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Drosophila melanogaster enhanced adult sensory threshold (east),


LOCUS       NM_001201602            7579 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant D, mRNA.
ACCESSION   NM_001201602
VERSION     NM_001201602.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7579)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7579)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7579)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7579)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7579)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7579)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7579)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7579)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7579)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7579)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7579)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7579)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7579)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7579)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7579)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7579)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7579)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7579)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001201602.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7579
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7579
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="enhanced adult sensory threshold"
                     /map="2C2-2C4"
                     /db_xref="FLYBASE:FBgn0261954"
                     /db_xref="GeneID:46006"
     CDS             267..7172
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="CG4399 gene product from transcript CG4399-RD;
                     CG4399-PD; east-PD; enhanced adult salt tolerance;
                     suppressor of white-spotted"
                     /codon_start=1
                     /product="enhanced adult sensory threshold, isoform D"
                     /protein_id="NP_001188531.1"
                     /db_xref="FLYBASE:FBpp0292166"
                     /db_xref="GeneID:46006"
                     /db_xref="FLYBASE:FBgn0261954"
                     /translation="MSSRKVPGGSGGADESTAAAAPLDDNANASVEIPDSSEEPAMGV
                     GEEMSIISKTRTSTLSVEPAKEPTVTAELEGEKELESNPVSKTPRSTPTPTLTPAVTP
                     TASDGVAAKSVRVTRHSSPLLLIISPTTSRREVGDGELDTEEPTGSGGQRKSSVERSL
                     APVIRGRKSIKDLKEAKEVKSEEPPAAASESRAASGVTPGQVKEQHVADGNEMESLPI
                     TDKKDHKDTKDKGDERETDQEEEKEKSADTEIIADTEKTSEKQKYTEKDKAADKDGGK
                     EKDIDANKDIDKEKEKVKEVLPPVVPIAPVTPTCNRVTRKSHAQEQAINTRVTRNRRQ
                     SSTVGANSTASLVAASSSVTEQPPPSRGRRKKPVVVAPPLEPAVKRKRSQDVEADSDA
                     NNSTKYSKVEVVKSEEAEAPEEDSSAVPIKQESVDGNEVSSISPTVTPTPTPAPTPAP
                     VPGSRRGRGRPQNRNSSSPATTTRATRLSKAGSPVILTPVAQEPAPPKRRRVGSSTRK
