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Drosophila melanogaster slipper (slpr), transcript variant D, mRNA.


LOCUS       NM_001201631            4945 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001201631
VERSION     NM_001201631.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4945)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4945)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4945)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4945)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4945)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4945)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4945)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4945)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4945)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4945)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4945)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4945)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4945)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4945)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4945)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4945)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4945)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4945)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4945)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4945)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4945)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4945)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4945)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001201631.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4945
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4945
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="slipper"
                     /map="7D17-7D17"
                     /db_xref="FLYBASE:FBgn0030018"
                     /db_xref="GeneID:44111"
     CDS             596..4042
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /EC_number="2.7.11.25"
                     /note="CG2272 gene product from transcript CG2272-RD;
                     CG2272-PD; slpr-PD; mixed lineage protein kinase 2;
                     slipper"
                     /codon_start=1
                     /product="slipper, isoform D"
                     /protein_id="NP_001188560.1"
                     /db_xref="FLYBASE:FBpp0292852"
                     /db_xref="GeneID:44111"
                     /db_xref="FLYBASE:FBgn0030018"
                     /translation="MLPISEEQQLQQQQQQQQLEQLHHPQIPEIPIPDLEQVETQVGD
                     GSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFV
                     TDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQ
                     TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAG
                     KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKIT
                     DFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKG
                     FDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACS
                     KFTLTPQESFHYMQECWRKEIAGVLHDLREKEKELRNKEEQLLRVQNEQREKANLLKI
                     REQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAE
                     QPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSF
                     SKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPN
                     NNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLT
                     SQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSS
                     ETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPA
                     NGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTP
                     LTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAEVDTADAD
                     ADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFA
                     TYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRA
