caggcggcga ctatggtcaa
     2761 aagaacttcc ttacccattt ccaatcaaat ttaccaccac gtttccagcg ccagcaacag
     2821 caacaacagc agcagctgcc gcgcttggag aagagcgcct cggcaagcag tgcattcgat
     2881 agcaattccc gctacctcca gaagggagga gtaagcggag gaggcggtgg tgtaagtgga
     2941 ggagcgcaag ccaatgctgg ccagggtcgc agcatctccg gcggttatgt gcagcgtggt
     3001 gcaagtgtcg gaggaagcag cggatacgga cgaaatcgtc acgacagcag cagtgctcgg
     3061 gaggatcagg atctggatca gcagcgtttc acccgtggcc aggactatcg gcaggcacaa
     3121 gctctgccgc gcagcatatc tgagaactcg caccgtaaga ccagcgtctc atcggctggc
     3181 gacgatgtgc tgggtggctc gtgctcctca tgggcggagc aaacggatgc cgagcagaag
     3241 gtgcaccatc ggcaccgcga ggagagcttc tcctcgtcgc acagccatga ctcggcagtg
     3301 caaataaaga tcctgcaacg cccggcccga cagccgagcc tcagtgagga gtcctcgacc
     3361 cagcagaaac agctgcccgc ctcgccgcag cagcaaaaga cgctgacgac agatcccatg
     3421 cctacccaga ttctgcgacg cagcgtggat atcgataagt ccggtgatga gcgcgcggag
     3481 gacaagtctg cattggaatc tgatgacaag gcgaagtcgg ctggcaaggt ggaggaggac
     3541 aagagcggca ataagcgggt aagtcccagg agcggagctg cttgcggagg tcgaggtggc
     3601 cgtggttatg ccggcagctc tggtggatca tccgtcggat cgggcagtag ctaccgcggc
     3661 cagagaaatg ccagcgattg gggaagcagt cgtggaagcg gcggcgccgg cggcaggcgc
     3721 tactacggca gcggcggtga gcaatcggag cactccgagg atgtggacga ggagtgttac
     3781 agcagtggag gaggcggagc cgctcgtcgc agcccaaagg aatcgggcaa cggtgcgccc
     3841 aattccggtg cgtcggcaaa caaggcagga ttctcgccac gcggcgaacc atctagacgt
     3901 ggtcgaggcg gcctctctag cggaggaggc gcctctgctt cttgttaccg tcgacagccc
     3961 gtgggcactg gatccgctgg tggatctggt tcgggcggat cgggccgcag ctatggcaga
     4021 cttggctacg aggaatatgg caagcaacag cgaacttccg agtcggagac ggacctagac
     4081 aagaccaagc agaaccagct ggcactcagc gccggcctgc acaaaccaag caaggatgac
     4141 aaggatttgc ctgcgcttgg gggcgaggag aaggacaaga ctgccgccct ggcgcctgcc
     4201 cataacactg ccctgctagc aaaggatgaa ttacagaaag atgcagcggg tcgcctgccg
     4261 ttgcctcccg gcctcgcagc acctggctct gcagtgggat ccgttactgc cacatcctca
     4321 tcggtcgtag ttcccggtgc agcggacaag aagaagattg aatcctgcgc cgttgtcggc
     4381 ggtgagaagg tgacgggtag caagttgccc gccattgggg aaaagacttc gctcggcgcc
     4441 gttggctcgg gtccatcaac cagtcttcta ctggacgccg gcgcacccgt caacacgatt
     4501 atatttgaga actccacgta caagcagcag gcagctgccg cttccgtggt aaccaaaccc
     4561 ggaacgctct cggtgtcaag cagtggcgcc accatgaccg tggacagcct gtccagcgca
     4621 ctctcccaaa tgagtttcgg cggcaaggcg acggcggcgg gctctggcga tgattcgcag
     4681 gatatgaaac taggatttag cttcggtgac gatcccacca cacccctcaa ggttgtggat
     4741 aacatcgata aaacggccag tcagcagcag caacagcagc agcaacaaca ctctcaacag
     4801 caacaacaac agcagcagca gcaaaacaat tcgacggcgg atcttaacat gaagatagcc
     4861 agcgtaaaga aggtttggga gtcagccacg cccatgtccg acggcccatc gccagcacag
     4921 gtgcagcagc aacagcaaca gcagccccaa cagcaacaac agtcccaggt gcaggtggcg
     4981 gcgcagcagc aacaacagca ggtggtggga ccgcagcagg caggtgacga cggcagtggt
     5041 cacatgagcg ccgcctcctt tgtggcagcc gtggccgcct cacagcatca gcagcaacac
     5101 cagcaaatgc cgcactacgc ggtgtcggcg gtgcacatgc agagccacca ccaccaacag
     5161 cagcagcaac agcagcaggc agcggtggcg gcagcgcagg cgcagcacca ccagcagcaa
     5221 caggcacagg cgcaccacca gcaccatgca ctttcctcgc cgggcccggt gcccggtagt
     5281 catggccatg gctacagtca tggatcgccg ttcgacgctg gatcgttgga gcaacagttc
