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Drosophila melanogaster adenosine deaminase acting on RNA,


LOCUS       NM_001258548            6954 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant F (Adar), mRNA.
ACCESSION   NM_001258548
VERSION     NM_001258548.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6954)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6954)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6954)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6954)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6954)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6954)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6954)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6954)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6954)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6954)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6954)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6954)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6954)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6954)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6954)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6954)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6954)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6954)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258548.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6954
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6954
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="Adenosine deaminase acting on RNA"
                     /map="2B9-2B9"
                     /db_xref="FLYBASE:FBgn0026086"
                     /db_xref="GeneID:31130"
     CDS             808..2643
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /EC_number="3.5.4.37"
                     /EC_number="3.5.4.4"
                     /note="CG12598 gene product from transcript CG12598-RF;
                     CG12598-PF; Adar-PF; hypoxia, anoxia, sensitive 2;
                     adenosine deaminase acting on rna; hypnos-2; adenosine
                     deaminases acting on RNA"
                     /codon_start=1
                     /product="adenosine deaminase acting on RNA, isoform F"
                     /protein_id="NP_001245477.1"
                     /db_xref="FLYBASE:FBpp0293951"
                     /db_xref="GeneID:31130"
                     /db_xref="FLYBASE:FBgn0026086"
                     /translation="MNGYNRKLPQKRGYEMPKYSDPKKKMCKERIPQPKNTVAMLNEL
                     RHGLIYKLESQTGPVHAPLFTISVEVDGQKYLGQGRSKKVARIEAAATALRSFIQFKD
                     GAVLSPLKPAGNLDFTSDEHLENDVSKSAITVDGQKKVPDKGPVMLLYELFNDVNFEC
                     INIDGAQNNCRFKMTVTINEKKFDGTGPSKKTAKNAAAKAALASLCNISYSPMVVPQK
                     NVPLPIDDKSSSMELPQIHADTIGRLVLEKFMEVIKGQEAYSRRKVLAGIVMTENMNF
                     CEAKVISVSTGTKCVSGEHMSVNGAVLNDSHAEIVSRRCLLKYLYAQLDLQCNQATAY
                     QSIFVRNTDGQYPYKLKSGVHFHLYINTAPCGDARIFSPHENDTGVDKHPNRKARGQL
                     RTKIESGEGTIPVKSSDGIQTWDGVLQGQRLLTMSCSDKIARWNIVGIQGSLLSSIIE
                     PVYLHSIVLGSLLHPEHMYRAVCGRIEKSIQGLPPPYHLNKPRLALVTSAEPRNQAKA
                     PNFGINWTIGDTELEVVNSLTGRTIGGQVSRITKQAFFVKYGFLMANLPGILVRKVTT
                     DYGQTKANVKDYQIAKLELFSAFKREDLGSWLKKPIEQDEFGLAE"
     misc_feature    910..1098
