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Drosophila melanogaster slipper (slpr), transcript variant B, mRNA.


LOCUS       NM_001201629            5165 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001201629
VERSION     NM_001201629.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5165)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5165)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5165)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5165)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5165)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5165)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5165)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5165)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5165)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5165)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5165)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5165)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5165)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5165)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5165)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5165)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5165)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5165)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5165)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5165)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5165)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5165)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5165)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001201629.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5165
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5165
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="slipper"
                     /map="7D17-7D17"
                     /db_xref="FLYBASE:FBgn0030018"
                     /db_xref="GeneID:44111"
     CDS             795..4262
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /EC_number="2.7.11.25"
                     /note="CG2272 gene product from transcript CG2272-RB;
                     CG2272-PB; slpr-PB; mixed lineage protein kinase 2;
                     slipper"
                     /codon_start=1
                     /product="slipper, isoform B"
                     /protein_id="NP_001188558.1"
                     /db_xref="FLYBASE:FBpp0292850"
                     /db_xref="GeneID:44111"
                     /db_xref="FLYBASE:FBgn0030018"
                     /translation="MLPISEEQQLQQQQQQQQLEQLHHPQIPEIPIPDLEQVETQVGD
                     GSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFV
                     TDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQ
                     TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAG
                     KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKIT
                     DFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKG
                     FDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACS
                     KFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQRE
                     KANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTIT
                     AVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQ
                     TSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIP
                     IILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNN
                     NNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLY
                     LVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDS
                     SSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLT
                     MYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAE
                     VDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTS
                     SASISFATYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHP
                     DVIKLRAQEQRQQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDDHNDPQHQHHSAGSS
                     KIRALFNLFTRSRKKYSKLAEHNMVGGPEFCAIDPYQTDLAMGGSSRSLKRKGKKPQT
                     QSCEQLERC"
     misc_feature    933..1106
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="Src Homology 3 domain of Mixed Lineage Kinases;
