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Drosophila melanogaster embryonic lethal abnormal vision (elav),


LOCUS       NM_001258518           10506 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant D, mRNA.
ACCESSION   NM_001258518
VERSION     NM_001258518.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 10506)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10506)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10506)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 10506)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 10506)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 10506)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 10506)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 10506)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 10506)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 10506)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 10506)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 10506)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 10506)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 10506)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 10506)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 10506)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 10506)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 10506)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 10506)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 10506)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 10506)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 10506)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 10506)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001258518.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..10506
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..10506
                     /gene="elav"
                     /locus_tag="Dmel_CG4262"
                     /gene_synonym="44C11; 9F8A9; CG4262; dHuR; Dmel\CG4262;
                     EC7; EG:65F1.2; Elav; ElaV; ELav; ELAV; elav-1; elav-2;
                     elav-3; Elav-9F8A9; END1-2; fliJ; l(1)1Be; l(1)EC7;
                     l(1)G0031; l(1)G0319; weg"
                     /note="embryonic lethal abnormal vision"
                     /map="1B7-1B8"
                     /db_xref="FLYBASE:FBgn0260400"
                     /db_xref="GeneID:31000"
     CDS             498..1949
                     /gene="elav"
                     /locus_tag="Dmel_CG4262"
                     /gene_synonym="44C11; 9F8A9; CG4262; dHuR; Dmel\CG4262;
                     EC7; EG:65F1.2; Elav; ElaV; ELav; ELAV; elav-1; elav-2;
                     elav-3; Elav-9F8A9; END1-2; fliJ; l(1)1Be; l(1)EC7;
                     l(1)G0031; l(1)G0319; weg"
                     /note="CG4262 gene product from transcript CG4262-RD;
                     CG4262-PD; elav-PD; embryonic lethal abnormal visual
                     system; weniger; embryonic lethal abnormal vision;
