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LOCUS NM_001201643 6200 bp mRNA linear INV 26-DEC-2023 variant E (Hecw), mRNA. ACCESSION NM_001201643 VERSION NM_001201643.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6200) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6200) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6200) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6200) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6200) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6200) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6200) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6200) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6200) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6200) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6200) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6200) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6200) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6200) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6200) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6200) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6200) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6200) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6200) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6200) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6200) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6200) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6200) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_001201643.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6200 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6200 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="Hecw ubiquitin protein ligase" /map="8F1-8F2" /db_xref="FLYBASE:FBgn0261931" /db_xref="GeneID:31905" CDS 353..4624 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="CG42797 gene product from transcript CG42797-RE; CG42797-PE; Hecw-PE" /codon_start=1 /product="hecw ubiquitin protein ligase, isoform E" /protein_id="NP_001188572.1" /db_xref="FLYBASE:FBpp0292727" /db_xref="GeneID:31905" /db_xref="FLYBASE:FBgn0261931" /translation="MEPPAAPVPLQPLAASSACLADRSPVDPIAVRLQQEEQAEGDDE EEEEEEEDDDDDPKEEEAFYEARNGNESDELEQAFQSALTLTNDVHVSVSEVEEHEPP LASRNQEVAEVEEQQQQLGACALPQPSEACSKETREPRHHQTLLSTKSCETPANNATL SPTNSYNGSIGSDGGSSVGGGARRKSWTLSPQSGGSTPLSGAKKKTKTGAPTTTLSNA NGDGFNLWVARECFETVPAEMVDTLSMAEVDEEVDEEEDEEAAAVESLLGAAAALQAS AHVQRRQQQQHHQHLRQPSPPQHRPLERSWPPRAVGRDLKLQGDVFQFDILDTDERLA EEMAQGSGSSNNSPLATPPVRFKPLLKKKIGPDSYINTISTQKVPVHQSYEFPTFPSS SAVGSSSSSPNSLQFPYLRQHRPLTRALSNGKASSSEEQASPRLLLSPKRPRSPPSGC STRSASPLDISLSPEQHSPTRGRGVGGALQDAVPPGTPTFHGQRPQQRLLKRVGGGAG AGATGGATGSPLVCPPTPTHHARRHARLQAVTANSSLASGGAIPSDPPAVSSQLDYIY LQDGGQEQGQEQSDEVVHISSTRLPSIPERSAAAAAAAAAAAAGAALMEPGTGTVSGS SGAGAAGEPPLPPAWEARMDSHGRIFYIDHTTRTTSWQRPGAAPSGGPAGREQHHRQQ LDRRYQSIRRTITNESRAAQLYNLPTSANSNANSTAPAAPPPATAIHPAILMLCRPDF YSLLHTNEAALAIYNRNAALKHMVMRIRRDPPCFQRYQYNKDLVALVNTFAQMSRELP SCWETKLDQSGKQFFIDHQHRRTSFMDPRLPVECPRVVRHRQQHSQQQSSVGYYYPDL