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Drosophila melanogaster bifid (bi), transcript variant E, mRNA.


LOCUS       NM_001258599            5390 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001258599
VERSION     NM_001258599.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5390)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5390)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5390)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5390)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5390)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5390)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5390)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5390)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5390)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5390)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5390)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5390)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5390)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5390)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5390)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5390)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5390)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5390)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5390)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5390)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5390)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5390)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5390)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_001258599.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5390
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5390
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="bifid"
                     /map="4C3-4C4"
                     /db_xref="FLYBASE:FBgn0000179"
                     /db_xref="GeneID:31379"
     CDS             456..3368
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /exception="nonconsensus splice site"
                     /note="CG3578 gene product from transcript CG3578-RE;
                     unusual splice; CG3578-PE; bi-PE; opomoter-blind;
                     quadroon; optomotor blind; optomotor-blind; optimotor
                     blind; optomer-blind; optomotorblind;
                     lethal(l)optomotor-blind; Optimotor-blind; optomotor-blind
                     gene; optomoter blind; optomoter-blind"
                     /codon_start=1
                     /product="bifid, isoform E"
                     /protein_id="NP_001245528.1"
                     /db_xref="FLYBASE:FBpp0301041"
                     /db_xref="GeneID:31379"
                     /db_xref="FLYBASE:FBgn0000179"
                     /translation="MRYDVQELLFHQSAEDPFARFANGMAYHPFLQLTQRPTDFSVSS
                     LLTAGSNNNNSGNTNSGNNNSNSNNNTNSNTNNTNNLVAVSPTGGGAQLSPQSNHSSS
                     NTTTTSNTNNSSSNNNNNNSTHNNNNNHTNNNNNNNNNTSQKQGHHLSTTEEPPSPAG
                     TPPPTIVGLPPIPPPNNNSSSSSSNNSASAAAHPSHHPTAAHHSPSTGAAAPPAGATG
                     LPPPTPPHHLQQQQQQQQHPAPPPPPYFPAAALAALAGSPAGPHPGLYPGGGLRFPPH
                     HPGAHPHAHHLGSAYTTAEDVVLASAVAHQLHPAMRPLRALQPEDDGVVDDPKVTLEG
                     KDLWEKFHKLGTEMVITKSGRQMFPQMKFRVSGLDAKAKYILLLDIVAADDYRYKFHN
                     SRWMVAGKADPEMPKRMYIHPDSPTTGEQWMQKVVSFHKLKLTNNISDKHGFTILNSM
                     HKYQPRFHLVRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKGF
                     RDTGAGKREKNYRQALMSNRGSDSDKLNPTHVSSSRAPLHLGHAGRPPHLHPHAALLD
                     NQQDDDDKLLDVVGPPQSPLLPLSHSLQQMHAHQHSALAAWFNHLAGAGAGASEHAAA
                     AAANASAEDALRRRLQADADVERDGSDSSCSESVGGSTGGAFRPTSTGSPKEAVGAAA
                     AAAAAGLNPGGGSYPSPNISVGPPIHPSPHLLPYLYPHGLYPPPHLGLLHNPAAAAAM
                     SPAGLNPGLLFNAQLALAAQHPALFGHAYAAAGHTPVSPLQGLKSHRFSPYSLPGSLG
                     SAFDAVTPGSNANRSGDPPGGGGGGLGGGVVENGPRSLSSSPRPRPASHSPPTRPISM