     5341 cagcaagagg attatcccag tccacagcag caacagcagg cgcaccagaa gaccaagcag
     5401 ttgcagcagc agcagcatct gggcatgtca ccgccgccca gccagcagca acagcagcag
     5461 cactcgcaac agcagcagca agcacagcac cagcaacaac agcagcaggc ccatcagcag
     5521 cagcaacagc agcagcagcc ttcattctac caggcgtcac cgcagttcgg cgttggaggc
     5581 attcccacta tccccagtcc gccggccgtg gtgtacaact cgtcgcagat gccgccaccg
     5641 tcgcaggggg gtaatctgta cgctccattc cattcgctcg atcattcgag ccgttcgccc
     5701 gcctactcgg cggcggcggc cgcccacagc tacccgaacc cttatgcggc agcagcagcg
     5761 gcggcggcgg cagcggccgc tggcggaggt cccttcaatg tcaacgtgaa cgcatatgcg
     5821 atgcagactc cgcacggcgg cagcctaccg cccacagcgc ccacaccgga catgtactcg
     5881 aacctctctt cgcagtttcg attgggcggt ggtccgggtc ccggacccgg tccctttggc
     5941 cagcccagct cgcagcagtt aagcaatccg agcaatcatg ctgcggtggc tataatttcg
     6001 tcaagcagca actccatgat gtcgtcaggt gcggccaaac cgccgcagag ccagcagaca
     6061 atcggtgcca ttggctccaa gtcggcaggt agcggtggcg gtccaggacc aggacctggt
     6121 ccctatgcca ccacccagac gtatatgaat ctttatgcgg ctccaccgcc gcaacatcca
     6181 ggacaaggtg gaccaccgcc gggtgcccat cagctgcagt cgaacagttt ctactcgaat
     6241 tcggcgccag gcggtccgag cggaccacag ttctacggtg gtccgccgcc gcagggcaat
     6301 ggtggagcgc agagctatgg actggccacc gcggccggca tgtatggcgg ccatcagggc
     6361 ggaccgcccg gctccaatgg gccgccggga ccgccgcagt cgcagcacac gatgggcacg
     6421 ttcaacacgc cgttcatgaa ctcgcagctg ctgacggcgg ccagcattaa tcagtaccgc
     6481 ggcggaccaa cgcctggagc ggcttatctc aagggtaacc agggccagac acacatgcaa
     6541 gactcgatgg gtcgtcagct gaagagtccg ctgagcgctg acatgagcct cggtctggcc
     6601 aagcaggtgc agtcgcagcc cagtccaccg catcacaaga actacggcgc gtgggatctg
     6661 cagaaccagg tgcttcagca gcagcagcag caatctcagc agcaacagca gcagcaacag
     6721 cgccaggtcg gcggcggcaa tggtccgagc atgaacgcct tgggcggtcg cggcagtgga
     6781 gcggtgggca gcggcagcgg caacggcgga ggaggaggag gaggagctgg tgggtcccaa
     6841 gtgggcggca atggcggcgg taacggcgtt ggcagcgtgg gccaaagtgg cggcggcggc
     6901 cagggacgct atcccacgcc cattcagcgg cccaacaact atccgcagca tccgcaacaa
     6961 cagcagcaac aacagcagca acagcaacag cagagagagc aggcggcagc tgccgccgtg
     7021 gcggctcagc gggcacagaa tatgcgacag gtgaccggtg ccggcggagg cgtggccgga
     7081 agtgcaggtg gcggtggtag tcaaacacca gtgggaccgg ccggcggcaa tggtggcccc
     7141 ggtggcgcag gaggaggcgg tggagctggc ggtgcagcag gatcaggacc cggaaagccc
     7201 tactatgcga ataacgctag cggagcggcc gttgcggcca atcgaggtga gtggcatgcg
     7261 aactgagtgc cagatggtca ccacccatcg accagccgat cccagccacc caccataaca
     7321 aacccggaat aactatgtac gagtacgaaa cagaaacaca atgatgcaaa ttgataacga
     7381 aggaggatgg ccaagagaat gagcaacagc tggaggaatg tattgcatcc aaaacgagaa
     7441 tatgaacgta aacagagcaa gtcaggagta aaactatata tgtggaatat aatcaagtta
     7501 ccgagcgaga cacaggcatc cgaataataa gcccacaaaa tatgtgaaag gggcgatgcg
     7561 agtagaatag tgctatagct gtttggggga atccccgtca caatcgcaaa atggcaactc
     7621 agctaaatca ccgtagcgag gaggaaatta atttaaatcg caatttgaaa gtaagaaaaa
     7681 agttaagacg aaagttaaga atcaacagga aacgagtaag gaatacctaa atgcaagaag
     7741 aaatatttaa caaaaatgaa cagaatacaa caccatgcca caccacaaca cacacacaca
     7801 cacacatgca tacatttaca tatacataca tacatacaga atagcagatt gtattttttg
     7861 tcaaacaaat ttacataata atatattact tttatatact t