                     TVSASSLAPSSQGGAGDEDSKDSMASSMDDLLMAAADIKQEKLTPDFDDSLMPEGLPS
                     TSGASSANGHSCTEPLTVDTEINVKPADSKVKPKESPVVAVEESPSQSETQSAKVSAH
                     AGKAPSLSPDMISEGVSAVSVRKFYKKPEFLENNLGIEKDPELGEIVQTVSNNDTETD
                     VEMAVDGEVNQPSTPKSQDKKKEEQEKNQKSGLKAAKKAPAKLEPKAEDISEILTDVP
                     VDISTEAVEIIEEAEEDTCSNSSIKPGELRLDESNDEPELLLEDALIVNGDENETPDQ
                     PEEKEDQVEFFHTGEYDDFEHEIMVELAKEGVLDASGNALSQQKVELEHPEDVTLHES
                     KNDIEAEESVERKPLKDPSVADEMEDMNEESYIDIKDQTNQLLVEHLAEEAMEADCGP
                     EDNKENLSTSASSTAADGLDIQLAIKEDDDEEKPLAVIADEQKPGLLLTNDMKVDEKP
                     NGKQESVCDEHVQLVPNLRQEQEIHLQNLGLLTHQAAEHRRKCLLEAQARQAQMQLQQ
                     HHHHQHKRQGARGGGSATHVESSGTLKTVIKLNRSSNGGVSGSGGLPTGTVIHGGCGS
                     SSASSTSSSSVGSATRKSSGTLGSGAGAGAGVRRQSLKMTFQKGRARGHGAADRSADQ
                     YGAHAEDSYYTIQNENEDSSHSESQGQTDHGFYQMVKKDEKEKILIPEKASSFKFHPG
                     RLCEDQCYYCSGKFGLYDTPCHVGQIKSVERQQKILANEEKLTVDNCLCDACFRHVDR
                     RANVPSYKKRLSASGHLEMGSAAGSALEKQFAGDSGVITESGGEAGSTAAVAVQQRSC
                     GVKDCVEAARHSLRRKCIRKRVKKYQLSLEIPAGSSNVGLCEAHYNTVIQFSGCVLCK
                     RRLGKNHMYNITTQDTIRLEKALSEMGIPVQLGMGTAVCKLCRYFANLLIKPPDSTKA
                     QKAEFVKNYRKRLLKVHNLQDGSHELSEADEEEAPNATETERPTSDGHEDPEMPMVAD
                     YDGPTDSNSSSSSTAALDTSKQMSKLQAILQQNVGADAAGAAGTGTVAASPGGSGSGA
                     DISNVLRGNPNISMRELFHGEEELGVQFKVPFGCSSSQRTPEGWTRVQTFLQYDEPTR
                     RLWEELQKPYGNQSSFLRHLILLEKYYRNGDLVLAPHASSNATVYTETVRQRLNSFDH
                     GHCGGLNIAGSPSSSGSGKRSGVPQPTGASVLATALTTPLTSHSSSSASISSEQHSSV
                     DPVIPLVDLNDDDEGEDGAGGAGERESTNRQQDVILECLRTASVDKLTKQLSSNAVTI
                     IARPKDKSQLSCNSGSSTSISSSSSAISSPEEVAVTKVTAVAPVQSKDAPPLAPASSG
                     VSNSRSILKTNLLGMNKAVELVPLTTAPHAYKPTGCHKPEKQQKILDVANKQPGSQGE
                     PVPSSALLGLQSKLKPPTHQQQVSGSGAGTSGSQKPSNVAQLLSSPPELISLHRRQTS
                     GAAAGSSSFLQGKRLQLPRSGAGPSGAGTGTGAGAAGSRSAGGPPPPNVVILPDALTP
                     QERHESKSWKPTLIPLEDQHKVPNKSHALYQTADGRRLPALVQVQSGGKPYLISIFDY
                     NRMCILRREKLMRDQLLKSNAKPKPQNQQQQQGQTHQQQQNSAASAAAFSNMVKLAQQ
                     HTARQQLQQLQQKPQQQQQLPTLQPGGVRLARLPQKLLMPPLTNPQIGSQAPNLQPLL
                     SSTLDNSNNCWLWKNFPDPNQYLLNGNGGGAGSSSSKLPHLTAKPATATSSSGAANKS
                     AGSLFTLKQQQHQQKLIDNAIMSKIPKSLTVIPQQMGGNTGGDMGGSSSSGKD"
ORIGIN      
        1 attctctttc acttcctttt cgcctgcttt gttgctgtcg tcgctgtgac agttatgcta
       61 gttgttagtg tgcgtgtcgt gtccgtatat tcttcacatc acagtcaacc aatgggacca
      121 aatcactgcg actcgaactg gacacaatca gcatcggatc gcagggaaca acaggaggtg
      181 gtggagcagc agcgccagaa ggcgtcgggg gagcggccat cataggagca gcaacgtcgg
      241 cagcagctgc ccagggcccc tcgagaatgt ctagccggaa ggtgccagga ggctctggag
      301 gagctgacga atccacagca gcagctgccc ccctggatga taatgccaat gccagtgtgg
      361 agattccaga cagcagcgag gagccagcaa tgggcgtcgg cgaagagatg tctatcataa