                     embryonic lethal, abnormal vision; embryonically lethal
                     abnormal vision"
                     /codon_start=1
                     /product="embryonic lethal abnormal vision, isoform D"
                     /protein_id="NP_001245447.1"
                     /db_xref="FLYBASE:FBpp0298002"
                     /db_xref="GeneID:31000"
                     /db_xref="FLYBASE:FBgn0260400"
                     /translation="MDFIMANTGAGGGVDTQAQLMQSAAAAAAVAATNAAAAPVQNAA
                     AVAAAAQLQQQQVQQAILQVQQQQTQQAVAAAAAAVTQQLQQQQQAVVAQQAVVQQQQ
                     QQAAAVVQQAAVQQAVVPQPQQAQPNTNGNAGSGSQNGSNGSTETRTNLIVNYLPQTM
                     TEDEIRSLFSSVGEIESVKLIRDKSQVYIDPLNPQAPSKGQSLGYGFVNYVRPQDAEQ
                     AVNVLNGLRLQNKTIKVSFARPSSDAIKGANLYVSGLPKTMTQQELEAIFAPFGAIIT
                     SRILQNAGNDTQTKGVGFIRFDKREEATRAIIALNGTTPSSCTDPIVVKFSNTPGSTS
                     KIIQPQLPAFLNPQLVRRIGGAMHTPVNKGLARFSPMAGDMLDVMLPNGLGAAAAAAT
                     TLASGPGGAYPIFIYNLAPETEEAALWQLFGPFGAVQSVKIVKDPTTNQCKGYGFVSM
                     TNYDEAAMAIRALNGYTMGNRVLQVSFKTNKAK"
     misc_feature    933..1946
                     /gene="elav"
                     /locus_tag="Dmel_CG4262"
                     /gene_synonym="44C11; 9F8A9; CG4262; dHuR; Dmel\CG4262;
                     EC7; EG:65F1.2; Elav; ElaV; ELav; ELAV; elav-1; elav-2;
                     elav-3; Elav-9F8A9; END1-2; fliJ; l(1)1Be; l(1)EC7;
                     l(1)G0031; l(1)G0319; weg"
                     /note="ELAV/HuD family splicing factor; Region:
                     ELAV_HUD_SF; TIGR01661"
                     /db_xref="CDD:273741"
ORIGIN      
        1 atttcatttc cacgccaacc atcgtgcgcc gcggtctgaa cgctcctgcc acagaaaaag
       61 aaaataaaag caaggaaaat tctaatcgaa taccaaatat cgtgcttgtg tgctctttcc
      121 gcaattgatt ttttttaagt agtgcatgac aataaccgtt gagttgactc caaccgaagt
      181 aaccataact ggaagctgac aacagccatt ggccggaatc tcatctcaca ccgagcgaaa
      241 tacggcgacg ccagcgttta tttattaaaa acgattacat tacaacaaac accaaagtcc
      301 tggacaaccg aagagagtgt gggagaaaat cgaagcagag agcaaggagg agcgccgtga
      361 gagcgcgcgc gcaaggattt gagattgcaa agagaactta gcaattagtt cgctttgttt
      421 gtccagccaa acaacaacaa caaccaacca gctccccaaa accaactaca cacatactcg
      481 ctccctaaac taaaacaatg gactttatta tggcaaatac cggagctggc ggcggagtag
      541 acacacaggc acagctaatg cagagtgccg ctgcagccgc agcagtggcg gcaacaaacg
      601 cggccgccgc tcccgtacag aatgcagccg ccgtggcggc cgccgcccag ctgcagcagc
      661 aacaggtgca acaggcaatc ctgcaggtgc agcagcagca gacacagcaa gcggtggccg
      721 cggccgctgc cgcagtgacc cagcagctcc aacagcaaca gcaggctgtc gtggcccaac
      781 aggctgtagt gcagcagcaa caacagcagg cggcggcagt ggtgcaacag gcggcggtcc
      841 aacaggctgt ggtgccccag ccgcagcagg cgcagcccaa tacgaatggc aatgcaggat
      901 cgggatcgca aaatggcagc aacggcagca cggagacgcg cacaaacctt attgtcaact
      961 acttgccgca aacaatgacc gaagacgaga tccgttcgct cttctccagc gtcggcgaga
