Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster hyperkinetic, transcript variant I (Hk),


LOCUS       NM_001258683            3536 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001258683
VERSION     NM_001258683.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3536)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3536)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3536)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3536)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3536)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3536)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3536)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3536)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3536)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3536)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3536)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3536)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3536)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3536)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3536)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3536)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3536)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3536)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3536)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3536)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3536)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3536)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3536)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258683.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3536
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3536
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="Hyperkinetic"
                     /map="9B4-9B5"
                     /db_xref="FLYBASE:FBgn0263220"
                     /db_xref="GeneID:31955"
     CDS             1157..2338
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="CG43388 gene product from transcript CG43388-RI;
                     CG43388-PI; Hk-PI; kvbeta channel subunit; hyperk;
                     hyperkinetic"
                     /codon_start=1
                     /product="hyperkinetic, isoform I"
                     /protein_id="NP_001245612.1"
                     /db_xref="FLYBASE:FBpp0300315"
                     /db_xref="GeneID:31955"
                     /db_xref="FLYBASE:FBgn0263220"
                     /translation="MCRAPIASLDCMEEFSGTGGHLDFGRSISLGSNPALPLRHGSTP
                     TPGLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAHS
                     ETEIGKILQRAGWKRTAYVITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDI
                     VIIHKADPMCPMEEVVRAMSYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIV
                     EQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKS
                     FSWTEDEINRNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSL
                     KHEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERILENKPVRPPMISTLAL
                     R"
     misc_feature    1298..2299
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="AKR6B family of aldo-keto reductase (AKR); Region:
                     AKR_AKR6B1; cd19142"
                     /db_xref="CDD:381368"
     misc_feature    order(1352..1360,1442..1444,1457..1459,1529..1531,
                     1646..1648,1736..1741,1814..1816,1901..1918,1928..1930,
                     1934..1936,2132..2134,2183..2197,2207..2209,2216..2221)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="putative active site [active]"
                     /db_xref="CDD:381368"
     misc_feature    order(1442..1444,1457..1459,1529..1531,1646..1648)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381368"
ORIGIN      
        1 ttcgtcctat tcgctgatag taaaccattg ggccagcggg tgaccatcgc cgtgttgctc
       61 ggtaaattcc ccaagcgccg aaatgaacca ctgacacgcc ctaggcgctt ctctatttgg
      121 ctaactggat atctggccat ctggcagtac cattggaacc atccatcccc agtcggaccc
      181 agcctcactc aattcaacgc acgtgcctgg tcatagactg gaaaaacagt tcaactggat
