Unfortunately due to lack of commercial feasibility, the SkyBLAST service has been suspended from December 1st, 2025.
All subscriptions for paid accounts have been paused. For further information or enquiries, please email [email protected]

Drosophila melanogaster enhanced adult sensory threshold (east),


LOCUS       NM_001258555            7498 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant E, mRNA.
ACCESSION   NM_001258555
VERSION     NM_001258555.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7498)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7498)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7498)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7498)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7498)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7498)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7498)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7498)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7498)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7498)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7498)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7498)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7498)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7498)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7498)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7498)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7498)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7498)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7498)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7498)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7498)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7498)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7498)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7498
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7498
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="enhanced adult sensory threshold"
                     /map="2C2-2C4"
                     /db_xref="FLYBASE:FBgn0261954"
                     /db_xref="GeneID:46006"
     CDS             282..7310
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="CG4399 gene product from transcript CG4399-RE;
                     CG4399-PE; east-PE; enhanced adult salt tolerance;
                     suppressor of white-spotted"
                     /codon_start=1
                     /product="enhanced adult sensory threshold, isoform E"
                     /protein_id="NP_001245484.1"
                     /db_xref="FLYBASE:FBpp0298290"
                     /db_xref="GeneID:46006"
                     /db_xref="FLYBASE:FBgn0261954"
                     /translation="MSSRKVPGGSGGADESTAAAAPLDDNANASVEIPDSSEEPAMGV
                     GEEMSIISKTRTSTLSVEPAKEPTVTAELEGEKELESNPVSKTPRSTPTPTLTPAVTP
                     TASDGVAAKSVRVTRHSSPLLLIISPTTSRREVGDGELDTEEPTGSGGQRKSSVERSL
                     APVIRGRKSIKDLKEAKEVKSEEPPAAASESRAASGVTPGQVKEQHVADGNEMESLPI
                     TDKKDHKDTKDKGDERETDQEEEKEKSADTEIIADTEKTSEKQKYTEKDKAADKDGGK
