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Drosophila melanogaster twenty-four (tyf), transcript variant J,


LOCUS       NM_001258590            6722 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001258590
VERSION     NM_001258590.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6722)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6722)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6722)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6722)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6722)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6722)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6722)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6722)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6722)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6722)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6722)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6722)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6722)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6722)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6722)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6722)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6722)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6722)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6722)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6722)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6722)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6722)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6722)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Oct 19, 2015 this sequence version replaced NM_001258590.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6722
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6722
                     /gene="tyf"
                     /locus_tag="Dmel_CG4857"
                     /gene_synonym="CG485; CG4857; Dmel\CG4857; EG:EG0007.12;
                     EG:EG0007.4; TYF"
                     /note="twenty-four"
                     /map="4B1-4B1"
                     /db_xref="FLYBASE:FBgn0026083"
                     /db_xref="GeneID:31363"
     CDS             725..6460
                     /gene="tyf"
                     /locus_tag="Dmel_CG4857"
                     /gene_synonym="CG485; CG4857; Dmel\CG4857; EG:EG0007.12;
                     EG:EG0007.4; TYF"
                     /note="CG4857 gene product from transcript CG4857-RJ;
                     CG4857-PJ; tyf-PJ; twenty four; TWENTY-FOUR"
                     /codon_start=1
                     /product="twenty-four, isoform J"
                     /protein_id="NP_001245519.1"
                     /db_xref="FLYBASE:FBpp0293712"
                     /db_xref="GeneID:31363"