      421 gcaaaacacg cacctcaact ttgtcagtgg agcccgctaa ggagccaaca gtaacagcag
      481 agctggaagg cgaaaaagag ctggaatcga atccagtctc caaaactcct aggtccacgc
      541 ctacgccaac ccttacgcca gccgtcacgc ctaccgccag tgatggagtg gcggccaaga
      601 gcgtgagggt tacccggcac tcgtcgccac tgcttctgat catctcgccc acgacaagta
      661 gacgtgaggt cggcgacgga gagctagaca ccgaggaacc aacgggatcg ggtggccaaa
      721 gaaagagctc cgtggagcga tctttggcgc ccgttatacg cggacgaaag tccatcaagg
      781 atctgaaaga agccaaagaa gtcaagtccg aggagccgcc tgccgcagca tcagagtcac
      841 gagctgcaag tggagtgacg cctggccagg tcaaggaaca gcatgtcgcg gatggcaacg
      901 aaatggaatc cttgccaatc acagacaaga aagaccacaa agacacaaaa gacaagggag
      961 atgagcggga aaccgatcag gaggaagaga aggaaaaatc agctgataca gaaataattg
     1021 cagatacaga aaaaacttcg gagaaacaaa agtatacaga gaaggacaaa gctgccgata
     1081 aagatggagg aaaagaaaaa gatattgatg caaataagga tatagataag gagaaggaaa
     1141 aggtcaagga agtacttccg ccagtggtgc ctatagcacc agtgacaccc acttgtaacc
     1201 gtgtcacacg taaatcacat gcccaggagc aggcgattaa cacgcgggtc actcgcaatc
     1261 gtcgccagtc ctctacagtt ggagccaact ccaccgcgtc tttggtagct gcatcctcct
     1321 cagtaacaga gcaaccccct ccatctcgcg gtcgacggaa gaagccagtg gtggtggctc
     1381 ctcccttgga gcctgcggta aaacggaagc gatcgcaaga tgttgaagcc gactcagacg
     1441 ccaacaacag cacgaaatac agcaaggtgg aagtggtaaa gtctgaggaa gctgaggcac
     1501 cagaggagga ctccagtgcc gtgcccatta agcaggaatc tgttgatggc aacgaggtca
     1561 gttctatttc tccaacagtc acgcccacac ccacacctgc gccaacacca gctccagtcc
     1621 cgggcagtcg acggggtcgt gggcgcccgc agaacaggaa ctcctcttcg cctgcaacca
     1681 caacgcgggc aacgcggcta agcaaggcgg gatcaccggt tatcctgacg ccagtagccc
     1741 aggaaccggc gccaccgaaa cggcggcgag tcggctccag cacacggaag actgtctcgg
     1801 ccagctcgct ggcacccagc tcgcagggcg gcgccgggga tgaggactcc aaggacagta
     1861 tggcctcgtc catggacgac ctgctgatgg ccgcagcaga tatcaagcag gagaagctga
     1921 cgcccgattt cgacgatagt ttgatgccag aaggcctgcc ctctacttct ggtgcgtcga
     1981 gtgccaatgg tcattcctgc accgaaccgc ttactgtgga cacggaaatt aatgttaagc
     2041 ccgctgattc caaagtaaaa ccaaaggagt caccggtggt agcagtcgag gaatctccat
     2101 cacaatccga aacgcaatct gcaaaggtgt cagcgcatgc ggggaaggct ccatctctta
     2161 gtccagatat gataagtgaa ggcgtgagcg cggtcagtgt tcgaaagttt tataagaagc
     2221 ctgagttcct ggaaaacaat ctgggcattg aaaaggatcc ggagctaggt gaaatcgttc
     2281 agacggttag taacaatgac acggaaacag atgtggagat ggctgttgat ggcgaggtga
     2341 atcaaccgtc aactcccaag tcgcaggata aaaagaaaga ggagcaggaa aagaatcaga
     2401 aatcagggct aaaggcagca aagaaggctc ctgctaagtt agaacctaaa gctgaagaca
     2461 tttctgaaat tcttactgac gttcctgttg atatttcgac tgaggcagta gaaattatag
     2521 aagaagcaga ggaagacact tgttcaaata gctcaatcaa accaggtgag ctccgactgg
     2581 acgagagcaa cgatgaacct gaactgcttc ttgaagacgc cctcatagtc aatggtgatg
     2641 agaatgagac accagatcaa ccggaggaaa aggaggacca ggtggagttc ttccatacag
     2701 gagaatacga cgactttgag cacgagatta tggtggagct ggcgaaggag ggggtgctag
     2761 atgccagcgg caatgcatta agtcagcaaa aggtagaact tgagcatccc gaggatgtaa