                     EKDIDANKDIDKEKEKVKEVLPPVVPIAPVTPTCNRVTRKSHAQEQAINTRVTRNRRQ
                     SSTVGANSTASLVAASSSVTEQPPPSRGRRKKPVVVAPPLEPAVKRKRSQDVEADSDA
                     NNSTKYSKVEVVKSEEAEAPEEDSSAVPIKQESVDGNEVSSISPTVTPTPTPAPTPAP
                     VPGSRRGRGRPQNRNSSSPATTTRATRLSKAGSPVILTPVAQEPAPPKRRRVGSSTRK
                     TVSASSLAPSSQGGAGDEDSKDSMASSMDDLLMAAADIKQEKLTPDFDDSLMPEGLPS
                     TSGASSANGHSCTEPLTVDTEINVKPADSKVKPKESPVVAVEESPSQSETQSAKVSAH
                     AGKAPSLSPDMISEGVSAVSVRKFYKKPEFLENNLGIEKDPELGEIVQTVSNNDTETD
                     VEMAVDGEVNQPSTPKSQDKKKEEQEKNQKSGLKAAKKAPAKLEPKAEDISEILTDVP
                     VDISTEAVEIIEEAEEDTCSNSSIKPGELRLDESNDEPELLLEDALIVNGDENETPDQ
                     PEEKEDQVEFFHTGEYDDFEHEIMVELAKEGVLDASGNALSQQKVELEHPEDVTLHES
                     KNDIEAEESVERKPLKDPSVADEMEDMNEESYIDIKDQTNQLLVEHLAEEAMEADCGP
                     EDNKENLSTSASSTAADGLDIQLAIKEDDDEEKPLAVIADEQKPGLLLTNDMKVDEKP
                     NGKQESVCDEHVQLVPNLRQEQEIHLQNLGLLTHQAAEHRRKCLLEAQARQAQMQLQQ
                     HHHHQHKRQGARGGGSATHVESSGTLKTVIKLNRSSNGGVSGSGGLPTGTVIHGGCGS
                     SSASSTSSSSVGSATRKSSGTLGSGAGAGAGVRRQSLKMTFQKGRARGHGAADRSADQ
                     YGAHAEDSYYTIQNENEGAKKFVVTTGNTGRKTNNRFSSTNNYHSTVALHGSNSALQY
                     YSSHSESQGQTDHGFYQMVKKDEKEKILIPEKASSFKFHPGRLCEDQCYYCSGKFGLY
                     DTPCHVGQIKSVERQQKILANEEKLTVDNCLCDACFRHVDRRANVPSYKKRLSASGHL
                     EMGSAAGSALEKQFAGDSGVITESGGEAGSTAAVAVQQRSCGVKDCVEAARHSLRRKC
                     IRKRVKKYQLSLEIPAGSSNVGLCEAHYNTVIQFSGCVLCKRRLGKNHMYNITTQDTI
                     RLEKALSEMGIPVQLGMGTAVCKLCRYFANLLIKPPDSTKAQKAEFVKNYRKRLLKVH
                     NLQDGSHELSEADEEEAPNATETERPTSDGHEDPEMPMVADYDGPTDSNSSSSSTAAL
                     DTSKQMSKLQAILQQNVGADAAGAAGTGTVAASPGGSGSGADISNVLRGNPNISMREL
                     FHGEEELGVQFKVPFGCSSSQRTPEGWTRVQTFLQYDEPTRRLWEELQKPYGNQSSFL
                     RHLILLEKYYRNGDLVLAPHASSNATVYTETVRQRLNSFDHGHCGGLNIAGSPSSSGS
                     GKRSGVPQPTGASVLATALTTPLTSHSSSSASISSEQHSSVDPVIPLVDLNDDDEGED
                     GAGGAGERESTNRQQDVILECLRTASVDKLTKQLSSNAVTIIARPKDKSQLSCNSGSS
                     TSISSSSSAISSPEEVAVTKVTAVAPVQSKDAPPLAPASSGVSNSRSILKTNLLGMNK
                     AVELVPLTTAPHAYKPTGCHKPEKQQKILDVANKQPGSQGEPVPSSALLGLQSKLKPP
                     THQQQVSGSGAGTSGSQKPSNVAQLLSSPPELISLHRRQTSGAAAGSSSFLQGKRLQL
                     PRSGAGPSGAGTGTGAGAAGSRSAGGPPPPNVVILPDALTPQERHESKSWKPTLIPLE
                     DQHKVPNKSHALYQTADGRRLPALVQVQSGGKPYLISIFDYNRMCILRREKLMRDQLL
                     KSNAKPKPQNQQQQQGQTHQQQQNSAASAAAFSNMVKLAQQHTARQQLQQLQQKPQQQ
                     QQLPTLQPGGVRLARLPQKLLMPPLTNPQIGSQAPNLQPLLSSTLDNSNNCWLWKNFP
                     DPNQYLLNGNGGGAGSSSSKLPHLTAKPATATSSSGAANKSAGSLFTLKQQQHQQKLI
                     DNAIMSKIPKSLTVIPQQMGGNTGGDMGGSSSSGKD"
ORIGIN      
        1 ggaattattc aagtgggcgt cgtgcgaaag tatttccgtg gcgaaaacta gtttaagaat
       61 cgcgagattc acccaatctt agtcaggatc aaaggagaaa gatattcttc acatcacagt
      121 caaccaatgg gaccaaatca ctgcgactcg aactggacac aatcagcatc ggatcgcagg
