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Drosophila melanogaster hyperkinetic, transcript variant H (Hk),


LOCUS       NM_001258682            3916 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001258682
VERSION     NM_001258682.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3916)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3916)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3916)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3916)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3916)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3916)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3916)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3916)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3916)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3916)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3916)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3916)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3916)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3916)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3916)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3916)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3916)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258682.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3916
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3916
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="Hyperkinetic"
                     /map="9B4-9B5"
                     /db_xref="FLYBASE:FBgn0263220"
                     /db_xref="GeneID:31955"
     CDS             1593..2717
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="CG43388 gene product from transcript CG43388-RH;
                     CG43388-PH; Hk-PH; kvbeta channel subunit; hyperk;
                     hyperkinetic"
                     /codon_start=1
                     /product="hyperkinetic, isoform H"
                     /protein_id="NP_001245611.1"
                     /db_xref="FLYBASE:FBpp0300314"
                     /db_xref="GeneID:31955"
                     /db_xref="FLYBASE:FBgn0263220"
                     /translation="MPTTASCRSISLGSNPALPLRHGSTPTPGLRYKNLGKSGLRISN
                     VGLGTWPVFSPGVSDDQAEAILKLAIESGINLFDISEAHSETEIGKILQRAGWKRTAY
                     VITTKVYWSTKSEERGLSRKHIIECVRASLQRLQLQYIDIVIIHKADPMCPMEVVRAM
                     SYVIQQGWAMYWGTARWSQVEIMEAYTNCRQFNCITPIVEQSEYHMFCREKCELYLPE
                     MYNKIGVGLMAWGPLSMALSDTQNGDKLFLPKGSFKTKSFSWTEDEINRNAALSPQGS
                     WGKDRIDEGRRHCDRLRDLAALAEKLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLH
                     QSLQSLQLLPRLSSSVMLELERILENKPVRPPMISTLALR"
     misc_feature    1680..2678
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="AKR6B family of aldo-keto reductase (AKR); Region:
                     AKR_AKR6B1; cd19142"
                     /db_xref="CDD:381368"
     misc_feature    order(1734..1742,1824..1826,1839..1841,1911..1913,
                     2028..2030,2115..2120,2193..2195,2280..2297,2307..2309,
                     2313..2315,2511..2513,2562..2576,2586..2588,2595..2600)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="putative active site [active]"
                     /db_xref="CDD:381368"
     misc_feature    order(1824..1826,1839..1841,1911..1913,2028..2030)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381368"
ORIGIN      
        1 ttcgtcctat tcgctgatag taaaccattg ggccagcggg tgaccatcgc cgtgttgctc
       61 ggtaaattcc ccaagcgccg aaatgaacca ctgacacgcc ctaggcgctt ctctatttgg
      121 ctaactggat atctggccat ctggcagtac cattggaacc atccatcccc agtcggaccc
      181 agcctcactc aattcaacgc acgtgcctgg tcatagactg gaaaaacagt tcaactggat
      241 aactggacaa ctgaaaaacc actgaggtcc ttccacaggc tcacgcacac aagcgcaagc
      301 aacaggactt gtttatcgac agcccctcgg ttgggcccca ctccaaactg gcccatcaat
      361 tttggttctc ctacccgcca ccgggcgctg gcggcggttc ctcaagaatc ataaaactaa
      421 ggaatcacgt ctaacaaata cgaattacaa gcgaaagaat acaaaaataa gaaaatacag
      481 aattaaatcg aaaacggaga tctctccctt tcagtctctc ctctctttct atctgcctat
      541 atgtctatct ctttcttaaa agacacactc agacacaccg cactcaccta acggtactaa
