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Drosophila melanogaster enhanced adult sensory threshold (east),


LOCUS       NM_001201601            7521 bp    mRNA    linear   INV 26-DEC-2023
            transcript variant C, mRNA.
ACCESSION   NM_001201601
VERSION     NM_001201601.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7521)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7521)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7521)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7521)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7521)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7521)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7521)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7521)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7521)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7521)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7521)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7521)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7521)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7521)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7521)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7521)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7521)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7521)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001201601.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7521
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7521
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="enhanced adult sensory threshold"
                     /map="2C2-2C4"
                     /db_xref="FLYBASE:FBgn0261954"
                     /db_xref="GeneID:46006"
     CDS             209..7114
                     /gene="east"
                     /locus_tag="Dmel_CG4399"
                     /gene_synonym="anon-WO03040301.224; CG4399; Dmel\CG4399;
                     East; EAST; EG:133E12.4; l(1)G0014; l(1)G0500; su(w[sp])"
                     /note="CG4399 gene product from transcript CG4399-RC;
                     CG4399-PC; east-PC; enhanced adult salt tolerance;
                     suppressor of white-spotted"
                     /codon_start=1
                     /product="enhanced adult sensory threshold, isoform C"
                     /protein_id="NP_001188530.1"
                     /db_xref="FLYBASE:FBpp0292165"
                     /db_xref="GeneID:46006"
                     /db_xref="FLYBASE:FBgn0261954"
                     /translation="MSSRKVPGGSGGADESTAAAAPLDDNANASVEIPDSSEEPAMGV
                     GEEMSIISKTRTSTLSVEPAKEPTVTAELEGEKELESNPVSKTPRSTPTPTLTPAVTP
                     TASDGVAAKSVRVTRHSSPLLLIISPTTSRREVGDGELDTEEPTGSGGQRKSSVERSL
                     APVIRGRKSIKDLKEAKEVKSEEPPAAASESRAASGVTPGQVKEQHVADGNEMESLPI
                     TDKKDHKDTKDKGDERETDQEEEKEKSADTEIIADTEKTSEKQKYTEKDKAADKDGGK
                     EKDIDANKDIDKEKEKVKEVLPPVVPIAPVTPTCNRVTRKSHAQEQAINTRVTRNRRQ
                     SSTVGANSTASLVAASSSVTEQPPPSRGRRKKPVVVAPPLEPAVKRKRSQDVEADSDA
