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Drosophila melanogaster beta amyloid protein precursor-like (Appl),


LOCUS       NM_001258520            5251 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant C, mRNA.
ACCESSION   NM_001258520
VERSION     NM_001258520.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5251)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5251)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5251)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5251)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5251)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5251)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5251)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5251)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5251)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5251)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5251)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5251)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5251)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5251)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5251)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5251)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5251)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5251)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258520.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5251
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5251
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="beta amyloid protein precursor-like"
                     /map="1B9-1B10"
                     /db_xref="FLYBASE:FBgn0000108"
                     /db_xref="GeneID:31002"
     CDS             207..2699
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="CG7727 gene product from transcript CG7727-RC;
                     CG7727-PC; Appl-PC; amyloid Precursor-Like protein;
                     APP-like; amyloid precursor protein-like; beta amyloid
                     protein precursor-like; amyloid precursor protein like;
                     beta-amyloid-protein-precursor-like"
                     /codon_start=1
                     /product="beta amyloid protein precursor-like, isoform C"
                     /protein_id="NP_001245449.1"
                     /db_xref="FLYBASE:FBpp0298293"
                     /db_xref="GeneID:31002"
                     /db_xref="FLYBASE:FBgn0000108"
                     /translation="MCAALRRNLLLRSLWVVLAIGTAQVQAYPNRDITNIVESSHYQK
                     IGGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFVR
                     WNQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMP
                     AAQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATAGG
                     SPNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVS
                     LKSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPST
                     AQPTSDPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADP
                     KAAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQA
                     LTEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLER
                     LIDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGIL
                     DKYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQ
                     QSQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEA
                     TVSSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRR
                     EFAQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQNVT
                     THHPIVREEKIVPNMQINGYENPTYKYFEVKE"
     misc_feature    <282..629