      601 taccattcca atcgtttcgg tacgcgtcgc gatcgcgtgt aatcaattgc caaattcgac
      661 aagaatcgtt actaaaatat aatcaaaatc aaattcgaca caacaagaac aacatcatca
      721 ccacaagtac aacatcagaa aaaaaacaca ttgagacagc aagaactcgc agaccgacga
      781 agagaagcaa cgcgatcgac agcgaaacga gcgcgaggcg aaaaaggaag agcaggacgc
      841 tatcaactac aagcgcgaca aggagcaacg cgaggcccgt ctgctggact ttgagatacg
      901 ccgccagcag aagcgggacg agcagcagca gcagcgccag cagcagcaac aactgcagca
      961 gcaccgcgag catctgcagc agcagcatcg cgatcagcag cagtccagcg agaaaagtcc
     1021 gcccacctcg tccaccgcag ccgccgccca ccagacacat tcgcattcgc agcagcaaca
     1081 gcagcggcag catttgcatc tgcagcaaca gcatctgcag cagcagcaac agcagcagca
     1141 acaacagtca acgggcagcg gcagcagcaa cacaccagtg accccaaagt tgcagacacc
     1201 tccccccgat cgatcgctgc cccccgcctt ccggagtcgc tccatcgagc gggagattct
     1261 ttacgagcgg aagcgattct cgcagccgga aaccggcgag atcaaggagc tcgatagtac
     1321 gacatcatca tcctccacac agcagacctt ccctggcagc gcagtcgggg cgggcagagg
     1381 agcgtcagca gcggtacctg gaagcgggac agcgatagcg gttgcagtag caggagcggg
     1441 agcgggacaa tcggcgacat tggcggggcc gccggcaacg gccgcagctg ccacagctgc
     1501 gatcataccg attctgccgc tcggcgttgc aacgctgcgc gatgattcca ccgaatctga
     1561 gcagtccgtg acctgtgcgc acaaccagct cgatgcctac caccgcatca tgtcgttcga
     1621 tcagtttggg ctccaatccg gcgctaccat tgcgccatgg atccacacca acgccgggac
     1681 tgcggtacaa gaatctgggc aaaagcgggt tgcgtatctc gaatgtggga ttgggtacct
     1741 ggccggtatt ttcgccgggc gtgagcgatg accaggcgga ggcaatcctt aagctggcca
     1801 tcgagagcgg tatcaatctg ttcgacatct cggaggcgca ctcggagacg gagatcggca
     1861 agatactgca gcgggcgggc tggaagagga ccgcctatgt catcaccacg aaggtctact
     1921 ggagcaccaa gtcggaggaa cgtggtctct cccggaaaca catcatcgaa tgtgttcgtg
     1981 ccagtttgca gcgattgcag ctgcagtaca tcgatatcgt catcatccac aaggcggatc
     2041 ccatgtgtcc catggaggtg gtgcgcgcca tgagctacgt gatacagcag ggctgggcaa
     2101 tgtattgggg caccgctcga tggagccagg tggagatcat ggaggcctat accaactgcc
     2161 gccagttcaa ctgcatcacg cccattgtgg agcagtccga gtaccatatg ttctgtcgcg
     2221 aaaagtgcga actctacctg ccggagatgt acaacaagat cggagtgggc ctcatggcct
     2281 ggggtccact ctcgatggcc ctcagcgaca cccagaatgg ggacaagctt ttcctgccca
     2341 agggctcctt caagacgaag agcttctcgt ggaccgagga cgagatcaat cgtaatgccg
     2401 ctctgtcgcc gcagggcagt tggggtaagg accggatcga tgaggggcgc cgccactgcg
     2461 accgtctccg cgaccttgcc gccctcgccg agaagctggg ctgcagcccc acccagctgt
     2521 ccatcgcctg gtcgctgaaa catgagccag tgcaatgcct gctgctgggc gccacatcgg
     2581 cggagcagct gcaccaaagt ctgcagtcgt tgcagctgct gccacgactc tcatcgagcg
     2641 ttatgctgga gctggaaagg atattggaaa acaagccggt gcggccgccg atgatctcga
     2701 ccttggcgct ccggtgacaa tcagcgtgcc cgcaggggcc gctcagcctg agcggtggcg
     2761 gaccctgcgg cgccgattcg cccaagcacg aggatgaggc cttcatcgag gaggtggacg
     2821 ctgccaagga cgctgccaag caaggcttct gcctcatcca gtgacaaaag gagtccttag
     2881 ataacgataa taaatttttg aaagtgatta gcagtaaaac tagcctaagt agcaatacca
     2941 tgacgacaac aataagcaag caggagcagc aacagcagca gcagcagcaa caacagcagc
     3001 aacatctcca gcctcagcag tatgtgcaac tacagcagca acatttgatg gccagcggca
     3061 gcaccagcga ttcggcggca gctgttccca ttgcagctga actccagttc gactccctga
     3121 ataacaataa caacaacaac aataataata ccaatggcag tccggaacag gcactgccca
     3181 ccagcgatga acgccaaaaa cgtcgctccc tgctcaactt taagtccctg gactttcatc
     3241 taaagtccct gtacagtggc ctacggagta actcaggaac aactccaccc agtcaaccga
     3301 atagctctgt tccggcggtg gatcagccgc agcgtagaat gccctatttg cgggtggaga
     3361 gtgttgatcc cgaggagcca agaggatcag ttctgcccgg acattcgccc agctttctgt
     3421 caccctacag tggcgttggc ggtggagccg gaagcctgca gttgccctca aacgatggag
     3481 gcaccatcag gagatcctca acatccgaca ttgttaattg cagacgggga gggggagcag
     3541 ggggatcggg cggaggagca gcctctgccc aggacagcag gaggccgagc acatcggatt
     3601 tgctcagaaa ggcaagggaa cgaaagggca gtgaggccag gatgggcaga agtgtctccc
     3661 acagtgggct aaccaggggc ggacccggcg gaggaggtgg tggcctgggc gggagacgaa
     3721 ccagcatggc cttctaaaaa cagaaataat agtgaaaaaa aaaaaaacta tggaaaaaaa
     3781 aacttaagca atgaggtatg gcgaaaaaaa aaactgttga tcaaatctga atcagaaata
     3841 ggctgacaaa atggcgctta tgaattttta tctagtgaaa agaaaattaa aaaaaaaaga
     3901 aaacaagaaa aaaata