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LOCUS NM_001201618 2060 bp mRNA linear INV 26-DEC-2023 (MAPk-Ak2), transcript variant E, mRNA. ACCESSION NM_001201618 VERSION NM_001201618.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 2060) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 2060) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 2060) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 2060) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 2060) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 2060) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 2060) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 2060) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 2060) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 2060) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 2060) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 2060) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 2060) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 2060) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 2060) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 2060) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 2060) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 2060) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 2060) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 2060) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 2060) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 2060) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 2060) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..2060 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..2060 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="MAP kinase activated protein-kinase-2" /map="5B8-5B8" /db_xref="FLYBASE:FBgn0013987" /db_xref="GeneID:44573" CDS 173..1252 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /EC_number="2.7.11.17" /note="CG3086 gene product from transcript CG3086-RE; CG3086-PE; MAPk-Ak2-PE; MAP kinase-activated protein kinase 2; MAP kinase activated protein kinase-2" /codon_start=1 /product="MAP kinase activated protein-kinase-2, isoform E" /protein_id="NP_001188547.1" /db_xref="FLYBASE:FBpp0292066" /db_xref="GeneID:44573" /db_xref="FLYBASE:FBgn0013987" /translation="MLSLQNQRQPKTTPLTDDYVTSNTVLGYGINGKVVQCTHRRTQQ NYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFKDRKCLLVVMECMEGGEL FQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLLYTTTQPNATLK LTDFGFAKETFTSYTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGVVMYIIMCGFPP FYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPSKRLRIQDVI SNKWIAQYNAVPQTPLCTGRMLKEAEETWPEVQEEMTRSLATMRVDYDQMQIKALDKS NNPLLTKRRKKIEEMELYMANATRN" misc_feature 224..1012 /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; Region: STKc_MAPKAPK; cd14089" /db_xref="CDD:270991" misc_feature order(248..265,272..274,311..313,317..319,392..394, 452..463,473..475,479..481,593..598,602..604,608..613, 617..619,656..661,668..670,710..724,728..730) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="active site" /db_xref="CDD:270991" misc_feature order(248..265,272..274,311..313,317..319,392..394, 452..463,611..613,617..619,656..661) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="ATP binding site [chemical binding]; other site" /db_xref="CDD:270991" misc_feature order(260..262,473..475,479..481,593..598,602..604, 608..610,668..670,710..724,728..730) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270991" misc_feature order(656..688,698..724) /gene="MAPk-Ak2" /locus_tag="Dmel_CG3086" /gene_synonym="CG3086; Dmel\CG3086; dMK2; DmMAPKAPK-2; MAPKAP; MAPKAPK-2; MK2" /note="activation loop (A-loop); other site" /db_xref="CDD:270991" ORIGIN 1 ccgaccctca atgacgccga aatcgttaag caaataagtt gcccataaat cgttaaccaa 61 aattggcttt ccattcacga taacaatgaa aagaagcgtc ttgcaataat gaaatcaatt 121 taaagctttg tttaattgca caaaaacgaa ttaaagatca gccgattcca gaatgctttc 181 tctgcagaat caacggcaac cgaagaccac cccactgacg gacgactacg tgacctcgaa 241 cacggttctg ggctacggga tcaacgggaa ggtggtgcag tgcacccatc gccgcaccca 301 acagaactat gccctcaagg tgctgttgga cagtgaaagg gcgcgtcgcg aagtggacct 361 gcattggcgg gtcagcggat gccggtacat tgtgaacatc attgatgtgt acgagaacac 421 gtttaaggac aggaagtgcc tcctggtggt catggagtgc atggagggcg gcgagctctt 481 ccagagaatt caggacaagg ccgacggtgc ctttacggag cgggaggcgg cccagataat 541 gcacgagatc tgcgcggccg tagactatct gcacagtcgc gacatagcgc atcgcgatct 601 caagccggag aacttgctgt acaccaccac tcagccgaat gcgaccctta aattgacgga 661 ctttggcttc gccaaggaga cattcaccag ttacacgctg cagacgccct gctacactcc 721 ctattacgtg gctcctgagg ttctgggccc ggagaagtac gacaagagct gcgacatctg 781 gtcgctgggc gtggtgatgt acatcattat gtgcggattc ccgccgttct acagcaacca 841 cggcctagcc atatcgcccg gcatgaaaaa tcgcatccgc accggccagt atgactttcc 901 cgatccggag tggacgaatg tgagccaggc ggcaaaggat ctgatcaagg gcatgctgaa 961 cgtggacccc agcaagcgtc tgcgcatcca ggacgtcatt agcaacaagt ggattgccca 1021 gtacaatgct gttccacaga caccgctctg cacgggtcgc atgctaaagg aggccgagga 1081 aacctggccg gaagtgcagg aggagatgac gcgctcactg gccaccatgc gcgtagacta 1141 cgatcagatg caaatcaagg cgctggacaa gtcgaacaac ccgctgctga cgaagcgcag 1201 gaaaaagatc gaggagatgg agttatacat ggccaatgcg acgcgcaact agacaacgag 1261 gaatccagag cgactaacac ggccaacccg ggagtgagat gagatgagat gaggagagat 1321 gggcgtagga tgtaggatgg gcgaaccatc ggtttaacac ttaagcggat aacaatgttg 1381 tacaatgctt tacaaaaacg ataaatacta ctatactacg acggcggcaa gatctgctat 1441 taactaatat actacgatga cagcaacctt tgcaaaacaa ctactccatg ttattgttac 1501 gttacgtttt cttattcatt ttgtcccatt atctatctat ccatttccag tcaagggttc 1561 ttagggtatt ttgtagtctg aaaagtgctc ttttgtaaaa gaaactataa agcgtaatgc 1621 gcaaataacg aacttaagta aagccaagtg caagcctagc tagccagcca gcccagccga 1681 atattcaaaa tgtctcggta tcgcgtgaaa gtgtttcgtt tttcgattcc cttttttttt 1741 ttaaatatta ttttccaaaa acgtgtcatt tgtaaccgaa ccgtttttta cgtgtacgtg 1801 actttgatta taattatata tatatatgta tatgtataac cgtctgtgta tgtatggcat 1861 atgtgtggag aaacaattat acagccagtt cacgttagca ttaatctgcg caagattcag 1921 tgttgtttat aacttttatt tgctgattct gcaagcgata taccatttta ccgtatagca 1981 tatttgtagt ccataaacaa caagatcatc ccccaaatta ataaaaacaa atcaagctta 2041 ttttactatg attaaaacat