                     NNSTKYSKVEVVKSEEAEAPEEDSSAVPIKQESVDGNEVSSISPTVTPTPTPAPTPAP
                     VPGSRRGRGRPQNRNSSSPATTTRATRLSKAGSPVILTPVAQEPAPPKRRRVGSSTRK
                     TVSASSLAPSSQGGAGDEDSKDSMASSMDDLLMAAADIKQEKLTPDFDDSLMPEGLPS
                     TSGASSANGHSCTEPLTVDTEINVKPADSKVKPKESPVVAVEESPSQSETQSAKVSAH
                     AGKAPSLSPDMISEGVSAVSVRKFYKKPEFLENNLGIEKDPELGEIVQTVSNNDTETD
                     VEMAVDGEVNQPSTPKSQDKKKEEQEKNQKSGLKAAKKAPAKLEPKAEDISEILTDVP
                     VDISTEAVEIIEEAEEDTCSNSSIKPGELRLDESNDEPELLLEDALIVNGDENETPDQ
                     PEEKEDQVEFFHTGEYDDFEHEIMVELAKEGVLDASGNALSQQKVELEHPEDVTLHES
                     KNDIEAEESVERKPLKDPSVADEMEDMNEESYIDIKDQTNQLLVEHLAEEAMEADCGP
                     EDNKENLSTSASSTAADGLDIQLAIKEDDDEEKPLAVIADEQKPGLLLTNDMKVDEKP
                     NGKQESVCDEHVQLVPNLRQEQEIHLQNLGLLTHQAAEHRRKCLLEAQARQAQMQLQQ
                     HHHHQHKRQGARGGGSATHVESSGTLKTVIKLNRSSNGGVSGSGGLPTGTVIHGGCGS
                     SSASSTSSSSVGSATRKSSGTLGSGAGAGAGVRRQSLKMTFQKGRARGHGAADRSADQ
                     YGAHAEDSYYTIQNENEDSSHSESQGQTDHGFYQMVKKDEKEKILIPEKASSFKFHPG
                     RLCEDQCYYCSGKFGLYDTPCHVGQIKSVERQQKILANEEKLTVDNCLCDACFRHVDR
                     RANVPSYKKRLSASGHLEMGSAAGSALEKQFAGDSGVITESGGEAGSTAAVAVQQRSC
                     GVKDCVEAARHSLRRKCIRKRVKKYQLSLEIPAGSSNVGLCEAHYNTVIQFSGCVLCK
                     RRLGKNHMYNITTQDTIRLEKALSEMGIPVQLGMGTAVCKLCRYFANLLIKPPDSTKA
                     QKAEFVKNYRKRLLKVHNLQDGSHELSEADEEEAPNATETERPTSDGHEDPEMPMVAD
                     YDGPTDSNSSSSSTAALDTSKQMSKLQAILQQNVGADAAGAAGTGTVAASPGGSGSGA
                     DISNVLRGNPNISMRELFHGEEELGVQFKVPFGCSSSQRTPEGWTRVQTFLQYDEPTR
                     RLWEELQKPYGNQSSFLRHLILLEKYYRNGDLVLAPHASSNATVYTETVRQRLNSFDH
                     GHCGGLNIAGSPSSSGSGKRSGVPQPTGASVLATALTTPLTSHSSSSASISSEQHSSV
                     DPVIPLVDLNDDDEGEDGAGGAGERESTNRQQDVILECLRTASVDKLTKQLSSNAVTI
                     IARPKDKSQLSCNSGSSTSISSSSSAISSPEEVAVTKVTAVAPVQSKDAPPLAPASSG
                     VSNSRSILKTNLLGMNKAVELVPLTTAPHAYKPTGCHKPEKQQKILDVANKQPGSQGE
                     PVPSSALLGLQSKLKPPTHQQQVSGSGAGTSGSQKPSNVAQLLSSPPELISLHRRQTS
                     GAAAGSSSFLQGKRLQLPRSGAGPSGAGTGTGAGAAGSRSAGGPPPPNVVILPDALTP
                     QERHESKSWKPTLIPLEDQHKVPNKSHALYQTADGRRLPALVQVQSGGKPYLISIFDY
                     NRMCILRREKLMRDQLLKSNAKPKPQNQQQQQGQTHQQQQNSAASAAAFSNMVKLAQQ
                     HTARQQLQQLQQKPQQQQQLPTLQPGGVRLARLPQKLLMPPLTNPQIGSQAPNLQPLL
                     SSTLDNSNNCWLWKNFPDPNQYLLNGNGGGAGSSSSKLPHLTAKPATATSSSGAANKS
                     AGSLFTLKQQQHQQKLIDNAIMSKIPKSLTVIPQQMGGNTGGDMGGSSSSGKD"
ORIGIN      
        1 cgttatttcg cttcgcaccg tgtttgcgtt cacaactctt gttcggtcaa ccaatgggac
       61 caaatcactg cgactcgaac tggacacaat cagcatcgga tcgcagggaa caacaggagg
      121 tggtggagca gcagcgccag aaggcgtcgg gggagcggcc atcataggag cagcaacgtc
      181 ggcagcagct gcccagggcc cctcgagaat gtctagccgg aaggtgccag gaggctctgg
      241 aggagctgac gaatccacag cagcagctgc ccccctggat gataatgcca atgccagtgt