                     Region: SH3_MLK; cd11876"
                     /db_xref="CDD:212809"
     misc_feature    order(948..950,954..956,963..965,975..977,1044..1049,
                     1086..1088,1092..1097)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212809"
     misc_feature    1194..1961
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="Catalytic domain of the Serine/Threonine Kinases,
                     Mixed Lineage Kinases; Region: STKc_MLK; cd14061"
                     /db_xref="CDD:270963"
     misc_feature    order(1197..1211,1221..1223,1254..1256,1260..1262,
                     1359..1361,1404..1415,1425..1427,1431..1433,1545..1547,
                     1551..1553,1557..1562,1566..1568,1623..1625,1632..1634,
                     1674..1685)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="active site"
                     /db_xref="CDD:270963"
     misc_feature    order(1197..1211,1221..1223,1254..1256,1260..1262,
                     1359..1361,1404..1415,1425..1427,1545..1547,1551..1553,
                     1557..1562,1566..1568,1623..1625)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="ATP binding site [chemical binding]; other site"
                     /db_xref="CDD:270963"
     misc_feature    order(1209..1211,1425..1427,1431..1433,1545..1547,
                     1551..1553,1557..1559,1632..1634,1674..1685)
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="polypeptide substrate binding site [polypeptide
                     binding]; other site"
                     /db_xref="CDD:270963"
     misc_feature    1620..1685
                     /gene="slpr"
                     /locus_tag="Dmel_CG2272"
                     /gene_synonym="CG2272; D-MLK; Dmel\CG2272; dMLK; dMLK2;
                     Jnkkk; JNKKK; Mlk; MLK; Mlk2; MLK2; Slpr"
                     /note="activation loop (A-loop); other site"
                     /db_xref="CDD:270963"
ORIGIN      
        1 agtacatttg cgaatggaac tagtataaat gcagcaactg gtttatgtga gccacaacaa
       61 aatgatcgac aaaaccttgt tctaccacaa atattaacaa ttaccaatat aaaggtattt
      121 aaacaactac cttgatcaca attttagtta aaattatgcc aacgaactgg aaccaaaatc
      181 ccaggtgaac cgcaaatgta accagttcac tcggctgggt ccaaagacca gttcaattaa
      241 actagttcac atttgaacag tgcaactcta gttttttttt tttaatacat atgtgtttaa
      301 aaaacatatg cagaaacggg ctaataaaac ggatataacc gattgcacag gatcaaggat
      361 agatcaaaat aaccgacgac gttaacggcg actgcgactg cgagagagcg accatggtgt
      421 gcagcagcgc gtgtgcgtgt gtgtgtgttt tgtaccgtgt tgtctgattg tgtgccgttg
      481 ttgttgtgat tgttgttctc gctgttgcta ttgtttttgc tcttgtgcgt gtggtcaacg
      541 gacggacaga cggacggaca gtgggacaca aggagagtgg agaatccgaa tccggtgggc
      601 aggagagcag gattagccgc aacatcctta ccccgaaaca aaagcaagtt aaaaagcgaa
      661 ggaagcaaag agaaaacaac aaaaaaggaa aagaagcaga aaacaaaaac aaagaagaga
      721 ttcatggttt ccatgtcgcc aactgtgcgc ctctgatgcc ctcgcaggtc tcccgaggat
      781 tggacaccac caacatgctg ccgatcagcg aggagcagca gctgcaacag cagcagcagc
      841 agcagcagtt agagcaactg catcatccgc agataccaga gattcccata ccagatctag
      901 agcaagtcga gacccaggtg ggcgatggca gcctgtggac cgcgctgtat gactacgatg
      961 cccagggcga ggatgagctg acactgcgac gcggcgaaat cgttgtggtc ctgtccacgg
     1021 acagcgaggt gtctggcgat gtgggctggt ggaccggcaa gattggagat aaggtcggtg
     1081 tctttcccaa ggactttgtc accgatgagg acccactgca actgaatgtc tcgtccgcca
     1141 ttggcgacat ccagccgcat gagatcgaat acaatgagct ggacatcaag gaagttatcg
     1201 gctccggtgg cttctgcaag gtccatcgtg gctactacga tggcgaggag gtggctatta
     1261 agattgccca tcaaacgggc gaggatgata tgcagaggat gcgggacaat gtcctgcagg
     1321 aggccaaact gttttgggcc ctcaagcacg aaaatatagc agccctgcga ggagtatgtc
     1381 tgaataccaa actctgtctg gtgatggagt atgccagggg aggaagtctc aatcgcatac
     1441 tggctggcaa gataccaccc gatgtactag tcaactgggc cattcagata gccagaggca
     1501 tgaactatct gcacaatgag gcgcccatgt cgatcataca tcgcgacctc aagtcctcca
     1561 atgtgctgat ctacgaggcc atcgagggca atcatctgca gcagaagacg ctcaagatca
     1621 cggatttcgg tttggccagg gagatgtaca acacgcagag gatgagtgcg gcgggcacgt
     1681 acgcttggat gccaccggag gtcatcagcg ttagcaccta ttccaaattc tccgatgttt
     1741 ggagctacgg tgtcttgctg tgggaactga taacgggcga gacgccctac aagggcttcg
