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Drosophila melanogaster beta amyloid protein precursor-like (Appl),


LOCUS       NM_001258519            6331 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant B, mRNA.
ACCESSION   NM_001258519
VERSION     NM_001258519.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6331)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6331)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6331)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6331)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6331)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6331)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6331)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6331)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6331)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6331)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6331)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6331)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6331)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6331)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6331)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6331)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6331)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6331)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6331)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6331)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6331)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6331)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6331)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6331
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6331
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="beta amyloid protein precursor-like"
                     /map="1B9-1B10"
                     /db_xref="FLYBASE:FBgn0000108"
                     /db_xref="GeneID:31002"
     CDS             193..2865
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="CG7727 gene product from transcript CG7727-RB;
                     CG7727-PB; Appl-PB; amyloid Precursor-Like protein;
                     APP-like; amyloid precursor protein-like; beta amyloid
                     protein precursor-like; amyloid precursor protein like;
                     beta-amyloid-protein-precursor-like"
                     /codon_start=1
                     /product="beta amyloid protein precursor-like, isoform B"
                     /protein_id="NP_001245448.1"
                     /db_xref="FLYBASE:FBpp0298292"
                     /db_xref="GeneID:31002"
                     /db_xref="FLYBASE:FBgn0000108"
                     /translation="MCAALRRNLLLRSLWVVLAIGTAQVQAASPRWEPQIAVLCEAGQ
                     IYQPQYLSEEGRWVTDLSKKTTGPTCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKI
                     GGWCRQGALNAAKCKGSHRWIKPFRCLGPFQSDALLVPEGCLFDHIHNASRCWPFVRW
                     NQTGAAACQERGMQMRSFAMLLPCGISVFSGVEFVCCPKHFKTDEIHVKKTDLPVMPA
                     AQINSANDELVMNDEDDSNDSNYSKDANEDDLDDEDDLMGDDEEDDMVADEAATAGGS
                     PNTGSSGDSNSGSLDDINAEYDSGEEGDNYEEDGAGSESEAEVEASWDQSGGAKVVSL
                     KSDSSSPSSAPVAPAPEKAPVKSESVTSTPQLSASAAAFVAANSGNSGTGAGAPPSTA
