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Drosophila melanogaster histone methyltransferase 4-20, transcript


LOCUS       NM_001258524            5149 bp    mRNA    linear   INV 26-DEC-2023
            variant B (Hmt4-20), mRNA.
ACCESSION   NM_001258524
VERSION     NM_001258524.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5149)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5149)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5149)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5149)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5149)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5149)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5149)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5149)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5149)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5149)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5149)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5149)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5149)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5149)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5149)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5149)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5149)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5149)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5149)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5149)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5149)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5149)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5149)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5149
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5149
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="Histone methyltransferase 4-20"
                     /map="1B13-1B14"
                     /db_xref="FLYBASE:FBgn0025639"
                     /db_xref="GeneID:31015"
     CDS             88..3990
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /EC_number="2.1.1.362"
                     /EC_number="2.1.1.372"
                     /note="CG13363 gene product from transcript CG13363-RB;
                     CG13363-PB; Hmt4-20-PB; histone methyltransferase 4-20;
                     Suv4-20"
                     /codon_start=1
                     /product="histone methyltransferase 4-20, isoform B"
                     /protein_id="NP_001245453.1"
                     /db_xref="FLYBASE:FBpp0300875"
                     /db_xref="GeneID:31015"
                     /db_xref="FLYBASE:FBgn0025639"
                     /translation="MVVGSNHTRRGETGSRFTNSSSSSSTSGGPTASASSTTSVTSSL
                     ATNSTSTSTAAALLSSMSHKSHGPPPSAPPSAHHQTNQQHHQVAHSQPHATHYQQTNQ
                     HPSHHHQSHQSSNGSGGGSAGSGSGSGSVVSGLNGCNGSAVSRLSQSTGMSPRELSEN
                     DDLATSLILDPHLGFQTHKMNIRFRPLKVDTQQLKAIVDDFIHTQNYDIAIQRIYEGP
                     WIPRHLKNKNKIATKRLHDHIVRYLRVFDKDSGFAIEACYRYTLEEQRGAKISSTKRW
                     SKNDKIECLVGCIAELTEAEEAALLHSGKNDFSVMYSCRKNCAQLWLGPAAYINHDCR
                     ANCKFLATGRDTACVKVLRDIEVGEEITCFYGEDFFGDSNRYCECETCERRGTGAFAG
                     KDDGLMLGLSMGLGLASSGPGNNGGYRLRETDNRINRIKSRANSTNSTSNSNSNTNDS
                     TGPSETSSTNGLVASGGAGGATGAAMLPTPSQQSTGGKEATAAVSLLEKKLPNVVVSP
                     LTMKELRQKGMTKYDAEMIMANAAYQQQHHHQHHFHHHHHHHHHHHNHGQHASTGAEA
                     TAAVQQMAAMQKPGVGGTGAAGNAGATTVSSVAAGAGSEVNGGRSTSLRKSMRVNSTS
                     SSISTASADEVIAPVVAASISLPSKAPVVLMPRCKPAQMAIAALHQSQQRQLRRSERQ
                     KEKLTDGESSDTSSEQQKKEQKQQDHQLPQKMFSLAEEPQPEKSEEKQQEQQKRVTRN
                     SAGRVGLVARLATAHNNNIATTTNSSSSSNKATTITNCNNHNSNNSSRINHNSNLSSR
                     LSVKSRKPAPSEASSIPSSTSSENQQQQATRRSCSPTPAYKKNLLASFDPDPPSTQGI
                     KEQLKDESVTYSPVKQKRSRRAAALAAAQSIHCEALGGFPTGSTGSQRKRAQAGEPTT
                     SCSSTTISNVEPLLKTPERRLKLTLRMKRSPILDEVIELGTSLSNGGAGRGAPGSHRE