                     /db_xref="FLYBASE:FBgn0026083"
                     /translation="MNNEQTPSSSDTPADRVASGGAAAKLPTIIPDTPIVSIAAGTMS
                     ESTTTTTVTKTTPTPFPQEQLMTMMSDHVAKADAQLDEACRNQGAKDEDSQGAAPVAA
                     NHVATSGSSSRGNDPKKSSSPSNSHSSGNHAATADAAKGSAAEAAAGDTSFSQVFAML
                     KDSPSAELSRPNRRVLQYGATAKGKTQDDQNVGKRQKKKKTKYDTWEDSDFNDLDDAS
                     LKKLLEEAYWYRNPGDRKNKSERFLQMLKKAEYDEEISYRAIKSCLTINPSALTSSAA
                     TGSSGGSSSSAGHNSSYNSTNHRSTDPGQRHKQGGSLQDLVEAAHRSELATTSAAAAA
                     AATAAATQRFNCDYQLSGRSNRRQQQQQQQHNQNATSSASASKKIKNLNVSGRQREGG
                     SLPSSVNFEPASSAMEAKQNKQQAQPSTEAAGGSFSGSVGNKHHHRSSTGSCSSLITQ
                     SRDTEANNQFDLDMDDATGVGASAVVGASGDQDDNMLEQLDPQNPSMKFLIDALNDTP
                     LEARYTGAGKKFLIDDRLHFSVLELSARRKLQQQAQYLAALTGQFGLGLEEEKRKVEA
                     GYVSLNDNYTACSSVYGGGAGSPAAVEGSKPSTSSSAVSGGSNCGASSDALSSDLRPA
                     KIGRMVPAAAAVAAAPMGGKTTTRQLDENGNALGDGFGGSAASGSSGASGASAAASSS
                     NGNGNANQFTALITPTVGSSVPTSTVAHRQNSVSTLLSTGTNTTTTAMAAAAVAASYS
                     QLQQAPVGGAAGTVSGIGIGMQQPTKQKTKKKSQQERNTTTVDVESVAGYRGNDPVEQ
                     LVKYIENDVNGGGNSAAGQRKKERKKQNKLKKSNSLEELRTCSKMEVDDLKRQSATTE
                     MMRHKKGTNNASSGGSSSTASGSSNSGKHNSASVADINKNCNKEQQQQSTPTVQVRNS
                     NNPGTQQRKGERRSWGTEELQYLGDHQEISAAWSELETVGQKELPLALPALARMSELD
                     ALNTVLSETAEFHVVTKKKKPKKQRAVTMDDAAVAAAAVTGGNLQRMQQITKSASSNI
                     MSQRMHYYTPYNSNNGGGSVNYKQQQQQSQQYQEHYQAPQGQHHHHHHHHHHHHHHHS
                     GSAVSNQVDSSRRKSTSSMPPSEKSDSSDLDSVHSLPIQTGKKKSLGGGNNKQRGAPS
                     ASQRQAKQNNNAAAPISYADIARNKQEALNNATASDTELELGDKMQIKSGGKSKSRPD
                     FPELPGAVTAVAASGGAANQATVVSSQNTPPSSSSSISYSQSLNATPPSSSSDAESTN
                     SPELLAQVQIPAYSMITPTLTASMISSVSSSVASTSSTSCSPPALQKSKSVEHDTSYS
                     CNSSNLDQQYPALEKTVKRHSTNNVSVAVAASTSASASSSLYNFAAAAKQQLTENTHS
                     AVSPPAAVTTTSTAVAASAPAPTTVTVPAAVTVPCYSSSSTHGSTQTSTSTASSAIAA
                     LPSGKAKAKPKELSPSSSCSKKPTKPSQDVPSISLSISTTPRATTSTSTTTTQKTTAA
                     TQTEGAKKLIGGIHKLPSSSCIAKGAGAVLEATAGRRAVIILNDDREAGRSNNEFIFG
                     DFNEDELKLFDDNLDDEEEGQHKQSSNKKQQTEGESDVTQDDTEDVDQDLDKELECLG
                     RRPEKKQERQQDISASSDQHLNDSGAASDAVNSSASLDMLSISAEAAQSSPNAGATAT
                     SSSVASPINSSTPSGASSASASTSTSSSSVSISSSSGGNGAACLASVSGMLGGVANQS
                     GDSGIYAAANTSIKEHVNTFLSKASSSEETLPSPNSISMQQLETCNDIEAAIIAAARA
                     AAAARSTSCSRSNSQEQDALQPQVKTKATPNPEAKMVLPVFVTYNNNNNDDDDDEEDD
                     ESLQELSFMADLKADAATEDIAMQPPPPSCPAMMTNTELIVDYIAKTWNAIANSKYVT
                     YYNEQEQEQET"
ORIGIN      
        1 atcccactaa ttagttgcaa aacgggcagg caatctcgtg ttgattagta agatgcaagc
