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Drosophila melanogaster prage, transcript variant E (prage), mRNA.


LOCUS       NM_001201599            3629 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001201599
VERSION     NM_001201599.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3629)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3629)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3629)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3629)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3629)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3629)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3629)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3629)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3629)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3629)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3629)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3629)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3629)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3629)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3629)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3629)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3629)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3629)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3629)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3629)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3629)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3629)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3629)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On May 8, 2012 this sequence version replaced NM_001201599.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3629
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3629
                     /gene="prage"
                     /locus_tag="Dmel_CG42666"
                     /old_locus_tag="Dmel_CG14799"
                     /old_locus_tag="Dmel_CG14801"
                     /gene_synonym="CG14799; CG14800; CG14801; CG17968;
                     CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1"
                     /map="2B9-2B12"
                     /db_xref="FLYBASE:FBgn0283741"
                     /db_xref="GeneID:31136"
     CDS             598..3156
                     /gene="prage"
                     /locus_tag="Dmel_CG42666"
                     /old_locus_tag="Dmel_CG14799"
                     /old_locus_tag="Dmel_CG14801"
                     /gene_synonym="CG14799; CG14800; CG14801; CG17968;
                     CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1"
                     /note="CG42666 gene product from transcript CG42666-RE;
                     CG42666-PE; prage-PE"
                     /codon_start=1
                     /product="prage, isoform E"
                     /protein_id="NP_001188528.1"
                     /db_xref="FLYBASE:FBpp0291798"
                     /db_xref="GeneID:31136"
                     /db_xref="FLYBASE:FBgn0283741"
                     /translation="MLLAEIGQQENMLPPPYVAAIKRKIDPEQQQQRKQHRSNILGCN
                     KSSSINCSSINGDNRHLQRQQGKMYYNSSSRPFWRKCRSAAPTNLMTTIPTNNDLCNT
                     AAAATYDKMQSCNKNSSSRITTTNNNVTTTSNISGNSSNKRCPQKYTGNTLAVNSNML
                     AYQQQATAGGKNSTRKSRHNNNKQNHQQQQQQQQQQFDHIHKRNGTAGGTGSECSPAA
                     PTSNWLQRGYGRQFVHSSCIEDKLLGHHNPGHRNSTSSDATSEDIDSSSELPNKSKGN
                     SCAGSIHASGGSKSRSKRHQKQSGQQTRNPDHNGQRTGAATPCTGQKAKQGNAKWRQQ
                     QPNPSSNNQQQQMQQQMQQQKRGRNKKPGKWSNNIIDNPNSNHGGSSQQKTCDSSSSS
                     ALSSPTSSATTSATSSPTNSPTSYPRANGNRKRIEAALEWRREQELGRQNANFLVPPL
                     RQYEQLEFDDKTVVQQLRRHIIDNHLLRVYGFPVDSVVHEGAIEIFKCMPHMSFAAAL
