Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster twenty-four (tyf), transcript variant H,


LOCUS       NM_001258589            8146 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001258589
VERSION     NM_001258589.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8146)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8146)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8146)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8146)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8146)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8146)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8146)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8146)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8146)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8146)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8146)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8146)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8146)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8146)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8146)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8146)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8146)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8146)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8146)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8146)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8146)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8146)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8146)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Oct 19, 2015 this sequence version replaced NM_001258589.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8146
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8146
                     /gene="tyf"
                     /locus_tag="Dmel_CG4857"
                     /gene_synonym="CG485; CG4857; Dmel\CG4857; EG:EG0007.12;
                     EG:EG0007.4; TYF"
                     /note="twenty-four"
                     /map="4B1-4B1"
                     /db_xref="FLYBASE:FBgn0026083"
                     /db_xref="GeneID:31363"
     CDS             190..5193
                     /gene="tyf"
                     /locus_tag="Dmel_CG4857"
                     /gene_synonym="CG485; CG4857; Dmel\CG4857; EG:EG0007.12;
                     EG:EG0007.4; TYF"
                     /note="CG4857 gene product from transcript CG4857-RH;
                     CG4857-PH; tyf-PH; twenty four; TWENTY-FOUR"
                     /codon_start=1
                     /product="twenty-four, isoform H"
                     /protein_id="NP_001245518.1"
                     /db_xref="FLYBASE:FBpp0293710"
                     /db_xref="GeneID:31363"
                     /db_xref="FLYBASE:FBgn0026083"
                     /translation="MLKKAEYDEEISYRAIKSCLTINPSALTSSAATGSSGGSSSSAG
                     HNSSYNSTNHRSTDPGQRHKQGGSLQDLVEAAHRSELATTSAAAAAAATAAATQRFNC
                     DYQLSGRSNRRQQQQQQQHNQNATSSASASKKIKNLNVSGRQREGGSLPSSVNFEPAS