       61 ctagagcaaa cgccgattta gcaatctcaa cggcttgccc ctacaaacaa caaacagcat
      121 ttgtcaaccc tggcacgcag cgtagttagc aacactgctt tttagccaaa aaaaaaaaaa
      181 aataaaaaaa atgaatatgg aaagagacca gtgcttttta aagaaattcg aagtcagtgg
      241 gccgcaaggg gtcgccaaag actaaacaga cgcacctgct accacccacc gccccttgtc
      301 gctcgtccgc atgaccagaa caacaacaaa tgctgcaaaa cacccaatcc gtgcgcacac
      361 atttccgtat tccggtctgt ttgcgagcaa tccgcatccc cgtgcccagg aacctacgta
      421 aatgccgcga gcaaaggttt gagccggagg agagctactg acgacaggcc tgtcaagtgc
      481 agcaggagtc caaactgatg cgcaataggt gggctcccct gtgcctcaaa ccgtctggaa
      541 gtcgagagga atcgttagga atcggcggaa cagcctgcag agcacttgca gtcgcggtgg
      601 caaccacacg gcggctgggc agctgggcta cctagaaaca tcgcgaagag aagaaacagt
      661 ttattcgagg aattcgaatg gcatttgttt ttctccttcg ttgcatgcca ccaaacgaaa
      721 gaagatgaac aatgaacaaa cgccgtcatc atcggacaca ccggcggatc gtgtggcatc
      781 tggtggagca gctgccaaac tgccaacgat cataccggac acgcccatcg tctcgattgc
      841 cgctggcacg atgagcgaga gcaccacgac gaccaccgtc accaaaacaa cgccgacgcc
      901 gttcccacag gagcagctta tgaccatgat gtcagaccat gtggcgaagg cagacgcgca
      961 gcttgacgag gcctgtagga accagggggc caaagacgag gacagccaag gagcggcacc
     1021 agtggctgcc aaccatgtag ccaccagcgg cagtagcagc agaggcaatg accccaagaa
     1081 gtcatcatcc cctagtaata gccatagctc tggtaaccac gcagccacgg cagacgctgc
     1141 caaaggatcc gcagcagaag cagcagcagg agatacgtcc ttctcgcagg tctttgccat
     1201 gctaaaggat tcgcccagcg ctgaactgtc gcgaccaaac cgcagggtac tccagtacgg
     1261 agccactgcc aagggcaaga cccaggacga tcagaatgtc ggcaagcgac agaagaagaa
     1321 aaagacaaaa tacgatacct gggaagatag cgattttaat gatctggacg acgcatcatt
     1381 gaagaaactt ctcgaagagg cctactggta tcgaaatcct ggcgacagga agaacaagag
     1441 cgagcgattt ctgcaaatgc tcaaaaaggc tgagtacgac gaagagatct cttatcgtgc
     1501 catcaaatcc tgcctcacaa tcaacccatc cgcactaacg tccagtgcag caacaggctc
     1561 gagcggcggg agcagcagca gtgcagggca caacagcagc tataattcca ccaatcaccg
     1621 gtcaacggat cccggccagc ggcacaagca gggcggctcc ctgcaggatc tcgttgaggc
     1681 ggcgcaccgc agcgaactgg ccacaacctc ggcggcggcg gcagcagcag cgacagcggc
     1741 agcaacccaa cgtttcaact gtgattacca gctgagtggt cgctccaatc gccggcagca
     1801 gcagcagcaa cagcagcaca accaaaacgc cacctcctcc gcatccgcat ccaaaaagat
     1861 caagaactta aacgtctcgg gccggcagcg cgaaggaggc agcctgccca gcagtgttaa
     1921 ctttgagccg gcatcgtctg ccatggaagc caagcagaat aagcaacagg ctcagccttc
     1981 gacagaagct gcaggtggct cgttttcggg gtcggtcggt aacaagcacc accaccgcag
     2041 cagcaccggc agttgcagca gcctgataac tcaatcgcgc gatacggagg caaacaatca
     2101 gttcgacttg gacatggacg atgcgacggg tgttggtgcc agcgccgttg tcggtgccag
     2161 cggcgaccaa gacgacaaca tgttggagca attggatcct cagaacccct cgatgaagtt
     2221 tctgattgac gccctaaacg acacgccatt ggaggccagg tacaccggtg ccggcaaaaa
