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Drosophila melanogaster NFAT nuclear factor (NFAT), transcript


LOCUS       NM_001169275            5243 bp    mRNA    linear   INV 26-DEC-2023
            variant D, mRNA.
ACCESSION   NM_001169275
VERSION     NM_001169275.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5243)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5243)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5243)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5243)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5243)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5243)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5243)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5243)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5243)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5243)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5243)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5243)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5243)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5243)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5243)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5243)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5243)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5243)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5243)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5243)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5243)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5243)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5243)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_001169275.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5243
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5243
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="NFAT nuclear factor"
                     /map="12A9-12B2"
                     /db_xref="FLYBASE:FBgn0030505"
                     /db_xref="GeneID:32321"
     CDS             713..4345
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="CG11172 gene product from transcript CG11172-RD;
                     CG11172-PD; NFAT-PD; NFAT homolog; Rel domain protein;
                     drosophila TonEBP; misexpression suppressor of Ras 1"
                     /codon_start=1
                     /product="NFAT nuclear factor, isoform D"
                     /protein_id="NP_001162746.1"
                     /db_xref="FLYBASE:FBpp0290665"
                     /db_xref="GeneID:32321"
                     /db_xref="FLYBASE:FBgn0030505"
                     /translation="MLLKFTKTSGAGPSAVPLLTTAPATVTSSASMQATTTSYAARGT
                     GMRMTMSTNSTMSARIHRKGFRIPSKRQPGKGLPGKLHTITRTGPGKMVPGKRIPQRP
                     HPPPCDNSNDSGLGFDQHTELRSSAGAGGVTDPAANGGSGSNSGQRSSLLVNSALTNT
                     VAAAAAAAAAAVASNTLQQHQQHHQQQQQQQQQQQQQQQQQQQQQQQQQHSPQQHLIR
                     AIPVSRFISARNVTRVANKRQPTTPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGS
                     RGAVKDRSGNGFPIVRLTGYDKVAVLQVFIGTDIGRVAPHMFYQACKVAGKNSTQCNE
                     KKVDGTMVIEIDFKPETDMTITCDCVGILKERNVDVEHRFPEHLAQKNKKKSTRCRMV
                     FRTQLTRDDGTTETLQVCSNPIICTQPPGVPEICKKSLNSCPVDGGLELFIIGKNFLK
                     DTHVVFQETYDSVNGDDPATEIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPP
                     YLHQNILKPVQVQVSIVSSGKKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFM
                     DTTSASNASGSSGWSAAGGSGNNTSTGDNVEAKHEIDSGMMPPPITTQIPMGVRRSSL
                     PSVTPMITDQQLVHLNAVAASAEALKTELDDSNSHSPLTGESTPDSPNAALQYHRFAR
                     KPSLDTIMYDQSNSLPGFPTVVAPATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVV
                     QQHQQMQEQMHEQQQQQQQQQQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNG
                     TTEPALFTTSAVIDHALTDILQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNS
                     SPLTQDIILNSEPAAALAGAAALGGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAA
                     TAVVPNILAPHQVTMANSILNDIAMQPEPTQQDAAVAALALSNIMMSPPTAASGVGVG
                     DTLPPTPATMQPEVAATATSTAVSNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQA
                     AVGVSGNPAETASDPLVDLLLNHSNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGHH
                     GHSHGHGHSRVTGHVSGHVTSHHRGHHLPVVPPTPQESLIVALASENALQKSVATAAV
                     TTNGAVMTQQASAPNTAGSILPAAVGAVAAAAAVAVQPPIPQELTTMSDQDLISYINP
                     STFDQL"
     misc_feature    1475..1966
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of tonicity-responsive enhancer binding protein
                     (TonEBP); Region: RHD-n_TonEBP; cd07882"
                     /db_xref="CDD:143642"
     misc_feature    order(1514..1516,1523..1525,1529..1546,1802..1804,
                     1808..1813,1865..1867,1871..1873,1964..1966)
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143642"
     misc_feature    1976..2332
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="Immunoglobulin-like fold, Plexins, Transcription
                     factors (IPT). IPTs are also known as Transcription factor
                     ImmunoGlobin (TIG) domains. They are present in
                     intracellular transcription factors, cell surface
                     receptors (such as plexins and scatter factor...; Region:
                     IPT; cl15674"
                     /db_xref="CDD:472823"
ORIGIN      
        1 gcagctctgt gcaacaagtt gaaaaataga agaagcaaat agaaacagcg tccgcaaata
       61 gtgcgcaaaa tagtgttttt ttgttaacgt gcaacagtga cattgttaag ccattgaatg
      121 caagtgacag tgggaccaga aaaacaatgc aaaacacttg gccacgcaac aataacaatt
      181 gagcaaggcg cacacacaca cacatgtgca ggcacccact cgtgtaagag aaaaaaagag
      241 atagcgcgag tgtgtgagtg agcgagaggc aagaactgta actgtaatat aattgataaa
      301 acaaaaaacg tcaggagcag gaatccagtg aaagagcggc tgtggctgag ggaaagagag
      361 agagagagag agagagcgag taagaggaca gcgaaaaaga gctgaaaaag gaggaggaat
      421 tgttgttgct aaaaatagca acaaatagac agggcacgaa gaagaagaag acgacggcaa
      481 ataagagcaa gaagaagaag cgttgacgca ggcaaaagtc gcagccttgt tggccacttg
      541 gactcttact ttgtcccgtt agccagctaa cgctctcccg gcgagcaaca acaacaacaa
      601 caaacatcga tagcagcaat aacaataacg atatcaagga atacgagatc agcatcatca
      661 acacaaaaca aaacaaaaac aacaacaaca agtacgacga cggaccaaaa ctatgctttt
      721 gaaattcaca aaaaccagtg gcgctggacc ctcggccgta ccgctactga ccaccgcccc
      781 cgcgacagtc accagttcgg cgtccatgca ggcaacaaca acaagttacg cggcccgtgg
      841 aacaggcatg agaatgacca tgtccaccaa ttccacaatg agtgcgcgta tacatcgaaa
      901 aggatttcgc ataccatcga aaagacagcc gggtaaggga ttgcccggca agttgcacac
      961 cataaccagg acgggtcctg gcaaaatggt tcctgggaag cgaataccac agcgacccca
     1021 tccgccgccc tgcgacaact cgaacgacag tgggctgggt ttcgatcagc acacggagct
     1081 gagatcctcg gcaggagctg ggggcgttac tgatccggcg gccaatggag gcagtggctc
     1141 caactctggc cagcgatcca gtttgctggt caatagcgct ttaaccaaca cagtggctgc
     1201 tgcagcagcc gcagcagctg ccgcggtggc cagcaacacg ttgcagcagc atcagcagca
     1261 ccatcaacag cagcagcagc aacagcagca acaacagcag cagcagcagc aacaacaaca
     1321 acagcagcag cagcaacaac attcaccgca gcagcattta atcagagcga tacctgtatc
     1381 aagattcata tcggccagga atgtcacgcg tgtggcgaac aaacgtcaac ccactacacc
     1441 gctgaacagc gtcgccagct ccaacgatgg ccaggtgcag ctggagattt tgtcgcagcc
     1501 ggagcaacag caccgggcac gctatcaaac ggagggcagc cgcggtgccg tcaaggatcg
     1561 cagcggcaat ggattcccga tcgtccgact gaccggatac gataaggttg ccgtcctcca
     1621 ggtcttcatc ggcacggaca ttggacgcgt ggcaccgcac atgttctatc aggcctgcaa
     1681 ggttgccggc aagaactcga cgcagtgcaa cgagaagaag gtcgacggca ccatggtcat
     1741 tgagatcgat ttcaagcccg aaacggacat gaccatcaca tgcgattgcg ttggaatctt
     1801 gaaggaacgc aatgtggatg tggagcaccg atttcccgag catctggcgc aaaagaacaa
     1861 gaagaaatcg actcgctgcc ggatggtgtt ccgcacccag ctgacccgtg acgatggcac
     1921 caccgagacc ctccaggtct gctcgaatcc aatcatctgc actcaaccac ctggcgtgcc
     1981 ggaaatatgc aagaaatcct taaactcatg tcccgttgat ggcggcctcg agcttttcat