     1021 ttgagtcggt gaagctgata cgcgacaagt cgcaggtcta catcgatcct ctcaatccgc
     1081 aggcgcccag caagggccaa agtctgggct acggctttgt taactatgtc cggccgcaag
     1141 atgccgagca ggctgttaat gttctaaacg gcctgcgact gcagaacaaa accataaagg
     1201 tgtcgtttgc ccgcccgtcg tccgatgcca ttaaaggcgc caacctttat gtgtcggggc
     1261 tgccaaagac gatgacccag caggaactgg aggccatctt cgcaccattc ggagcaataa
     1321 tcacatcgcg cattctgcag aacgctggca acgatacgca gacgaaagga gtaggcttta
     1381 ttcgattcga taagcgggag gaggccacaa gggctatcat tgccttgaac ggtactacac
     1441 catccagctg cacagacccc atagtggtaa aattctccaa tacgcccggc agcaccagta
     1501 agatcatcca gccgcagctg cccgctttcc tcaatcccca actggtgcga cgcatcgggg
     1561 gcgccatgca cacgccagtt aacaagggtc tggcccggtt ttcaccaatg gcgggcgaca
     1621 tgctggacgt aatgctgccc aatggactag gagcggcggc ggcggcggcc acaacgctgg
     1681 ccagtgggcc tggcggcgcg tatcccattt tcatctacaa cttggcgccg gaaacggagg
     1741 aggctgccct gtggcagctg tttggtccat ttggagctgt gcaatcggta aagattgtca
     1801 aggatcccac aacgaatcag tgcaagggct acggcttcgt ttcgatgacc aactacgatg
     1861 aggcggccat ggccattcgg gcgctcaacg gctacaccat gggcaatcgg gtgctgcagg
     1921 tcagcttcaa gaccaacaaa gccaagtaga gcggcccaaa tggaagtgga caaggacgca
     1981 gcgggagcac cagcaaccac aacccattat cttgaatcta aacctgacca cacaacacac
     2041 atatataaat atgcatggta taacggtaac taagcgcaac aaaacagtat gtgtacaaca
     2101 cacaagaaaa aaacaagaaa gtagcaggca ggagaaaata ctctttccac taaacgacaa
     2161 cgaaacggcg gaaatccccc taaaaacaca aatctcctcc ccaaaaccgc cggccaaaag
     2221 cgttgcaata gaaaaattct tcttgtttag catttaagta aaaaacctta actaaacgaa
     2281 gcgagcagaa gaagttataa gatcgggaga agcgaatagg tagggggttg agaaagaaca
     2341 atgagatttt aagaaataat attgcaaaat gaaaacacac tgtggcagtg gcagctgtga
     2401 aaggtcaaag gttggcacag tcgatctagt cacaaagcaa aacaaagaaa tcaaccaaac
     2461 aaacacaaaa cacacaaaaa cgaaaacaaa tttaacttta ttagcaaaaa agaaaatgag
     2521 aaattttaaa aatttattaa ctttaagtaa aacgcagcaa tgaaatcttc caaacaaaag
     2581 aaagcaaaac agcaaatctg tttgttacac ttcaactttt tctaccataa aaactttgaa
     2641 tcttgatact aaacctaaag cagaattaag aaaatagagg aattcagtgt ctacacttta
     2701 tacatgtact gtgcttacag gacaccagtt tggcttgatc aaagagcgca ggataaaaag
     2761 tatttaaggg gcaattagga ggatcgcgca tataataggt atatatgcat aacatggagg
     2821 ctgctacagt attacaagaa acataaaaat taaaactata tacttaataa acgagcacgt
     2881 ttaataattc taaaaatatg tgtatattca tatgtatatg cgataattct atgtttgcct
     2941 agatatacaa ctaaatatag aaatttaaag tgttttttat gttttgtatt tgttttctac
     3001 actaagaaaa cgaaacgaat tccgattgaa tcaagccaaa ctcatgtccc ttaagcacaa
     3061 gcaaactcag tgaaaactga agaaaaacat agaaatcata aaaaaatgat tgacagaaag
     3121 ctagcgacgt gaaaaaaaaa gtaatacaat aatttatgcg caaatttaaa atgttttact
     3181 gaagtaaata attgttagtg aatattgata ctgtaaatgt gcgcgtgtgc gcacaggtgc
     3241 ctgcagatat atagtccgct atataacgac gcatgctggc gtaggcacac cttatatact
     3301 ttatataatg tatagttcaa ggagcaagta agcataaaca aaaaaacact tgctaaacca
     3361 aaacaatttt agcgttaaaa accaagcgta gcacaaaaaa ttactacaaa accaaacagt
