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Drosophila melanogaster hyperkinetic, transcript variant F (Hk),


LOCUS       NM_001258681            3788 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001258681
VERSION     NM_001258681.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3788)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3788)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3788)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3788)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3788)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3788)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3788)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3788)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3788)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3788)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3788)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3788)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3788)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3788)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3788)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3788)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3788)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3788)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3788)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3788)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3788)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3788)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3788)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258681.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3788
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3788
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="Hyperkinetic"
                     /map="9B4-9B5"
                     /db_xref="FLYBASE:FBgn0263220"
                     /db_xref="GeneID:31955"
     CDS             494..2590
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="CG43388 gene product from transcript CG43388-RF;
                     CG43388-PF; Hk-PF; kvbeta channel subunit; hyperk;
                     hyperkinetic"
                     /codon_start=1
                     /product="hyperkinetic, isoform F"
                     /protein_id="NP_001245610.1"
                     /db_xref="FLYBASE:FBpp0300312"
                     /db_xref="GeneID:31955"
                     /db_xref="FLYBASE:FBgn0263220"
                     /translation="MTPPRLSRYLMAVRGGRDGEQHSKNSQTDEEKQRDRQRNEREAK
                     KEEQDAINYKRDKEQREARLLDFEIRRQQKRDEQQQQRQQQQQLQQHREHLQQQHRDQ
                     QQSSEKSPPTSSTAAAAHQTHSHSQQQQQRQHLHLQQQHLQQQQQQQQQQSTGSGSSN
                     TPVTPKLQTPPPDRSLPPAFRSRSIEREILYERKRFSQPETGEIKELDSTTSSSSTQQ
                     TFPGSAVGAGRGASAAVPGSGTAIAVAVAGAGAGQSATLAGPPATAAAATAAIIPILP
                     LGVATLRDDSTESEQSVTCAHNQLDAYHRIMCRAPIASLDCMEEFSGTGGHLDFGRSI
                     SLGSNPALPLRHGSTPTPGLRYKNLGKSGLRISNVGLGTWPVFSPGVSDDQAEAILKL
                     AIESGINLFDISEAHSETEIGKILQRAGWKRTAYVITTKVYWSTKSEERGLSRKHIIE
                     CVRASLQRLQLQYIDIVIIHKADPMCPMEVVRAMSYVIQQGWAMYWGTARWSQVEIME
                     AYTNCRQFNCITPIVEQSEYHMFCREKCELYLPEMYNKIGVGLMAWGPLSMALSDTQN
                     GDKLFLPKGSFKTKSFSWTEDEINRNAALSPQGSWGKDRIDEGRRHCDRLRDLAALAE
                     KLGCSPTQLSIAWSLKHEPVQCLLLGATSAEQLHQSLQSLQLLPRLSSSVMLELERIL
                     ENKPVRPPMISTLALR"
     misc_feature    1553..2551
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /old_locus_tag="Dmel_CG32688"
                     /old_locus_tag="Dmel_CG34319"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="AKR6B family of aldo-keto reductase (AKR); Region:
                     AKR_AKR6B1; cd19142"
                     /db_xref="CDD:381368"
     misc_feature    order(1607..1615,1697..1699,1712..1714,1784..1786,
                     1901..1903,1988..1993,2066..2068,2153..2170,2180..2182,
                     2186..2188,2384..2386,2435..2449,2459..2461,2468..2473)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="putative active site [active]"
                     /db_xref="CDD:381368"
     misc_feature    order(1697..1699,1712..1714,1784..1786,1901..1903)
                     /gene="Hk"
                     /locus_tag="Dmel_CG43388"
                     /gene_synonym="CG17779; CG2287; CG32688; CG34319; CG43388;
                     Dmel\CG43388; Dm_X:51771; hk; HK; lincRNA.975"
                     /note="catalytic tetrad [active]"
                     /db_xref="CDD:381368"
ORIGIN      
        1 gagtgttagt cgagtagagg ccgctcctca aagtgggaat gctccgaaaa aataataaaa