     2041 tatcggcaag aactttctga aggacacaca cgtggtgttt caggagacat acgacagcgt
     2101 caacggtgac gatccggcca cggaaattgc agtgcgccag cagctcatcg gcggtacagc
     2161 cgctctttgg gaacagagtg ttctgccgga taaggagtac cttcaccaga ctcatctgat
     2221 atgcacggtg ccaccgtatc tgcaccagaa catcctgaaa ccggtccagg ttcaagtgtc
     2281 gatcgtctcc agcggcaaga agagcgaacc gcatacgttc acctacacgg ccaagggaca
     2341 gtacacgacg ctggcggcgg ccagcacgtt aagtaacaca atccacgccc aagatgtgag
     2401 cggtttcatg gacaccacat cagcgtccaa tgcgagtggc tccagtggtt ggagtgcggc
     2461 aggcggttcc ggcaacaata catctacagg cgataatgtg gaggccaaac acgagatcga
     2521 ttcgggcatg atgcctccgc ccattaccac ccaaataccg atgggcgttc gacgctcctc
     2581 gctgcccagt gtcacaccca tgatcacgga ccaacagctg gtccatctca acgcagtggc
     2641 ggccagtgcc gaggccctga agacggaact cgacgacagc aactcgcata gcccactgac
     2701 cggtgaatcc acaccggata gccccaacgc agccttgcag tatcatcgct ttgcacgaaa
     2761 gcccagcctg gacaccatta tgtacgatca gtcgaacagt ctgcccggtt tcccgaccgt
     2821 tgtggcgccg gctacagctg ccgccgtggc cgctgcagtt gatattgatc cgacggcggt
     2881 ggccgtggcg gtggaactgg ccgtaaaaaa tgagattgtc aagcatgtcg tacagcagca
     2941 ccagcagatg caggagcaaa tgcacgagca gcagcagcag caacagcagc agcaacaaca
     3001 acaacaacag cagcaacaac aacaacccca acagcagcag cagcaacagg tgcacaagtt
     3061 tattgacgag ctgaccaaat ccacatcggt ggtttccagc aatggtacca ccgaaccagc
     3121 tctgttcacc acctcggcgg tgatcgatca tgccctgacc gatattctgc aggccaaagt
     3181 tggcattgcg ccgcccaatg tggtgctgga aaggagtttg tccctaagct ccacaaattc
     3241 cagcagctcc atgagcggca gtgagagttc gccgaatagt tcacctttga cgcaggatat
     3301 catactcaat tcagaaccgg cagcagctct ggccggagct gctgccttgg gtggcccggc
     3361 gcctgtcgat gtcaccggtg gtctgtccac cgatatcatt atgaatcccg ccgtttcacc
     3421 atcgactatt ttgtgctccg caaatggagc ggccactgcc gtagtgccga atatactcgc
     3481 acctcaccaa gtgaccatgg ccaactccat tttgaacgat attgccatgc agccggaacc
     3541 aacacagcag gatgcagcag tagcagcctt ggcgttgagc aacatcatga tgagtccacc
     3601 caccgcggca tcgggtgtgg gagttggtga cacactgcca ccaacaccag ctactatgca
     3661 gccagaggtc gcagccactg ccacatccac tgcggtcagc aacatgatta ttaaggcggc
     3721 ggcggacttt ataaccaccc aggagcagga gcaacaccac taccatcacc acggtcgcat
     3781 ccactcccat tcgccacagg cagctgtcgg agtgagcggt aatcctgccg agacggcatc
     3841 ggatccattg gttgacctgc tattgaacca ctcaaacaca ccagaaacag cggctgctgc
     3901 cgctgccgca gtagctgtag aagcagccaa cttccagtcg atgaatcaca gtcaccacag
     3961 ccatcatggt catcatggtc acagtcacgg ccacggccat agtcgcgtca caggacacgt
     4021 atccgggcat gtgaccagcc accatcgtgg tcaccacttg ccggtggtgc cgccgacacc
     4081 acaagaatct ctgatcgttg cgctggccag cgagaatgct ctgcaaaagt cggtggccac
     4141 cgccgcagtg accaccaatg gagcagtgat gacgcaacag gcatctgccc cgaacacagc
     4201 gggtagcata cttccggcag cggttggagc ggtagctgcg gcggccgccg tggcggtgca
     4261 gccgcccatt ccccaggagc tgaccacgat gtcggatcag gatctgatca gctacatcaa
     4321 cccgagcacc tttgatcagc tttaaacggc ttcagatcaa caaattaaac tatgtggact
     4381 tgcttttttt tttatcaact ataaatgtca ctcctacaca ggcttaggct taagtatata
     4441 tgtagtatat agagacatac acaaacaaac gataagacgg aataaaggtt tcatgtggac
     4501 caactttttg accaagagaa aggagtaaaa acgggatcag agaataaaaa ccacaaacac
     4561 aaacagattt gtagctttag atttgcttac gtttaggcat aaaccctatt taatataatt
     4621 acctaaattt aatgtttttt ttttttttga ttttttttgc tattttaata ttgatttaaa
     4681 aaacaaatga tgaacttatc tcaaaaggtt aaattaaaac aatgataacg actgccatat
     4741 acctatgaaa tatgaagtga aatcccgaaa gtgaagaatg aaaaccgaaa atgaaaaatt
     4801 cagttatcaa ccttgaaaat cgataattat agaaagaacc aactttcata aaacaaatgt
     4861 tgattacgct ctttgctgga agacctattt ttataattaa gtctgatttg aaaacttcct
     4921 ttttatttgt ttgagaattt taggtatatt ttacaattaa agcctaacta aatgttttgg
     4981 cagtaaaatt aagcttattt aattttgggt caaaagaaaa ccacgaaaag aaattattat
     5041 tatacagtta ataatttata aaaaaaaaat acatattatg tgtagctacg aatataatga
     5101 atatgcgaga aattccaaaa gacttttgat ttaaagaaaa tgcaattatt attttgttta
     5161 tggtttaatc atttttattt tcaattatat tgaaggaacg acgaacacac acaaataaag
     5221 ttgtaactga tgttattact att