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Drosophila melanogaster NFAT nuclear factor (NFAT), transcript


LOCUS       NM_001169274            5935 bp    mRNA    linear   INV 26-DEC-2023
            variant C, mRNA.
ACCESSION   NM_001169274
VERSION     NM_001169274.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5935)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5935)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5935)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5935)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5935)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5935)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5935)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5935)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5935)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5935)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5935)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5935)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5935)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5935)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5935)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5935)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5935)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5935)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5935)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5935)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5935)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5935)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5935)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_001169274.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5935
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5935
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="NFAT nuclear factor"
                     /map="12A9-12B2"
                     /db_xref="FLYBASE:FBgn0030505"
                     /db_xref="GeneID:32321"
     CDS             380..4126
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="CG11172 gene product from transcript CG11172-RC;
                     CG11172-PC; NFAT-PC; NFAT homolog; Rel domain protein;
                     drosophila TonEBP; misexpression suppressor of Ras 1"
                     /codon_start=1
                     /product="NFAT nuclear factor, isoform C"
                     /protein_id="NP_001162745.1"
                     /db_xref="FLYBASE:FBpp0290664"
                     /db_xref="GeneID:32321"
                     /db_xref="FLYBASE:FBgn0030505"
                     /translation="MRFTYNQYKHYESGYRIPSKMHNLSHNNNNNSNNNNNGGGHTNN
                     NNNGNNSGHHYAHHNNSNNGGNNNTNFQAYQHHYKSNFGMRMTMSTNSTMSARIHRKG
                     FRIPSKRQPGKGLPGKLHTITRTGPGKMVPGKRIPQRPHPPPCDNSNDSGLGFDQHTE
                     LRSSAGAGGVTDPAANGGSGSNSGQRSSLLVNSALTNTVAAAAAAAAAAVASNTLQQH
                     QQHHQQQQQQQQQQQQQQQQQQQQQQQQQHSPQQHLIRAIPVSRFISARNVTRVANKR
                     QPTTPLNSVASSNDGQVQLEILSQPEQQHRARYQTEGSRGAVKDRSGNGFPIVRLTGY
                     DKVAVLQVFIGTDIGRVAPHMFYQACKVAGKNSTQCNEKKVDGTMVIEIDFKPETDMT
                     ITCDCVGILKERNVDVEHRFPEHLAQKNKKKSTRCRMVFRTQLTRDDGTTETLQVCSN
                     PIICTQPPGVPEICKKSLNSCPVDGGLELFIIGKNFLKDTHVVFQETYDSVNGDDPAT
                     EIAVRQQLIGGTAALWEQSVLPDKEYLHQTHLICTVPPYLHQNILKPVQVQVSIVSSG
                     KKSEPHTFTYTAKGQYTTLAAASTLSNTIHAQDVSGFMDTTSASNASGSSGWSAAGGS
                     GNNTSTGDNVEAKHEIDSGMMPPPITTQIPMGVRRSSLPSVTPMITDQQLVHLNAVAA
                     SAEALKTELDDSNSHSPLTGESTPDSPNAALQYHRFARKPSLDTIMYDQSNSLPGFPT
                     VVAPATAAAVAAAVDIDPTAVAVAVELAVKNEIVKHVVQQHQQMQEQMHEQQQQQQQQ
