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Drosophila melanogaster beta amyloid protein precursor-like (Appl),


LOCUS       NM_001258521            5425 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant D, mRNA.
ACCESSION   NM_001258521
VERSION     NM_001258521.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5425)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5425)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5425)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5425)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5425)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5425)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5425)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5425)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5425)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5425)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5425)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5425)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5425)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5425)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5425)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5425)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5425)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5425)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5425)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5425)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5425)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5425)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5425)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258521.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5425
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5425
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="beta amyloid protein precursor-like"
                     /map="1B9-1B10"
                     /db_xref="FLYBASE:FBgn0000108"
                     /db_xref="GeneID:31002"
     CDS             207..2873
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="CG7727 gene product from transcript CG7727-RD;
                     CG7727-PD; Appl-PD; amyloid Precursor-Like protein;
                     APP-like; amyloid precursor protein-like; beta amyloid
                     protein precursor-like; amyloid precursor protein like;
                     beta-amyloid-protein-precursor-like"
                     /codon_start=1
                     /product="beta amyloid protein precursor-like, isoform D"
                     /protein_id="NP_001245450.1"
                     /db_xref="FLYBASE:FBpp0298294"
                     /db_xref="GeneID:31002"
                     /db_xref="FLYBASE:FBgn0000108"
                     /translation="MCAALRRNLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQ
                     IYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKI
                     GGWCRQGALNAAKCKGSHRWIKPFRCLEGPFQSDALLVPEGCLFDHIHNASRCWPFVR
                     WNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMP
                     AAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATAGG
                     SPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVS
                     LKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPST
                     AQPTSDPYFTHFDPHYEHQSYKVSQKEAQQRLEESHREKVTRVMKDWSDLEEKYQDMR
                     LADPKAAQSFKQRMTARFQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQA
                     LTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLER
                     LIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGIL
                     DKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQ
                     QSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEA
                     TVSSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRR
