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Drosophila melanogaster slipper (slpr), transcript variant C, mRNA.


LOCUS       NM_001201630            5594 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001201630
VERSION     NM_001201630.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5594)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5594)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5594)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5594)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5594)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5594)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5594)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5594)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5594)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5594)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5594)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5594)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5594)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5594)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5594)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5594)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5594)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5594)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5594)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5594)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5594)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5594)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5594)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001201630.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5594
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5594
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="slipper"
                     /map="7D17-7D17"
                     /db_xref="FLYBASE:FBgn0030018"
                     /db_xref="GeneID:44111"
     CDS             795..4241
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /EC_number="2.7.11.25"
                     /note="CG2272 gene product from transcript CG2272-RC;
                     CG2272-PC; slpr-PC; mixed lineage protein kinase 2;
                     slipper"
                     /codon_start=1
                     /product="slipper, isoform C"
                     /protein_id="NP_001188559.1"
                     /db_xref="FLYBASE:FBpp0292851"
                     /db_xref="GeneID:44111"
                     /db_xref="FLYBASE:FBgn0030018"
                     /translation="MLPISEEQQLQQQQQQQQLEQLHHPQIPEIPIPDLEQVETQVGD
                     GSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFV
                     TDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQ
                     TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAG
                     KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKIT
                     DFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKG
                     FDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACS
                     KFTLTPQESFHYMQECWRKEIAGVLHDLREKEKELRNKEEQLLRVQNEQREKANLLKI
                     REQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAE
                     QPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSF
                     SKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPN
                     NNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLT
                     SQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSS
                     ETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPA
                     NGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTP
                     LTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAEVDTADAD
                     ADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFA
                     TYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRA
                     QEQRQQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDDHNDPQHQHHSAGSSKIRALFN
                     LFTRSRKKYSKLAEHNMVGGPEFCAIDPYQTDLAMGGSSRSLKRKGKKPQTQSCEQLE
                     RC"
     misc_feature    933..1106
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="Src Homology 3 domain of Mixed Lineage Kinases;