                     QPTSDPYFTHFDPHYEHQSYKVSQKRLEESHREKVTRVMKDWSDLEEKYQDMRLADPK
                     AAQSFKQRMTARFQTSVQALEEEGNAEKHQLAAMHQQRVLAHINQRKREAMTCYTQAL
                     TEQPPNAHHVEKCLQKLLRALHKDRAHALAHYRHLLNSGGPGGLEAAASERPRTLERL
                     IDIDRAVNQSMTMLKRYPELSAKIAQLMNDYILALRSKDDIPGSSLGMSEEAEAGILD
                     KYRVEIERKVAEKERLRLAEKQRKEQRAAEREKLREEKLRLEAKKVDDMLKSQVAEQQ
                     SQPTQSSTQSQAQQQQQEKSLPGKELGPDAALVTAANPNLETTKSEKDLSDTEYGEAT
                     VSTKVQTVLPTVDDDAVQRAVEDVAAAVAHQEAEPQVQHFMTHDLGHRESSFSLRREF
                     AQHAHAAKEGRNVYFTLSFAGIALMAAVFVGVAVAKWRTSRSPHAQGFIEVDQVGCQN
                     VTTHHPIVREEKIVPNMQINGYENPTYKYFEVKE"
     misc_feature    268..786
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="amyloid A4; Region: A4_EXTRA; smart00006"
                     /db_xref="CDD:128326"
     misc_feature    1354..1932
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="E2 domain of amyloid precursor protein; Region:
                     APP_E2; pfam12925"
                     /db_xref="CDD:463752"
     misc_feature    2086..>2238
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="DDRGK domain; Region: DDRGK; pfam09756"
                     /db_xref="CDD:370664"
     misc_feature    2692..2853
                     /gene="Appl"
                     /locus_tag="Dmel_CG7727"
                     /gene_synonym="Abeta; APP; APP-like; appl; APPL;
                     BcDNA:GH04413; CG7727; dAbeta; dAPPl; dAPPL; Dmel\CG7727;
                     EG:65F1.5"
                     /note="Beta-amyloid precursor protein C-terminus; Region:
                     APP_amyloid; pfam10515"
                     /db_xref="CDD:463129"
ORIGIN      
        1 aggaccccga gaaccagcga caaagtgtta aacgaatagc caacaaagca aatacaatta
       61 accagaactg gaagcacgtc agtccagccg cagaagcagc taagttcaga ccaaactcgg
      121 agattcccag ccaggagata ggaccaggag ccaaccagac gaggagcaaa gaagcagaaa
      181 agagtgcgaa caatgtgcgc cgcgctgcgt cgtaatttgt tgctgaggag cctctgggtc
      241 gtcctggcca ttggcactgc tcaggttcag gccgcatcgc cgcgatggga gccccagatt
      301 gccgttctct gtgaggccgg acaaatctac cagccgcagt atctttccga ggagggacgc
      361 tgggtgacgg accttagcaa gaagacaacc ggtcccacat gtttgcgtga taaaatggat
      421 ttgcttgatt actgcaagaa ggcctatccc aaccgagaca taaccaacat tgtggagtcg
      481 tcccactacc agaagatcgg cggctggtgt cgccaggggg cattgaatgc ggctaagtgc
      541 aagggatccc accgatggat caagccattc cgctgtctcg gaccattcca atctgacgcc
      601 ctgctagttc ccgagggctg tctgttcgac cacatccaca acgcctcccg atgctggcca
      661 tttgtgaggt ggaaccaaac cggagcagcc gcttgccagg agcgcggaat gcagatgcgc
      721 agcttcgcca tgcttctgcc ctgcggaatc tcggtcttct ccggagtgga gttcgtctgc
      781 tgtcccaagc acttcaaaac cgatgaaatt catgtaaaga agaccgactt gccggtgatg
      841 ccggcagctc agatcaatag cgccaatgac gagctggtga tgaatgacga agacgacagc
      901 aacgactcga actactcgaa ggatgccaat gaagacgatc tggacgatga ggatgatttg
      961 atgggtgatg atgaggagga cgatatggtg gcggatgagg cagctaccgc aggcggaagc
     1021 cccaacaccg gttcctcagg tgactcaaat agcggatctt tggatgacat aaatgcggag
     1081 tacgatagcg gagaggaggg tgacaactac gaggaggacg gtgctggttc cgaaagcgag
     1141 gctgaggttg aggcctcctg ggatcagagc ggaggggcga aggttgtgtc cctaaaaagc