VDGNCLSATSGHINASPASSVSGVPPLPPPRPSSSSSSSRSSHGHGHNCNTTSAISCA LNADRSAYGAAGMASAGATAAGYEDVPIAYNEKVIAFLRQPNILEILRERQGQHTMSR QLREKINILRVEGVPALERLGHDLQLTILLSLFEQEIMGFVPIEERSPQGSPVLNSRM PQRAPPPFRRDFEAKLRSFYRKLESKGYGQGPHKLKLHIRRSHLLEDAFRRIMSANKK DLQRGRLAVLWDTEEGLDYGGPSREFFFLLSRELFNPYYGLFEYSANDTYTVQVSPLS AFVDNCHDWFRFSGRVLGLALVHQYLLDAFFTRPFYKALLRLPVALSDLESLDNEFHQ SLQWIRDNDIGTGVDLGLTFCVTEELLGSVVDRELKPGGKNIIINEKNKKEYLERMIK WRLERGVQEQTESLVRGFYEVIDSRLVSVFDARELELVIAGTAEIDTNDWRLNTEYRS GYHDNHQVIVWFWQVIERFSNEQRLRLLQFVTGTSSIPYEGFSALRGSTGPRRFCIEK WGKPNALPRAHTCFNRLDLPPYPTPELLYEKLLLAVEETNTFGIE" misc_feature <1574..2029 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="large tegument protein UL36; Provisional; Region: PHA03247" /db_xref="CDD:223021" misc_feature 2255..2344 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="WW domain; Region: WW; pfam00397" /db_xref="CDD:459800" misc_feature 2555..2725 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="Helical box domain of E3 ubiquitin-protein ligase HECW1; Region: HECW1_helix; pfam18436" /db_xref="CDD:465766" misc_feature 3545..4615 /gene="Hecw" /locus_tag="Dmel_CG42797" /old_locus_tag="Dmel_CG3003" /old_locus_tag="Dmel_CG3099" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional...; Region: HECTc; cd00078" /db_xref="CDD:238033" misc_feature order(3563..3565,3656..3658,3689..3691,3872..3874, 4400..4402,4505..4510,4517..4531,4589..4591,4610..4612) /gene="Hecw" /locus_tag="Dmel_CG42797" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="catalytic cleft [active]" /db_xref="CDD:238033" misc_feature order(3956..3958,3965..3970,3974..3979,3986..3988, 4010..4012,4016..4018,4028..4030,4034..4036,4052..4054, 4067..4069,4118..4120,4130..4132) /gene="Hecw" /locus_tag="Dmel_CG42797" /gene_synonym="BT058014.1; CG3003; CG3099; CG42797; Dmel\CG42797" /note="E2 interaction site [active]" /db_xref="CDD:238033" ORIGIN 1 ccattgacat ctggtcacat tgcactagac ccgaaatata tattttattt agcttttgca 61 atatccttaa attaacaatt gatcaactaa agccacggcc ttgcgggcag tgagcacagc 121 acagcacggc ccagaactgg actcaatggc tggaggacgc gaaatgctcc ggtcggaagg 181 cagcaaacat cagaacgcca aagtagagca actgcagctg taactgtaac tgttaaccct 241 gggttggtcg cgggggcggg gtggcagtgg tggttgtgga ccaggaagag gaagagcaag 301 ggtgctggga aagaggaaga gcacatcttg aggccaggag gcaaacgagc caatggagcc 361 accagctgca ccggtacccc tacagccact ggcagcatct tccgcctgcc tggcggacag 421 gagtccagtg gatcccattg cagtcagact gcagcaggag gagcaggcag aaggagatga 481 cgaggaggag gaggaggaag aggaggacga tgatgatgat cccaaagaag aggaggcctt 541 ctacgaggcg cgcaacggca acgaaagtga cgagctggaa caggccttcc agagtgccct 601 taccctgacc aacgatgtcc atgtgagtgt cagcgaagtg gaggaacatg aaccgccctt 661 ggcatcgaga aatcaggagg tggcagaggt ggaggagcag cagcagcagc tgggggcctg 721 cgcactgccg cagcccagcg aagcctgctc aaaggagacc agggaaccgc gccaccacca 781 gacgctgctt tccaccaaat cttgcgagac gccggccaat aatgccacgc tctcgccgac 841 caactcctac aatggcagca ttggcagcga cggcggcagc agtgtgggcg gtggcgcccg 901 ccgcaagtcc tggaccctgt cgccgcaaag cggtggctcc acgcccctga gcggagccaa 961 gaagaagacc aagacgggtg cgccaaccac aacactgtcc aatgctaatg gcgacggttt 1021 