                     EFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQNVT
                     THHPIVREEKIVPNMQINGYENPTYKYFEVKE"
     misc_feature    282..803
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="amyloid A4; Region: A4_EXTRA; smart00006"
                     /db_xref="CDD:128326"
     misc_feature    1371..1949
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="E2 domain of amyloid precursor protein; Region:
                     APP_E2; pfam12925"
                     /db_xref="CDD:463752"
     misc_feature    <2082..2255
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="PAT complex subunit CCDC47; Region: CCDC47;
                     cl46382"
                     /db_xref="CDD:480722"
     misc_feature    2712..2861
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="Beta-amyloid precursor protein C-terminus; Region:
                     APP_amyloid; pfam10515"
                     /db_xref="CDD:463129"
ORIGIN      
        1 actcgcagtc gtttgtgagc gttcgcagcg ccagcaaagt gttaaacgaa tagccaacaa
       61 agcaaataca attaaccaga actggaagca cgtcagtcca gccgcagaag cagctaagtt
      121 cagaccaaac tcggagattc ccagccagga gataggacca ggagccaacc agacgaggag
      181 caaagaagca gaaaagagtg cgaacaatgt gcgccgcgct gcgtcgtaat ttgttgctga
      241 ggagcctctg ggtcgtcctg gccattggca ctgctcaggt tcaggccgca tcgccgcgat
      301 gggagcccca gattgccgtt ctctgtgagg ccggacaaat ctaccagccg cagtatcttt
      361 ccgaggaggg acgctgggtg acggacctta gcaagaagac aaccggtccc acatgtttgc
      421 gtgataaaat ggatttgctt gattactgca agaaggccta tcccaaccga gacataacca
      481 acattgtgga gtcgtcccac taccagaaga tcggcggctg gtgtcgccag ggggcattga
      541 atgcggctaa gtgcaaggga tcccaccgat ggatcaagcc attccgctgt ctcgaaggac
      601 cattccaatc tgacgccctg ctagttcccg agggctgtct gttcgaccac atccacaacg
      661 cctcccgatg ctggccattt gtgaggtgga accaaaccgg agcagccgct tgccaggagc
      721 gcggaatgca gatgcgcagc ttcgccatgc ttctgccctg cggaatctcg gtcttctccg
      781 gagtggagtt cgtctgctgt cccaagcact tcaaaaccga tgaaattcat gtaaagaaga
      841 ccgacttgcc ggtgatgccg gcagctcaga tcaatagcgc caatgacgag ctggtgatga
      901 atgacgaaga cgacagcaac gactcgaact actcgaagga tgccaatgaa gacgatctgg
      961 acgatgagga tgatttgatg ggtgatgatg aggaggacga tatggtggcg gatgaggcag
     1021 ctaccgcagg cggaagcccc aacaccggtt cctcaggtga ctcaaatagc ggatctttgg
     1081 atgacataaa tgcggagtac gatagcggag aggagggtga caactacgag gaggacggtg
     1141 ctggttccga aagcgaggct gaggttgagg cctcctggga tcagagcgga ggggcgaagg
     1201 ttgtgtccct aaaaagcgat tcctcatccc cgtctagcgc tccggttgct cccgcccccg
     1261 agaaggcacc tgtgaagtcc gaatcggtca cgagcactcc tcagctgtct gcctctgccg
     1321 ctgcttttgt agctgccaat tctggaaact cgggaaccgg agccggagca ccaccatcca
     1381 ctgcacaacc cacatcggat ccctacttca cccattttga tccgcactac gagcaccaga
     1441 gctacaaagt aagtcagaaa gaagcccaac agcgccttga ggaatcgcac cgcgagaagg
     1501 tcacgcgcgt tatgaaggac tggtccgatc tcgaggagaa gtaccaggac atgcgcctag
     1561 cggatcccaa ggcagcccag tcatttaagc agcggatgac ggctcgcttc caggcactcg
     1621 aggaagaagg caacgccgag aagcaccagc tggccgccat gcaccagcag cgcgttttgg
     1681 cccacatcaa ccagcggaag cgcgaggcca tgacctgcta cacccaggcc ctgactgagc
     1741 agcccccgaa tgcccaccac gttgagaagt gtctacagaa gctgctgcgc gccctgcaca
     1801 aggaccgggc ccacgccttg gcccactacc ggcacctatt gaactctgga ggacctggtg
     1861 gactagaagc agctgcttcg gagcgtccac gcacgctgga gcgcctaatc gacatcgata
     1921 gagccgtaaa ccagtcgatg accatgctca agcgctatcc ggagctctcc gccaagattg
     1981 cccagctgat gaatgactac attctggcac tgcgcagcaa ggatgacatt cccggctcct
     2041 cgctgggaat gagcgaggag gcggaggccg gcattctgga caagtaccgc gtcgagatcg
     2101 agcgcaaggt ggccgagaaa gagcgactac ggctggcgga gaagcagcgc aaggagcagc
     2161 gtgccgctga gcgggaaaaa ctgcgcgagg agaagctgcg cctggaggcc aaaaaggtgg
     2221 acgacatgct caagtcacag gtggccgagc agcagtccca gccgacccag tcgtcaaccc
     2281 aatcgcaggc gcagcagcag cagcaggaaa agagccttcc cggcaaggag ctgggtcccg