     2821 ctctacacga atcaaaaaat gacatagaag ccgaagaatc ggttgaacgt aagcctctta
     2881 aggacccgtc ggttgcggac gaaatggagg acatgaatga ggaatcctat attgacatta
     2941 aggaccagac aaatcaactg ttagttgaac acttggcaga agaggccatg gaagcggact
     3001 gcggtcccga ggataacaag gagaacttgt ccacgtctgc ttcgagcacc gctgccgatg
     3061 gtctagatat tcagttggcc atcaaggagg atgacgacga ggagaaaccg cttgcagtta
     3121 tcgctgacga acagaagcct gggctgctgt tgaccaatga catgaaagtg gatgagaaac
     3181 caaatggcaa gcaggaatcg gtctgtgatg agcacgttca gctggtgcca aaccttcgtc
     3241 aagaacagga aattcactta caaaatctgg gcctactcac gcaccaggcc gctgaacata
     3301 ggcgcaagtg tctgcttgag gcacaggccc gccaggcgca aatgcagctc cagcaacatc
     3361 accaccatca gcacaagcga caaggagcgc gcggaggagg cagtgccact catgtggaat
     3421 ccagcggtac tttgaagaca gtcatcaagc tgaacaggag cagcaacgga ggagtaagcg
     3481 gtagtggcgg cctgcctact ggtacagtta tccatggagg ctgtggctcc tcttcagctt
     3541 cttccacgtc ctcctcctcg gtgggcagtg ccacacgtaa gtcaagcggg accttgggct
     3601 caggagcggg agcaggagct ggcgttcgcc ggcagtcgct taagatgaca ttccagaagg
     3661 gtcgggctcg tggtcacggt gctgcggatc gatccgccga tcagtatggc gcccacgccg
     3721 aggactccta ctacaccatt caaaacgaga acgaagattc gtcccactcg gaaagtcagg
     3781 gacagacgga ccacggcttc tatcagatgg tcaaaaagga cgaaaaggag aagatcctca
     3841 ttccggaaaa ggcctcctcg tttaagtttc acccagggag actgtgcgaa gaccagtgct
     3901 actactgtag cggaaagttt ggcctctatg acaccccctg ccatgttgga caaataaagt
     3961 ccgtggagcg ccagcagaag atcctagcca acgaggagaa gctcaccgtg gataactgct
     4021 tgtgcgacgc atgttttcga cacgtggacc gccgggcaaa tgtgccatcc tataagaagc
     4081 gtctttccgc ttcaggtcac ttggagatgg ggtctgcagc gggatctgca ctagagaaac
     4141 agtttgctgg cgacagcggc gtcattacgg aatcgggtgg cgaagctggt tctacggcag
     4201 ctgtggccgt gcagcaacga tcttgtggcg tgaaggactg cgtcgaagcg gcacgacact
     4261 cgctgcggcg caagtgcata cgcaagagag taaagaagta tcagctcagc ctggagattc
     4321 ccgcaggctc gtcgaacgtg gggctgtgtg aggcacatta caatacggtc atccaatttt
     4381 ccggctgcgt tctttgcaag cgtagattag gcaagaacca tatgtacaac ataaccacgc
     4441 aggacacaat tcgactggaa aaggcgctgt ccgagatggg catcccagtt cagcttggca
     4501 tgggcactgc agtctgcaag ctgtgtcgct attttgccaa ccttttgata aagccaccgg
     4561 atagcaccaa ggcacaaaag gcggaattcg tgaagaacta cagaaagagg ctcctcaagg
     4621 tgcataatct gcaggatggc agtcatgagc tgtccgaagc ggatgaagaa gaggcaccta
     4681 atgcaacgga gacagaaagg ccaacctcag acggacacga agatcccgag atgcccatgg
     4741 tagcggacta tgatggacct accgactcca attccagtag ttcttcgact gcagccctgg
     4801 acaccagcaa acaaatgtcc aagcttcagg ccatcctgca gcaaaatgtg ggagcggatg
     4861 cggcaggagc tgcgggaaca ggaactgttg cagcaagtcc cggaggaagc ggatctgggg
     4921 cagatatctc taacgtattg cgagggaatc cgaacatttc catgcgcgaa cttttccacg
     4981 gcgaggaaga gctgggtgtg cagttcaagg tgccgttcgg atgcagcagc agccagcgta
     5041 ctccggaggg ctggacacga gtgcagactt tcctacaata cgatgagccg acgcgccgcc
     5101 tctgggagga gttgcaaaag ccgtacggaa atcagagctc atttctgcgc cacttgatac
     5161 tattagagaa gtactaccga aacggagatc tcgtcctagc accgcatgct tcctccaatg