                     SAMEAKQNKQQAQPSTEAAGGSFSGSVGNKHHHRSSTGSCSSLITQSRDTEANNQFDL
                     DMDDATGVGASAVVGASGDQDDNMLEQLDPQNPSMKFLIDALNDTPLEARYTGAGKKF
                     LIDDRLHFSVLELSARRKLQQQAQYLAALTGQFGLGLEEEKRKVEAGYVSLNDNYTAC
                     SSVYGGGAGSPAAVEGSKPSTSSSAVSGGSNCGASSDALSSDLRPAKIGRMVPAAAAV
                     AAAPMGGKTTTRQLDENGNALGDGFGGSAASGSSGASGASAAASSSNGNGNANQFTAL
                     ITPTVGSSVPTSTVAHRQNSVSTLLSTGTNTTTTAMAAAAVAASYSQLQQAPVGGAAG
                     TVSGIGIGMQQPTKQKTKKKSQQERNTTTVDVESVAGYRGNDPVEQLVKYIENDVNGG
                     GNSAAGQRKKERKKQNKLKKSNSLEELRTCSKMEVDDLKRQSATTEMMRHKKGTNNAS
                     SGGSSSTASGSSNSGKHNSASVADINKNCNKEQQQQSTPTVQVRNSNNPGTQQRKGER
                     RSWGTEELQYLGDHQEISAAWSELETVGQKELPLALPALARMSELDALNTVLSETAEF
                     HVVTKKKKPKKQRAVTMDDAAVAAAAVTGGNLQRMQQITKSASSNIMSQRMHYYTPYN
                     SNNGGGSVNYKQQQQQSQQYQEHYQAPQGQHHHHHHHHHHHHHHHSGSAVSNQVDSSR
                     RKSTSSMPPSEKSDSSDLDSVHSLPIQTGKKKSLGGGNNKQRGAPSASQRQAKQNNNA
                     AAPISYADIARNKQEALNNATASDTELELGDKMQIKSGGKSKSRPDFPELPGAVTAVA
                     ASGGAANQATVVSSQNTPPSSSSSISYSQSLNATPPSSSSDAESTNSPELLAQVQIPA
                     YSMITPTLTASMISSVSSSVASTSSTSCSPPALQKSKSVEHDTSYSCNSSNLDQQYPA
                     LEKTVKRHSTNNVSVAVAASTSASASSSLYNFAAAAKQQLTENTHSAVSPPAAVTTTS
                     TAVAASAPAPTTVTVPAAVTVPCYSSSSTHGSTQTSTSTASSAIAALPSGKAKAKPKE
                     LSPSSSCSKKPTKPSQDVPSISLSISTTPRATTSTSTTTTQKTTAATQTEGAKKLIGG
                     IHKLPSSSCIAKGAGAVLEATAGRRAVIILNDDREAGRSNNEFIFGDFNEDELKLFDD
                     NLDDEEEGQHKQSSNKKQQTEGESDVTQDDTEDVDQDLDKELECLGRRPEKKQERQQD
                     ISASSDQHLNDSGAASDAVNSSASLDMLSISAEAAQSSPNAGATATSSSVASPINSST
                     PSGASSASASTSTSSSSVSISSSSGGNGAACLASVSGMLGGVANQSGDSGIYAAANTS
                     IKEHVNTFLSKASSSEETLPSPNSISMQQLETCNDIEAAIIAAARAAAAARSTSCSRS
                     NSQEQDALQPQVKTKATPNPEAKMVLPVFVTYNNNNNDDDDDEEDDESLQELSFMADL
                     KADAATEDIAMQPPPPSCPAMMTNTELIVDYIAKTWNAIANSKYVTYYNEQEQEQET"
ORIGIN      
        1 gcggtcggta cttcatcagt tcgcataagg aactcagaag gacaaaatac gatacctggg
       61 aagatagcga ttttaatgat ctggacgacg catcattgaa gaaacttctc gaagaggcct
      121 actggtatcg aaatcctggc gacaggaaga acaagagcga gcgatttctg gtaagttttg
      181 gctcatcaaa tgctcaaaaa ggctgagtac gacgaagaga tctcttatcg tgccatcaaa
      241 tcctgcctca caatcaaccc atccgcacta acgtccagtg cagcaacagg ctcgagcggc
      301 gggagcagca gcagtgcagg gcacaacagc agctataatt ccaccaatca ccggtcaacg
      361 gatcccggcc agcggcacaa gcagggcggc tccctgcagg atctcgttga ggcggcgcac
      421 cgcagcgaac tggccacaac ctcggcggcg gcggcagcag cagcgacagc ggcagcaacc
      481 caacgtttca actgtgatta ccagctgagt ggtcgctcca atcgccggca gcagcagcag
      541 caacagcagc acaaccaaaa cgccacctcc tccgcatccg catccaaaaa gatcaagaac
      601 ttaaacgtct cgggccggca gcgcgaagga ggcagcctgc ccagcagtgt taactttgag
      661 ccggcatcgt ctgccatgga agccaagcag aataagcaac aggctcagcc ttcgacagaa
      721 gctgcaggtg gctcgttttc ggggtcggtc ggtaacaagc accaccaccg cagcagcacc
      781 ggcagttgca gcagcctgat aactcaatcg cgcgatacgg aggcaaacaa tcagttcgac