                     AETAQAVTVINYHDGLTNRAEEEVANSTDSGNSSPQSLDSESGGEWSGSECESSNSSS
                     SSAGEAALGLELKYCHFVPVERSLSKPCARCKRHFLVDELTGQYLTHEECQYHSGKYQ
                     RYYDGVSHGRWTCCNEGEESSPGCCLGDRHVWSGSVVGVNGPYYDFVRTEHRGSGEDE
                     PAVYALDCEMSYTGRGLDVTKVSLVALNGQLVYEHFVRPVCDIIDYNTQYSGITETDL
                     CSGAKSLAEVQRDLLQLITADTILIGHGLENDLRALRLVHNTLIDTSISFPHCNGFPY
                     RRALRHLTKVHLKRDIQAGDGTTGHSSFEDSRACMELMLWRVNRELDPAWSWDD"
     misc_feature    <2437..2547
                     /gene="prage"
                     /locus_tag="Dmel_CG42666"
                     /old_locus_tag="Dmel_CG14799"
                     /old_locus_tag="Dmel_CG14801"
                     /gene_synonym="CG14799; CG14800; CG14801; CG17968;
                     CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1"
                     /note="Pleckstrin homology-like domain; Region: PH-like;
                     cl17171"
                     /db_xref="CDD:473070"
     misc_feature    2653..3108
                     /gene="prage"
                     /locus_tag="Dmel_CG42666"
                     /old_locus_tag="Dmel_CG14799"
                     /old_locus_tag="Dmel_CG14801"
                     /gene_synonym="CG14799; CG14800; CG14801; CG17968;
                     CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1"
                     /note="DEDDh 3'-5' exonuclease domain of RNA exonuclease
                     1, -3 and similar eukaryotic proteins; Region: REX1_like;
                     cd06145"
                     /db_xref="CDD:99848"
     misc_feature    order(2662..2673,2677..2679,2896..2901,2905..2913,
                     3064..3066,3079..3081)
                     /gene="prage"
                     /locus_tag="Dmel_CG42666"
                     /gene_synonym="CG14799; CG14800; CG14801; CG17968;
                     CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1"
                     /note="active site"
                     /db_xref="CDD:99848"
     misc_feature    order(2662..2673,2677..2679,2896..2901,2905..2910,
                     3064..3066,3079..3081)
                     /gene="prage"
                     /locus_tag="Dmel_CG42666"
                     /gene_synonym="CG14799; CG14800; CG14801; CG17968;
                     CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1"
                     /note="substrate binding site [chemical binding]; other
                     site"
                     /db_xref="CDD:99848"
     misc_feature    order(2662..2664,2668..2670,2911..2913,3064..3066,
                     3079..3081)
                     /gene="prage"
                     /locus_tag="Dmel_CG42666"
                     /gene_synonym="CG14799; CG14800; CG14801; CG17968;
                     CG42666; Dmel\CG42666; EG:131F2.2; EG:137E7.1; prg; REXO1"
                     /note="catalytic site [active]"
                     /db_xref="CDD:99848"
ORIGIN      
        1 ctttgttgtt gtttgtccaa gctgttgggc ggtgcgctag gctaaccgtt ctattcttgt
       61 taataattgg agtgatttaa acaagttgcg cgtgcattgt gcttgcgaaa gtagattcag
      121 tgtgcaaatg attagcgaaa cagcgagttc ccaatttggt gccattttct caattttcat
      181 ggcccggggt ttactttcga gtgctgcgtc gtagatcgtg gttttttttt tgctcccaaa
      241 gaagtgacgt ccaacgggaa atatacaata tacacatgac tcttttgctt ttccgcgtgt
      301 ttattgtgct tattttttat gtgagtgcga cagccagtgc ccagagtagt gctgatgcat
      361 ccgaaagaaa tagtgatgca aacagaacca taagtagtgg cagccaaaca cgaaactgtc
      421 cttggaggta caaggcttcg acagccccac atgttgcagc taaaggagca acatcagtgt
      481 aactgacagc aaaaaaaaaa acattcggca gtcaaaagca tacacagcag acgcaacatc
      541 agcatttaga gaaataagtt cgcaaagttc gcgtccaacg gcaacaggca gtgcaacatg
      601 ctgctggcgg aaatcgggca acaggaaaac atgctaccgc ccccctacgt agcagcaatc