                     Region: SH3_MLK; cd11876"
                     /db_xref="CDD:212809"
     misc_feature    order(948..950,954..956,963..965,975..977,1044..1049,
                     1086..1088,1092..1097)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212809"
     misc_feature    1194..1961
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mixed Lineage Kinases; Region: STKc_MLK; cd14061"
                     /db_xref="CDD:270963"
     misc_feature    order(1197..1211,1221..1223,1254..1256,1260..1262,
                     1359..1361,1404..1415,1425..1427,1431..1433,1545..1547,
                     1551..1553,1557..1562,1566..1568,1623..1625,1632..1634,
                     1674..1685)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="active site"
                     /db_xref="CDD:270963"
     misc_feature    order(1197..1211,1221..1223,1254..1256,1260..1262,
                     1359..1361,1404..1415,1425..1427,1545..1547,1551..1553,
                     1557..1562,1566..1568,1623..1625)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270963"
     misc_feature    order(1209..1211,1425..1427,1431..1433,1545..1547,
                     1551..1553,1557..1559,1632..1634,1674..1685)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270963"
     misc_feature    1620..1685
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270963"
ORIGIN      
        1 agtacatttg cgaatggaac tagtataaat gcagcaactg gtttatgtga gccacaacaa
       61 aatgatcgac aaaaccttgt tctaccacaa atattaacaa ttaccaatat aaaggtattt
      121 aaacaactac cttgatcaca attttagtta aaattatgcc aacgaactgg aaccaaaatc
      181 ccaggtgaac cgcaaatgta accagttcac tcggctgggt ccaaagacca gttcaattaa
      241 actagttcac atttgaacag tgcaactcta gttttttttt tttaatacat atgtgtttaa
      301 aaaacatatg cagaaacggg ctaataaaac ggatataacc gattgcacag gatcaaggat
      361 agatcaaaat aaccgacgac gttaacggcg actgcgactg cgagagagcg accatggtgt
      421 gcagcagcgc gtgtgcgtgt gtgtgtgttt tgtaccgtgt tgtctgattg tgtgccgttg
      481 ttgttgtgat tgttgttctc gctgttgcta ttgtttttgc tcttgtgcgt gtggtcaacg
      541 gacggacaga cggacggaca gtgggacaca aggagagtgg agaatccgaa tccggtgggc
      601 aggagagcag gattagccgc aacatcctta ccccgaaaca aaagcaagtt aaaaagcgaa
      661 ggaagcaaag agaaaacaac aaaaaaggaa aagaagcaga aaacaaaaac aaagaagaga
      721 ttcatggttt ccatgtcgcc aactgtgcgc ctctgatgcc ctcgcaggtc tcccgaggat
      781 tggacaccac caacatgctg ccgatcagcg aggagcagca gctgcaacag cagcagcagc
      841 agcagcagtt agagcaactg catcatccgc agataccaga gattcccata ccagatctag
      901 agcaagtcga gacccaggtg ggcgatggca gcctgtggac cgcgctgtat gactacgatg
      961 cccagggcga ggatgagctg acactgcgac gcggcgaaat cgttgtggtc ctgtccacgg
     1021 acagcgaggt gtctggcgat gtgggctggt ggaccggcaa gattggagat aaggtcggtg
     1081 tctttcccaa ggactttgtc accgatgagg acccactgca actgaatgtc tcgtccgcca
     1141 ttggcgacat ccagccgcat gagatcgaat acaatgagct ggacatcaag gaagttatcg
     1201 gctccggtgg cttctgcaag gtccatcgtg gctactacga tggcgaggag gtggctatta
     1261 agattgccca tcaaacgggc gaggatgata tgcagaggat gcgggacaat gtcctgcagg
     1321 aggccaaact gttttgggcc ctcaagcacg aaaatatagc agccctgcga ggagtatgtc
     1381 tgaataccaa actctgtctg gtgatggagt atgccagggg aggaagtctc aatcgcatac
     1441 tggctggcaa gataccaccc gatgtactag tcaactgggc cattcagata gccagaggca
     1501 tgaactatct gcacaatgag gcgcccatgt cgatcataca tcgcgacctc aagtcctcca
     1561 atgtgctgat ctacgaggcc atcgagggca atcatctgca gcagaagacg ctcaagatca
     1621 cggatttcgg tttggccagg gagatgtaca acacgcagag gatgagtgcg gcgggcacgt
     1681 acgcttggat gccaccggag gtcatcagcg ttagcaccta ttccaaattc tccgatgttt
     1741 ggagctacgg tgtcttgctg tgggaactga taacgggcga gacgccctac aagggcttcg
     1801 atccgttgtc cgtggcctat ggcgtggctg ttaacacgct gacattgccc ataccaaaaa
     1861 cctgccccga gacgtgggga gccctgatga agagctgctg gcaaacggat ccgcacaagc
     1921 gaccgggctt caaggagatt ctcaaacagc tggagagcat cgcatgctcc aaattcaccc
     1981 taacgcccca ggagtcgttt cactacatgc aggaatgctg gcgaaaggag atcgctggag
     2041 tgctacacga tttgcgcgaa aaagaaaagg aactgcgcaa caaggaagag cagctgctca
     2101 gggtgcaaaa cgagcagcgc gaaaaggcga atctcctgaa gatccgggag cagaatctgc
     2161 gcgagcgtga aagagtgttg atcgaacggg agcttgtcat gttgcagccg gtgccatcga