      181 gaacaacagg aggtggtgga gcagcagcgc cagaaggcgt cgggggagcg gccatcatag
      241 gagcagcaac gtcggcagca gctgcccagg gcccctcgag aatgtctagc cggaaggtgc
      301 caggaggctc tggaggagct gacgaatcca cagcagcagc tgcccccctg gatgataatg
      361 ccaatgccag tgtggagatt ccagacagca gcgaggagcc agcaatgggc gtcggcgaag
      421 agatgtctat cataagcaaa acacgcacct caactttgtc agtggagccc gctaaggagc
      481 caacagtaac agcagagctg gaaggcgaaa aagagctgga atcgaatcca gtctccaaaa
      541 ctcctaggtc cacgcctacg ccaaccctta cgccagccgt cacgcctacc gccagtgatg
      601 gagtggcggc caagagcgtg agggttaccc ggcactcgtc gccactgctt ctgatcatct
      661 cgcccacgac aagtagacgt gaggtcggcg acggagagct agacaccgag gaaccaacgg
      721 gatcgggtgg ccaaagaaag agctccgtgg agcgatcttt ggcgcccgtt atacgcggac
      781 gaaagtccat caaggatctg aaagaagcca aagaagtcaa gtccgaggag ccgcctgccg
      841 cagcatcaga gtcacgagct gcaagtggag tgacgcctgg ccaggtcaag gaacagcatg
      901 tcgcggatgg caacgaaatg gaatccttgc caatcacaga caagaaagac cacaaagaca
      961 caaaagacaa gggagatgag cgggaaaccg atcaggagga agagaaggaa aaatcagctg
     1021 atacagaaat aattgcagat acagaaaaaa cttcggagaa acaaaagtat acagagaagg
     1081 acaaagctgc cgataaagat ggaggaaaag aaaaagatat tgatgcaaat aaggatatag
     1141 ataaggagaa ggaaaaggtc aaggaagtac ttccgccagt ggtgcctata gcaccagtga
     1201 cacccacttg taaccgtgtc acacgtaaat cacatgccca ggagcaggcg attaacacgc
     1261 gggtcactcg caatcgtcgc cagtcctcta cagttggagc caactccacc gcgtctttgg
     1321 tagctgcatc ctcctcagta acagagcaac cccctccatc tcgcggtcga cggaagaagc
     1381 cagtggtggt ggctcctccc ttggagcctg cggtaaaacg gaagcgatcg caagatgttg
     1441 aagccgactc agacgccaac aacagcacga aatacagcaa ggtggaagtg gtaaagtctg
     1501 aggaagctga ggcaccagag gaggactcca gtgccgtgcc cattaagcag gaatctgttg
     1561 atggcaacga ggtcagttct atttctccaa cagtcacgcc cacacccaca cctgcgccaa
     1621 caccagctcc agtcccgggc agtcgacggg gtcgtgggcg cccgcagaac aggaactcct
     1681 cttcgcctgc aaccacaacg cgggcaacgc ggctaagcaa ggcgggatca ccggttatcc
     1741 tgacgccagt agcccaggaa ccggcgccac cgaaacggcg gcgagtcggc tccagcacac
     1801 ggaagactgt ctcggccagc tcgctggcac ccagctcgca gggcggcgcc ggggatgagg
     1861 actccaagga cagtatggcc tcgtccatgg acgacctgct gatggccgca gcagatatca
     1921 agcaggagaa gctgacgccc gatttcgacg atagtttgat gccagaaggc ctgccctcta
     1981 cttctggtgc gtcgagtgcc aatggtcatt cctgcaccga accgcttact gtggacacgg
     2041 aaattaatgt taagcccgct gattccaaag taaaaccaaa ggagtcaccg gtggtagcag
     2101 tcgaggaatc tccatcacaa tccgaaacgc aatctgcaaa ggtgtcagcg catgcgggga
     2161 aggctccatc tcttagtcca gatatgataa gtgaaggcgt gagcgcggtc agtgttcgaa
     2221 agttttataa gaagcctgag ttcctggaaa acaatctggg cattgaaaag gatccggagc
     2281 taggtgaaat cgttcagacg gttagtaaca atgacacgga aacagatgtg gagatggctg
     2341 ttgatggcga ggtgaatcaa ccgtcaactc ccaagtcgca ggataaaaag aaagaggagc
     2401 aggaaaagaa tcagaaatca gggctaaagg cagcaaagaa ggctcctgct aagttagaac
     2461 ctaaagctga agacatttct gaaattctta ctgacgttcc tgttgatatt tcgactgagg
     2521 cagtagaaat tatagaagaa gcagaggaag acacttgttc aaatagctca atcaaaccag
     2581 gtgagctccg actggacgag agcaacgatg aacctgaact gcttcttgaa gacgccctca