                     QQQQQQQQQQQPQQQQQQQVHKFIDELTKSTSVVSSNGTTEPALFTTSAVIDHALTDI
                     LQAKVGIAPPNVVLERSLSLSSTNSSSSMSGSESSPNSSPLTQDIILNSEPAAALAGA
                     AALGGPAPVDVTGGLSTDIIMNPAVSPSTILCSANGAATAVVPNILAPHQVTMANSIL
                     NDIAMQPEPTQQDAAVAALALSNIMMSPPTAASGVGVGDTLPPTPATMQPEVAATATS
                     TAVSNMIIKAAADFITTQEQEQHHYHHHGRIHSHSPQAAVGVSGNPAETASDPLVDLL
                     LNHSNTPETAAAAAAAVAVEAANFQSMNHSHHSHHGHHGHSHGHGHSRVTGHVSGHVT
                     SHHRGHHLPVVPPTPQESLIVALASENALQKSVATAAVTTNGAVMTQQASAPNTAGSI
                     LPAAVGAVAAAAAVAVQPPIPQELTTMSDQDLISYINPSTFDQL"
     misc_feature    1256..1747
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="N-terminal sub-domain of the Rel homology domain
                     (RHD) of tonicity-responsive enhancer binding protein
                     (TonEBP); Region: RHD-n_TonEBP; cd07882"
                     /db_xref="CDD:143642"
     misc_feature    order(1295..1297,1304..1306,1310..1327,1583..1585,
                     1589..1594,1646..1648,1652..1654,1745..1747)
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="DNA binding site [nucleotide binding]"
                     /db_xref="CDD:143642"
     misc_feature    1757..2113
                     /gene="NFAT"
                     /locus_tag="Dmel_CG11172"
                     /gene_synonym="CG11172; Dmel\CG11172; dNFAT; EP1335;
                     MESR1; NF-AT5; Nfat; NFAT5"
                     /note="Immunoglobulin-like fold, Plexins, Transcription
                     factors (IPT). IPTs are also known as Transcription factor
                     ImmunoGlobin (TIG) domains. They are present in
                     intracellular transcription factors, cell surface
                     receptors (such as plexins and scatter factor...; Region:
                     IPT; cl15674"
                     /db_xref="CDD:472823"
ORIGIN      
        1 tggtagatac aaacaattaa agcaactgca gagcaaattt accaacaaac aaagcaacaa
       61 cacacaaaac aaatgtacaa agtcaatcca aaattacaaa tattaattta aaacacaaag
      121 aaacaattaa atgtgccaac aatatttacc aaatcaacaa aaacaataca agtcagaggg
      181 aagacaacaa aatcgatgcc tgtaaacata attataaaat atactaaaag cacttatccc
      241 aaaaagagaa cgagaaactc gaggagagag tagaaagagt ggaaagaaca atcactaatc
      301 gaaaataaat taattgcacc acaaatagcc ataagagtta attaaagtta tttaaagagt
      361 ccagtgaaaa tcaatcaaaa tgcgattcac ctacaatcag tataaacatt atgagtccgg
      421 ttatcggatt ccatctaaaa tgcataatct gagccataat aacaacaata atagtaataa
      481 taataataat gggggtggcc acaccaacaa caacaacaat ggcaacaata gtggccatca
      541 ctatgcccat cacaataata gcaacaatgg cggcaataac aacacaaatt tccaagccta
      601 tcagcatcat tacaaaagta atttcggcat gagaatgacc atgtccacca attccacaat
      661 gagtgcgcgt atacatcgaa aaggatttcg cataccatcg aaaagacagc cgggtaaggg
      721 attgcccggc aagttgcaca ccataaccag gacgggtcct ggcaaaatgg ttcctgggaa
      781 gcgaatacca cagcgacccc atccgccgcc ctgcgacaac tcgaacgaca gtgggctggg
      841 tttcgatcag cacacggagc tgagatcctc ggcaggagct gggggcgtta ctgatccggc
      901 ggccaatgga ggcagtggct ccaactctgg ccagcgatcc agtttgctgg tcaatagcgc
      961 tttaaccaac acagtggctg ctgcagcagc cgcagcagct gccgcggtgg ccagcaacac
     1021 gttgcagcag catcagcagc accatcaaca gcagcagcag caacagcagc aacaacagca
     1081 gcagcagcag caacaacaac aacagcagca gcagcaacaa cattcaccgc agcagcattt
     1141 aatcagagcg atacctgtat caagattcat atcggccagg aatgtcacgc gtgtggcgaa
     1201 caaacgtcaa cccactacac cgctgaacag cgtcgccagc tccaacgatg gccaggtgca
     1261 gctggagatt ttgtcgcagc cggagcaaca gcaccgggca cgctatcaaa cggagggcag
     1321 ccgcggtgcc gtcaaggatc gcagcggcaa tggattcccg atcgtccgac tgaccggata
     1381 cgataaggtt gccgtcctcc aggtcttcat cggcacggac attggacgcg tggcaccgca
