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LOCUS NM_001258522 6324 bp mRNA linear INV 26-DEC-2023 transcript variant E, mRNA. ACCESSION NM_001258522 VERSION NM_001258522.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6324) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6324) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6324) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6324) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6324) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6324) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6324) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6324) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6324) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6324) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6324) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6324) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6324) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6324) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6324) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6324) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6324) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6324) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6324) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6324) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6324) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6324) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6324) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jul 15, 2014 this sequence version replaced NM_001258522.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6324 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6324 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="beta amyloid protein precursor-like" /map="1B9-1B10" /db_xref="FLYBASE:FBgn0000108" /db_xref="GeneID:31002" CDS 207..2858 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="CG7727 gene product from transcript CG7727-RE; CG7727-PE; Appl-PE; amyloid Precursor-Like protein; APP-like; amyloid precursor protein-like; beta amyloid protein precursor-like; amyloid precursor protein like; beta-amyloid-protein-precursor-like" /codon_start=1 /product="beta amyloid protein precursor-like, isoform E" /protein_id="NP_001245451.1" /db_xref="FLYBASE:FBpp0298295" /db_xref="GeneID:31002" /db_xref="FLYBASE:FBgn0000108" /translation="MCAALRRNLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQ IYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKI GGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFVRW NQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPA AQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATAGGS PNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSL KSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTA QPTSDPYFTHFDPHYEHQSYKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPKAAQS FKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQALTEQP PNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERLIDID RAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILDKYRV EIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQSQPT QSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEATVSST KVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREFAQH AHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQNVTTHHPI VREEKIVPNMQINGYENPTYKYFEVKE" misc_feature 282..800 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="amyloid A4; Region: A4_EXTRA; smart00006" /db_xref="CDD:128326" misc_feature 1368..1934 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="E2 domain of amyloid precursor protein; Region: APP_E2; pfam12925" /db_xref="CDD:463752" misc_feature 2088..