     2341 acgcagctct ggtcacagcg gccaatccca acctagagac caccaaaagc gagaaggatc
     2401 tgtcggacac tgagtatggg gaggcaacag tgagcagcac caaggtgcag accgtgctgc
     2461 caacggtcga cgacgatgcc gtccagcggg cagtggagga cgtagccgcc gccgtcgccc
     2521 accaggaggc cgagccgcag gtgcagcact tcatgaccca cgacctgggc caccgcgaat
     2581 cgagcttctc gctgcgccgc gagttcgcgc aacatgcaca cgcggccaaa gagggccgca
     2641 acgtctactt cacgctctcc ttcgccggga tcgccctgat ggcggccgtt ttcgttggcg
     2701 tggccgtggc caaatggcga acatcgcgct cgccgcacgc ccagggcttc atcgaggtcg
     2761 accagaacgt cacaacacac catcccattg tgcgcgagga gaagatcgtg cccaacatgc
     2821 agatcaatgg gtacgagaat ccgacctaca agtatttcga agtgaaagag taagcgagat
     2881 ggcaagatgg cagcatgggc gcggctggca agagcgagcg agtggcacac atcaacaaca
     2941 acagtaaacg caactgcagc caccgcgatt tcaaaatgga aaaacttaag cgtattatta
     3001 aagcagatgg gaagagaaat gatttttttt cgtgaaatga gcgcagtttc aataagaaag
     3061 aatgaaaggg tagaagaaga aagataaatt caataaatgg taatatatct atatattaaa
     3121 ttaaagcaag cagaaaggca acaatataaa gcaagcaatt aaatttaagt atttgaatgt
     3181 ttaacaaaac gccgtaaaca tcctttccag ctctctcttt ctcttcccct gtctctgtct
     3241 ctgtcccatc accacacaca cacacatcaa caacaatggc acacactcac acacacttgc
     3301 ctctaacttt gtgattcttc ttgagcgcca gctacgcaaa gagagtagaa gtgctgaagt
     3361 gaagatcata cacgcagccg aacgaagagt ggtggagcgg gggaggagag gatggagaag
     3421 agcggaagaa gagcaaaaca aaagatattc ctagtaaata aattgtcgac acacacatca
     3481 catccacatt caaacaccga gtcacccgca gaacagtcac acccacactc acacatacag
     3541 tgtcaggaat gcgcaaaaaa gacacaaacg cattcatgcc tgcttcgtag catatttttg
     3601 agcgtttcgt ggcattagaa cgcttgcaag ccgatcgcaa ttcttaccaa aaacctacgc
     3661 cattaattag agcggcagcg agagctaaaa gataagagca ggaggcagaa acaccaacac
     3721 acagacacgg aatctcgcac actgagacac ttgtgaacct aagagctacc tacgcgtact
     3781 aatccctata cgatcgtgca tatgcgcttg tgtatatgtc gaactttctc tctctgtaag
     3841 ccacacacac tcaccagaga agggaataga acacacaaac catacacaaa ccacacacgc
     3901 atacacgcaa aatatataca aaatatttac agcaaagcca gaagaaatgt ccataaatgt
     3961 atttatgtat ctatacacga gccacacaaa gcaaaggtcg aaggtcagcc agctagggaa
     4021 gaatgacgac gcttggcggg ctttgaatat aatatacgaa tcagctatgt aacagaaaca
     4081 atgcaaaacg ctaagctaat tgcagacaga aacaaaagaa ggaaaaccaa atattaaaat
     4141 gaaagcgaac aaattttaga actttttctg catattttgt gtgtaagtcg atggtcgaac
     4201 aaaaacaaca agaacaaaaa gaatttctct cttttttacg tacattttca ccgaaaagac
     4261 agcacaaaac aagacagcag ttacaactca caactcacag ctcacaccca cacagcacac
     4321 acacacacac acacacgctg cacacacaca cacacacaca cactgaacgg agcccttgag
     4381 ccaagtagag ttgagttgtt gcatttcata tcgaaggctt cgcaagtgtt gcataattgc
     4441 cttagagcca actgcggcag aaatcagata agcgggctcg gcgaatcgca aaatccagag
     4501 agctcgcagc tcggagacgg caccacctgg agtggacgct tcgaagaacc cgaggcccag
     4561 agataaacca atttgaaacg gctagttcat ttcacggctc gattgcttgg caaatatttg
     4621 gcctgttttg ttcgagcatc gagatactgt tactcaatca agcccaataa tcgaaatgct
     4681 ttccccgctg aaagccgaca agtggctgcc cttctcagtt cgttttccat ttacgattta
     4741 cgtttaattt ccattgccaa attggccatt ttcttggtgt gactcacttc ggctgagatt
     4801 aagtgaaagc acacactaac acatcacagc tgaaattcat gttcagatca aagctaaatc
     4861 aaaagtgcag cgaaagtcga tatttttcaa atgtacaaaa acaaaactgg aaactgagaa
     4921 aacaacacct aaattcaaac caaaatattt gctgtacctc aaaatatata tattctgttt
     4981 catacattaa tttgtgacta gccagctttc gatcggttta agcttaggca ttattcgtgg
     5041 ccccattttc agcataagtt ctcattcgaa ttaaactaaa ttgtattggc aattggcaat
     5101 tggcaatttg aacggcatga atcttgggat tgtttagatc acttggctct attgaaaaga
     5161 tccgggctaa gattgttacc acgttttaaa agcatggcaa tcaaggcaaa tcaacggcgc
     5221 tccgcgacac acacataaac agacgcgtta tataatgtat tacaaacata tatatatttc
     5281 aagaggaaaa cccaaatggc aaatcaacta cacaaaaagc aaataagaag aaatcttact
     5341 agtcaaagct tgaatatttt ttattttatt cattaatgca acaagaacaa caacaaaaat
     5401 gaaaaaagta tacatatata taaat