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="amyloid A4; Region: A4_EXTRA; smart00006"
                     /db_xref="CDD:128326"
     misc_feature    1197..1775
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="E2 domain of amyloid precursor protein; Region:
                     APP_E2; pfam12925"
                     /db_xref="CDD:463752"
     misc_feature    1929..>2081
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="DDRGK domain; Region: DDRGK; pfam09756"
                     /db_xref="CDD:370664"
     misc_feature    2538..2687
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="Beta-amyloid precursor protein C-terminus; Region:
                     APP_amyloid; pfam10515"
                     /db_xref="CDD:463129"
ORIGIN      
        1 actcgcagtc gtttgtgagc gttcgcagcg ccagcaaagt gttaaacgaa tagccaacaa
       61 agcaaataca attaaccaga actggaagca cgtcagtcca gccgcagaag cagctaagtt
      121 cagaccaaac tcggagattc ccagccagga gataggacca ggagccaacc agacgaggag
      181 caaagaagca gaaaagagtg cgaacaatgt gcgccgcgct gcgtcgtaat ttgttgctga
      241 ggagcctctg ggtcgtcctg gccattggca ctgctcaggt tcaggcctat cccaaccgag
      301 acataaccaa cattgtggag tcgtcccact accagaagat cggcggctgg tgtcgccagg
      361 gggcattgaa tgcggctaag tgcaagggat cccaccgatg gatcaagcca ttccgctgtc
      421 tcggaccatt ccaatctgac gccctgctag ttcccgaggg ctgtctgttc gaccacatcc
      481 acaacgcctc ccgatgctgg ccatttgtga ggtggaacca aaccggagca gccgcttgcc
      541 aggagcgcgg aatgcagatg cgcagcttcg ccatgcttct gccctgcgga atctcggtct
      601 tctccggagt ggagttcgtc tgctgtccca agcacttcaa aaccgatgaa attcatgtaa
      661 agaagaccga cttgccggtg atgccggcag ctcagatcaa tagcgccaat gacgagctgg
      721 tgatgaatga cgaagacgac agcaacgact cgaactactc gaaggatgcc aatgaagacg
      781 atctggacga tgaggatgat ttgatgggtg atgatgagga ggacgatatg gtggcggatg
      841 aggcagctac cgcaggcgga agccccaaca ccggttcctc aggtgactca aatagcggat
      901 ctttggatga cataaatgcg gagtacgata gcggagagga gggtgacaac tacgaggagg
      961 acggtgctgg ttccgaaagc gaggctgagg ttgaggcctc ctgggatcag agcggagggg
     1021 cgaaggttgt gtccctaaaa agcgattcct catccccgtc tagcgctccg gttgctcccg
     1081 cccccgagaa ggcacctgtg aagtccgaat cggtcacgag cactcctcag ctgtctgcct
     1141 ctgccgctgc ttttgtagct gccaattctg gaaactcggg aaccggagcc ggagcaccac
     1201 catccactgc acaacccaca tcggatccct acttcaccca ttttgatccg cactacgagc
     1261 accagagcta caaagtaagt cagaaacgcc ttgaggaatc gcaccgcgag aaggtcacgc
     1321 gcgttatgaa ggactggtcc gatctcgagg agaagtacca ggacatgcgc ctagcggatc
     1381 ccaaggcagc ccagtcattt aagcagcgga tgacggctcg cttccagact tctgttcagg
     1441 cactcgagga agaaggcaac gccgagaagc accagctggc cgccatgcac cagcagcgcg
     1501 ttttggccca catcaaccag cggaagcgcg aggccatgac ctgctacacc caggccctga
     1561 ctgagcagcc cccgaatgcc caccacgttg agaagtgtct acagaagctg ctgcgcgccc
     1621 tgcacaagga ccgggcccac gccttggccc actaccggca cctattgaac tctggaggac
     1681 ctggtggact agaagcagct gcttcggagc gtccacgcac gctggagcgc ctaatcgaca
     1741 tcgatagagc cgtaaaccag tcgatgacca tgctcaagcg ctatccggag ctctccgcca
     1801 agattgccca gctgatgaat gactacattc tggcactgcg cagcaaggat gacattcccg
     1861 gctcctcgct gggaatgagc gaggaggcgg aggccggcat tctggacaag taccgcgtcg
     1921 agatcgagcg caaggtggcc gagaaagagc gactacggct ggcggagaag cagcgcaagg
     1981 agcagcgtgc cgctgagcgg gaaaaactgc gcgaggagaa gctgcgcctg gaggccaaaa
     2041 aggtggacga catgctcaag tcacaggtgg ccgagcagca gtcccagccg acccagtcgt
     2101 caacccaatc gcaggcgcag cagcagcagc aggaaaagag ccttcccggc aaggagctgg
     2161 gtcccgacgc agctctggtc acagcggcca atcccaacct agagaccacc aaaagcgaga
     2221 aggatctgtc ggacactgag tatggggagg caacagtgag cagcaccaag gtgcagaccg
     2281 tgctgccaac ggtcgacgac gatgccgtcc agcgggcagt ggaggacgta gccgccgccg