     2641 tagtcaatgg tgatgagaat gagacaccag atcaaccgga ggaaaaggag gaccaggtgg
     2701 agttcttcca tacaggagaa tacgacgact ttgagcacga gattatggtg gagctggcga
     2761 aggagggggt gctagatgcc agcggcaatg cattaagtca gcaaaaggta gaacttgagc
     2821 atcccgagga tgtaactcta cacgaatcaa aaaatgacat agaagccgaa gaatcggttg
     2881 aacgtaagcc tcttaaggac ccgtcggttg cggacgaaat ggaggacatg aatgaggaat
     2941 cctatattga cattaaggac cagacaaatc aactgttagt tgaacacttg gcagaagagg
     3001 ccatggaagc ggactgcggt cccgaggata acaaggagaa cttgtccacg tctgcttcga
     3061 gcaccgctgc cgatggtcta gatattcagt tggccatcaa ggaggatgac gacgaggaga
     3121 aaccgcttgc agttatcgct gacgaacaga agcctgggct gctgttgacc aatgacatga
     3181 aagtggatga gaaaccaaat ggcaagcagg aatcggtctg tgatgagcac gttcagctgg
     3241 tgccaaacct tcgtcaagaa caggaaattc acttacaaaa tctgggccta ctcacgcacc
     3301 aggccgctga acataggcgc aagtgtctgc ttgaggcaca ggcccgccag gcgcaaatgc
     3361 agctccagca acatcaccac catcagcaca agcgacaagg agcgcgcgga ggaggcagtg
     3421 ccactcatgt ggaatccagc ggtactttga agacagtcat caagctgaac aggagcagca
     3481 acggaggagt aagcggtagt ggcggcctgc ctactggtac agttatccat ggaggctgtg
     3541 gctcctcttc agcttcttcc acgtcctcct cctcggtggg cagtgccaca cgtaagtcaa
     3601 gcgggacctt gggctcagga gcgggagcag gagctggcgt tcgccggcag tcgcttaaga
     3661 tgacattcca gaagggtcgg gctcgtggtc acggtgctgc ggatcgatcc gccgatcagt
     3721 atggcgccca cgccgaggac tcctactaca ccattcaaaa cgagaacgaa ggtgcgaaaa
     3781 agtttgttgt aactactggt aataccggcc gcaagactaa taaccgtttc agctcaacta
     3841 acaactacca ctcgacggta gccttgcacg gtagcaactc tgcgctccag tactattcgt
     3901 cccactcgga aagtcaggga cagacggacc acggcttcta tcagatggtc aaaaaggacg
     3961 aaaaggagaa gatcctcatt ccggaaaagg cctcctcgtt taagtttcac ccagggagac
     4021 tgtgcgaaga ccagtgctac tactgtagcg gaaagtttgg cctctatgac accccctgcc
     4081 atgttggaca aataaagtcc gtggagcgcc agcagaagat cctagccaac gaggagaagc
     4141 tcaccgtgga taactgcttg tgcgacgcat gttttcgaca cgtggaccgc cgggcaaatg
     4201 tgccatccta taagaagcgt ctttccgctt caggtcactt ggagatgggg tctgcagcgg
     4261 gatctgcact agagaaacag tttgctggcg acagcggcgt cattacggaa tcgggtggcg
     4321 aagctggttc tacggcagct gtggccgtgc agcaacgatc ttgtggcgtg aaggactgcg
     4381 tcgaagcggc acgacactcg ctgcggcgca agtgcatacg caagagagta aagaagtatc
     4441 agctcagcct ggagattccc gcaggctcgt cgaacgtggg gctgtgtgag gcacattaca
     4501 atacggtcat ccaattttcc ggctgcgttc tttgcaagcg tagattaggc aagaaccata
     4561 tgtacaacat aaccacgcag gacacaattc gactggaaaa ggcgctgtcc gagatgggca
     4621 tcccagttca gcttggcatg ggcactgcag tctgcaagct gtgtcgctat tttgccaacc
     4681 ttttgataaa gccaccggat agcaccaagg cacaaaaggc ggaattcgtg aagaactaca
     4741 gaaagaggct cctcaaggtg cataatctgc aggatggcag tcatgagctg tccgaagcgg
     4801 atgaagaaga ggcacctaat gcaacggaga cagaaaggcc aacctcagac ggacacgaag
     4861 atcccgagat gcccatggta gcggactatg atggacctac cgactccaat tccagtagtt
     4921 cttcgactgc agccctggac accagcaaac aaatgtccaa gcttcaggcc atcctgcagc
     4981 aaaatgtggg agcggatgcg gcaggagctg cgggaacagg aactgttgca gcaagtcccg