      841 ttggacatgg acgatgcgac gggtgttggt gccagcgccg ttgtcggtgc cagcggcgac
      901 caagacgaca acatgttgga gcaattggat cctcagaacc cctcgatgaa gtttctgatt
      961 gacgccctaa acgacacgcc attggaggcc aggtacaccg gtgccggcaa aaagttccta
     1021 atcgacgacc ggttgcattt ttccgtcctg gagctgtctg ccaggaggaa gctgcagcag
     1081 caggcacaat acctggccgc cctcaccgga caatttggtc tcggcctgga ggaggagaag
     1141 cgcaaggtag aggccggcta cgtgtcgctc aacgacaact acacggcgtg ctcctcagtt
     1201 tacggcggcg gtgcaggttc gccagctgcc gtggagggca gcaagccctc tacctcctcc
     1261 tcggccgtgt ctggcggtag caactgcggt gcctcctctg acgcactgtc tagcgatctg
     1321 cgacctgcga agattggacg catggtcccc gccgcagcgg cagtggcagc tgcgccaatg
     1381 ggtggcaaga cgactactcg acagctagac gagaatggaa atgcattggg cgatggtttc
     1441 gggggcagtg cagccagtgg ctccagtggc gccagtggcg ccagtgctgc cgccagcagt
     1501 agcaacggca acggtaacgc aaaccagttc acagctctaa taacccccac ggtgggatcc
     1561 agtgtaccca cctctactgt cgctcaccgt cagaatagtg tctccacgct gctctccacg
     1621 ggcaccaaca ctacaacaac ggccatggca gcggcggcgg tggctgcatc ctacagccag
     1681 ttgcaacagg caccggtcgg aggcgcggct ggaacggttt ctgggatcgg cattggcatg
     1741 cagcagccca ccaagcagaa gacgaagaag aagtcgcagc aggagcgcaa caccaccacc
     1801 gtcgatgtgg agtcggttgc cggctatagg ggcaatgatc ctgttgagca gctcgtcaag
     1861 tacattgaaa acgatgtcaa cggtggcgga aacagtgccg ctggacagcg caagaaggag
     1921 cgcaagaagc aaaacaagct caagaagagc aactcgttgg aggagctgcg cacctgctca
     1981 aaaatggagg tggacgattt gaagcgccag tcggcgacca cggagatgat gcgacataag
     2041 aagggcacga acaatgcatc ctcgggcgga tcgtcgtcga cggcctctgg ttcctcaaac
     2101 agtggcaagc acaactcggc atccgtggcg gatattaaca aaaactgcaa caaggagcag
     2161 caacagcaat cgacgccgac ggtgcaagtg cgcaacagca acaatccagg aacgcagcag
     2221 cggaagggcg agcgtcggtc ctggggcacc gaggagttgc agtacctggg tgaccaccag
     2281 gaaatatccg ctgcctggtc ggagctggag actgtgggcc agaaggagct gccgctggcg
     2341 ctgcccgcct tggcgcgcat gtccgaactg gatgccctga ataccgtctt gtcggagacc
     2401 gctgagttcc atgtggttac caagaagaag aaaccaaaga agcagcgtgc tgttaccatg
     2461 gacgatgcgg cggtggctgc agctgccgtc acgggcggca acttacagcg catgcagcag
     2521 atcaccaagt ccgcgtcctc caacatcatg tcccagcgga tgcactacta tactccgtac
     2581 aacagcaaca atggtggagg cagtgtcaac tataagcaac agcagcaaca gagccaacag
     2641 taccaggagc actaccaggc gccacagggg cagcaccacc atcaccacca tcatcatcac
     2701 caccatcatc accatcacag cggctcggcg gtttcgaatc aggtggatag ctcacggcgc
     2761 aagtccacgt cgtctatgcc cccatcggag aaatctgact ccagtgatct cgactcggtc
     2821 cactccctgc ccatccagac ggggaagaag aagagcctag gcggtggcaa caacaaacaa
     2881 cggggggcgc cgtcagccag tcaacgccag gccaagcaaa acaacaatgc tgcagccccc
     2941 atttcgtatg cggatatcgc ccggaacaag caggaggctc taaacaatgc cacggccagc
     3001 gacaccgagt tggagctggg cgacaagatg cagatcaaga gtggcggcaa atccaagtcg
     3061 cgacccgatt tcccggagct gccaggtgct gttacggcag tggctgccag tggaggtgca
     3121 gccaatcagg cgacggttgt cagcagccaa aatacgccac catcctcgtc cagttccatc
     3181 agttattcgc agagtctcaa tgcaacgccg cccagcagca gcagcgatgc ggagtccacc