     2341 tcgcccacca ggaggccgag ccgcaggtgc agcacttcat gacccacgac ctgggccacc
     2401 gcgaatcgag cttctcgctg cgccgcgagt tcgcgcaaca tgcacacgcg gccaaagagg
     2461 gccgcaacgt ctacttcacg ctctccttcg ccgggatcgc cctgatggcg gccgttttcg
     2521 ttggcgtggc cgtggccaaa tggcgaacat cgcgctcgcc gcacgcccag ggcttcatcg
     2581 aggtcgacca gaacgtcaca acacaccatc ccattgtgcg cgaggagaag atcgtgccca
     2641 acatgcagat caatgggtac gagaatccga cctacaagta tttcgaagtg aaagagtaag
     2701 cgagatggca agatggcagc atgggcgcgg ctggcaagag cgagcgagtg gcacacatca
     2761 acaacaacag taaacgcaac tgcagccacc gcgatttcaa aatggaaaaa cttaagcgta
     2821 ttattaaagc agatgggaag agaaatgatt ttttttcgtg aaatgagcgc agtttcaata
     2881 agaaagaatg aaagggtaga agaagaaaga taaattcaat aaatggtaat atatctatat
     2941 attaaattaa agcaagcaga aaggcaacaa tataaagcaa gcaattaaat ttaagtattt
     3001 gaatgtttaa caaaacgccg taaacatcct ttccagctct ctctttctct tcccctgtct
     3061 ctgtctctgt cccatcacca cacacacaca catcaacaac aatggcacac actcacacac
     3121 acttgcctct aactttgtga ttcttcttga gcgccagcta cgcaaagaga gtagaagtgc
     3181 tgaagtgaag atcatacacg cagccgaacg aagagtggtg gagcggggga ggagaggatg
     3241 gagaagagcg gaagaagagc aaaacaaaag atattcctag taaataaatt gtcgacacac
     3301 acatcacatc cacattcaaa caccgagtca cccgcagaac agtcacaccc acactcacac
     3361 atacagtgtc aggaatgcgc aaaaaagaca caaacgcatt catgcctgct tcgtagcata
     3421 tttttgagcg tttcgtggca ttagaacgct tgcaagccga tcgcaattct taccaaaaac
     3481 ctacgccatt aattagagcg gcagcgagag ctaaaagata agagcaggag gcagaaacac
     3541 caacacacag acacggaatc tcgcacactg agacacttgt gaacctaaga gctacctacg
     3601 cgtactaatc cctatacgat cgtgcatatg cgcttgtgta tatgtcgaac tttctctctc
     3661 tgtaagccac acacactcac cagagaaggg aatagaacac acaaaccata cacaaaccac
     3721 acacgcatac acgcaaaata tatacaaaat atttacagca aagccagaag aaatgtccat
     3781 aaatgtattt atgtatctat acacgagcca cacaaagcaa aggtcgaagg tcagccagct
     3841 agggaagaat gacgacgctt ggcgggcttt gaatataata tacgaatcag ctatgtaaca
     3901 gaaacaatgc aaaacgctaa gctaattgca gacagaaaca aaagaaggaa aaccaaatat
     3961 taaaatgaaa gcgaacaaat tttagaactt tttctgcata ttttgtgtgt aagtcgatgg
     4021 tcgaacaaaa acaacaagaa caaaaagaat ttctctcttt tttacgtaca ttttcaccga
     4081 aaagacagca caaaacaaga cagcagttac aactcacaac tcacagctca cacccacaca
     4141 gcacacacac acacacacac acgctgcaca cacacacaca cacacacact gaacggagcc
     4201 cttgagccaa gtagagttga gttgttgcat ttcatatcga aggcttcgca agtgttgcat
     4261 aattgcctta gagccaactg cggcagaaat cagataagcg ggctcggcga atcgcaaaat
     4321 ccagagagct cgcagctcgg agacggcacc acctggagtg gacgcttcga agaacccgag
     4381 gcccagagat aaaccaattt gaaacggcta gttcatttca cggctcgatt gcttggcaaa
     4441 tatttggcct gttttgttcg agcatcgaga tactgttact caatcaagcc caataatcga
     4501 aatgctttcc ccgctgaaag ccgacaagtg gctgcccttc tcagttcgtt ttccatttac
     4561 gatttacgtt taatttccat tgccaaattg gccattttct tggtgtgact cacttcggct
     4621 gagattaagt gaaagcacac actaacacat cacagctgaa attcatgttc agatcaaagc
     4681 taaatcaaaa gtgcagcgaa agtcgatatt tttcaaatgt acaaaaacaa aactggaaac
     4741 tgagaaaaca acacctaaat tcaaaccaaa atatttgctg tacctcaaaa tatatatatt
     4801 ctgtttcata cattaatttg tgactagcca gctttcgatc ggtttaagct taggcattat
     4861 tcgtggcccc attttcagca taagttctca ttcgaattaa actaaattgt attggcaatt
     4921 ggcaattggc aatttgaacg gcatgaatct tgggattgtt tagatcactt ggctctattg
     4981 aaaagatccg ggctaagatt gttaccacgt tttaaaagca tggcaatcaa ggcaaatcaa
     5041 cggcgctccg cgacacacac ataaacagac gcgttatata atgtattaca aacatatata
     5101 tatttcaaga ggaaaaccca aatggcaaat caactacaca aaaagcaaat aagaagaaat
     5161 cttactagtc aaagcttgaa tattttttat tttattcatt aatgcaacaa gaacaacaac
     5221 aaaaatgaaa aaagtataca tatatataaa t