     1801 atccgttgtc cgtggcctat ggcgtggctg ttaacacgct gacattgccc ataccaaaaa
     1861 cctgccccga gacgtgggga gccctgatga agagctgctg gcaaacggat ccgcacaagc
     1921 gaccgggctt caaggagatt ctcaaacagc tggagagcat cgcatgctcc aaattcaccc
     1981 taacgcccca ggagtcgttt cactacatgc aggaatgctg gcgaaaggag atcgctggag
     2041 tgctacacga tttgcgcgaa aaagaaaagc gtttccaaac catcgaagag gaactgcgca
     2101 acaaggaaga gcagctgctc agggtgcaaa acgagcagcg cgaaaaggcg aatctcctga
     2161 agatccggga gcagaatctg cgcgagcgtg aaagagtgtt gatcgaacgg gagcttgtca
     2221 tgttgcagcc ggtgccatcg aaacgcaaac acaaaaaggg caaaaagaac aaaccactgc
     2281 agatatcgct gcccacgggc ttccggcaca cgattacggc tgtacgcgac aaggcggaac
     2341 agccgggatc accttccttc tccggattgc gcatcgtggc actgaccgat gggcacaagg
     2401 gcaagacgtg gggcccgtcg acgatgcacc agcgggagcg atccctattg ccttcgcaac
     2461 tgagcggcgg tcagccggaa tggcccgccc agacctcaac tcactcctca ttcagcaaga
     2521 gtgctccgaa tctggacaag aagcagcagc agcagaacca gcaacaggtg gcctcgctga
     2581 caccgccgcc gggtttggga attttgggtg gaagtggagg cgctggtggg acgccggcca
     2641 caccattgtt gtacccaggt atacccatta tactaacgcg ccccaacaac aacaacattg
     2701 gcaattgtaa agccatcacc accaccatca caactaccac caccacaacc accaacaaca
     2761 acaacaacaa caacaacagc atctccgcca acaacaacaa tcagctaaat aatattagta
     2821 ctattaatag caataacaat aacaatcaaa ctaacctgac ctcccaaccg aacacgataa
     2881 ttgtcctcca aaacggccgg aacaactcca acagcagcac caccagtcaa tccccagcca
     2941 agatctacca tcgcgccagg agccaggagt acggacttga tcatccgctt gcttatcagc
     3001 caccaccact ctatttggta acggatgaca gctcggaaac ggacaccgtt gccagtccga
     3061 ccggttgctt tcacttcctg aagtccggca attcatcggc ggccagtggt gccgtgcatc
     3121 tgcatcgctt tggcggcagt ctgggcaaca gtccagctgt gggcagaaag aagcattcgc
     3181 tggacagcag cagtcatcat ccgcctgcga acggtagcaa tagctttgca ctgcccaacc
     3241 agttaactct gccatcggag gataacaata cgtatgacca tgccttctat cgggatgtga
     3301 tcaaaaagat gtccatggcc agcagcgaaa gggtaaactc caaatccagt ggcgacctga
     3361 ccatgtacaa ctccagcaca ccgctgactg ccagggattg cgatgatgcg gaggaggcct
     3421 tcgagggtgg acgctttcag cgtaactttt ccggctcgca gtttccacgg cactgcttct
     3481 tcaccaggca ggaggaggaa ggggaagcag aggatgagga cgcggtggcg gcggaggtgg
     3541 acacagcaga tgcggatgcc gacgatgagt gtcaagtgcc cgccagtcag atgcgccaga
     3601 actccaccac gtcgcgcaag agttcagtga ccttccagag cgtcagtttc gaagagcccg
     3661 attttgtggc cacgccgcga acgactgcca gatcggatct atatacatcc agtgcctcaa
     3721 ttagcttcgc cacctaccgc tccgcctcgc catcgctgtc ctcatcgtcc accactgcgt
     3781 ccgcctcacc gtccattgct tctacggaag ccgtgaacgg ctatcacatg caggagaact
     3841 ccatactgaa tacgcgtcgg atgcaagatg ttcagccgca tcccgatgtc attaagctgc
     3901 gggcccagga acagcgccag cagaccaaga accaaaagaa gcaacggccc aagcacataa
     3961 ccaaatccaa gtctgttgag gcgccagtcg agggacagca ccatgaacat gatgaccaca
     4021 atgatcccca gcaccagcat cactcggctg gatcgagcaa aatccgtgcc cttttcaatc
     4081 tctttacgcg ctcgcgaaag aagtacagca agctggcgga gcacaacatg gtcggtggac
     4141 ccgagttctg tgccattgat ccctatcaaa ccgatttggc gatggggggc agcagtcgct
     4201 ctttgaagcg caaaggcaaa aagccgcaga cgcaatcctg cgagcaactg gagcgatgct
     4261 aaagtcccag ttgtgcgccg tgctgcagtg ttgctgttgg agttggccgc cagatgagaa
     4321 ccgcctaatt agctcattgt tttatattaa aactgtagac taagtcagac gcaaaggaag
     4381 agcgaagaga tgaaacagca ggcgaggatt agccatagct aatgtgtgaa attagtaggg
     4441 cccagagata cagataccta tccgaattct ttccgtctaa cgaaatcata gaactaaaca
     4501 aaaaacccct ctgtccgcgg ttggcatttc ataataaccg aattgttcct aacgaatgca
     4561 atatgttgtg cgaaattcac aaatcaagtt aatccctaat tagtccagtg atttgttttg
     4621 tttttttttt tgtgccagag gagtggctag aaaattgcaa tgtgtagcac agaagtgagg
     4681 acgaactttt gaggatcaaa cggatagata gactaacgcc gcttgtacgt agacaaacag
     4741 acacggagag aaaaaacgtg tgcatgggcc aatggcaaaa tatattgaac taaaccatat
     4801 acataaatgt gtaacaattg gattaacatt aagctatatt tataccgatg cgtaagtgcg
     4861 tccttacaca ttacacatta cacacatctt agttgaacta agttctagtt ttgtaggaac
     4921 tcgaacattt ttttggagtc cttcctcctt ttttttcacc ccctcaatct ttgtaagaga
     4981 tattttccaa aatttccatc gcttgcggca tttcgtttgg cttaagtaca cttaacgaaa
     5041 agttgcggtg cacattaatt ttaatttgat attcgacttt tttggtattt tgagcacagt
     5101 tttatttaca tacatttatt atgcaatcgg gttttccatt ttatttattt atgatttatt
     5161 tctac