                     QEQRQQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDDHNDPQHQHHSAGSSKIRALFN
                     LFTRSRKKYSKLAEHNMVGGPEFCAIDPYQTDLAMGGSSRSLKRKGKKPQTQSCEQLE
                     RC"
     misc_feature    734..907
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="Src Homology 3 domain of Mixed Lineage Kinases;
                     Region: SH3_MLK; cd11876"
                     /db_xref="CDD:212809"
     misc_feature    order(749..751,755..757,764..766,776..778,845..850,
                     887..889,893..898)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212809"
     misc_feature    995..1762
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mixed Lineage Kinases; Region: STKc_MLK; cd14061"
                     /db_xref="CDD:270963"
     misc_feature    order(998..1012,1022..1024,1055..1057,1061..1063,
                     1160..1162,1205..1216,1226..1228,1232..1234,1346..1348,
                     1352..1354,1358..1363,1367..1369,1424..1426,1433..1435,
                     1475..1486)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="active site"
                     /db_xref="CDD:270963"
     misc_feature    order(998..1012,1022..1024,1055..1057,1061..1063,
                     1160..1162,1205..1216,1226..1228,1346..1348,1352..1354,
                     1358..1363,1367..1369,1424..1426)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270963"
     misc_feature    order(1010..1012,1226..1228,1232..1234,1346..1348,
                     1352..1354,1358..1360,1433..1435,1475..1486)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270963"
     misc_feature    1421..1486
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270963"
ORIGIN      
        1 agtacatttg cgaatggaac tagtataaat gcagcaactg gtttatgtga gccacaacaa
       61 aatgatcgac aaaaccttgt tctaccacaa atattaacaa ttaccaatat aaagaaacgg
      121 gctaataaaa cggatataac cgattgcaca ggatcaagga tagatcaaaa taaccgacga
      181 cgttaacggc gactgcgact gcgagagagc gaccatggtg tgcagcagcg cgtgtgcgtg
      241 tgtgtgtgtt ttgtaccgtg ttgtctgatt gtgtgccgtt gttgttgtga ttgttgttct
      301 cgctgttgct attgtttttg ctcttgtgcg tgtggtcaac ggacggacag acggacggac
      361 agtgggacac aaggagagtg gagaatccga atccggtggg caggagagca ggattagccg
      421 caacatcctt accccgaaac aaaagcaagt taaaaagcga aggaagcaaa gagaaaacaa
      481 caaaaaagga aaagaagcag aaaacaaaaa caaagaagag attcatggtt tccatgtcgc
      541 caactgtgcg cctctgatgc cctcgcaggt ctcccgagga ttggacacca ccaacatgct
      601 gccgatcagc gaggagcagc agctgcaaca gcagcagcag cagcagcagt tagagcaact
      661 gcatcatccg cagataccag agattcccat accagatcta gagcaagtcg agacccaggt
      721 gggcgatggc agcctgtgga ccgcgctgta tgactacgat gcccagggcg aggatgagct
      781 gacactgcga cgcggcgaaa tcgttgtggt cctgtccacg gacagcgagg tgtctggcga
      841 tgtgggctgg tggaccggca agattggaga taaggtcggt gtctttccca aggactttgt
      901 caccgatgag gacccactgc aactgaatgt ctcgtccgcc attggcgaca tccagccgca
      961 tgagatcgaa tacaatgagc tggacatcaa ggaagttatc ggctccggtg gcttctgcaa
     1021 ggtccatcgt ggctactacg atggcgagga ggtggctatt aagattgccc atcaaacggg
     1081 cgaggatgat atgcagagga tgcgggacaa tgtcctgcag gaggccaaac tgttttgggc
     1141 cctcaagcac gaaaatatag cagccctgcg aggagtatgt ctgaatacca aactctgtct
     1201 ggtgatggag tatgccaggg gaggaagtct caatcgcata ctggctggca agataccacc
     1261 cgatgtacta gtcaactggg ccattcagat agccagaggc atgaactatc tgcacaatga
     1321 ggcgcccatg tcgatcatac atcgcgacct caagtcctcc aatgtgctga tctacgaggc
     1381 catcgagggc aatcatctgc agcagaagac gctcaagatc acggatttcg gtttggccag
     1441 ggagatgtac aacacgcaga ggatgagtgc ggcgggcacg tacgcttgga tgccaccgga
     1501 ggtcatcagc gttagcacct attccaaatt ctccgatgtt tggagctacg gtgtcttgct
     1561 gtgggaactg ataacgggcg agacgcccta caagggcttc gatccgttgt ccgtggccta
     1621 tggcgtggct gttaacacgc tgacattgcc cataccaaaa acctgccccg agacgtgggg
     1681 agccctgatg aagagctgct ggcaaacgga tccgcacaag cgaccgggct tcaaggagat
     1741 tctcaaacag ctggagagca tcgcatgctc caaattcacc ctaacgcccc aggagtcgtt