      241 aactggacaa ctgaaaaacc actgaggtcc ttccacaggc tcacgcacac aagcgcaagc
      301 aacaggactt gtttatcgac agcccctcgg ttgggcccca ctccaaactg gcccatcaat
      361 tttggttctc ctacccgcca ccgggcgctg gcggcggttc ctcaagaatc ataaaactaa
      421 ggaatcacgt ctaacaaata cgaattacaa gcgaaagaat acaaaaataa gaaaatacag
      481 aattaaatcg aaaacggaga tctctccctt tcagtctctc ctctctttct atctgcctat
      541 atgtctatct ctttcttaaa agacacactc agacacaccg cactcaccta acggtactaa
      601 taccattcca atcgtttcgg tacgcgtcgc gatcgcgtgt aatcaattgc caaattcgac
      661 aagaatcgtt actaaaatat aatcaaaatc aaattcgaca caacaagaac aacatcatca
      721 ccacaagtac aacatcagaa aaaaaacaca ttgagacagc aagaactcgc agaccgacga
      781 agagaagcaa cgcgatcgac agcgaaacga gcgcgaggcg aaaaaggaag agcaggacgc
      841 tatcaactac aaggagctcg atagtacgac atcatcatcc tccacacagc agaccttccc
      901 tggcagcgca gtcggggcgg gcagaggagc gtcagcagcg gtacctggaa gcgggacagc
      961 gatagcggtt gcagtagcag gagcgggagc gggacaatcg gcgacattgg cggggccgcc
     1021 ggcaacggcc gcagctgcca cagctgcgat cataccgatt ctgccgctcg gcgttgcaac
     1081 gctgcgcgat gattccaccg aatctgagca gtccgtgacc tgtgcgcaca accagctcga
     1141 tgcctaccac cgcatcatgt gccgggctcc cattgcgtca ctcgactgta tggaggagtt
     1201 cagtggtacg ggcggtcatc ttgatttcgg tcgttcgatc agtttgggct ccaatccggc
     1261 gctaccattg cgccatggat ccacaccaac gccgggactg cggtacaaga atctgggcaa
     1321 aagcgggttg cgtatctcga atgtgggatt gggtacctgg ccggtatttt cgccgggcgt
     1381 gagcgatgac caggcggagg caatccttaa gctggccatc gagagcggta tcaatctgtt
     1441 cgacatctcg gaggcgcact cggagacgga gatcggcaag atactgcagc gggcgggctg
     1501 gaagaggacc gcctatgtca tcaccacgaa ggtctactgg agcaccaagt cggaggaacg
     1561 tggtctctcc cggaaacaca tcatcgaatg tgttcgtgcc agtttgcagc gattgcagct
     1621 gcagtacatc gatatcgtca tcatccacaa ggcggatccc atgtgtccca tggaggaagt
     1681 ggtgcgcgcc atgagctacg tgatacagca gggctgggca atgtattggg gcaccgctcg
     1741 atggagccag gtggagatca tggaggccta taccaactgc cgccagttca actgcatcac
     1801 gcccattgtg gagcagtccg agtaccatat gttctgtcgc gaaaagtgcg aactctacct
     1861 gccggagatg tacaacaaga tcggagtggg cctcatggcc tggggtccac tctcgatggc
     1921 cctcagcgac acccagaatg gggacaagct tttcctgccc aagggctcct tcaagacgaa
     1981 gagcttctcg tggaccgagg acgagatcaa tcgtaatgcc gctctgtcgc cgcagggcag
     2041 ttggggtaag gaccggatcg atgaggggcg ccgccactgc gaccgtctcc gcgaccttgc
     2101 cgccctcgcc gagaagctgg gctgcagccc cacccagctg tccatcgcct ggtcgctgaa
     2161 acatgagcca gtgcaatgcc tgctgctggg cgccacatcg gcggagcagc tgcaccaaag
     2221 tctgcagtcg ttgcagctgc tgccacgact ctcatcgagc gttatgctgg agctggaaag
     2281 gatattggaa aacaagccgg tgcggccgcc gatgatctcg accttggcgc tccggtgaca
     2341 atcagcgtgc ccgcaggggc cgctcagcct gagcggtggc ggaccctgcg gcgccgattc
     2401 gcccaagcac gaggatgagg ccttcatcga ggaggtggac gctgccaagg acgctgccaa
     2461 gcaaggcttc tgcctcatcc agtgacaaaa ggagtcctta gataacgata ataaattttt
     2521 gaaagtgatt agcagtaaaa ctagcctaag tagcaatacc atgacgacaa caataagcaa
     2581 gcaggagcag caacagcagc agcagcagca acaacagcag caacatctcc agcctcagca
     2641 gtatgtgcaa ctacagcagc aacatttgat ggccagcggc agcaccagcg attcggcggc
     2701 agctgttccc attgcagctg aactccagtt cgactccctg aataacaata acaacaacaa
     2761 caataataat accaatggca gtccggaaca ggcactgccc accagcgatg aacgccaaaa
     2821 acgtcgctcc ctgctcaact ttaagtccct ggactttcat ctaaagtccc tgtacagtgg
     2881 cctacggagt aactcaggaa caactccacc cagtcaaccg aatagctctg ttccggcggt
     2941 ggatcagccg cagcgtagaa tgccctattt gcgggtggag agtgttgatc ccgaggagcc
     3001 aagaggatca gttctgcccg gacattcgcc cagctttctg tcaccctaca gtggcgttgg
     3061 cggtggagcc ggaagcctgc agttgccctc aaacgatgga ggcaccatca ggagatcctc
     3121 aacatccgac attgttaatt gcagacgggg agggggagca gggggatcgg gcggaggagc
     3181 agcctctgcc caggacagca ggaggccgag cacatcggat ttgctcagaa aggcaaggga
     3241 acgaaagggc agtgaggcca ggatgggcag aagtgtctcc cacagtgggc taaccagggg
     3301 cggacccggc ggaggaggtg gtggcctggg cgggagacga accagcatgg ccttctaaaa
     3361 acagaaataa tagtgaaaaa aaaaaaaact atggaaaaaa aaacttaagc aatgaggtat
     3421 ggcgaaaaaa aaaactgttg atcaaatctg aatcagaaat aggctgacaa aatggcgctt
     3481 atgaattttt atctagtgaa aagaaaatta aaaaaaaaag aaaacaagaa aaaaat