      301 ggagattcca gacagcagcg aggagccagc aatgggcgtc ggcgaagaga tgtctatcat
      361 aagcaaaaca cgcacctcaa ctttgtcagt ggagcccgct aaggagccaa cagtaacagc
      421 agagctggaa ggcgaaaaag agctggaatc gaatccagtc tccaaaactc ctaggtccac
      481 gcctacgcca acccttacgc cagccgtcac gcctaccgcc agtgatggag tggcggccaa
      541 gagcgtgagg gttacccggc actcgtcgcc actgcttctg atcatctcgc ccacgacaag
      601 tagacgtgag gtcggcgacg gagagctaga caccgaggaa ccaacgggat cgggtggcca
      661 aagaaagagc tccgtggagc gatctttggc gcccgttata cgcggacgaa agtccatcaa
      721 ggatctgaaa gaagccaaag aagtcaagtc cgaggagccg cctgccgcag catcagagtc
      781 acgagctgca agtggagtga cgcctggcca ggtcaaggaa cagcatgtcg cggatggcaa
      841 cgaaatggaa tccttgccaa tcacagacaa gaaagaccac aaagacacaa aagacaaggg
      901 agatgagcgg gaaaccgatc aggaggaaga gaaggaaaaa tcagctgata cagaaataat
      961 tgcagataca gaaaaaactt cggagaaaca aaagtataca gagaaggaca aagctgccga
     1021 taaagatgga ggaaaagaaa aagatattga tgcaaataag gatatagata aggagaagga
     1081 aaaggtcaag gaagtacttc cgccagtggt gcctatagca ccagtgacac ccacttgtaa
     1141 ccgtgtcaca cgtaaatcac atgcccagga gcaggcgatt aacacgcggg tcactcgcaa
     1201 tcgtcgccag tcctctacag ttggagccaa ctccaccgcg tctttggtag ctgcatcctc
     1261 ctcagtaaca gagcaacccc ctccatctcg cggtcgacgg aagaagccag tggtggtggc
     1321 tcctcccttg gagcctgcgg taaaacggaa gcgatcgcaa gatgttgaag ccgactcaga
     1381 cgccaacaac agcacgaaat acagcaaggt ggaagtggta aagtctgagg aagctgaggc
     1441 accagaggag gactccagtg ccgtgcccat taagcaggaa tctgttgatg gcaacgaggt
     1501 cagttctatt tctccaacag tcacgcccac acccacacct gcgccaacac cagctccagt
     1561 cccgggcagt cgacggggtc gtgggcgccc gcagaacagg aactcctctt cgcctgcaac
     1621 cacaacgcgg gcaacgcggc taagcaaggc gggatcaccg gttatcctga cgccagtagc
     1681 ccaggaaccg gcgccaccga aacggcggcg agtcggctcc agcacacgga agactgtctc
     1741 ggccagctcg ctggcaccca gctcgcaggg cggcgccggg gatgaggact ccaaggacag
     1801 tatggcctcg tccatggacg acctgctgat ggccgcagca gatatcaagc aggagaagct
     1861 gacgcccgat ttcgacgata gtttgatgcc agaaggcctg ccctctactt ctggtgcgtc
     1921 gagtgccaat ggtcattcct gcaccgaacc gcttactgtg gacacggaaa ttaatgttaa
     1981 gcccgctgat tccaaagtaa aaccaaagga gtcaccggtg gtagcagtcg aggaatctcc
     2041 atcacaatcc gaaacgcaat ctgcaaaggt gtcagcgcat gcggggaagg ctccatctct
     2101 tagtccagat atgataagtg aaggcgtgag cgcggtcagt gttcgaaagt tttataagaa
     2161 gcctgagttc ctggaaaaca atctgggcat tgaaaaggat ccggagctag gtgaaatcgt
     2221 tcagacggtt agtaacaatg acacggaaac agatgtggag atggctgttg atggcgaggt
     2281 gaatcaaccg tcaactccca agtcgcagga taaaaagaaa gaggagcagg aaaagaatca
     2341 gaaatcaggg ctaaaggcag caaagaaggc tcctgctaag ttagaaccta aagctgaaga
     2401 catttctgaa attcttactg acgttcctgt tgatatttcg actgaggcag tagaaattat
     2461 agaagaagca gaggaagaca cttgttcaaa tagctcaatc aaaccaggtg agctccgact
     2521 ggacgagagc aacgatgaac ctgaactgct tcttgaagac gccctcatag tcaatggtga
     2581 tgagaatgag acaccagatc aaccggagga aaaggaggac caggtggagt tcttccatac
     2641 aggagaatac gacgactttg agcacgagat tatggtggag ctggcgaagg agggggtgct