     3241 aactcgccgg agctgctggc gcaggtgcag ataccggctt acagcatgat cacgccaact
     3301 ctaacagcct ccatgatcag cagtgtcagc agttctgtcg ccagcacctc ttccacatcc
     3361 tgctcaccgc cagctctgca gaaatccaag agcgtggagc acgacaccag ctacagctgc
     3421 aatagtagca acttggatca acagtatccg gcactagaaa agaccgtcaa gcggcatagc
     3481 accaacaacg tgtctgtggc cgtcgcagcc tccacctcgg catcggcgtc ctcctcgttg
     3541 tacaactttg cagcggcagc caagcagcag ctgacagaga acacccattc ggccgtatcg
     3601 ccgccggcag ctgtaacaac tacctcaacc gcagtcgcag cctcagctcc agctccaact
     3661 acagttacag ttccagctgc agttacagtt ccttgttatt cctcatcctc cacacacggc
     3721 tcgactcaaa cttcaacttc tactgcatcg tctgctatag cagctttacc ctcgggcaag
     3781 gccaaggcca agccaaagga gctatctccc agcagcagtt gcagcaagaa gccaacgaag
     3841 cctagtcaag atgtgccgtc aatcagtctg tccatttcca ccacgccaag ggcgacgacc
     3901 agcaccagca ctactactac acaaaagacc acggctgcca cgcagaccga gggagccaaa
     3961 aagctaatcg gcgggatcca caagctgccc agtagcagtt gtattgcgaa gggagccgga
     4021 gccgttttgg aggccaccgc cggcaggcgt gctgttatca tactcaacga tgatcgcgaa
     4081 gcaggcagga gcaacaatga gttcatattc ggtgatttca acgaggatga gctaaaactc
     4141 ttcgacgaca acttggatga tgaggaggag ggccagcaca agcagtcttc aaacaagaaa
     4201 cagcaaactg aaggggaatc tgatgtgacc caagatgaca ccgaagacgt ggaccaagat
     4261 ctggacaagg aactggaatg cctgggacga cgaccagaga agaagcaaga gcgacagcag
     4321 gatatcagcg ccagcagcga tcagcatctg aatgattctg gtgcggcttc ggatgcagtc
     4381 aacagctcag ccagccttga catgctctca atttctgcag aggcggcaca atcgtcacct
     4441 aatgcggggg caaccgctac ctcatccagc gtcgccagtc ccattaactc gtccacgccc
     4501 tcgggtgctt cgtccgcatc ggcgagcacg tccacctcat cgtcctcggt ctcgatttca
     4561 tcatcgtcgg gcggcaacgg tgccgcttgt cttgcatccg tttccggtat gcttggtgga
     4621 gtggccaatc agtccgggga cagcggcatc tatgctgccg ccaacacgtc tattaaggag
     4681 cacgttaaca ctttcctaag caaggccagc agcagcgagg agacgctgcc gagtcccaac
     4741 tccatatcga tgcaacagct ggaaacatgc aacgacatcg aggcggccat catagccgca
     4801 gcccgtgctg ccgctgctgc ccggagcacc agctgcagtc gcagcaactc tcaggagcag
     4861 gatgccttgc agccgcaggt caagaccaag gcgactccca atccggaggc gaagatggtt
     4921 ctgcctgtgt ttgtgaccta caacaacaac aacaacgacg acgatgacga cgaggaggac
     4981 gacgagagcc tgcaagaact gagcttcatg gccgacctta aggcggatgc agccacggag
     5041 gatattgcaa tgcagccgcc accgccttca tgtccggcga tgatgaccaa cacggaacta
     5101 atcgtcgact acatcgccaa aacctggaat gccattgcca acagtaagta cgtaacgtac
     5161 tacaacgagc aagagcagga gcaggagacc tagaaaccac acaaacagca atcgctgcag
     5221 cgtcagcgaa atcgaaatca gcaacatcgg cgtcaatcac aatagcaacg tcagcaatat
     5281 cggcagcaat ctaacgagag catccaacgt cggctgaaat caggagagca gattggttgg
     5341 aatagagtgt tctaaaagtt aaaatttttt ttttttttgc tgggctattg tttatatatc
     5401 taccgatatc gtacacacac tatatattat tgcaataatg atacgcttta atgctaatta
     5461 atgtaacgag tcgatagccg aactattgat taacttttgc aagcgcggca gccgaggatc
     5521 agggtagaca tctaacccat ggggtcaccg ttgtcaagaa gtatcttcag gtgtttccag
     5581 tgtgagtgca ggagtacagg atcgtgtcgg ctagggttcc ggtgccgcat gcctaatagg
     5641 ttaactgttg cagaaagaaa attttataga gaaggagagc gttcagctgt gaataagaag