                     SPTTPPSLMKQPRGGGAGAGVAQSQHSPSELKSMEKMVNGLEVQHNGSAAAAAAALQL
                     AEEAAQHHHHTQAHHQQQQHQSHHQQQHHQQPAQPHPHHQTHLHSHHGATTGGTDQ"
     misc_feature    <1233..1409
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="Optomotor-blind protein N-terminal region; Region:
                     Optomotor-blind; pfam11078"
                     /db_xref="CDD:337907"
     misc_feature    1431..1985
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="DNA-binding domain of T-box transcription factor 2
                     and 3, and related T-box proteins; Region:
                     T-box_TBX2_3-like; cd20188"
                     /db_xref="CDD:410314"
     misc_feature    order(1518..1523,1752..1754,1761..1763,1800..1805,
                     1914..1925,1938..1940,1947..1952,1959..1979)
                     /gene="bi"
                     /locus_tag="Dmel_CG3578"
                     /gene_synonym="BI; CG3578; dm-omb; Dm-omb; Dm-OMB;
                     Dmel\CG3578; l(1)bi; l(1)omb; omb; Omb; OMB; Qd; T3; TBX2"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:410314"
ORIGIN      
        1 cagtttgaat gcgaccggcg tgtagttcgt gtcgtcatcg ccgctctgtc gcttttgtcg
       61 cctgtcgttt gtcgcttttg tcgcccgtcg tcgtttctcg tcgtttgttg tttctcccta
      121 cgttcgttgt tcgttgatcg tcgtgtcgcc atatccacat tctttatcca aatcgccgtt
      181 tcccttttgt gctctttttt ttgcgttctt ccttcttgca atgaaacatg aatttttttg
      241 aaacaacaag aagagaaata aagtgtacaa gtcagtgagt gtcccaaaca aaaagtttta
      301 aaaaaaaaga aacaaaaaca agtacctgta gaacaaaaac aaaataaagc atctaaaaat
      361 ttcaaaagtc aaactagaga gatccctttt ttggagagat cgccgtggga aaccctttct
      421 gcatgacgca cttggttgtt tgaaacggtt atgtgatgag atacgacgtc caggagctgc
      481 tatttcatca gtctgctgag gatccattcg ccaggttcgc caatgggatg gcatatcatc
      541 catttctgca gctaacgcaa cgacccactg acttcagcgt ttcctcgctg ttgacggcgg
      601 gtagcaacaa taacaacagc ggcaacacca acagcggaaa caacaactcc aattccaaca
      661 acaacaccaa ttcaaacacc aataacacca acaatctcgt ggccgtttca ccaacgggtg
      721 gtggtgcgca gttatcgccg caaagcaacc acagcagcag caacaccacc accaccagca
      781 acaccaacaa ctccagttcc aataacaaca ataataacag tacccataat aataacaaca
      841 accacacgaa taacaacaac aataataata ataacacaag tcaaaagcaa ggacaccact
      901 tgagcaccac cgaggaaccg ccatcgcccg ctggcacacc accgcccaca attgttggtc
      961 taccgccaat accaccgccc aacaacaaca gcagtagcag cagcagcaac aactcagctt
     1021 cagccgccgc ccatccgtcg caccacccaa ccgccgcaca tcactcaccc agtacgggtg
     1081 ccgccgcacc gcccgccggc gccacaggct tgccgccacc cacaccgccg caccacctgc
     1141 aacaacaaca gcagcaacaa cagcacccgg ccccaccacc accaccgtac tttccagctg
     1201 cggcactggc cgctctagct ggaagtccgg ccggaccgca tccgggtctg tatcccggcg
     1261 gtggattgcg cttcccgccg caccacccag gtgcccatcc gcacgcccat catctgggca
     1321 gcgcctatac taccgccgag gacgtcgtcc ttgcctcggc cgtcgcccat cagctgcatc
     1381 cggcgatgcg accgctgcgg gcgcttcagc ccgaggacga tggcgtcgtc gatgatccca
     1441 aggtcacgct ggagggcaaa gacctgtggg agaagttcca caaactgggc acggaaatgg
     1501 tcatcaccaa gagcggcaga caaatgtttc cgcaaatgaa atttcgtgtt tcgggactgg
     1561 atgccaaggc taaatacatc ttgctactgg acattgtggc ggcggacgat tatcgttata
     1621 aatttcataa tagtcgctgg atggtggctg gcaaagcgga tcccgagatg ccaaaacgca
     1681 tgtatatcca tccagattcg cccacaacgg gtgagcaatg gatgcagaaa gttgtttcat
     1741 ttcacaaatt aaaattgacc aacaatatta gtgataaaca tggatttacg atcctgaact
     1801 cgatgcacaa gtaccagccg cgtttccacc tggtgcgagc caatgacatc ctgaagctgc
     1861 cgtactccac gtttcgcacg tacgtcttca aggagaccga gttcatcgcc gtcacagcat
     1921 atcaaaatga gaagataact caattgaaaa tcgataacaa tccgtttgcg aagggctttc
     1981 gtgatactgg tgccggcaag cgggaaaaga attacaggca ggcactgatg tcgaaccgag
     2041 ggtccgattc ggacaagttg aatccgacgc atgtgagcag ctcgcgggca ccgctccacc
     2101 tgggccacgc cggccgtccg cctcatctgc atccccatgc cgccctgctt gataatcagc
     2161 aggacgacga cgacaagctc ctggacgtgg tgggtccgcc acagagtccg ctactcccgc