       61 agaggaaaaa aacaccaatt taaataagtc aaataattaa cgaacgtgag aaatacaaaa
      121 atgcaaacaa atggcaatcg tgttgatgtg tagatattga aattgatatt gactgtgaat
      181 taactttaat gcaatcagtg tgcccaccgc aattccaaat tacgtgcgtg acttggtcac
      241 actaccgcaa aatgcatatc tgtctggttg ccgcgaacac tcgcagctgg gcattaatcc
      301 tcccgagaag atgacactaa ttgggccgcg gtcaactttg gttgtgttta gtgttttggg
      361 ttcagtgttt agctttatgt ttttagtggg ccgcatgttg gtgctcagtg tcagtttcgc
      421 ctggctcttc ggccgcaact gacgactgtt gattccgtgt gggcttttca cctgtcgaaa
      481 ggtgcgaatt agtatgacac cgcctcggct gagtcgctat ttgatggcag tgcgtggtgg
      541 gcgcgatggg gagcagcaca gcaagaactc gcagaccgac gaagagaagc aacgcgatcg
      601 acagcgaaac gagcgcgagg cgaaaaagga agagcaggac gctatcaact acaagcgcga
      661 caaggagcaa cgcgaggccc gtctgctgga ctttgagata cgccgccagc agaagcggga
      721 cgagcagcag cagcagcgcc agcagcagca acaactgcag cagcaccgcg agcatctgca
      781 gcagcagcat cgcgatcagc agcagtccag cgagaaaagt ccgcccacct cgtccaccgc
      841 agccgccgcc caccagacac attcgcattc gcagcagcaa cagcagcggc agcatttgca
      901 tctgcagcaa cagcatctgc agcagcagca acagcagcag caacaacagt caacgggcag
      961 cggcagcagc aacacaccag tgaccccaaa gttgcagaca cctccccccg atcgatcgct
     1021 gccccccgcc ttccggagtc gctccatcga gcgggagatt ctttacgagc ggaagcgatt
     1081 ctcgcagccg gaaaccggcg agatcaagga gctcgatagt acgacatcat catcctccac
     1141 acagcagacc ttccctggca gcgcagtcgg ggcgggcaga ggagcgtcag cagcggtacc
     1201 tggaagcggg acagcgatag cggttgcagt agcaggagcg ggagcgggac aatcggcgac
     1261 attggcgggg ccgccggcaa cggccgcagc tgccacagct gcgatcatac cgattctgcc
     1321 gctcggcgtt gcaacgctgc gcgatgattc caccgaatct gagcagtccg tgacctgtgc
     1381 gcacaaccag ctcgatgcct accaccgcat catgtgccgg gctcccattg cgtcactcga
     1441 ctgtatggag gagttcagtg gtacgggcgg tcatcttgat ttcggtcgtt cgatcagttt
     1501 gggctccaat ccggcgctac cattgcgcca tggatccaca ccaacgccgg gactgcggta
     1561 caagaatctg ggcaaaagcg ggttgcgtat ctcgaatgtg ggattgggta cctggccggt
     1621 attttcgccg ggcgtgagcg atgaccaggc ggaggcaatc cttaagctgg ccatcgagag
     1681 cggtatcaat ctgttcgaca tctcggaggc gcactcggag acggagatcg gcaagatact
     1741 gcagcgggcg ggctggaaga ggaccgccta tgtcatcacc acgaaggtct actggagcac
     1801 caagtcggag gaacgtggtc tctcccggaa acacatcatc gaatgtgttc gtgccagttt
     1861 gcagcgattg cagctgcagt acatcgatat cgtcatcatc cacaaggcgg atcccatgtg
     1921 tcccatggag gtggtgcgcg ccatgagcta cgtgatacag cagggctggg caatgtattg
     1981 gggcaccgct cgatggagcc aggtggagat catggaggcc tataccaact gccgccagtt
     2041 caactgcatc acgcccattg tggagcagtc cgagtaccat atgttctgtc gcgaaaagtg
     2101 cgaactctac ctgccggaga tgtacaacaa gatcggagtg ggcctcatgg cctggggtcc
     2161 actctcgatg gccctcagcg acacccagaa tggggacaag cttttcctgc ccaagggctc
     2221 cttcaagacg aagagcttct cgtggaccga ggacgagatc aatcgtaatg ccgctctgtc
     2281 gccgcagggc agttggggta aggaccggat cgatgagggg cgccgccact gcgaccgtct
     2341 ccgcgacctt gccgccctcg ccgagaagct gggctgcagc cccacccagc tgtccatcgc
     2401 ctggtcgctg aaacatgagc cagtgcaatg cctgctgctg ggcgccacat cggcggagca
     2461 gctgcaccaa agtctgcagt cgttgcagct gctgccacga ctctcatcga gcgttatgct
     2521 ggagctggaa aggatattgg aaaacaagcc ggtgcggccg ccgatgatct cgaccttggc
     2581 gctccggtga caatcagcgt gcccgcaggg gccgctcagc ctgagcggtg gcggaccctg
     2641 cggcgccgat tcgcccaagc acgaggatga ggccttcatc gaggaggtgg acgctgccaa
     2701 ggacgctgcc aagcaaggct tctgcctcat ccagtgacaa aaggagtcct tagataacga
     2761 taataaattt ttgaaagtga ttagcagtaa aactagccta agtagcaata ccatgacgac
     2821 aacaataagc aagcaggagc agcaacagca gcagcagcag caacaacagc agcaacatct
     2881 ccagcctcag cagtatgtgc aactacagca gcaacatttg atggccagcg gcagcaccag
     2941 cgattcggcg gcagctgttc ccattgcagc tgaactccag ttcgactccc tgaataacaa
     3001 taacaacaac aacaataata ataccaatgg cagtccggaa caggcactgc ccaccagcga
     3061 tgaacgccaa aaacgtcgct ccctgctcaa ctttaagtcc ctggactttc atctaaagtc
     3121 cctgtacagt ggcctacgga gtaactcagg aacaactcca cccagtcaac cgaatagctc
     3181 tgttccggcg gtggatcagc cgcagcgtag aatgccctat ttgcgggtgg agagtgttga
     3241 tcccgaggag ccaagaggat cagttctgcc cggacattcg cccagctttc tgtcacccta
     3301 cagtggcgtt ggcggtggag ccggaagcct gcagttgccc tcaaacgatg gaggcaccat
     3361 caggagatcc tcaacatccg acattgttaa ttgcagacgg ggagggggag cagggggatc
     3421 gggcggagga gcagcctctg cccaggacag caggaggccg agcacatcgg atttgctcag
     3481 aaaggcaagg gaacgaaagg gcagtgaggc caggatgggc agaagtgtct cccacagtgg
     3541 gctaaccagg ggcggacccg gcggaggagg tggtggcctg ggcgggagac gaaccagcat
     3601 ggccttctaa aaacagaaat aatagtgaaa aaaaaaaaaa ctatggaaaa aaaaacttaa
     3661 gcaatgaggt atggcgaaaa aaaaaactgt tgatcaaatc tgaatcagaa ataggctgac
     3721 aaaatggcgc ttatgaattt ttatctagtg aaaagaaaat taaaaaaaaa agaaaacaag
     3781 aaaaaaat