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="first double-stranded RNA binding motif of STRBP,
                     ILF3, RED1, RED2 and similar proteins; Region:
                     DSRM_STRBP_RED-like_rpt1; cd19865"
                     /db_xref="CDD:380694"
     misc_feature    order(910..912,919..924,931..936,940..942,982..987,
                     991..993,997..999,1048..1056,1063..1065)
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="RNA binding site [nucleotide binding]; other site"
                     /db_xref="CDD:380694"
     misc_feature    1234..>1374
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="double-stranded RNA binding motif (DSRM)
                     superfamily; Region: DSRM_SF; cl00054"
                     /db_xref="CDD:444671"
     misc_feature    1513..2628
                     /gene="Adar"
                     /locus_tag="Dmel_CG12598"
                     /gene_synonym="adar; ADAR; ADAR1; adr; cg12598; CG12598;
                     dadar; dAdar; dADAR; Dmel\CG12598; EG:BACN35H14.1;
                     hypnos-2"
                     /note="tRNA-specific and double-stranded RNA adenosine
                     deaminase (RNA-specific editase); Region: ADEAMc;
                     smart00552"
                     /db_xref="CDD:214718"
ORIGIN      
        1 tattgtgata actgctcaca tcgctagatt ccgagcaaca aaaaagcgac gaagggtcat
       61 tgttattttt tctaatgcaa tgtaatgcag caaatgtgca gatttgaaca agtgtaacgc
      121 gatttatgtt taatccgcat cgaggaacca aatcgaagta aacgcgcggc cagagaaaag
      181 agcagcaccg caccgaagat aaaacaaaca agcattgatt tgtttgtccg gccatgtcag
      241 tgtgtgtgtc acaagggctt gcaagtgtgt gcgtgtgtcc gtgcgtgtac gtgggtgctt
      301 ttttttttct cccgagtgcc gccaagtgaa atatgcaatt gcacgccact gcagttgcag
      361 ccacacaaat cctatcctaa tcgacgaaac agcgaagcga ggaggctaga atcggctgcc
      421 caacgaagag agcagaaccg ttaacaaatg acactctgcc gatacagcga agtaaaaatc
      481 aataattaga gcaaaaagag tcatgttaaa cagcgctaat aacaattctc cccagcacaa
      541 gtgcataatt caattcggca atatttgata tatatggtaa tatcaaatga agaaccgtgt
      601 caatgatact tgctttggtg ccataaaaag caagtcctct agaagacgcg agttactaca
      661 tgcctacaca caaaacgggt ccttaaaatg aagtttgaat gcttttcgtt gtactgtaca
      721 gtgttaaaag taaatgccta aatactcttg atttcactat taatgcatac gtatccatag
      781 ccggtgagtg caccatccga tatcaacatg aatggctata accgaaaatt gccacaaaaa
      841 cgtggctatg agatgccaaa atactctgat ccaaaaaaga aaatgtgcaa ggagcgcatt
      901 ccccagccga agaacacggt ggccatgctg aatgagctaa gacatggact gatttacaaa
      961 ttggagtcac agactggtcc ggtacacgca cctctattca cgatatccgt ggaggtcgat
     1021 ggacagaaat acttgggcca gggccgtagt aaaaaagttg cacgcatcga agcagcagca
     1081 actgcactgc gcagctttat acagtttaag gatggagcag ttctgtcgcc tctgaagccg
     1141 gcgggcaact tggactttac cagcgatgaa catcttgaaa atgatgtcag caaaagtgct
     1201 attactgttg acggtcagaa gaaggttcca gataagggtc ctgtcatgct cctctacgaa
     1261 ttatttaatg acgttaattt cgaatgcatt aatattgacg gcgcccagaa caattgtcgc
     1321 ttcaaaatga ccgtcacaat caacgaaaag aagttcgatg gaacaggtcc ttccaaaaag
     1381 acggcgaaaa atgcggcagc taaggcggca cttgcttcgt tatgcaatat ttcctacagt
     1441 ccaatggtgg tgccacagaa gaacgtaccc ctgccaatcg acgacaagtc gtcatcgatg
     1501 gagttgcctc agatacacgc ggatacgatt ggtcggttgg tcttagaaaa gttcatggaa
     1561 gtaatcaagg gccaggaggc ttactcgcgt cgaaaggtat tagcgggcat tgtaatgact