     5701 gaaatcataa ctaaatgaag tgatcttacg aaagcttcaa gtgaatattt atttaacata
     5761 agttgaccga gatttaaacg tttttttttt tttcgcctca agaagcgatg gtcagatagt
     5821 gatgttcaat caagcatttg gatctgcttt tgttaattta caaccttctg gatcccgaaa
     5881 acgcaacgtt ttaccattac tattactatt attgtacttt aataattatt atgcaaacgt
     5941 tttttcgtca ttgtttcata tgcccaattt ttgggcgcgt tgtttggagg aaatcctaat
     6001 cctagatatt aaaccgagtc aacgtcgcgt gtacatagtg gaccagaagt cgtgtgggca
     6061 gttcgatctc tgtgttatgg attagtggaa acagaacaaa tcagaacagg atagaacaga
     6121 gcaaaacaga aagccccacg gaagatattt gatatgtgtg tatgataacg actatttaaa
     6181 gtaaactatg taaggccgct tctttgctcc ggctagccat aaataagcct caagaggaga
     6241 gtatgttaaa ccgaataacc gaatgcaaac agagaaccac aaaataccgg caaaaacact
     6301 attatgcact tacgaaaaat gccgccgttt agctgggaga gcctcagatg gtctctccga
     6361 gggtatagaa gtatagatat cgtaactatt taaacaagaa ttaatttaaa agtaacaaac
     6421 acgaaaaagt tcggcagtga agaaatgaat tggagtcaaa ggcggatacg gagaaacaaa
     6481 caaacaataa gcgttaagta aactcgtaag tataaagagc gcaactaaat tgctatcaat
     6541 aggaatatac attatatacg tgcatctatt aacgtaactt tttttttttt aaatgcaaac
     6601 gttaaccgtt taaaatcgag tatgtaacag caggtagcag ttaggtgaac aaaagtcgga
     6661 ataaaattac ggaaataaat cattaattta aagtatctaa agtgcgaatc gagaaagcct
     6721 atttaaagct aatcattaaa acatttaaaa gtcccatttg gaatgcccag aggaagtggg
     6781 catgtccgaa taaacagaac aaacagtgcg aaatgttttt tagatatatg tgaaactgtt
     6841 ttgcttcaat cgctgtatat tttgaaaata aaagttaagt aatatgccgt aaagcgggac
     6901 atgtattcaa caccactcaa caccccgagt cctgaccctt gaaccttgac ccttgaccct
     6961 ctaaaactcc gcatgcaaca ctcggccaga gctgttgctg tgctgctcta aaccatgtta
     7021 gccatccgca gcagaatcaa aagtcagagc aggagaattt taactgagtt gctaggagga
     7081 cgataatatg gaatatatga aatatttgta tctgtaccac acacattaag caaacattaa
     7141 ggaaacacac actagtttac aaatttggcc ttttggcggt taccttaagg agcgttatat
     7201 tttctaatta aaattctaaa gcgaatgagt gtatccgaac ccagctaact gtaggtttat
     7261 catacgaata ttaataccaa cctgcgaatg gaataaacct gtcaaaatat tgtttagtga
     7321 attgtatttc aaacaaatta tttaaatact acgtgtttta tagtcgactg gttattatac
     7381 ccgttactcg tagagtaaaa gggtatacta gatacattga aaagtatgta acaggcagaa
     7441 ggaagacttt ccgaccatat aaagtatata tatattcttg atcagcatca atagccacgt
     7501 ccgtctgtcc gtatgaacgt cgagatctca ggaactataa aaggtagatg gttgagattc
     7561 agcataaaga ttctagagac atagacgcag tataagtttg ttgacccatg ttgccacgcc
     7621 cactctaacg cccacaaacc gcacaaaaat gtcacgccca cacttttgaa gaatttttaa
     7681 atgaaaaatg ataaaatttc gcgttcgcat tcacattagc tgagtaacgg gtatgtgata
     7741 gttggggaac tcgactatag cattccctct tgtttttcgc cagtaaacat tacttccttt
     7801 tacatccaac gctcttttcg aaaatatcaa aacagttttt ccgttctatt tagaaaacac
     7861 atgtttaatt tcagcaaact caaattagtc taagaaacgt gttttaaaga cgtacatctt
     7921 tcgtgtaaac tagtgttata tatgtacaac cactaagtca aactaagcca atgtacactg
     7981 caacaatttt agacaattga gaactaacga gaaacagaaa caagatacac aaaaccgaat
     8041 atataagggt atggaaaaga acatgaaatt aaattatacg ataggccagt aattaaacat
     8101 aatactgaaa tattattaat tacttataaa caaacggaaa aaacac