                     GTAGEGSVRSALNLTGSSSNGIEYEILRMEGISEHGNDDDEDEEEDDEEPAAEEEEEP
                     PPKEELQLVNKKQRKKQRSRSRSSQRRSPAPSSVYGTPQKKRLRLIFGNESHTIDIPP
                     AAAEGSGSGLDDLNSSGGGGDESFNASYASSTSLTVNTSSSSTSSSSGVGGATSTSAE
                     PVDSSTVGPPIAAQSPSSTTSSSFQSACTSTTNSNSYFPNGKQRAAGEDSYAMHYYQL
                     GKFAGTPSPGQGQAIVSSSSGSSGGGGSGAGFLSMPKHTFGTCALLAPTSFACLQNQP
                     QISQQKTSSGGGAGVVPTSTSTGAVTSHHHTNNHHGQK"
     misc_feature    832..1257
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="SET (Su(var)3-9, Enhancer-of-zeste, Trithorax)
                     domain superfamily; Region: SET; cl40432"
                     /db_xref="CDD:394802"
     misc_feature    order(886..891,1063..1080,1102..1110,1174..1185)
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="active site"
                     /db_xref="CDD:380914"
     misc_feature    order(886..891,1066..1080,1180..1182)
                     /gene="Hmt4-20"
                     /locus_tag="Dmel_CG13363"
                     /gene_synonym="BcDNA:LD36415; CG13363; Dmel\CG13363;
                     dSuv4-20; EG:115C2.10; hmt4-20; Su(var)4-20; Suv4-20;
                     SUV4-20; Suv4.20"
                     /note="SAM binding site [polypeptide binding]; other site"
                     /db_xref="CDD:380914"
ORIGIN      
        1 caaacaaata ttcaattcca gcgatgtttc ccagcaccac ccacttgtgt ttatgatagt
       61 ttatgcccag aaagactgtc gtgcagaatg gtcgtcggct ctaaccacac gcggcgcggt
      121 gaaactggca gcagatttac aaacagcagc agctccagca gcacaagcgg tggccccacc
      181 gcttcggcca gtagcaccac cagcgtaacg tcttcactag ccaccaattc cacgtcgaca
      241 tcgacggctg cggctctgtt gtcgtccatg tcccacaaga gccatggccc tccgccatcc
      301 gcacctccat ctgcacacca ccagacgaac cagcagcacc accaggtggc ccacagccag
      361 ccacatgcca cccattacca acagacaaac cagcacccta gccaccatca ccagtcccat
      421 cagtcttcga acggcagtgg cggaggatct gctggatcgg gatctggatc tggatcggtg
      481 gttagtggac tcaatggttg caacggcagc gccgtcagcc gcctatcgca atccactggg
      541 atgtcgccgc gggaactgtc cgagaacgat gacctggcca catcgctgat cctcgatccg
      601 catcttggat ttcagaccca caagatgaac atacgctttc ggcctcttaa ggtggacacg
      661 caacaactga aagcgatcgt ggacgacttt atccacacgc agaactacga tatagccatc
      721 cagcgcatat acgaggggcc gtggataccg cgtcatctca agaacaagaa caagattgcc
      781 accaagcggc tccacgatca tatcgtccga tacctgcgcg tctttgacaa ggatagcggc
      841 tttgcaatcg aggcctgcta cagatacaca ctggaagagc aacggggcgc caagattagc
      901 tcgacgaagc gctggtcgaa gaacgacaag atcgaatgcc tggttggctg catcgccgag
      961 ctgacagagg cggaggaggc cgctctgctg cactctggca aaaatgactt ctcagtaatg
     1021 tacagttgtc gcaagaactg cgcccaattg tggctgggac cggctgccta tatcaaccac
     1081 gattgtcgcg ccaactgcaa gtttttggcc accggcaggg acacagcgtg tgtaaaggtc
     1141 ctgcgcgaca ttgaggtagg ggaggagata acctgcttct acggcgagga cttctttggg
     1201 gattccaatc gctattgtga gtgcgaaacg tgcgaacgcc gtgggactgg agccttcgcc
     1261 gggaaagatg atggcctgat gctggggctc agtatgggac tcggcttggc cagcagtgga
     1321 cctggtaata atggcggcta tcgtctgagg gagacagaca atcggattaa ccgcatcaag
     1381 agccgagcca actccacaaa cagcacctca aacagcaaca gtaatacaaa tgattccact
     1441 ggccctagcg agactagtag cacaaatgga ttggtggctt ctggcggagc aggaggagcc
     1501 actggtgccg cgatgctgcc cacaccctcg caacaatcaa ctggcggcaa ggaggccaca
     1561 gccgccgtct ctttgctcga aaagaaactt ccgaatgttg ttgtttcacc gctgaccatg
     1621 aaggagctgc gccaaaaggg aatgactaag tacgatgccg agatgatcat ggccaacgca
     1681 gcttaccagc agcagcacca tcatcagcat catttccatc accaccatca tcatcatcac
     1741 catcaccaca atcatggcca gcatgcaagt actggagccg aggctacagc ggctgtacag
     1801 caaatggcgg ccatgcagaa gccaggagtt ggcggaacag gagctgcagg aaatgctgga
     1861 gcaacgacag tgagcagcgt ggcagccgga gcgggctccg aggttaatgg tggtcgttcc
     1921 accagtctac gcaagtctat gcgcgttaac agcaccagca gcagcatttc caccgcctcc
     1981 gcggacgagg tgatcgcacc cgtggtcgcg gcgagcattt cgctgcccag caaggcaccg