     1801 tcactacatg caggaatgct ggcgaaagga gatcgctgga gtgctacacg atttgcgcga
     1861 aaaagaaaag gaactgcgca acaaggaaga gcagctgctc agggtgcaaa acgagcagcg
     1921 cgaaaaggcg aatctcctga agatccggga gcagaatctg cgcgagcgtg aaagagtgtt
     1981 gatcgaacgg gagcttgtca tgttgcagcc ggtgccatcg aaacgcaaac acaaaaaggg
     2041 caaaaagaac aaaccactgc agatatcgct gcccacgggc ttccggcaca cgattacggc
     2101 tgtacgcgac aaggcggaac agccgggatc accttccttc tccggattgc gcatcgtggc
     2161 actgaccgat gggcacaagg gcaagacgtg gggcccgtcg acgatgcacc agcgggagcg
     2221 atccctattg ccttcgcaac tgagcggcgg tcagccggaa tggcccgccc agacctcaac
     2281 tcactcctca ttcagcaaga gtgctccgaa tctggacaag aagcagcagc agcagaacca
     2341 gcaacaggtg gcctcgctga caccgccgcc gggtttggga attttgggtg gaagtggagg
     2401 cgctggtggg acgccggcca caccattgtt gtacccaggt atacccatta tactaacgcg
     2461 ccccaacaac aacaacattg gcaattgtaa agccatcacc accaccatca caactaccac
     2521 caccacaacc accaacaaca acaacaacaa caacaacagc atctccgcca acaacaacaa
     2581 tcagctaaat aatattagta ctattaatag caataacaat aacaatcaaa ctaacctgac
     2641 ctcccaaccg aacacgataa ttgtcctcca aaacggccgg aacaactcca acagcagcac
     2701 caccagtcaa tccccagcca agatctacca tcgcgccagg agccaggagt acggacttga
     2761 tcatccgctt gcttatcagc caccaccact ctatttggta acggatgaca gctcggaaac
     2821 ggacaccgtt gccagtccga ccggttgctt tcacttcctg aagtccggca attcatcggc
     2881 ggccagtggt gccgtgcatc tgcatcgctt tggcggcagt ctgggcaaca gtccagctgt
     2941 gggcagaaag aagcattcgc tggacagcag cagtcatcat ccgcctgcga acggtagcaa
     3001 tagctttgca ctgcccaacc agttaactct gccatcggag gataacaata cgtatgacca
     3061 tgccttctat cgggatgtga tcaaaaagat gtccatggcc agcagcgaaa gggtaaactc
     3121 caaatccagt ggcgacctga ccatgtacaa ctccagcaca ccgctgactg ccagggattg
     3181 cgatgatgcg gaggaggcct tcgagggtgg acgctttcag cgtaactttt ccggctcgca
     3241 gtttccacgg cactgcttct tcaccaggca ggaggaggaa ggggaagcag aggatgagga
     3301 cgcggtggcg gcggaggtgg acacagcaga tgcggatgcc gacgatgagt gtcaagtgcc
     3361 cgccagtcag atgcgccaga actccaccac gtcgcgcaag agttcagtga ccttccagag
     3421 cgtcagtttc gaagagcccg attttgtggc cacgccgcga acgactgcca gatcggatct
     3481 atatacatcc agtgcctcaa ttagcttcgc cacctaccgc tccgcctcgc catcgctgtc
     3541 ctcatcgtcc accactgcgt ccgcctcacc gtccattgct tctacggaag ccgtgaacgg
     3601 ctatcacatg caggagaact ccatactgaa tacgcgtcgg atgcaagatg ttcagccgca
     3661 tcccgatgtc attaagctgc gggcccagga acagcgccag cagaccaaga accaaaagaa
     3721 gcaacggccc aagcacataa ccaaatccaa gtctgttgag gcgccagtcg agggacagca
     3781 ccatgaacat gatgaccaca atgatcccca gcaccagcat cactcggctg gatcgagcaa
     3841 aatccgtgcc cttttcaatc tctttacgcg ctcgcgaaag aagtacagca agctggcgga
     3901 gcacaacatg gtcggtggac ccgagttctg tgccattgat ccctatcaaa ccgatttggc
     3961 gatggggggc agcagtcgct ctttgaagcg caaaggcaaa aagccgcaga cgcaatcctg
     4021 cgagcaactg gagcgatgct aaagtcccag ttgtgcgccg tgctgcagtg ttgctgttgg
     4081 agttggccgc cagatgagaa ccgcctaatt agctcattgt tttatattaa aactgtagac
     4141 taagtcagac gcaaaggaag agcgaagaga tgaaacagca ggcgaggatt agccatagct
     4201 aatgtgtgaa attagtaggg cccagagata cagataccta tccgaattct ttccgtctaa
     4261 cgaaatcata gaactaaaca aaaaacccct ctgtccgcgg ttggcatttc ataataaccg
     4321 aattgttcct aacgaatgca atatgttgtg cgaaattcac aaatcaagtt aatccctaat
     4381 tagtccagtg atttgttttg tttttttttt tgtgccagag gagtggctag aaaattgcaa
     4441 tgtgtagcac agaagtgagg acgaactttt gaggatcaaa cggatagata gactaacgcc
     4501 gcttgtacgt agacaaacag acacggagag aaaaaacgtg tgcatgggcc aatggcaaaa
     4561 tatattgaac taaaccatat acataaatgt gtaacaattg gattaacatt aagctatatt
     4621 tataccgatg cgtaagtgcg tccttacaca ttacacatta cacacatctt agttgaacta
     4681 agttctagtt ttgtaggaac tcgaacattt ttttggagtc cttcctcctt ttttttcacc
     4741 ccctcaatct ttgtaagaga tattttccaa aatttccatc gcttgcggca tttcgtttgg
     4801 cttaagtaca cttaacgaaa agttgcggtg cacattaatt ttaatttgat attcgacttt
     4861 tttggtattt tgagcacagt tttatttaca tacatttatt atgcaatcgg gttttccatt
     4921 ttatttattt atgatttatt tctac