>2240 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="DDRGK domain; Region: DDRGK; pfam09756" /db_xref="CDD:370664" misc_feature 2697..2846 /gene="Appl" /locus_tag="Dmel_CG7727" /gene_synonym="Abeta; APP; APP-like; appl; APPL; BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727; EG:65F1.5" /note="Beta-amyloid precursor protein C-terminus; Region: APP_amyloid; pfam10515" /db_xref="CDD:463129" ORIGIN 1 actcgcagtc gtttgtgagc gttcgcagcg ccagcaaagt gttaaacgaa tagccaacaa 61 agcaaataca attaaccaga actggaagca cgtcagtcca gccgcagaag cagctaagtt 121 cagaccaaac tcggagattc ccagccagga gataggacca ggagccaacc agacgaggag 181 caaagaagca gaaaagagtg cgaacaatgt gcgccgcgct gcgtcgtaat ttgttgctga 241 ggagcctctg ggtcgtcctg gccattggca ctgctcaggt tcaggccgca tcgccgcgat 301 gggagcccca gattgccgtt ctctgtgagg ccggacaaat ctaccagccg cagtatcttt 361 ccgaggaggg acgctgggtg acggacctta gcaagaagac aaccggtccc acatgtttgc 421 gtgataaaat ggatttgctt gattactgca agaaggccta tcccaaccga gacataacca 481 acattgtgga gtcgtcccac taccagaaga tcggcggctg gtgtcgccag ggggcattga 541 atgcggctaa gtgcaaggga tcccaccgat ggatcaagcc attccgctgt ctcggaccat 601 tccaatctga cgccctgcta gttcccgagg gctgtctgtt cgaccacatc cacaacgcct 661 cccgatgctg gccatttgtg aggtggaacc aaaccggagc agccgcttgc caggagcgcg 721 gaatgcagat gcgcagcttc gccatgcttc tgccctgcgg aatctcggtc ttctccggag 781 tggagttcgt ctgctgtccc aagcacttca aaaccgatga aattcatgta aagaagaccg 841 acttgccggt gatgccggca gctcagatca atagcgccaa tgacgagctg gtgatgaatg 901 acgaagacga cagcaacgac tcgaactact cgaaggatgc caatgaagac gatctggacg 961 atgaggatga tttgatgggt gatgatgagg aggacgatat ggtggcggat gaggcagcta 1021 ccgcaggcgg aagccccaac accggttcct caggtgactc aaatagcgga tctttggatg 1081 acataaatgc ggagtacgat agcggagagg agggtgacaa ctacgaggag gacggtgctg 1141 gttccgaaag cgaggctgag gttgaggcct cctgggatca gagcggaggg gcgaaggttg 1201 tgtccctaaa aagcgattcc tcatccccgt ctagcgctcc ggttgctccc gcccccgaga 1261 aggcacctgt gaagtccgaa tcggtcacga gcactcctca gctgtctgcc tctgccgctg 1321 cttttgtagc tgccaattct ggaaactcgg gaaccggagc cggagcacca ccatccactg 1381 cacaacccac atcggatccc tacttcaccc attttgatcc gcactacgag caccagagct 1441 acaaacgcct tgaggaatcg caccgcgaga aggtcacgcg cgttatgaag gactggtccg 1501 atctcgagga gaagtaccag gacatgcgcc tagcggatcc caaggcagcc cagtcattta 1561 agcagcggat gacggctcgc ttccagactt ctgttcaggc actcgaggaa gaaggcaacg 1621 ccgagaagca ccagctggcc gccatgcacc agcagcgcgt tttggcccac atcaaccagc 1681 ggaagcgcga ggccatgacc tgctacaccc aggccctgac tgagcagccc ccgaatgccc 1741 accacgttga gaagtgtcta cagaagctgc tgcgcgccct gcacaaggac cgggcccacg 1801 ccttggccca ctaccggcac ctattgaact ctggaggacc tggtggacta gaagcagctg 1861 cttcggagcg tccacgcacg ctggagcgcc taatcgacat cgatagagcc gtaaaccagt 1921 cgatgaccat gctcaagcgc tatccggagc tctccgccaa gattgcccag ctgatgaatg 1981 actacattct ggcactgcgc agcaaggatg acattcccgg ctcctcgctg ggaatgagcg 2041 aggaggcgga ggccggcatt ctggacaagt accgcgtcga gatcgagcgc aaggtggccg 2101 agaaagagcg actacggctg gcggagaagc agcgcaagga gcagcgtgcc gctgagcggg 2161 aaaaactgcg cgaggagaag ctgcgcctgg aggccaaaaa ggtggacgac atgctcaagt 2221 cacaggtggc cgagcagcag tcccagccga cccagtcgtc aacccaatcg caggcgcagc 2281 agcagcagca ggaaaagagc cttcccggca aggagctggg tcccgacgca gctctggtca 2341 cagcggccaa tcccaaccta gagaccacca aaagcgagaa ggatctgtcg gacactgagt 2401 atggggaggc aacagtgagc agcaccaagg tgcagaccgt gctgccaacg gtcgacgacg 2461 atgccgtcca gcgggcagtg gaggacgtag ccgccgccgt cgcccaccag gaggccgagc 2521 cgcaggtgca gcacttcatg acccacgacc tgggccaccg cgaatcgagc ttctcgctgc 2581 gccgcgagtt cgcgcaacat gcacacgcgg ccaaagaggg ccgcaacgtc tacttcacgc 2641 tctccttcgc cgggatcgcc ctgatggcgg ccgttttcgt tggcgtggcc gtggccaaat 2701 ggcgaacatc gcgctcgccg cacgcccagg gcttcatcga ggtcgaccag aacgtcacaa 2761 cacaccatcc cattgtgcgc gaggagaaga tcgtgcccaa catgcagatc aatgggtacg 2821 agaatccgac ctacaagtat ttcgaagtga aagagtaagc gagatggcaa gatggcagca 2881 tgggcgcggc tggcaagagc gagcgagtgg cacacatcaa caacaacagt aaacgcaact 2941 gcagccaccg cgatttcaaa atggaaaaac ttaagcgtat tattaaagca gatgggaaga 3001 gaaatgattt tttttcgtga aatgagcgca gtttcaataa gaaagaatga aagggtagaa 