     1621 gaaaacatga atttttgtga agccaaagtt atttcagttt cgacgggcac caagtgtgtc
     1681 agcggtgagc atatgagtgt gaacggagct gtcctaaatg attcccatgc tgaaatagtc
     1741 tccaggcgtt gtcttctcaa atatttatat gcacagctgg accttcagtg caatcaggcc
     1801 acagcatatc agtcgatttt cgtgaggaat actgatgggc aataccctta taaactaaaa
     1861 tccggggtac atttccattt gtatataaat acagcacctt gtggggatgc acggatattt
     1921 agtcctcacg aaaacgacac tggtgttgat aaacatccaa atagaaaagc tcgtggccag
     1981 ctgcgcacca aaatcgagtc cggtgagggg acgattccag tgaaaagcag tgatggtatc
     2041 cagacgtggg atggcgtatt gcagggccaa cgcctgctaa caatgtcgtg ctcggataaa
     2101 attgcccgtt ggaacatcgt gggcatccaa ggctcactat tgtcttccat aattgaaccg
     2161 gtgtacctgc attcgattgt gctgggaagc ctgttgcatc cggagcacat gtaccgcgca
     2221 gtttgcggcc gaattgagaa gtccattcaa ggcctgccac cgccgtacca tctgaacaag
     2281 ccgcgcctgg cactagtcac ttcggccgag ccgcggaatc aggccaaggc tcccaacttc
     2341 gggatcaatt ggaccattgg ggacaccgag ctggaagtgg tgaactcgct aaccggtcga
     2401 accattggcg gccaggtgtc tcgcatcaca aagcaggcgt ttttcgttaa gtatggattt
     2461 ctaatggcaa acttgcccgg tattttagtc cgcaaagtaa ccactgacta tgggcaaacc
     2521 aaagctaacg ttaaggacta tcagatcgca aagctagaat tgttctctgc attcaagcga
     2581 gaagaccttg gcagctggct gaagaaaccc attgaacaag acgagttcgg tcttgccgaa
     2641 tgactgcact cagcactatt atataatttt aaaaaagaca acagcaacgg caagcaatta
     2701 atagaattag acgacataga ttttatgaca aattctgata tagaatgcaa attatattgg
     2761 gtgcaagcac atcgctatga tataccactt catatgattg acaacctgcc aactttgcgt
     2821 acccattgca atagcaagca caaagatgct tatgctcgaa atataaagaa cagctctaga
     2881 atatttatag aatagaatgt agtttttatg ctggaactga gtaaaggagt attatggcgt
     2941 ttttttttga atcaattcat ttttaaattg gctaaagcaa tttctttatc atttaagttt
     3001 gtgacttgtt ttgttatttg aatgaatgcg atgcgttgcg atgtcgtcgt aaccacactg
     3061 tcgaaacttt caagtgagtt gtgtctttcg ttttccgtat tttatatggt aaatatggta
     3121 atatggaatg ttacgaaaca gttaaaagat atatataaaa ccaaaaacca acaagtacac
     3181 tcaatgaata acaataatcc aaacagaaat ctagaattcg ttctcttatc gattaagcaa
     3241 tgtattttgt taagtaatgt tatttgcaac gacataataa ttataataat aataaagtca
     3301 cgcttaatat aagcataaga acattttagg tgaatctgcg ttaatttcgc gtacttttct
     3361 tcagatcaga tataaaccta agctttaatc gattttcaat gaataaaact gtgttcttgg
     3421 ttgaaaaaca ttatatctat gtaacaacat tttatcaatt aaattacgta gatttctttg
     3481 catattagtt gatacaaatc acatgcaagc gaaagcagat aagaataaaa atacatatat
     3541 tagttaccaa ttttgtagca tgctgataaa ggcatttgaa ctacctaact aagtcttatc
     3601 atgaagcttg tatcgctatt tcgtatattg tagaaataca tactatatta gttgtggtta
     3661 cttgtacatc ataatacctt ctcttaaatt tacttccgcc ctgagttctt ccggttgttc
     3721 gttcaatttg aaatgacaat tgttaatggt caaatcaata actactcttc caacgtcgat
     3781 tgacgtattc caatttaaaa caaggcgatt tggctcctct tttattgtgt acttgaaaat
     3841 gctacgacga atgatctagt caaatgtggt aacctaataa agccatagtc tcctaccatt
     3901 cagttatgtg aaataaatat tacgtcgaag ttgcatagaa aacgaaaatg aaaaggactg
     3961 catgacatta gagcagcaca gcatattttg ttgcagttgc agtttgtccg aatcgtctta
     4021 atctcactca cgacctcgaa aaggtttgag taccgacttc ttgcgatata atttttcatt
     4081 taaagccgta aaatttcttt aagtactaaa attcaaccgc ttaattcgtc caatgccgtt
     4141 tataattaac aagctacttc gaagtttaat ttcctttgac tttctcacag tccacttaat
     4201 gatactttta gtagtaattt acatgattgc ttcgcaactt gtatccttca ctaccgagtg
     4261 aacctgatgg gctgattgtg ttttaaaaat gaaaaagaat taattgttaa ctttttcagc