     5041 gaggaagcgg atctggggca gatatctcta acgtattgcg agggaatccg aacatttcca
     5101 tgcgcgaact tttccacggc gaggaagagc tgggtgtgca gttcaaggtg ccgttcggat
     5161 gcagcagcag ccagcgtact ccggagggct ggacacgagt gcagactttc ctacaatacg
     5221 atgagccgac gcgccgcctc tgggaggagt tgcaaaagcc gtacggaaat cagagctcat
     5281 ttctgcgcca cttgatacta ttagagaagt actaccgaaa cggagatctc gtcctagcac
     5341 cgcatgcttc ctccaatgcc acggtttaca cagagactgt tcgtcagcgg ctgaattcgt
     5401 ttgatcacgg tcactgcggt ggattgaaca tcgcaggcag cccttcttct tcgggttccg
     5461 gcaagcgcag tggagttcct caacctacgg gtgccagtgt gctggccacc gccctcacaa
     5521 cacccttgac aagccattca tcctcctctg catccatttc ctccgaacag cattcgtcgg
     5581 ttgatcctgt cattccgctg gtagacctca atgatgacga tgaaggcgaa gatggggcag
     5641 gaggagcggg cgaaagggag tcgacaaata ggcagcagga cgtaatcttg gaatgcctta
     5701 gaactgcctc tgtggacaag ctgactaagc agctcagctc gaatgcggtg acgattatcg
     5761 cccggcccaa agacaaatcg cagctctcct gcaacagcgg atcctccacg tccatttcca
     5821 gctcctcgtc cgctatttcc tcgccggagg aagtggccgt cactaaggtt acagcagtcg
     5881 caccagtcca gtccaaggat gcaccgccac tggcgccagc aagtagcggt gttagcaaca
     5941 gtcgtagtat ccttaaaacc aacctcttgg gcatgaacaa ggccgtggaa ctcgtgccct
     6001 taacgactgc cccccacgct tacaagccaa ctggatgcca taagcctgag aaacagcaaa
     6061 agattcttga cgtggccaat aagcagcccg gtagccaggg ggaaccggta ccatcaagcg
     6121 ccttgcttgg cctgcagtca aagctaaagc ctccaacgca tcagcagcag gtcagcggat
     6181 caggagcggg aactagtggt tctcagaagc catctaatgt ggcgcaattg cttagctctc
     6241 caccggagct aatcagcttg catcgacggc agaccagcgg agcagcagcg gggtccagca
     6301 gcttccttca gggcaagagg cttcaacttc cacgatctgg agcagggcct tcaggagcgg
     6361 gaacgggaac aggcgctgga gcagcaggaa gccgcagtgc gggtggacca ccaccgccca
     6421 atgtggtcat actgccggac gccttaaccc cccaggagcg acacgagagc aagagctgga
     6481 agccaacgct gataccgctg gaggatcagc acaaggtgcc gaacaaatca catgctcttt
     6541 atcagaccgc cgacggtcga aggttgcccg ccctggtgca agtgcagtct ggtggcaagc
     6601 catacctcat ctctatcttc gactataacc gcatgtgcat cttgcgaagg gaaaagctga
     6661 tgcgggacca gttgctcaag agtaacgcca agccaaagcc gcagaaccag caacagcagc
     6721 agggccaaac gcaccagcag cagcagaatt ccgccgcatc ggcggctgcc ttctccaaca
     6781 tggtgaagtt ggcccagcaa cacacggcgc gacagcagct tcagcagctg caacagaagc
     6841 cacaacagca gcaacaattg cccactttgc agccaggtgg ggtgcgactt gcccggctgc
     6901 cgcaaaaact actgatgcca ccactgacta atccgcagat tggcagtcaa gcacccaact
     6961 tacagccgtt gctgtctagt acgctggata acagcaacaa ctgctggctg tggaaaaact
     7021 ttcctgatcc caatcagtat ctgctaaatg gaaacggagg gggtgccggg agctcctcca
     7081 gcaagttgcc acatctcacg gccaaaccag ccacggcaac tagtagctcc ggagcggcca
     7141 acaaatcagc aggaagccta tttaccctca agcagcagca gcaccagcag aaactcatcg
     7201 acaacgctat catgtcaaag atacccaaaa gtctgacagt aataccgcag cagatgggtg
     7261 gtaataccgg tggcgatatg gggggcagca gctcctccgg caaggactga tgacggcgaa
     7321 ggagggcgcc atggccatta gccgtagcgc cggaggtaac ccggcgaagt agtaggatca
     7381 acaagcaggc gacgtgcagc ttaagcggcg atcttcagaa caagaggtga ccagcggcgg
     7441 ctccatggat atcacaaact ccacaattcc atggctgcag tagaataagt gatacact