     2281 gttcctaatc gacgaccggt tgcatttttc cgtcctggag ctgtctgcca ggaggaagct
     2341 gcagcagcag gcacaatacc tggccgccct caccggacaa tttggtctcg gcctggagga
     2401 ggagaagcgc aaggtagagg ccggctacgt gtcgctcaac gacaactaca cggcgtgctc
     2461 ctcagtttac ggcggcggtg caggttcgcc agctgccgtg gagggcagca agccctctac
     2521 ctcctcctcg gccgtgtctg gcggtagcaa ctgcggtgcc tcctctgacg cactgtctag
     2581 cgatctgcga cctgcgaaga ttggacgcat ggtccccgcc gcagcggcag tggcagctgc
     2641 gccaatgggt ggcaagacga ctactcgaca gctagacgag aatggaaatg cattgggcga
     2701 tggtttcggg ggcagtgcag ccagtggctc cagtggcgcc agtggcgcca gtgctgccgc
     2761 cagcagtagc aacggcaacg gtaacgcaaa ccagttcaca gctctaataa cccccacggt
     2821 gggatccagt gtacccacct ctactgtcgc tcaccgtcag aatagtgtct ccacgctgct
     2881 ctccacgggc accaacacta caacaacggc catggcagcg gcggcggtgg ctgcatccta
     2941 cagccagttg caacaggcac cggtcggagg cgcggctgga acggtttctg ggatcggcat
     3001 tggcatgcag cagcccacca agcagaagac gaagaagaag tcgcagcagg agcgcaacac
     3061 caccaccgtc gatgtggagt cggttgccgg ctataggggc aatgatcctg ttgagcagct
     3121 cgtcaagtac attgaaaacg atgtcaacgg tggcggaaac agtgccgctg gacagcgcaa
     3181 gaaggagcgc aagaagcaaa acaagctcaa gaagagcaac tcgttggagg agctgcgcac
     3241 ctgctcaaaa atggaggtgg acgatttgaa gcgccagtcg gcgaccacgg agatgatgcg
     3301 acataagaag ggcacgaaca atgcatcctc gggcggatcg tcgtcgacgg cctctggttc
     3361 ctcaaacagt ggcaagcaca actcggcatc cgtggcggat attaacaaaa actgcaacaa
     3421 ggagcagcaa cagcaatcga cgccgacggt gcaagtgcgc aacagcaaca atccaggaac
     3481 gcagcagcgg aagggcgagc gtcggtcctg gggcaccgag gagttgcagt acctgggtga
     3541 ccaccaggaa atatccgctg cctggtcgga gctggagact gtgggccaga aggagctgcc
     3601 gctggcgctg cccgccttgg cgcgcatgtc cgaactggat gccctgaata ccgtcttgtc
     3661 ggagaccgct gagttccatg tggttaccaa gaagaagaaa ccaaagaagc agcgtgctgt
     3721 taccatggac gatgcggcgg tggctgcagc tgccgtcacg ggcggcaact tacagcgcat
     3781 gcagcagatc accaagtccg cgtcctccaa catcatgtcc cagcggatgc actactatac
     3841 tccgtacaac agcaacaatg gtggaggcag tgtcaactat aagcaacagc agcaacagag
     3901 ccaacagtac caggagcact accaggcgcc acaggggcag caccaccatc accaccatca
     3961 tcatcaccac catcatcacc atcacagcgg ctcggcggtt tcgaatcagg tggatagctc
     4021 acggcgcaag tccacgtcgt ctatgccccc atcggagaaa tctgactcca gtgatctcga
     4081 ctcggtccac tccctgccca tccagacggg gaagaagaag agcctaggcg gtggcaacaa
     4141 caaacaacgg ggggcgccgt cagccagtca acgccaggcc aagcaaaaca acaatgctgc
     4201 agcccccatt tcgtatgcgg atatcgcccg gaacaagcag gaggctctaa acaatgccac
     4261 ggccagcgac accgagttgg agctgggcga caagatgcag atcaagagtg gcggcaaatc
     4321 caagtcgcga cccgatttcc cggagctgcc aggtgctgtt acggcagtgg ctgccagtgg
     4381 aggtgcagcc aatcaggcga cggttgtcag cagccaaaat acgccaccat cctcgtccag
     4441 ttccatcagt tattcgcaga gtctcaatgc aacgccgccc agcagcagca gcgatgcgga
