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LOCUS NM_001258607 1913 bp mRNA linear INV 26-DEC-2023 (MAPk-Ak2), transcript variant F, mRNA. ACCESSION NM_001258607 VERSION NM_001258607.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 1913) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 1913) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 1913) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 1913) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 1913) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 1913) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 1913) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 1913) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 1913) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 1913) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 1913) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 1913) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 1913) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 1913) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 1913) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 1913) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 1913) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 1913) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 1913) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 1913) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 1913) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 1913) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 1913) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_001258607.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..1913 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..1913 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="MAP kinase activated protein-kinase-2" /map="5B8-5B8" /db_xref="FLYBASE:FBgn0013987" /db_xref="GeneID:44573" CDS 26..1105 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /EC_number="2.7.11.17" /note="CG3086 gene product from transcript CG3086-RF; CG3086-PF; MAPk-Ak2-PF; MAP kinase-activated protein kinase 2; MAP kinase activated protein kinase-2" /codon_start=1 /product="MAP kinase activated protein-kinase-2, isoform F" /protein_id="NP_001245536.1" /db_xref="FLYBASE:FBpp0300801" /db_xref="GeneID:44573" /db_xref="FLYBASE:FBgn0013987" /translation="MLSLQNQRQPKTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQ NYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGEL FQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLK LTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPP FYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVI SNKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLATMRVDYDQMQIKALDKS NNPLLTKRRKKIEEMELYMANATRN" misc_feature 77..865 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; Region: STKc_MAPKAPK; cd14089" /db_xref="CDD:270991" misc_feature order(101..118,125..127,164..166,170..172,245..247, 305..316,326..328,332..334,446..451,455..457,461..466, 470..472,509..514,521..523,563..577,581..583) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="active site" /db_xref="CDD:270991" misc_feature order(101..118,125..127,164..166,170..172,245..247, 305..316,464..466,470..472,509..514) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270991" misc_feature order(113..115,326..328,332..334,446..451,455..457, 461..463,521..523,563..577,581..583) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270991" misc_feature order(509..541,551..577) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="activation loop (A-loop); other site" /db_xref="CDD:270991" ORIGIN 1 cagttaaaga tcagccgatt ccagaatgct ttctctgcag aatcaacggc aaccgaagac 61 caccccactg acggacgact acgtgacctc gaacacggtt ctgggctacg ggatcaacgg 121 gaaggtggtg cagtgcaccc atcgccgcac ccaacagaac tatgccctca aggtgctgtt 181 ggacagtgaa agggcgcgtc gcgaagtgga cctgcattgg cgggtcagcg gatgccggta 241 cattgtgaac atcattgatg tgtacgagaa cacgtttaag gacaggaagt gcctcctggt 301 ggtcatggag tgcatggagg gcggcgagct cttccagaga attcaggaca aggccgacgg 361 tgcctttacg gagcgggagg cggcccagat aatgcacgag atctgcgcgg ccgtagacta 421 tctgcacagt cgcgacatag cgcatcgcga tctcaagccg gagaacttgc tgtacaccac 481 cactcagccg aatgcgaccc ttaaattgac ggactttggc ttcgccaagg agacattcac 541 cagttacacg ctgcagacgc cctgctacac tccctattac gtggctcctg aggttctggg 601 cccggagaag tacgacaaga gctgcgacat ctggtcgctg ggcgtggtga tgtacatcat 661 tatgtgcgga ttcccgccgt tctacagcaa ccacggccta gccatatcgc ccggcatgaa 721 aaatcgcatc cgcaccggcc agtatgactt tcccgatccg gagtggacga atgtgagcca 781 ggcggcaaag gatctgatca agggcatgct gaacgtggac cccagcaagc gtctgcgcat 841 ccaggacgtc attagcaaca agtggattgc ccagtacaat gctgttccac agacaccgct 901 ctgcacgggt cgcatgctaa aggaggccga ggaaacctgg ccggaagtgc aggaggagat 961 gacgcgctca ctggccacca tgcgcgtaga ctacgatcag atgcaaatca aggcgctgga 1021 caagtcgaac aacccgctgc tgacgaagcg caggaaaaag atcgaggaga tggagttata 1081 catggccaat gcgacgcgca actagacaac gaggaatcca gagcgactaa cacggccaac 1141 ccgggagtga gatgagatga gatgaggaga gatgggcgta ggatgtagga tgggcgaacc 1201 atcggtttaa cacttaagcg gataacaatg ttgtacaatg ctttacaaaa acgataaata 1261 ctactatact acgacggcgg caagatctgc tattaactaa tatactacga tgacagcaac 1321 ctttgcaaaa caactactcc atgttattgt tacgttacgt tttcttattc attttgtccc 1381 attatctatc tatccatttc cagtcaaggg ttcttagggt attttgtagt ctgaaaagtg 1441 ctcttttgta aaagaaacta taaagcgtaa tgcgcaaata acgaacttaa gtaaagccaa 1501 gtgcaagcct agctagccag ccagcccagc cgaatattca aaatgtctcg gtatcgcgtg 1561 aaagtgtttc gtttttcgat tccctttttt tttttaaata ttattttcca aaaacgtgtc 1621 atttgtaacc gaaccgtttt ttacgtgtac gtgactttga ttataattat atatatatat 1681 gtatatgtat aaccgtctgt gtatgtatgg catatgtgtg gagaaacaat tatacagcca 1741 gttcacgtta gcattaatct gcgcaagatt cagtgttgtt tataactttt atttgctgat 1801 tctgcaagcg atataccatt ttaccgtata gcatatttgt agtccataaa caacaagatc 1861 atcccccaaa ttaataaaaa caaatcaagc ttattttact atgattaaaa cat