     4321 acggcacgaa gtaggcaatt gagttttaag ctattgaatt tggaagcgta gcttatggga
     4381 aatttgctga tgctgaatac aaatataata ggaaaaccat cagggctttt taaatgtgaa
     4441 attatatttt aagtggagag gacattattt ataattttca atagtggtat tcttcaaatt
     4501 acgtcgatag caaaaattta attatagatt tcctttaagt tcaaagtgat acatgtacac
     4561 catttttttt cctgcgcatg ctaaaaatat attggcatat tatttgtgaa aaagaaaaaa
     4621 aaacttgcga gtttttctcc attacttgat taaataataa tatgacgata taattgactt
     4681 aagtaatatt tgcaaaaata ccgcgtatga tggataaacc aaagttgatc ttatataaaa
     4741 tactgtgata ctaaatttta ctagtacttc cagcatagct gcattttatc cattcttaaa
     4801 tattctatga taagcagcag cagataataa tcaatgacta tataggaaaa caaaaatttt
     4861 taaatggcat gcaccatgct tgtctacatt agattttcaa ataagaaatt ttacaaacta
     4921 gattaatacg tatggaatgg tgggtataac attgggactc ctcaaatatc atttttaatt
     4981 gcaaaataaa acaataggct ctcgaatgca gcgtacacag gaaaacttca gtcaactaat
     5041 ttctattgcg aaaagataca ctaaattaaa ccctataaaa cgtaggctag tcgtcaagtc
     5101 ggtatattca agaaccagct aataaacgtt caacacgtat tagaatacct agctaagaac
     5161 acacaatgat aactatgaga attttttaaa tatacttagt tggaagaaga tcagacatat
     5221 acaatagtat gctagtcgag tcctctactc ttgttatgga atggttttaa ccattcacct
     5281 actaagttgg tttgcctatc ggttcgcatt cacattattt cataatataa ttgaaaccag
     5341 tttgggaata aatagaaata gacatagaca tagtaaatat cacagtttga aatggatatt
     5401 gtacttggaa gttggaagtt ggacttacat gaataagtat acaaaacaaa aggttgctca
     5461 aattgcaaaa cacttggaaa gtatttctac atcttccaaa caaaaagcag tcctcagaaa
     5521 cacacttaga tgctatagaa ctataaaaca tgccgggttt tactatatat cccgctaaac
     5581 cagtgataag aagccgcgtt ctagaccaaa cccatatacc aactaccata tagcatgaag
     5641 acactaatca agctgcatac atatgtacga gctaaaggca gcaatccaac acagattata
     5701 ttaccacttg caattgtatt aatagttaga acatttgatg ttttgggagt tcaaggactg
     5761 tatgcaatca attatctaag acacaacatg ctaaacatat tgcagatccg gcaggatgcc
     5821 aagattgaat ctgttttacg tgctcctgag atcaagaatc attcattact gacattctgg
     5881 gctaaacgcg ttagaaaaag agaccaaaaa aacaatcata atttgggctt atctactagg
     5941 cattgcttac acatatttca ctaagtttac gaaacggata ttaaactacc aaagaaataa
     6001 acagtataat cgtggtaaat ttacatttac attacatcga gccaaaaaca ccttattaca
     6061 aaacatcaaa tattttttga ttccaccgaa acttgcaatt ttgatggaaa agtgggtttg
     6121 ggaatttagc aatgcggaca tccaaatata gatggctttt ctttagttta cgaacaagcc
     6181 cgtatttacc aggaaatcaa tatatgcata acttaatata tagaaataca cacttatacg
     6241 taaaactttg ttcttgaaaa agattagtgc atatatccaa aagatttaag caaataataa
     6301 acacttaata tctaaataca cagaacaaac tttaataaga actaggttta cacttcctac
     6361 acttaaactt cgcttgtcca cgtttcaaga aattcgcttg gataacgaat caataaaatt
     6421 ccaaaatagt aacagtctag tctgcgaatt acaaattcta tttgcaattt aagaaatatt
     6481 cttttaaaca ctaaaacact gaatacttgc aagaacgtag aaatcaattg catgcatcca
     6541 aaattgctcg tttagttata aaagaaatcc gtatgtacca ggaattctgt atatgcgtgg
     6601 cttaatacat ataaaataca tacacactta tacgtaaagc tttgttcaaa acttgatcaa
     6661 aatttagtgc aaatagccag gcgattcaaa tggaataata gcgagcaaga aagagcattg
     6721 ttaacagcta ccataaacat ttaagtcggc aaaaaccaat gtatcaataa cttaaacttt
     6781 taaaatagat tttacgatgg cctttttgtt ttataatcga ctgtcagcca ataaaatgat
     6841 ccccacgtca ttgaagacga aacttaaacc ctataagcct atgaatattt acacaatcgt
     6901 tcggtctcca actaatgtaa atgaaattta ataaattacc aataatatat agag