     4501 gtccaccaac tcgccggagc tgctggcgca ggtgcagata ccggcttaca gcatgatcac
     4561 gccaactcta acagcctcca tgatcagcag tgtcagcagt tctgtcgcca gcacctcttc
     4621 cacatcctgc tcaccgccag ctctgcagaa atccaagagc gtggagcacg acaccagcta
     4681 cagctgcaat agtagcaact tggatcaaca gtatccggca ctagaaaaga ccgtcaagcg
     4741 gcatagcacc aacaacgtgt ctgtggccgt cgcagcctcc acctcggcat cggcgtcctc
     4801 ctcgttgtac aactttgcag cggcagccaa gcagcagctg acagagaaca cccattcggc
     4861 cgtatcgccg ccggcagctg taacaactac ctcaaccgca gtcgcagcct cagctccagc
     4921 tccaactaca gttacagttc cagctgcagt tacagttcct tgttattcct catcctccac
     4981 acacggctcg actcaaactt caacttctac tgcatcgtct gctatagcag ctttaccctc
     5041 gggcaaggcc aaggccaagc caaaggagct atctcccagc agcagttgca gcaagaagcc
     5101 aacgaagcct agtcaagatg tgccgtcaat cagtctgtcc atttccacca cgccaagggc
     5161 gacgaccagc accagcacta ctactacaca aaagaccacg gctgccacgc agaccgaggg
     5221 agccaaaaag ctaatcggcg ggatccacaa gctgcccagt agcagttgta ttgcgaaggg
     5281 agccggagcc gttttggagg ccaccgccgg caggcgtgct gttatcatac tcaacgatga
     5341 tcgcgaagca ggcaggagca acaatgagtt catattcggt gatttcaacg aggatgagct
     5401 aaaactcttc gacgacaact tggatgatga ggaggagggc cagcacaagc agtcttcaaa
     5461 caagaaacag caaactgaag gggaatctga tgtgacccaa gatgacaccg aagacgtgga
     5521 ccaagatctg gacaaggaac tggaatgcct gggacgacga ccagagaaga agcaagagcg
     5581 acagcaggat atcagcgcca gcagcgatca gcatctgaat gattctggtg cggcttcgga
     5641 tgcagtcaac agctcagcca gccttgacat gctctcaatt tctgcagagg cggcacaatc
     5701 gtcacctaat gcgggggcaa ccgctacctc atccagcgtc gccagtccca ttaactcgtc
     5761 cacgccctcg ggtgcttcgt ccgcatcggc gagcacgtcc acctcatcgt cctcggtctc
     5821 gatttcatca tcgtcgggcg gcaacggtgc cgcttgtctt gcatccgttt ccggtatgct
     5881 tggtggagtg gccaatcagt ccggggacag cggcatctat gctgccgcca acacgtctat
     5941 taaggagcac gttaacactt tcctaagcaa ggccagcagc agcgaggaga cgctgccgag
     6001 tcccaactcc atatcgatgc aacagctgga aacatgcaac gacatcgagg cggccatcat
     6061 agccgcagcc cgtgctgccg ctgctgcccg gagcaccagc tgcagtcgca gcaactctca
     6121 ggagcaggat gccttgcagc cgcaggtcaa gaccaaggcg actcccaatc cggaggcgaa
     6181 gatggttctg cctgtgtttg tgacctacaa caacaacaac aacgacgacg atgacgacga
     6241 ggaggacgac gagagcctgc aagaactgag cttcatggcc gaccttaagg cggatgcagc
     6301 cacggaggat attgcaatgc agccgccacc gccttcatgt ccggcgatga tgaccaacac
     6361 ggaactaatc gtcgactaca tcgccaaaac ctggaatgcc attgccaaca gtaagtacgt
     6421 aacgtactac aacgagcaag agcaggagca ggagacctag aaaccacaca aacagcaatc
     6481 gctgcagcgt cagcgaaatc gaaatcagca acatcggcgt caatcacaat agcaacgtca
     6541 gcaatatcgg cagcaatcta acgagagcat ccaacgtcgg ctgaaatcag gagagcagat
     6601 tggttggaat agagtgttct aaaagttaaa attttttttt tttttgctgg gctattgttt
     6661 atatatctac cgatatcgta cacacactat atattattgc aataatgata cgctttaatg
     6721 ct