     1201 gattcctcat ccccgtctag cgctccggtt gctcccgccc ccgagaaggc acctgtgaag
     1261 tccgaatcgg tcacgagcac tcctcagctg tctgcctctg ccgctgcttt tgtagctgcc
     1321 aattctggaa actcgggaac cggagccgga gcaccaccat ccactgcaca acccacatcg
     1381 gatccctact tcacccattt tgatccgcac tacgagcacc agagctacaa agtaagtcag
     1441 aaacgccttg aggaatcgca ccgcgagaag gtcacgcgcg ttatgaagga ctggtccgat
     1501 ctcgaggaga agtaccagga catgcgccta gcggatccca aggcagccca gtcatttaag
     1561 cagcggatga cggctcgctt ccagacttct gttcaggcac tcgaggaaga aggcaacgcc
     1621 gagaagcacc agctggccgc catgcaccag cagcgcgttt tggcccacat caaccagcgg
     1681 aagcgcgagg ccatgacctg ctacacccag gccctgactg agcagccccc gaatgcccac
     1741 cacgttgaga agtgtctaca gaagctgctg cgcgccctgc acaaggaccg ggcccacgcc
     1801 ttggcccact accggcacct attgaactct ggaggacctg gtggactaga agcagctgct
     1861 tcggagcgtc cacgcacgct ggagcgccta atcgacatcg atagagccgt aaaccagtcg
     1921 atgaccatgc tcaagcgcta tccggagctc tccgccaaga ttgcccagct gatgaatgac
     1981 tacattctgg cactgcgcag caaggatgac attcccggct cctcgctggg aatgagcgag
     2041 gaggcggagg ccggcattct ggacaagtac cgcgtcgaga tcgagcgcaa ggtggccgag
     2101 aaagagcgac tacggctggc ggagaagcag cgcaaggagc agcgtgccgc tgagcgggaa
     2161 aaactgcgcg aggagaagct gcgcctggag gccaaaaagg tggacgacat gctcaagtca
     2221 caggtggccg agcagcagtc ccagccgacc cagtcgtcaa cccaatcgca ggcgcagcag
     2281 cagcagcagg aaaagagcct tcccggcaag gagctgggtc ccgacgcagc tctggtcaca
     2341 gcggccaatc ccaacctaga gaccaccaaa agcgagaagg atctgtcgga cactgagtat
     2401 ggggaggcaa cagtgagcac caaggtgcag accgtgctgc caacggtcga cgacgatgcc
     2461 gtccagcggg cagtggagga cgtagccgcc gccgtcgccc accaggaggc cgagccgcag
     2521 gtgcagcact tcatgaccca cgacctgggc caccgcgaat cgagcttctc gctgcgccgc
     2581 gagttcgcgc aacatgcaca cgcggccaaa gagggccgca acgtctactt cacgctctcc
     2641 ttcgccggga tcgccctgat ggcggccgtt ttcgttggcg tggccgtggc caaatggcga
     2701 acatcgcgct cgccgcacgc ccagggcttc atcgaggtcg accaggtggg ttgtcagaac
     2761 gtcacaacac accatcccat tgtgcgcgag gagaagatcg tgcccaacat gcagatcaat
     2821 gggtacgaga atccgaccta caagtatttc gaagtgaaag agtaagcgag atggcaagat
     2881 ggcagcatgg gcgcggctgg caagagcgag cgagtggcac acatcaacaa caacagtaaa
     2941 cgcaactgca gccaccgcga tttcaaaatg gaaaaactta agcgtattat taaagcagat
     3001 gggaagagaa atgatttttt ttcgtgaaat gagcgcagtt tcaataagaa agaatgaaag
     3061 ggtagaagaa gaaagataaa ttcaataaat ggtaatatat ctatatatta aattaaagca
     3121 agcagaaagg caacaatata aagcaagcaa ttaaatttaa gtatttgaat gtttaacaaa
     3181 acgccgtaaa catcctttcc agctctctct ttctcttccc ctgtctctgt ctctgtccca
     3241 tcaccacaca cacacacatc aacaacaatg gcacacactc acacacactt gcctctaact
     3301 ttgtgattct tcttgagcgc cagctacgca aagagagtag aagtgctgaa gtgaagatca
     3361 tacacgcagc cgaacgaaga gtggtggagc gggggaggag aggatggaga agagcggaag
     3421 aagagcaaaa caaaagatat tcctagtaaa taaattgtcg acacacacat cacatccaca
     3481 ttcaaacacc gagtcacccg cagaacagtc acacccacac tcacacatac agtgtcagga
     3541 atgcgcaaaa aagacacaaa cgcattcatg cctgcttcgt agcatatttt tgagcgtttc
     3601 gtggcattag aacgcttgca agccgatcgc aattcttacc aaaaacctac gccattaatt
     3661 agagcggcag cgagagctaa aagataagag caggaggcag aaacaccaac acacagacac
     3721 ggaatctcgc acactgagac acttgtgaac ctaagagcta cctacgcgta ctaatcccta