     3421 agagcaacag caaccatttt ttatataaca caaaaaagta aaatgaaaac aagtgaaaag
     3481 gaaaatactc acgaaggatg caaacaaaag tatagcaaag aggtttttct agctaagtga
     3541 ggtgctagag gacaaagaaa gcggctacgt attgacaagg attaatccgc atcctgctta
     3601 tataagaccc tacaaacccg tgtccaaacc tacaactttc gtggatcttt tgcgttactt
     3661 tatcagttga tcttctgtat atttctttgc ttctatggat agttgaagcg agagagcaag
     3721 acacagcaca cacacaaaca tcagcatata taatttcgat tctggactat atattccgta
     3781 tttgaatttg gttttgtttg atttctttgt ttgctttgta cacaaatcga atttaataat
     3841 aagcttttgc atccagccca taaaaccagt cagacccaac catgcatatt tatacaaatg
     3901 atttgtgttt gatttcttta tagagtttac cttaggaaac ccgacccaac cctttttgag
     3961 ttcactctcc aaatagcata aattcttgac ctaagtttca acaaacattg aacagaatcc
     4021 aaaaagaaaa ataggaattt attttacttt tattattatt acgtcaccta gcgctatgtg
     4081 taatcacgcg tatgtatatt accatatata tatatatata ttttttttta taattatagg
     4141 gtaaaaaata ttttttgttt gaacaaaatt cgcaacaaga actctagtca gaagatggaa
     4201 aacaagaata ttattatgat gaggcagccg catataagga ggaatagtag atcaaaacca
     4261 aaagaactat ggcaatttct agctaataaa atgattgaat gattgataga agccgcctgc
     4321 tcttcccttt ccaaagattt acccacttaa aacctctaag caaaagataa gcgaggcgaa
     4381 cggaaagcgt caaaggagat ttccagatga aaatgcaata cattatacac aatcaactag
     4441 tttatttata taacataccc acataagaac acactgtggg acaggagaac agaataaaat
     4501 cttgtgaaag ctaggaatgt acttgatttt gtttagttcg tatttctgtc atcacatatt
     4561 tttacacgca acacagacac aattcttaat ttaattaatt taatgtatac ttattttttt
     4621 tgtcaccgat gatcaaatta attgtattaa ttataattat tgtgcaatag ttttaaaatg
     4681 caactgaagg caaaacacaa caacaaattt tcaagtatct caaattataa tttcattagg
     4741 cgaggaaaac gagaaatgaa atatttgatc ttatgaaaca taattgtatg attactctat
     4801 acacaccgca aaacaagaaa gaaatgcaag cccagcaaca agaacaaaat ttaaaaatat
     4861 atatacaaca attatttttt aagcgaaatt gtatatgtat cacatgcata tacatattaa
     4921 tatctcatat tttttcttta ccaatttacc tattaagtaa gcaaagagcc aagaaaacaa
     4981 acgaaaacga aacaaaaaag attatttatt gtattttata attacgtaat tttatttaat
     5041 tcaatttgaa ttatatattc ccttgatttg aacaaagcta caagaaacaa gaagataatg
     5101 atatgataaa gaattagtct aattatacac acaacacaag agcagagacc caaaaagata
     5161 gatagagaga gagatagaga gagagagaga gatagaacga gctacagaag tctatataaa
     5221 atctataact tccaaactct ctctcctccc attctcccct tttctcttaa tatgtctctt
     5281 tttactctaa tgtgcggttt atatatttaa ttttgtacgt tgtattttat ttcgttcttc
     5341 atttcaattt tgttttacca gaaacctttt tgtgtttcag cttcagttta aaattatgat
     5401 tttatgctaa acctacttga attgtcacag caacaataac acaacacagc tatttagttg
     5461 atattctagc tatatacgat ctgtgcgtat gttactgcaa actcctgtga attctatcga
     5521 atgaatattt atattttgat tattattatt tagtatggcc tatttttttt cggtttgtgt
     5581 attttgcttt ttgtctaatt tcgcaacgaa catgtttact cttatgattt tatttgattt
     5641 ccgcaccaaa caagtaaaaa aaacccaaga aaaattttct ttcaataaaa agaaatcttg
     5701 atgaaaattt tagcatcatt tttatttgtt attttttggt tttgtttgtt tttaaaactg