     5221 ccacggttta cacagagact gttcgtcagc ggctgaattc gtttgatcac ggtcactgcg
     5281 gtggattgaa catcgcaggc agcccttctt cttcgggttc cggcaagcgc agtggagttc
     5341 ctcaacctac gggtgccagt gtgctggcca ccgccctcac aacacccttg acaagccatt
     5401 catcctcctc tgcatccatt tcctccgaac agcattcgtc ggttgatcct gtcattccgc
     5461 tggtagacct caatgatgac gatgaaggcg aagatggggc aggaggagcg ggcgaaaggg
     5521 agtcgacaaa taggcagcag gacgtaatct tggaatgcct tagaactgcc tctgtggaca
     5581 agctgactaa gcagctcagc tcgaatgcgg tgacgattat cgcccggccc aaagacaaat
     5641 cgcagctctc ctgcaacagc ggatcctcca cgtccatttc cagctcctcg tccgctattt
     5701 cctcgccgga ggaagtggcc gtcactaagg ttacagcagt cgcaccagtc cagtccaagg
     5761 atgcaccgcc actggcgcca gcaagtagcg gtgttagcaa cagtcgtagt atccttaaaa
     5821 ccaacctctt gggcatgaac aaggccgtgg aactcgtgcc cttaacgact gccccccacg
     5881 cttacaagcc aactggatgc cataagcctg agaaacagca aaagattctt gacgtggcca
     5941 ataagcagcc cggtagccag ggggaaccgg taccatcaag cgccttgctt ggcctgcagt
     6001 caaagctaaa gcctccaacg catcagcagc aggtcagcgg atcaggagcg ggaactagtg
     6061 gttctcagaa gccatctaat gtggcgcaat tgcttagctc tccaccggag ctaatcagct
     6121 tgcatcgacg gcagaccagc ggagcagcag cggggtccag cagcttcctt cagggcaaga
     6181 ggcttcaact tccacgatct ggagcagggc cttcaggagc gggaacggga acaggcgctg
     6241 gagcagcagg aagccgcagt gcgggtggac caccaccgcc caatgtggtc atactgccgg
     6301 acgccttaac cccccaggag cgacacgaga gcaagagctg gaagccaacg ctgataccgc
     6361 tggaggatca gcacaaggtg ccgaacaaat cacatgctct ttatcagacc gccgacggtc
     6421 gaaggttgcc cgccctggtg caagtgcagt ctggtggcaa gccatacctc atctctatct
     6481 tcgactataa ccgcatgtgc atcttgcgaa gggaaaagct gatgcgggac cagttgctca
     6541 agagtaacgc caagccaaag ccgcagaacc agcaacagca gcagggccaa acgcaccagc
     6601 agcagcagaa ttccgccgca tcggcggctg ccttctccaa catggtgaag ttggcccagc
     6661 aacacacggc gcgacagcag cttcagcagc tgcaacagaa gccacaacag cagcaacaat
     6721 tgcccacttt gcagccaggt ggggtgcgac ttgcccggct gccgcaaaaa ctactgatgc
     6781 caccactgac taatccgcag attggcagtc aagcacccaa cttacagccg ttgctgtcta
     6841 gtacgctgga taacagcaac aactgctggc tgtggaaaaa ctttcctgat cccaatcagt
     6901 atctgctaaa tggaaacgga gggggtgccg ggagctcctc cagcaagttg ccacatctca
     6961 cggccaaacc agccacggca actagtagct ccggagcggc caacaaatca gcaggaagcc
     7021 tatttaccct caagcagcag cagcaccagc agaaactcat cgacaacgct atcatgtcaa
     7081 agatacccaa aagtctgaca gtaataccgc agcagatggg tggtaatacc ggtggcgata
     7141 tggggggcag cagctcctcc ggcaaggact gatgacggcg aaggagggcg ccatggccat
     7201 tagccgtagc gccggaggta acccggcgaa gtagtaggat caacaagcag gcgacgtgca
     7261 gcttaagcgg cgatcttcag aacaagaggt gaccagcggc ggctccatgg atatcacaaa
     7321 ctccacaatt ccatggctgc agtagaataa gtgatacact aaaaaaaaaa aaaaacattg
     7381 gacggacaga aaagaaacag atgagaaacc aagataattc ttagattaca taacgttgtt
     7441 tgtgtataaa cgagatacgg ttacgaatac gattacaata taagtacgca ctagttaggc
     7501 actcaagccg atacgacaga tgcatgatgg agcagatgaa gttcccgatg cgaatgcgat
     7561 ttaggatacg gatatggat