     3781 tacgatcgtg catatgcgct tgtgtatatg tcgaactttc tctctctgta agccacacac
     3841 actcaccaga gaagggaata gaacacacaa accatacaca aaccacacac gcatacacgc
     3901 aaaatatata caaaatattt acagcaaagc cagaagaaat gtccataaat gtatttatgt
     3961 atctatacac gagccacaca aagcaaaggt cgaaggtcag ccagctaggg aagaatgacg
     4021 acgcttggcg ggctttgaat ataatatacg aatcagctat gtaacagaaa caatgcaaaa
     4081 cgctaagcta attgcagaca gaaacaaaag aaggaaaacc aaatattaaa atgaaagcga
     4141 acaaatttta gaactttttc tgcatatttt gtgtgtaagt cgatggtcga acaaaaacaa
     4201 caagaacaaa aagaatttct ctctttttta cgtacatttt caccgaaaag acagcacaaa
     4261 acaagacagc agttacaact cacaactcac agctcacacc cacacagcac acacacacac
     4321 acacacacgc tgcacacaca cacacacaca cacactgaac ggagcccttg agccaagtag
     4381 agttgagttg ttgcatttca tatcgaaggc ttcgcaagtg ttgcataatt gccttagagc
     4441 caactgcggc agaaatcaga taagcgggct cggcgaatcg caaaatccag agagctcgca
     4501 gctcggagac ggcaccacct ggagtggacg cttcgaagaa cccgaggccc agagataaac
     4561 caatttgaaa cggctagttc atttcacggc tcgattgctt ggcaaatatt tggcctgttt
     4621 tgttcgagca tcgagatact gttactcaat caagcccaat aatcgaaatg ctttccccgc
     4681 tgaaagccga caagtggctg cccttctcag ttcgttttcc atttacgatt tacgtttaat
     4741 ttccattgcc aaattggcca ttttcttggt gtgactcact tcggctgaga ttaagtgaaa
     4801 gcacacacta acacatcaca gctgaaattc atgttcagat caaagctaaa tcaaaagtgc
     4861 agcgaaagtc gatatttttc aaatgtacaa aaacaaaact ggaaactgag aaaacaacac
     4921 ctaaattcaa accaaaatat ttgctgtacc tcaaaatata tatattctgt ttcatacatt
     4981 aatttgtgac tagccagctt tcgatcggtt taagcttagg cattattcgt ggccccattt
     5041 tcagcataag ttctcattcg aattaaacta aattgtattg gcaattggca attggcaatt
     5101 tgaacggcat gaatcttggg attgtttaga tcacttggct ctattgaaaa gatccgggct
     5161 aagattgtta ccacgtttta aaagcatggc aatcaaggca aatcaacggc gctccgcgac
     5221 acacacataa acagacgcgt tatataatgt attacaaaca tatatatatt tcaagaggaa
     5281 aacccaaatg gcaaatcaac tacacaaaaa gcaaataaga agaaatctta ctagtcaaag
     5341 cttgaatatt ttttatttta ttcattaatg caacaagaac aacaacaaaa atgaaaaaag
     5401 tatacatata tataaataaa aaaaaacaac aaaaaaagaa aaaacaattg atatttacac
     5461 ttagtgaagc aaaaagcaaa acaaaaaaca aaaaaagcga aaagtataag cgaagaaagg
     5521 aacaaaaaaa caaaaatgat gcaaatgtgt aagaaataaa ccccgtcctg cataaataaa
     5581 attaaataaa agaataaaat aaatggaaac gtatagaata tcataaagta aagaagattt
     5641 acacgaaaat taaatgcaaa acaaacaaac aaaatacgag aaagcaagaa caacaaaatt
     5701 ataatgaaat cgcatgtgtt tttgtcgtag tctcatcatt gaaaaccaag tgaaagtaaa
     5761 taatataata ataaaaaaaa aaaaacaagt aaattgtaat gagaagaaac agcaaataag
     5821 agcaacaatt tgtgtaattc ttttagtcga actatgattt tttgacgagc agaaaactaa
     5881 gttggagaaa agtatataaa aatttaaata ttaaatgtac tcgaagacaa ttgtaattgc
     5941 aacaataatt gtacgctaca tatactatta taattgtgga aatatttcag cattctgtcc
     6001 tggcgactaa gccccgatat ttgatcttcg atcgacgatc gacgatcgac gatctttgat
     6061 tcttgtcaat ctatccggtt ggatatgttg ggcattatta cactatagcc gggggcgcaa
     6121 ggaacccagg aaaagccagg aaaattgtat aatgtttcac acaaagatcc aataatggaa
     6181 aaccaaatat aaaacgtaag aatgcggagg aaatacagaa caacaaagaa aagaaaacca
     6241 aaacaattct caatgtataa tcatataatt tgattttgaa tttttgtgtt ctttttcgaa
     6301 atattttgca taaataaaat aaaataacag g