     2041 gtggttctta tgccgcgttg caagccagct cagatggcca ttgctgcgct gcaccagagc
     2101 cagcagcgcc agcttagacg tagcgaacgc cagaaggaaa agctgacgga cggcgagagc
     2161 agcgacacca gcagcgagca gcaaaagaaa gagcagaagc agcaggatca ccaactgccg
     2221 caaaaaatgt tcagcctggc ggaggaacca caaccagaga agtcggagga gaagcaacag
     2281 gagcagcaga agcgtgtgac gcgaaatagt gcgggaagag taggattggt agccagatta
     2341 gccactgccc ataacaataa cattgcaacc acaacaaata gcagcagcag cagcaacaaa
     2401 gcaacaacga ttacaaattg taataatcat aatagtaata atagcagtag aattaatcat
     2461 aattcaaatc ttagcagtag acttagtgtt aaatcgagga agccagcacc aagtgaggcc
     2521 tcgtccatac cctcatccac atcatcagaa aatcagcagc agcaggcaac gcgtcgcagc
     2581 tgcagcccga ctcccgcgta caagaagaac cttttggcca gctttgatcc cgatcctccc
     2641 tccacccaag gaatcaagga gcagctaaag gacgaatcag ttacttattc gccggtcaag
     2701 cagaaacgta gcagaagggc cgctgctctg gcggcagcgc aaagtatcca ctgcgaagcg
     2761 ttgggcggat tccctaccgg ttcaactggt agccagcgaa agagggccca ggccggagaa
     2821 cctaccacct catgctcctc tacaaccatc agcaatgttg agcccctact gaagactcct
     2881 gagcgcaggc tgaagctaac gttgcgcatg aaacgctcac caatcctaga cgaagtaatt
     2941 gagctcggaa cgagtctgag caacggagga gctggtcgag gtgcaccagg ctcccatcgg
     3001 gaagggacag caggagaggg gtcagttaga agtgcgctaa acctaaccgg cagcagctca
     3061 aatggtattg aatacgagat actgcgcatg gagggtattt cagagcacgg caacgatgac
     3121 gatgaggacg aggaagaaga tgatgaagag ccagctgccg aggaagagga ggagccgccg
     3181 ccgaaggagg agctgcagct ggtgaacaag aagcagagaa agaagcagcg cagccggagc
     3241 aggagcagcc aacgcagatc gccggcccca agcagtgtat atggaacacc gcagaagaag
     3301 cgactccgct tgatctttgg caacgaatcc cacaccatag acattccacc agcagcagca
     3361 gagggatcgg gcagcggctt ggatgaccta aacagcagtg gaggcggtgg cgacgagtcc
     3421 ttcaatgcct cctacgccag cagcaccagt ctgacagtta atacatcctc aagcagtacc
     3481 agctcatcca gtggagtggg aggagctacg tccacctctg cagagccagt ggattcgtcc
     3541 acggttggac cgcccattgc tgcccaatca ccttcatcga cgaccagcag ctcctttcaa
     3601 tcggcctgca catcgaccac caacagcaac agctactttc ccaatggcaa gcaacgagct
     3661 gctggcgagg actcctatgc gatgcactac taccagctgg gcaaatttgc tggaacacca
     3721 agtccgggac agggtcaggc catcgtgagc agcagcagtg gttcgtcagg aggaggagga
     3781 tctggagctg gctttctgag catgcccaag cacacattcg gcacctgtgc tctcctggcc
     3841 cccaccagtt tcgcctgcct acagaatcag ccgcagatta gccagcagaa gaccagcagc
     3901 ggcggaggag caggagtggt gcccacctcc acttcaacgg gcgcagttac atctcaccat
     3961 catacaaaca accatcacgg ccagaaataa ccaacgactg atctccaagc aaattgacta
     4021 agcacagttg ccatttccat gagaagagga ggagcgcgta gggggagagt accgggcgag
     4081 gacatggtga agcaccaggt gcagagaagc aggaataaca agggatggag actgagaatg
     4141 gctgcgctgc tggcgtcgtt gcctttgctg ctgctgattc caagcacctt atagaaaccg
     4201 taggcttaga tcttagtcca agtagatgat ccctgatata cccgccctgg gttttcatat
     4261 tcgggaagca aagcaacagg ctgaccaatt tgttaatgcg aatccggata tataccagat
     4321 tgtaacttgt tttgtttttg ctttcttttc catttctctc tttctctttg tgatcacttc
     4381 ccgtttctcc caaccctttt actttgtgtc cgcgttgcat gtggcgcgtg tgtgtgtggt
     4441 gtgcttttat tttgcaggtg gcagtctgaa tcgtagaagt aggaaaaggt cgcagcaaag
     4501 ggcagcgtgt tgcaatcaca acaaaagcag cagcgggagc aaccggagca gcggcaacat
     4561 cggcagcagc aacagcagca gcagcaccac caccaccacc accaccagca atttgatagt
     4621 taaacggcta agaatagagt taaatcgcat tcaaatcatg tacagttgag aactaaccga
     4681 cctaaacagc ggacgagcag cccaggagcc actgtgaatc agaatgggag gatttaggac
     4741 gcaattagca gaggttttag acgccttgca tccgaaaccc aacttagctt tacaccaagc
     4801 aagcccctct gtttgttgca agataatgaa acaaccacat attcgaggat acttgggact
     4861 cccaccccac aatagccaac aagaaaacaa tagcgcagca gcggcaacca gaacagcaat
     4921 atataaataa taacatatat gcatggtgta tatacaagat atacgagaca aacttaatgt
     4981 taattactac aaagcgagct ggttgaagag accgaaagga ggaggagctt acactttcac
     5041 atacatataa caataacaat gtatataaac caaaaagcgg gaaatttaat tataaagcaa
     5101 gcgaaaacaa ttgaacagaa gattcaaata aaacgctaaa tacaactcg