     5761 tacgattttc gattaacaac cacttctttc ccgaatccta tacttgtttc cctctctgtc
     5821 tatctttctc tctcgctctc tctctaattt aaaaacctta agtcctctga cagtcacatg
     5881 aagaagatga aggaatcgat ctagtcaagg cccatctaac aagaggtgcc atcggaatcc
     5941 gttgatctca gctaaaaaga catccccaga cattcccagt cgtgtttggt ttagtcctcg
     6001 taactccacg atttaagggg gtatcccccg tgtaaaaaca gcccaaagat atgcattcca
     6061 gtttttgttg cttggtgtag actctgccag ttgcgatatt atttgtgtgc aaacaagaat
     6121 acttttaatt tgtgtaatgc cattatgttt agcgcttatg ataaatgaat ctcatagttt
     6181 agtttagcgg aggaagtacg gccacctctc ccttaattta tatatttgtg gggatatatt
     6241 gcaacgattt ctgtgtatga ttttgtcctg catttctgta ttgcttaatt ctgtgtaatt
     6301 tttgtaattc ttagagcaca gtttatctat catttcgatg ggcagagaac tggagatgct
     6361 tagcgatagc attaacgaaa cacaaaggat acctttacca atcattaaca agtatataaa
     6421 tataccattc tatatattat tatgattaaa ataatgacga cgtcgatggc gagaaagagg
     6481 aaactattta atttatttta ttaacatatt tatatcgatt aattaattaa taatatttat
     6541 cacatttcaa atgatatttc aaaatggaaa acactaaaaa aacgaataca agcaaatgag
     6601 aaaaagatat taatattata aatgtattta aaaatatacg attatgagtt tttcttgctt
     6661 tttgcatata tatgtatttc tctctatata atccatatca aacacaccaa acttttgttt
     6721 caagattaag ttggtttatt ttagtttaag ttcagactat tttggatatt ctttcaaagt
     6781 tagaattgag ttcaaatttt aaaattgtct tttgtacact ataggttggg tgttctttgc
     6841 gtcatcaatt ttaaaaataa tttttcatct cagaaaggtt ttggttgatt tacggttcct
     6901 ttctaccaac tatattttgt acagtgtatg tcatactaac acacacccac ttacacaccc
     6961 aattccctaa gtttgttgtg tgttctctct cgaaaagagt atgccctttg tttgctctta
     7021 tgatttcgct cagagtattt tcacgtacgc ttttttgctc ccagtgtatt gagccagctg
     7081 agaaggaaga taaaactatg aagatgatga tatggtattg cgttataagg aagacgaact
     7141 gctccgattt tggcatttaa gttgttcccc tttcgttcct tccgttgtgc atatgtgtgc
     7201 aagtatacac atgtatttat aaatatatta gtatttatta atggatatgt ataagggcat
     7261 acatacacat ctattaccga tcgatatgta gccaattttg gtttccggag ttccggtttt
     7321 aagtttgttg ttgtcgttgt tatacatagt attgtacgta tcctcactta ctatttttgt
     7381 ttcgtgtgat tttcggtaag taatcggaga agagcgcatc gatgatcgga aaaagtctaa
     7441 cgccgatctc aactaatttg ggcacacatt ttttcctaat aaacatttgg cagcaaaact
     7501 gatgatttct ctaaatgttt tctttctcgt tttattgatc tgtttgtagc aaaataaaaa
     7561 ctgtaaagct aacacatgca tatcctgcag caaaaagtat aataatttat aaagaatttt
     7621 ctaatttatt tctttctctt gatttatttc caggtgtgtg ttattgttgt tcgttcgatt
     7681 ttgaattgaa tttatgaaaa aagaaacaac caaaaaccat tttcaaacac atttcttcaa
     7741 gttgaatttc aattaaatta attgattact tggttaaagc gataatgatt gtgtacatat
     7801 ttgattgatt aacacgtaat attaactgta cttatttgaa gcatatacca cagatgtcca
     7861 cagatcccag tcctttattc caaatcccgg aactcccacc aatcgatgca catacatgat
     7921 ttgtattcca cacacacgta cacatacagg aatcacttgc gtttcgaatt gtattttcaa
     7981 taagaaaatc taagcgagca acagattatt ttgaatttca aggaattgga aattaaaggc
     8041 tttttctagt atatagattt aatttttaac cagcaaagca caatccaccg tcttcacaat
     8101 cactatttat cagtatttag ggtagtcaga ctaatataca gcgaactttt aaaaccttgc