taatctgtgg gtggcacgtg agtgcttcga aacagtgccc gctgaaatgg tggatactct 1081 gagcatggct gaagtggacg aggaggtgga tgaggaggag gacgaggagg cggctgccgt 1141 ggagagtctt ctgggagccg ctgctgccct ccaggccagt gcccatgtgc agcgccgtca 1201 gcagcagcag catcaccagc atcttcgcca gccctcgcca ccacagcatc gtccgctgga 1261 acgatcttgg ccgccgcgtg ccgttggtcg ggatctgaag cttcagggcg atgtctttca 1321 gttcgacatc ctggacacgg acgagcgact ggccgaggag atggcacagg gcagtgggag 1381 ttcgaataat tcacccctgg ccacgccgcc tgtgcgcttt aagccgctgc tgaagaaaaa 1441 gattggaccc gatagctaca tcaacacaat tagcacacaa aaggtgccgg tccaccagag 1501 ctatgagttc cccacctttc caagttcctc ggcagttgga tcgtcatctt cgtcgccgaa 1561 tagtctgcaa tttccgtatc tgcgccagca ccgtccgctc acccgtgccc tttccaatgg 1621 caaggccagt tcatcggagg agcaagcctc cccacgcctt ctgctctcac caaaacgtcc 1681 gcgaagtcct ccttccggtt gttccacgcg cagtgcctct ccattggata tcagcctgag 1741 tccagagcag cactcgccca ccagaggcag aggagtgggt ggtgctctgc aggatgcggt 1801 gccgcccgga actccaacat tccatggtca gcgaccgcag cagcggctgc tcaaacgtgt 1861 aggcggtgga gcaggagctg gtgctacggg aggcgcaacc ggctcgccat tggtatgtcc 1921 accaacgcct actcaccatg cccgtcggca tgcccgcctc caagccgtca ctgccaattc 1981 cagcctcgcc agcggaggag cgatcccctc ggatccgcca gccgtctcta gtcaattgga 2041 ttacatatat ctgcaagatg gtggccagga gcagggtcag gagcagtcag acgaagttgt 2101 gcacataagc agcacccgcc tgccctccat tccagaacgc agtgcagccg cagcagcggc 2161 ggcggcggca gcagcagctg gagccgctct catggaaccc ggaacgggta cggtatccgg 2221 gtctagtgga gctggagccg ctggagagcc accattgccg cctgcttggg aggcgcgtat 2281 ggacagccac ggacgcatct tctacatcga tcacacaacg cgaacaacct catggcaacg 2341 accaggagcg gcgccaagtg gaggaccagc aggcagagag caacatcatc gccagcagct 2401 ggataggcgg tatcaaagca tccgacgcac cattaccaat gagagtagag ctgcgcagct 2461 ttacaacctg ccaacctcgg cgaatagtaa tgccaattcc acagctccag ctgctcctcc 2521 gcccgccacg gctatacatc cagccatcct gatgctctgc cgcccggatt tctactccct 2581 actgcacacc aacgaagctg cactggccat ctacaatcgc aatgccgcac taaagcacat 2641 ggtcatgcgc atccgacgcg atccgccgtg cttccagcgg tatcagtaca acaaggatct 2701 ggtggcgctg gttaacacat tcgcccagat gagcagggaa ctgccctcgt gctgggagac 2761 caagctggat caatcgggca agcagttctt tattgatcac cagcatcgtc gcacctcatt 2821 catggatcct cgtctgccgg tggagtgtcc tcgtgtggta cgccatcgcc agcagcattc 2881 gcagcaacag tccagtgtgg gctactacta tccggatctg gtggatggca actgcctgtc 2941 cgccaccagt gggcatatta acgccagtcc agcatcatcg gtctccggtg taccgccctt 3001 acctccaccg agaccctcat cgtcgtcctc ctcgtccaga agtagccatg gacatggcca 3061 caactgcaac acaacgtcag ccatctcctg tgccctcaac gccgaccgtt cggcgtatgg 3121 tgccgctgga atggccagcg ctggagccac tgcagccggg tacgaagatg tgcccatcgc 3181 ctacaacgaa aaggtcattg ccttcctgcg ccagccgaac atcctggaga tcctgcgaga 3241 gcgccagggc cagcacacaa tgtcccgcca gttgcgtgag aaaatcaata tactgcgagt 3301 ggagggtgtt cccgcactcg aaagattggg ccatgaccta caactgacca ttttgctgag 3361 cctgttcgag caggagatca tgggctttgt tcctattgaa gagcgcagtc cgcagggatc 3421 gccggtcctc aactcccgga tgccacagcg tgcgccgcca ccatttcgca gagatttcga 3481 ggccaaactg cgcagtttct atcgcaaact agagtccaag ggctacggac aaggaccaca 3541 caagcttaaa ctgcacattc gtcgcagcca tttgctggag gacgccttcc ggcgcatcat 3601 gtccgccaac