      661 aagcgaaaga tcgatccaga gcaacagcag caacgcaagc agcacagaag caacatcctc
      721 ggatgcaaca agagcagcag catcaactgc agcagcatca acggcgacaa tcgacacctt
      781 cagaggcagc agggcaaaat gtattacaac tccagttcac gacccttttg gaggaaatgc
      841 agatcggctg ccccaacgaa tctcatgacc acaataccca ctaacaacga cttgtgcaac
      901 acagcagcag cggcaacata tgacaaaatg cagagttgca acaaaaacag cagtagccgt
      961 atcaccacca ccaacaacaa cgttactaca actagcaaca ttagcggcaa cagcagcaac
     1021 aagcgctgcc ctcagaagta caccggcaac accctagccg tcaacagtaa catgctggcc
     1081 tatcagcagc aagccaccgc cggtggcaag aactccactc ggaagagtcg tcacaacaac
     1141 aacaagcaaa atcatcagca gcaacaacaa caacagcagc agcagtttga tcatatccac
     1201 aagcgcaatg gaaccgctgg aggcaccgga tccgagtgct ctcccgctgc acccacatcc
     1261 aactggctcc aacggggcta cggacgacag tttgtccatt cttcatgcat cgaagacaaa
     1321 ctcctaggtc atcacaatcc gggccatcgc aatagcacca gcagcgacgc gaccagcgag
     1381 gatatagact ccagtagcga gcttccaaac aagtcgaagg gaaattcatg cgccggcagc
     1441 atccatgctt caggcggcag caagagtcgc tcgaagcgcc accaaaagca gtccggccag
     1501 cagactcgca atcccgatca caatggccaa aggaccggag cagctacccc ctgtacgggc
     1561 cagaaagcca agcaggggaa tgccaagtgg cgccagcagc aacccaatcc cagcagcaac
     1621 aaccaacagc agcagatgca acaacagatg caacagcaga agcgcggcag gaacaagaag
     1681 cccgggaagt ggagcaacaa catcattgac aacccaaaca gcaatcacgg cggcagcagt
     1741 caacagaaga cttgcgacag cagctcctcc tctgcgctga gttcgccaac cagttcggcc
     1801 accacatcgg ccaccagttc gcccaccaat tcgcccacca gttacccccg tgccaatgga
     1861 aatcggaagc ggatcgaagc ggcactggaa tggcgccggg agcaagagct tggtcgccag
     1921 aatgccaact tcctggttcc tcctctccgc cagtacgagc aactggagtt tgacgataaa
     1981 accgtggtgc agcaactgcg tcgacacatc atagataatc atctgctgag ggtctacggc
     2041 tttcccgtgg attcggtggt ccacgaaggc gccatcgaaa tcttcaagtg catgccgcac
     2101 atgagttttg cagccgcgct tgcggaaact gctcaggccg ttacagtgat caactaccac
     2161 gacggactga ccaaccgcgc cgaggaggag gtggccaatt cgaccgattc gggcaacagt
     2221 tcaccccaat ccttagactc cgaatcaggc ggcgagtgga gcggcagtga atgcgagtcc
     2281 tcgaactcat cgtcctcctc cgccggcgaa gcagcgctgg gtctcgagtt gaagtactgc
     2341 cattttgtgc cggtggaaag gagtctgtcc aagccttgtg cgcgctgcaa gcgccacttt
     2401 ctggttgacg agctgacggg tcagtatttg acccatgagg aatgccaata ccactcaggc
     2461 aagtaccagc ggtactacga tggcgtcagc cacggacgct ggacgtgctg caacgagggc
     2521 gaggaatcct cgccgggatg ctgcctgggc gaccgtcatg tgtggtcggg atcggtggtg
     2581 ggggtcaacg ggccctacta cgatttcgtt aggaccgagc accgaggatc cggcgaggac
     2641 gagcccgccg tatacgccct ggactgcgag atgagctaca cgggtcgtgg tctggacgtg
     2701 accaaggtct ccctggtggc actcaacggg caattggttt atgagcattt cgttcggccc
     2761 gtgtgcgaca taatagacta caacacccag tattcgggca ttacggaaac ggatctgtgt
     2821 tccggagcca agagtctggc cgaggtgcaa agggatctcc tccagctgat cacggcggac
     2881 accatcctta tcggacatgg attggaaaac gatctgcgag cgctacgctt ggttcacaac
     2941 accctgatcg acacctccat tagcttcccg cactgcaatg ggttccccta ccgccgggca
     3001 ctgcgtcacc tcacaaaggt tcacctgaag cgtgacattc aagctggcga cggcaccacg
     3061 ggacacagca gcttcgagga ctcgcgcgcc tgtatggaac tgatgctgtg gcgggtcaac
     3121 cgtgagctgg atcccgcttg gagctgggac gattagagga ctcgttcggg tgcgaatctg
     3181 tgacatttgg ggtggggtgg ggcattgggg gatgggcagc aagtactttt agttgttaag
     3241 ccagctcgta atagtactgt attcaaaaag aaaaacacaa tcgtaaaatc tcagctgggt
     3301 atctctcctg gcaatcggtt tctatagcac agactaactg atttatctcg gttaaacgta
     3361 taggtgccca ttgccagggg ttgggtcagc atatacatat acatatagaa tatatcaagt
     3421 aaatcgcaaa attgaaatga caaaaatggc aaaaggaagc aagcgaagga ggaggaggac
     3481 aagcccataa ttatatgcgg tacataaggc acattttgta agcgtatatt tatagataaa
     3541 tattacttta atctacatat gtatatacac atattgtttt ttttttttct tgattaattt
     3601 cgagccacga gaaaatgtac tgaagtttt