     2701 agatgccagc ggcaatgcat taagtcagca aaaggtagaa cttgagcatc ccgaggatgt
     2761 aactctacac gaatcaaaaa atgacataga agccgaagaa tcggttgaac gtaagcctct
     2821 taaggacccg tcggttgcgg acgaaatgga ggacatgaat gaggaatcct atattgacat
     2881 taaggaccag acaaatcaac tgttagttga acacttggca gaagaggcca tggaagcgga
     2941 ctgcggtccc gaggataaca aggagaactt gtccacgtct gcttcgagca ccgctgccga
     3001 tggtctagat attcagttgg ccatcaagga ggatgacgac gaggagaaac cgcttgcagt
     3061 tatcgctgac gaacagaagc ctgggctgct gttgaccaat gacatgaaag tggatgagaa
     3121 accaaatggc aagcaggaat cggtctgtga tgagcacgtt cagctggtgc caaaccttcg
     3181 tcaagaacag gaaattcact tacaaaatct gggcctactc acgcaccagg ccgctgaaca
     3241 taggcgcaag tgtctgcttg aggcacaggc ccgccaggcg caaatgcagc tccagcaaca
     3301 tcaccaccat cagcacaagc gacaaggagc gcgcggagga ggcagtgcca ctcatgtgga
     3361 atccagcggt actttgaaga cagtcatcaa gctgaacagg agcagcaacg gaggagtaag
     3421 cggtagtggc ggcctgccta ctggtacagt tatccatgga ggctgtggct cctcttcagc
     3481 ttcttccacg tcctcctcct cggtgggcag tgccacacgt aagtcaagcg ggaccttggg
     3541 ctcaggagcg ggagcaggag ctggcgttcg ccggcagtcg cttaagatga cattccagaa
     3601 gggtcgggct cgtggtcacg gtgctgcgga tcgatccgcc gatcagtatg gcgcccacgc
     3661 cgaggactcc tactacacca ttcaaaacga gaacgaagat tcgtcccact cggaaagtca
     3721 gggacagacg gaccacggct tctatcagat ggtcaaaaag gacgaaaagg agaagatcct
     3781 cattccggaa aaggcctcct cgtttaagtt tcacccaggg agactgtgcg aagaccagtg
     3841 ctactactgt agcggaaagt ttggcctcta tgacaccccc tgccatgttg gacaaataaa
     3901 gtccgtggag cgccagcaga agatcctagc caacgaggag aagctcaccg tggataactg
     3961 cttgtgcgac gcatgttttc gacacgtgga ccgccgggca aatgtgccat cctataagaa
     4021 gcgtctttcc gcttcaggtc acttggagat ggggtctgca gcgggatctg cactagagaa
     4081 acagtttgct ggcgacagcg gcgtcattac ggaatcgggt ggcgaagctg gttctacggc
     4141 agctgtggcc gtgcagcaac gatcttgtgg cgtgaaggac tgcgtcgaag cggcacgaca
     4201 ctcgctgcgg cgcaagtgca tacgcaagag agtaaagaag tatcagctca gcctggagat
     4261 tcccgcaggc tcgtcgaacg tggggctgtg tgaggcacat tacaatacgg tcatccaatt
     4321 ttccggctgc gttctttgca agcgtagatt aggcaagaac catatgtaca acataaccac
     4381 gcaggacaca attcgactgg aaaaggcgct gtccgagatg ggcatcccag ttcagcttgg
     4441 catgggcact gcagtctgca agctgtgtcg ctattttgcc aaccttttga taaagccacc
     4501 ggatagcacc aaggcacaaa aggcggaatt cgtgaagaac tacagaaaga ggctcctcaa
     4561 ggtgcataat ctgcaggatg gcagtcatga gctgtccgaa gcggatgaag aagaggcacc
     4621 taatgcaacg gagacagaaa ggccaacctc agacggacac gaagatcccg agatgcccat
     4681 ggtagcggac tatgatggac ctaccgactc caattccagt agttcttcga ctgcagccct
     4741 ggacaccagc aaacaaatgt ccaagcttca ggccatcctg cagcaaaatg tgggagcgga
     4801 tgcggcagga gctgcgggaa caggaactgt tgcagcaagt cccggaggaa gcggatctgg
     4861 ggcagatatc tctaacgtat tgcgagggaa tccgaacatt tccatgcgcg aacttttcca
     4921 cggcgaggaa gagctgggtg tgcagttcaa ggtgccgttc ggatgcagca gcagccagcg
     4981 tactccggag ggctggacac gagtgcagac tttcctacaa tacgatgagc cgacgcgccg
     5041 cctctgggag gagttgcaaa agccgtacgg aaatcagagc tcatttctgc gccacttgat