3061 gaagaaagat aaattcaata aatggtaata tatctatata ttaaattaaa gcaagcagaa 3121 aggcaacaat ataaagcaag caattaaatt taagtatttg aatgtttaac aaaacgccgt 3181 aaacatcctt tccagctctc tctttctctt cccctgtctc tgtctctgtc ccatcaccac 3241 acacacacac atcaacaaca atggcacaca ctcacacaca cttgcctcta actttgtgat 3301 tcttcttgag cgccagctac gcaaagagag tagaagtgct gaagtgaaga tcatacacgc 3361 agccgaacga agagtggtgg agcgggggag gagaggatgg agaagagcgg aagaagagca 3421 aaacaaaaga tattcctagt aaataaattg tcgacacaca catcacatcc acattcaaac 3481 accgagtcac ccgcagaaca gtcacaccca cactcacaca tacagtgtca ggaatgcgca 3541 aaaaagacac aaacgcattc atgcctgctt cgtagcatat ttttgagcgt ttcgtggcat 3601 tagaacgctt gcaagccgat cgcaattctt accaaaaacc tacgccatta attagagcgg 3661 cagcgagagc taaaagataa gagcaggagg cagaaacacc aacacacaga cacggaatct 3721 cgcacactga gacacttgtg aacctaagag ctacctacgc gtactaatcc ctatacgatc 3781 gtgcatatgc gcttgtgtat atgtcgaact ttctctctct gtaagccaca cacactcacc 3841 agagaaggga atagaacaca caaaccatac acaaaccaca cacgcataca cgcaaaatat 3901 atacaaaata tttacagcaa agccagaaga aatgtccata aatgtattta tgtatctata 3961 cacgagccac acaaagcaaa ggtcgaaggt cagccagcta gggaagaatg acgacgcttg 4021 gcgggctttg aatataatat acgaatcagc tatgtaacag aaacaatgca aaacgctaag 4081 ctaattgcag acagaaacaa aagaaggaaa accaaatatt aaaatgaaag cgaacaaatt 4141 ttagaacttt ttctgcatat tttgtgtgta agtcgatggt cgaacaaaaa caacaagaac 4201 aaaaagaatt tctctctttt ttacgtacat tttcaccgaa aagacagcac aaaacaagac 4261 agcagttaca actcacaact cacagctcac acccacacag cacacacaca cacacacaca 4321 cgctgcacac acacacacac acacacactg aacggagccc ttgagccaag tagagttgag 4381 ttgttgcatt tcatatcgaa ggcttcgcaa gtgttgcata attgccttag agccaactgc 4441 ggcagaaatc agataagcgg gctcggcgaa tcgcaaaatc cagagagctc gcagctcgga 4501 gacggcacca cctggagtgg acgcttcgaa gaacccgagg cccagagata aaccaatttg 4561 aaacggctag ttcatttcac ggctcgattg cttggcaaat atttggcctg ttttgttcga 4621 gcatcgagat actgttactc aatcaagccc aataatcgaa atgctttccc cgctgaaagc 4681 cgacaagtgg ctgcccttct cagttcgttt tccatttacg atttacgttt aatttccatt 4741 gccaaattgg ccattttctt ggtgtgactc acttcggctg agattaagtg aaagcacaca 4801 ctaacacatc acagctgaaa ttcatgttca gatcaaagct aaatcaaaag tgcagcgaaa 4861 gtcgatattt ttcaaatgta caaaaacaaa actggaaact gagaaaacaa cacctaaatt 4921 caaaccaaaa tatttgctgt acctcaaaat atatatattc tgtttcatac attaatttgt 4981 gactagccag ctttcgatcg gtttaagctt aggcattatt cgtggcccca ttttcagcat 5041 aagttctcat tcgaattaaa ctaaattgta ttggcaattg gcaattggca atttgaacgg 5101 catgaatctt gggattgttt agatcacttg gctctattga aaagatccgg gctaagattg 5161 ttaccacgtt ttaaaagcat ggcaatcaag gcaaatcaac ggcgctccgc gacacacaca 5221 taaacagacg cgttatataa tgtattacaa acatatatat atttcaagag gaaaacccaa 5281 atggcaaatc aactacacaa aaagcaaata agaagaaatc ttactagtca aagcttgaat 5341 attttttatt ttattcatta atgcaacaag aacaacaaca aaaatgaaaa aagtatacat 5401 atatataaat aaaaaaaaac aacaaaaaaa gaaaaaacaa ttgatattta cacttagtga 5461 agcaaaaagc aaaacaaaaa acaaaaaaag cgaaaagtat aagcgaagaa aggaacaaaa 5521 aaacaaaaat gatgcaaatg tgtaagaaat aaaccccgtc ctgcataaat aaaattaaat 5581 aaaagaataa aataaatgga aacgtataga atatcataaa gtaaagaaga tttacacgaa 5641 aattaaatgc aaaacaaaca aacaaaatac gagaaagcaa gaacaacaaa attataatga 5701 aatcgcatgt gtttttgtcg tagtctcatc attgaaaacc aagtgaaagt aaataatata 5761 ataataaaaa aaaaaaaaca agtaaattgt aatgagaaga aacagcaaat aagagcaaca 5821 atttgtgtaa ttcttttagt cgaactatga ttttttgacg agcagaaaac taagttggag 5881 aaaagtatat aaaaatttaa atattaaatg tactcgaaga caattgtaat tgcaacaata 5941 attgtacgct acatatacta ttataattgt ggaaatattt cagcattctg tcctggcgac 6001 taagccccga tatttgatct tcgatcgacg atcgacgatc gacgatcttt gattcttgtc 6061 aatctatccg gttggatatg ttgggcatta ttacactata gccgggggcg caaggaaccc 6121 aggaaaagcc aggaaaattg tataatgttt cacacaaaga tccaataatg gaaaaccaaa 6181 tataaaacgt aagaatgcgg aggaaataca gaacaacaaa gaaaagaaaa ccaaaacaat 6241 tctcaatgta taatcatata atttgatttt gaatttttgt gttctttttc gaaatatttt 6301 gcataaataa aataaaataa cagg