     2221 tcagccactc gctgcagcag atgcacgccc accagcactc cgctctggct gcctggttta
     2281 atcacttggc tggcgctgga gccggagcct ccgaacatgc agctgcggcg gcggccaatg
     2341 ccagtgcgga ggatgcactg cgtcgtcgct tgcaggcgga cgcggatgtg gagcgggatg
     2401 gcagcgattc gagttgctcg gaaagcgtcg gcggcagtac cggcggtgcc tttaggccca
     2461 cctcgacggg cagtcccaag gaggcggtgg gcgcggctgc agctgccgca gcggctggct
     2521 tgaatcccgg tggcggtagc tatccgtcac cgaatatatc ggtgggtccg cccattcacc
     2581 cgtcgccgca tttgttgcct tacctgtatc cacatggcct gtatccaccg ccgcatctgg
     2641 gcctgctgca caatcccgct gcagcggcgg ccatgagtcc ggctggcctg aatccgggtc
     2701 tgctcttcaa tgcccaactg gcgctggccg cccagcatcc ggctttgttt ggccacgcct
     2761 acgcggcggc gggtcacaca ccggtatcac cattacaagg cctaaagagc catcgctttt
     2821 cgccgtacag tttgcccggc agtttgggct ccgccttcga tgcagtgact cctggatcga
     2881 acgcaaatcg ctcgggagat cctccaggcg gcggcggcgg cggcctgggt ggtggtgtgg
     2941 tggagaatgg tcccaggagt ctgagttcca gccctcgtcc ccgacctgcc tcccactcgc
     3001 cgcccactcg accgatttcg atgtcaccca caacgccgcc atccctgatg aagcaaccac
     3061 gtggcggtgg tgctggcgcc ggtgtggccc aatcgcagca ctcgccttcg gaacttaaga
     3121 gcatggagaa gatggtcaac ggactggagg ttcaacacaa tggcagtgcg gcggcagcag
     3181 cggcggctct tcagctggcc gaggaagctg cccagcatca tcatcacacc caggcgcacc
     3241 accagcagca gcagcatcag tcgcaccacc agcaacagca ccaccagcaa ccggcacaac
     3301 cacatccgca ccaccagacc catctacact cgcaccatgg ggcgacaacg ggcggtacgg
     3361 atcagtgaca attactggac ggccgctccg attgtgagga tgccggtctc gaattggaac
     3421 tagagttgga ggaggatgtc gaggatctgg atcaggatcc ggatgagcag gacgaggatc
     3481 gcagctcggt catcgatctt gatctggacg tcgacgtctg accgcgaacg gatcagcgac
     3541 attgcctcta gcctctgaac tacacggcca ccgtctttgt ggtttagcgt agtgtatatg
     3601 tacatatata tatcggacga tttggaccct agactatagg catttgtagc atatatagtg
     3661 tgtattcctc tctcgttgcg aactcactct gcccgtttat cgccagtgtt aagtaacatc
     3721 tttttttttt tttgtctcgt ttctaagcaa agcctagccc ctagaaatcg ctggcgattc
     3781 gctggcaaag tgatggagag gtctaattga agacagaagg tagcaaaaac agaagaaaaa
     3841 aaaaaaataa cacaaaaagg aaacaaaaaa caggaaaaag ttaaggcgac gtggcaagag
     3901 aatcgtcgta acttttagcg ccttgaaggt tccagacttc aagatcaaac agacggaata
     3961 aaatgagaag taagggcaag gggctatcct cagacaaatt tatgtatcac ccatatatgt
     4021 atattgattg gattgaaaat agcaacatca aagatggcgc ctctttatat acatctagaa
     4081 cacgcatata tatatatata aatatatata tatagtatat atagaagctg gtatatatac
     4141 agaatgtaac cttagtaaaa catacaagaa aaaacaaaga aaaacaaaaa cccacaaaaa
     4201 aaaaatacca caaaaacaaa ataaatgcaa ttttttttct tagtcttagg tggatgaatt
     4261 ttttttttag taaacgtaaa taaaacctat atacatagaa tatatataca tgaataattt
     4321 atgtagcttt taagtaccaa gataccgtaa acactcaaaa aggaacacac acatgcagca
     4381 ccaacccctc acacacacaa ccacacacac acacaccagt gacgaatttt cttcgtagac
     4441 gatagaaaat gcttataaac tatataaact atgagaactt gagttttcct aattttacca
     4501 taatattttt ccaatttttt tttcgtactt ttaagttcta aaaccaaaga agaaagtaat
     4561 catttttttt ttttcgtatt tgtattttaa tttcggaacc ccctgagatg ctaatttagg
     4621 gcaagagttc tgtgtgtgtt taaatcataa atatatatgt atgcgtatat ataaactata
     4681 attgtattga taaaaaaaat ataatttttt tttagtaaag tacatttttt tgtgtaagac
     4741 gtattgaatc gaaaaaaaaa atgaaaagag ttgaattcaa cgcatgttcc tcgcataatt
     4801 taagagagag cgacaaagac gcagctaaca cacacccgca cgcacacacc tccctcgcac
     4861 accaatacac accagtacac tcacacagta cacacacaca caaccagtaa ggagaaaaaa
     4921 gcaagaaaat tcacaaaaaa aaaataataa attaaagtac atttccgtag cgatttgttt
     4981 tccttgtaac ccaataatat tgcaacacca cacaatcttc atcgcatcat catcatcatc
     5041 atcatgatca tcatcacctg tatcatcatc gcataggcat tcttatgatg aaagagaatt
     5101 attttttttt ttctgttggt tagctgtttt ttgaaaatga attatacgca aaagcaatat
     5161 taattatagt taattaaatt taaaacaaac gcaaacaacc cgaaacaaca agaacagcaa
     5221 aaacagcaac aacaagaaca acaagaacaa attatgtacg aaaggatata tatatttaaa
     5281 tatatatata tatgtatatg gataaaatta atgaagaagc aacaacacct catgtcactg
     5341 caattatata taaaattaat taaacaacaa caaaacaaag gaaattaaat