aagaaggacc tgcaacgcgg ccgactcgcc gtgctctggg atacggagga 3661 gggcctggac tatggcggac catcacgcga gttcttcttc ctactttcgc gcgaactgtt 3721 taatccgtac tacggactgt tcgagtactc agccaacgat acgtacaccg tgcaggtgtc 3781 accattgtcg gcgttcgtgg ataattgcca cgattggttc cgctttagtg gacgagtttt 3841 gggattggca ctggtacatc agtatctact ggacgcattc tttacgcgtc ccttttacaa 3901 ggcgctgctg cgcctgcccg tggctctcag tgatttggag tcgctggaca atgagttcca 3961 tcagtcgctc caatggatac gcgacaatga catcggcacg ggcgtggatc ttggcctaac 4021 gttctgtgtc acagaggagc tgcttggcag tgtggtggac agggaactga agcccggtgg 4081 caagaatatc atcatcaacg agaagaacaa aaaggagtac ttggagcgca tgattaagtg 4141 gcgtctggag cgcggtgttc aggagcagac cgagtcgctg gtgcgcggct tttacgaggt 4201 gatcgactcg cgcctcgttt ccgtctttga tgcccgagag ttggagctgg ttattgccgg 4261 cactgcagaa atagacacaa acgattggcg cctgaacaca gagtatcgtt ctggttacca 4321 tgataaccac caggtgatcg tttggttctg gcaggttatc gagcgcttta gcaacgagca 4381 gcgtcttcgt ctgcttcagt tcgtgactgg cacgtcgagc ataccgtacg aaggattctc 4441 ggcattacgc ggatcgactg gcccgaggcg tttctgcatc gagaagtggg gcaagccaaa 4501 tgcactgccc cgtgcccaca catgcttcaa tcggctggat ttgccgccgt atccaacacc 4561 cgaactgctg tacgagaagc tgctgctggc cgtcgaggag accaacacgt tcggcattga 4621 gtagacacgt gatattgcac ccacatacac atacacaaac aaaaacacat acacatacac 4681 atacagatac acaaaacacg cgcctaaacg ctttatttcg attttagaag tttttataac 4741 ttgcctaagt ctagaaattc gcgagctatg cagaaatcct agggatttgg acacaacaag 4801 ttgcagtttt tattgaatag caatgcattc tttgtaaatt agttttaaag ttcaatttaa 4861 ttttttcttc ttaatatgaa ccgttattgg ttatattagt ttgcgatgat tattcttaaa 4921 aatagaactt gttacgatta aatttaggta aacgagttag ttaatacttc gaatttgtta 4981 gctattttta ggcacctaaa tgctattaaa atccactggg atttctgcaa ccctcataat 5041 tgtactgtag ttatttatat acgtaggtgg tcccccttcc gaaaatgaac aaaattgtaa 5101 agcaaataaa tgcctagcca tagacagact tgctacttta ggcatggcat cccactagtt 5161 tgtagacaat ttgccttcgc cttcgtttgc cgttcattga atggaagtta cctcaagagc 5221 aaaacggctt gccagcgccg ccagtcatta gtcctaagat ctacacgccc ccggataatt 5281 tctaagccta agtatccttc gcttgactct gcctgattta cactcgaaac gttgccaact 5341 gccctctaga gaaaattacg acgcgtaaac gctgttccag atccagttca gcagtttcaa 5401 aaaaaaaaaa aaagagagca gagcaaatct acgccaatac ttaattagtt tataatgttg 5461 tctgagccta aactcgaatt caaactcaaa tttgaacatg cagttcttat aacatatata 5521 tctagatata tatatatata tatatatata tatttacccc tctcctttta cccaaaaact 5581 atgtaaatta tttttgaatt tacaaaagcc ccttaacaat cgccccatgt ggatgctttc 5641 gtgtgcatcc tcgcctgcca cttgaccaac tgacttgact ctggccagga taggctgcac 5701 atggcagctc cgatcgggct tatatataca aaacttggct gctgttttgc caacgattac 5761 gaattggtcc agtgcgttgc ttcggcttta ttggttcatt cggcgcatat aattaacgat 5821 aatatggaat tatatttaac gaaaacataa aatttccaac gtagctaatt aattgaatac 5881 caaaagcaaa aacaaataaa aaagaaaaca aatttgtatt tttatttata agtatttatc 5941 gaaagcaaga acgaaacgaa aaggtaacta aatggtgatt tgtttacatg tatttttggc 6001 attagttaat acggaaagcg acggagatgg agagagacag agctaaaggc agtgaaagag 6061 acagagaaag aaagataacg ctttttgaac tacttattga taaatgaaga ttgttttaat 6121 gaactattaa tgtgcgtgta tttatgaaca aattaactat aattacaaat aaataaatgt 6181 gagcctttta cttcaaaagc