     8161 taacgttgag tcagcatttt tttttacata tacccagatg ccttttatct tttaaaacat
     8221 taaacataaa atatgattga ttgattggta ttatttaaaa gatttcatat ttttcaaata
     8281 caatcgtagt acgcgtgaat gtatttatcc tgtgtaagat atattatttg gagttatact
     8341 cgattgagta agcaaattaa tatatttctt gagttaatta ggaatctccg actgatgtaa
     8401 ataaatctga tttcgatttt cattcttatt tcggttttca tcttgtgcca gtcattcgtc
     8461 cgtacagtgt gataatttgt gatctgtcat atatacatgc tcgtataagg aatatttcta
     8521 gtaataaacc tttgttgtac attttaagtt cgagtcaaga agaatttaag ttttatccca
     8581 atgccaatag gccgaagtgc aaaggctccg accacgccaa ccccccaccc cgtggtctta
     8641 tatgtaatgt ctagttatag agcgctatat agatacgatt ttacatcgtg aaaacgtaga
     8701 gctgaaatct ttgtttcatt tccgggatac cccgcaactt ccttatttac attgtgatct
     8761 ctgatttaat ctttcttcag ttgacatttt aaacaccctt tcgactgact ttccaaaacc
     8821 gaaagaaaaa ccgaactgcc caaggcaaaa agcaatgtgt aaattgaata atctaaataa
     8881 ataagcaaat taaaggttga tagcaactac acgcaaagac tgaggcaagc acaaaaaata
     8941 aaaatgaaac cagagaaaaa tcgaaaaaca gaagtcaaag cagagtcaat aaagcgaaat
     9001 aagtcatagt acgttaaggc aactgtgata aggcgaacaa accccccgcc aagaacccct
     9061 cttcagcaaa ccaccaccca aaaacaaaaa atatatatat taagtacaat acaatggaat
     9121 aaatgacact atgaccgaga gacttacttg tctagccgta agacgatctc tgaaataatg
     9181 tactttttgc gctgcgttgt gtattggtgt tttcgggtta actcactcaa acatgatgta
     9241 gttcttatac caagtttgat ttgaggtatt gattaataat gtttttgccc tcatctttga
     9301 ctgacgagac atttttttga agaaaatcgg acacagacat tcaaatccag tgtaaaaagc
     9361 gcattattcg tacactcacc agttgggcgc gatttcctgg aggccagcgt gctgccaggt
     9421 gttacggagc tgttccaaca gaaaggatac aggcatccca tggatgttgc ccgactgcga
     9481 ggtgctatgc agattgatgt ccgcatgtgc gtcgatccac accagggaca aattcggcgt
     9541 gtgttgcagg tgcccggcca cggatcctgc aatacgattc cgttatggat tctatcattg
     9601 gacgtaaaat cgagattggt cactcaccga agccgatcgc atgatcacca ccaatggcta
     9661 aaaactgcgt gttctccacg agcatgagtt tcacctgttc aatcagtgcc cgattgcagg
     9721 ccatgaagtc cgcgtagttt cggatgtggt gatagtgcac acgctgctgc tggagaaggg
     9781 gctcgtctac ggcgtactgc agatttccgt agtcccgtat caccaggcca tctggtcaat
     9841 aaaaacaaat atatgagatc caaactgaaa gggttgtttt aattacgaag gaaatattct
     9901 gcgattgacc agttgttccc ttctaatgct tttctaggcc agcgattttc aaaatccaac
     9961 aaaacgtttt ccgtagccga acccatttca aagttcgaaa gctgaaggga ggtagctgac
    10021 tcaccatgac tgctctgaag cacctgacgc agactgctct gccggagaag atctggcgcc
    10081 agttccacgc cctgcttggc ctgccccttt gcgaagggca ctccaatgat gcctagagat
    10141 tgctcaggtt ccctgggcgc agtgcttccg gtgctcttga gccggtggag gcggagagac
    10201 cttgaggcaa atttacggct ccaccacatt ttgcatgtga tctaggatct cttagattgg
    10261 atctgctcgc aatgctgtaa aatccacgac tgcgaggccg ggaatgaatg agacaacaac
    10321 gacggcgaca caacgacaat gagcacgaat gccaactatc tattgggttc tggaccccct
    10381 gataaagctt gagcgacagt tcagctggga tcggcggaca ttgtagttgc tgtatgagta
    10441 aagtgagagc cactggatgg gcgataaggc ggctatcgcc agatgacctt gatcctggct
    10501 cggacg