     2221 aacgcaaaca caaaaagggc aaaaagaaca aaccactgca gatatcgctg cccacgggct
     2281 tccggcacac gattacggct gtacgcgaca aggcggaaca gccgggatca ccttccttct
     2341 ccggattgcg catcgtggca ctgaccgatg ggcacaaggg caagacgtgg ggcccgtcga
     2401 cgatgcacca gcgggagcga tccctattgc cttcgcaact gagcggcggt cagccggaat
     2461 ggcccgccca gacctcaact cactcctcat tcagcaagag tgctccgaat ctggacaaga
     2521 agcagcagca gcagaaccag caacaggtgg cctcgctgac accgccgccg ggtttgggaa
     2581 ttttgggtgg aagtggaggc gctggtggga cgccggccac accattgttg tacccaggta
     2641 tacccattat actaacgcgc cccaacaaca acaacattgg caattgtaaa gccatcacca
     2701 ccaccatcac aactaccacc accacaacca ccaacaacaa caacaacaac aacaacagca
     2761 tctccgccaa caacaacaat cagctaaata atattagtac tattaatagc aataacaata
     2821 acaatcaaac taacctgacc tcccaaccga acacgataat tgtcctccaa aacggccgga
     2881 acaactccaa cagcagcacc accagtcaat ccccagccaa gatctaccat cgcgccagga
     2941 gccaggagta cggacttgat catccgcttg cttatcagcc accaccactc tatttggtaa
     3001 cggatgacag ctcggaaacg gacaccgttg ccagtccgac cggttgcttt cacttcctga
     3061 agtccggcaa ttcatcggcg gccagtggtg ccgtgcatct gcatcgcttt ggcggcagtc
     3121 tgggcaacag tccagctgtg ggcagaaaga agcattcgct ggacagcagc agtcatcatc
     3181 cgcctgcgaa cggtagcaat agctttgcac tgcccaacca gttaactctg ccatcggagg
     3241 ataacaatac gtatgaccat gccttctatc gggatgtgat caaaaagatg tccatggcca
     3301 gcagcgaaag ggtaaactcc aaatccagtg gcgacctgac catgtacaac tccagcacac
     3361 cgctgactgc cagggattgc gatgatgcgg aggaggcctt cgagggtgga cgctttcagc
     3421 gtaacttttc cggctcgcag tttccacggc actgcttctt caccaggcag gaggaggaag
     3481 gggaagcaga ggatgaggac gcggtggcgg cggaggtgga cacagcagat gcggatgccg
     3541 acgatgagtg tcaagtgccc gccagtcaga tgcgccagaa ctccaccacg tcgcgcaaga
     3601 gttcagtgac cttccagagc gtcagtttcg aagagcccga ttttgtggcc acgccgcgaa
     3661 cgactgccag atcggatcta tatacatcca gtgcctcaat tagcttcgcc acctaccgct
     3721 ccgcctcgcc atcgctgtcc tcatcgtcca ccactgcgtc cgcctcaccg tccattgctt
     3781 ctacggaagc cgtgaacggc tatcacatgc aggagaactc catactgaat acgcgtcgga
     3841 tgcaagatgt tcagccgcat cccgatgtca ttaagctgcg ggcccaggaa cagcgccagc
     3901 agaccaagaa ccaaaagaag caacggccca agcacataac caaatccaag tctgttgagg
     3961 cgccagtcga gggacagcac catgaacatg atgaccacaa tgatccccag caccagcatc
     4021 actcggctgg atcgagcaaa atccgtgccc ttttcaatct ctttacgcgc tcgcgaaaga
     4081 agtacagcaa gctggcggag cacaacatgg tcggtggacc cgagttctgt gccattgatc
     4141 cctatcaaac cgatttggcg atggggggca gcagtcgctc tttgaagcgc aaaggcaaaa
     4201 agccgcagac gcaatcctgc gagcaactgg agcgatgcta aagtcccagt tgtgcgccgt
     4261 gctgcagtgt tgctgttgga gttggccgcc agatgagaac cgcctaatta gctcattgtt
     4321 ttatattaaa actgtagact aagtcagacg caaaggaaga gcgaagagat gaaacagcag
     4381 gcgaggatta gccatagcta atgtgtgaaa ttagtagggc ccagagatac agatacctat
     4441 ccgaattctt tccgtctaac gaaatcatag aactaaacaa aaaacccctc tgtccgcggt
     4501 tggcatttca taataaccga attgttccta acgaatgcaa tatgttgtgc gaaattcaca
     4561 aatcaagtta atccctaatt agtccagtga tttgttttgt tttttttttt gtgccagagg
     4621 agtggctaga aaattgcaat gtgtagcaca gaagtgagga cgaacttttg aggatcaaac
     4681 ggatagatag actaacgccg cttgtacgta gacaaacaga cacggagaga aaaaacgtgt
     4741 gcatgggcca atggcaaaat atattgaact aaaccatata cataaatgtg taacaattgg
     4801 attaacatta agctatattt ataccgatgc gtaagtgcgt ccttacacat tacacattac
     4861 acacatctta gttgaactaa gttctagttt tgtaggaact cgaacatttt tttggagtcc
     4921 ttcctccttt tttttcaccc cctcaatctt tgtaagagat attttccaaa atttccatcg
     4981 cttgcggcat ttcgtttggc ttaagtacac ttaacgaaaa gttgcggtgc acattaattt
     5041 taatttgata ttcgactttt ttggtatttt gagcacagtt ttatttacat acatttatta
     5101 tgcaatcggg ttttccattt tatttattta tgatttattt ctacaaaaaa aaaaaaaaaa
     5161 aagcacaaga ataatcgcgc aaaagaaaga aagaaaaaaa aacctgtgat caaaaaacga
     5221 tgatgaaacg aaaaggaaat gatcattttt ttgtattatt tttatgaaaa ctttcaattg
     5281 tatatttata cttcatttta cgatttgttc attctacgtt tagtgctcga ttctatttca
     5341 atgtactttg tatattattg tattttccat gttggggcca agccaacccc aaaaaaaaaa
     5401 acaaacaaaa aaaaaagaag aaccaatacc cagaaacaga aatccgacaa taaaaccaac
     5461 ttaagacaat ctgccgacca gttttgattg cctcgcagct aaaaagcaca gagaaagtcc
     5521 aatgatccaa actaacattt aaattactta aacttattta aagtgaagct atcttttaat
     5581 gtcaatttaa cgtg