     5101 actattagag aagtactacc gaaacggaga tctcgtccta gcaccgcatg cttcctccaa
     5161 tgccacggtt tacacagaga ctgttcgtca gcggctgaat tcgtttgatc acggtcactg
     5221 cggtggattg aacatcgcag gcagcccttc ttcttcgggt tccggcaagc gcagtggagt
     5281 tcctcaacct acgggtgcca gtgtgctggc caccgccctc acaacaccct tgacaagcca
     5341 ttcatcctcc tctgcatcca tttcctccga acagcattcg tcggttgatc ctgtcattcc
     5401 gctggtagac ctcaatgatg acgatgaagg cgaagatggg gcaggaggag cgggcgaaag
     5461 ggagtcgaca aataggcagc aggacgtaat cttggaatgc cttagaactg cctctgtgga
     5521 caagctgact aagcagctca gctcgaatgc ggtgacgatt atcgcccggc ccaaagacaa
     5581 atcgcagctc tcctgcaaca gcggatcctc cacgtccatt tccagctcct cgtccgctat
     5641 ttcctcgccg gaggaagtgg ccgtcactaa ggttacagca gtcgcaccag tccagtccaa
     5701 ggatgcaccg ccactggcgc cagcaagtag cggtgttagc aacagtcgta gtatccttaa
     5761 aaccaacctc ttgggcatga acaaggccgt ggaactcgtg cccttaacga ctgcccccca
     5821 cgcttacaag ccaactggat gccataagcc tgagaaacag caaaagattc ttgacgtggc
     5881 caataagcag cccggtagcc agggggaacc ggtaccatca agcgccttgc ttggcctgca
     5941 gtcaaagcta aagcctccaa cgcatcagca gcaggtcagc ggatcaggag cgggaactag
     6001 tggttctcag aagccatcta atgtggcgca attgcttagc tctccaccgg agctaatcag
     6061 cttgcatcga cggcagacca gcggagcagc agcggggtcc agcagcttcc ttcagggcaa
     6121 gaggcttcaa cttccacgat ctggagcagg gccttcagga gcgggaacgg gaacaggcgc
     6181 tggagcagca ggaagccgca gtgcgggtgg accaccaccg cccaatgtgg tcatactgcc
     6241 ggacgcctta accccccagg agcgacacga gagcaagagc tggaagccaa cgctgatacc
     6301 gctggaggat cagcacaagg tgccgaacaa atcacatgct ctttatcaga ccgccgacgg
     6361 tcgaaggttg cccgccctgg tgcaagtgca gtctggtggc aagccatacc tcatctctat
     6421 cttcgactat aaccgcatgt gcatcttgcg aagggaaaag ctgatgcggg accagttgct
     6481 caagagtaac gccaagccaa agccgcagaa ccagcaacag cagcagggcc aaacgcacca
     6541 gcagcagcag aattccgccg catcggcggc tgccttctcc aacatggtga agttggccca
     6601 gcaacacacg gcgcgacagc agcttcagca gctgcaacag aagccacaac agcagcaaca
     6661 attgcccact ttgcagccag gtggggtgcg acttgcccgg ctgccgcaaa aactactgat
     6721 gccaccactg actaatccgc agattggcag tcaagcaccc aacttacagc cgttgctgtc
     6781 tagtacgctg gataacagca acaactgctg gctgtggaaa aactttcctg atcccaatca
     6841 gtatctgcta aatggaaacg gagggggtgc cgggagctcc tccagcaagt tgccacatct
     6901 cacggccaaa ccagccacgg caactagtag ctccggagcg gccaacaaat cagcaggaag
     6961 cctatttacc ctcaagcagc agcagcacca gcagaaactc atcgacaacg ctatcatgtc
     7021 aaagataccc aaaagtctga cagtaatacc gcagcagatg ggtggtaata ccggtggcga
     7081 tatggggggc agcagctcct ccggcaagga ctgatgacgg cgaaggaggg cgccatggcc
     7141 attagccgta gcgccggagg taacccggcg aagtagtagg atcaacaagc aggcgacgtg
     7201 cagcttaagc ggcgatcttc agaacaagag gtgaccagcg gcggctccat ggatatcaca
     7261 aactccacaa ttccatggct gcagtagaat aagtgataca ctaaaaaaaa aaaaaaacat
     7321 tggacggaca gaaaagaaac agatgagaaa ccaagataat tcttagatta cataacgttg
     7381 tttgtgtata aacgagatac ggttacgaat acgattacaa tataagtacg cactagttag
     7441 gcactcaagc cgatacgaca gatgcatgat ggagcagatg aagttcccga tgcgaatgcg
     7501 atttaggata cggatatgga t