     1441 catgttctat caggcctgca aggttgccgg caagaactcg acgcagtgca acgagaagaa
     1501 ggtcgacggc accatggtca ttgagatcga tttcaagccc gaaacggaca tgaccatcac
     1561 atgcgattgc gttggaatct tgaaggaacg caatgtggat gtggagcacc gatttcccga
     1621 gcatctggcg caaaagaaca agaagaaatc gactcgctgc cggatggtgt tccgcaccca
     1681 gctgacccgt gacgatggca ccaccgagac cctccaggtc tgctcgaatc caatcatctg
     1741 cactcaacca cctggcgtgc cggaaatatg caagaaatcc ttaaactcat gtcccgttga
     1801 tggcggcctc gagcttttca ttatcggcaa gaactttctg aaggacacac acgtggtgtt
     1861 tcaggagaca tacgacagcg tcaacggtga cgatccggcc acggaaattg cagtgcgcca
     1921 gcagctcatc ggcggtacag ccgctctttg ggaacagagt gttctgccgg ataaggagta
     1981 ccttcaccag actcatctga tatgcacggt gccaccgtat ctgcaccaga acatcctgaa
     2041 accggtccag gttcaagtgt cgatcgtctc cagcggcaag aagagcgaac cgcatacgtt
     2101 cacctacacg gccaagggac agtacacgac gctggcggcg gccagcacgt taagtaacac
     2161 aatccacgcc caagatgtga gcggtttcat ggacaccaca tcagcgtcca atgcgagtgg
     2221 ctccagtggt tggagtgcgg caggcggttc cggcaacaat acatctacag gcgataatgt
     2281 ggaggccaaa cacgagatcg attcgggcat gatgcctccg cccattacca cccaaatacc
     2341 gatgggcgtt cgacgctcct cgctgcccag tgtcacaccc atgatcacgg accaacagct
     2401 ggtccatctc aacgcagtgg cggccagtgc cgaggccctg aagacggaac tcgacgacag
     2461 caactcgcat agcccactga ccggtgaatc cacaccggat agccccaacg cagccttgca
     2521 gtatcatcgc tttgcacgaa agcccagcct ggacaccatt atgtacgatc agtcgaacag
     2581 tctgcccggt ttcccgaccg ttgtggcgcc ggctacagct gccgccgtgg ccgctgcagt
     2641 tgatattgat ccgacggcgg tggccgtggc ggtggaactg gccgtaaaaa atgagattgt
     2701 caagcatgtc gtacagcagc accagcagat gcaggagcaa atgcacgagc agcagcagca
     2761 gcaacagcag cagcaacaac aacaacaaca gcagcaacaa caacaacccc aacagcagca
     2821 gcagcaacag gtgcacaagt ttattgacga gctgaccaaa tccacatcgg tggtttccag
     2881 caatggtacc accgaaccag ctctgttcac cacctcggcg gtgatcgatc atgccctgac
     2941 cgatattctg caggccaaag ttggcattgc gccgcccaat gtggtgctgg aaaggagttt
     3001 gtccctaagc tccacaaatt ccagcagctc catgagcggc agtgagagtt cgccgaatag
     3061 ttcacctttg acgcaggata tcatactcaa ttcagaaccg gcagcagctc tggccggagc
     3121 tgctgccttg ggtggcccgg cgcctgtcga tgtcaccggt ggtctgtcca ccgatatcat
     3181 tatgaatccc gccgtttcac catcgactat tttgtgctcc gcaaatggag cggccactgc
     3241 cgtagtgccg aatatactcg cacctcacca agtgaccatg gccaactcca ttttgaacga
     3301 tattgccatg cagccggaac caacacagca ggatgcagca gtagcagcct tggcgttgag
     3361 caacatcatg atgagtccac ccaccgcggc atcgggtgtg ggagttggtg acacactgcc
     3421 accaacacca gctactatgc agccagaggt cgcagccact gccacatcca ctgcggtcag
     3481 caacatgatt attaaggcgg cggcggactt tataaccacc caggagcagg agcaacacca
     3541 ctaccatcac cacggtcgca tccactccca ttcgccacag gcagctgtcg gagtgagcgg
     3601 taatcctgcc gagacggcat cggatccatt ggttgacctg ctattgaacc actcaaacac
     3661 accagaaaca gcggctgctg ccgctgccgc agtagctgta gaagcagcca acttccagtc
     3721 gatgaatcac agtcaccaca gccatcatgg tcatcatggt cacagtcacg gccacggcca
     3781 tagtcgcgtc acaggacacg tatccgggca tgtgaccagc caccatcgtg gtcaccactt
     3841 gccggtggtg ccgccgacac cacaagaatc tctgatcgtt gcgctggcca gcgagaatgc
     3901 tctgcaaaag tcggtggcca ccgccgcagt gaccaccaat ggagcagtga tgacgcaaca
     3961 ggcatctgcc ccgaacacag cgggtagcat acttccggca gcggttggag cggtagctgc
     4021 ggcggccgcc gtggcggtgc agccgcccat tccccaggag ctgaccacga tgtcggatca
     4081 ggatctgatc agctacatca acccgagcac ctttgatcag ctttaaacgg cttcagatca
     4141 acaaattaaa ctatgtggac ttgctttttt ttttatcaac tataaatgtc actcctacac
     4201 aggcttaggc ttaagtatat atgtagtata tagagacata cacaaacaaa cgataagacg
     4261 gaataaaggt ttcatgtgga ccaacttttt gaccaagaga aaggagtaaa aacgggatca
     4321 gagaataaaa accacaaaca caaacagatt tgtagcttta gatttgctta cgtttaggca
     4381 taaaccctat ttaatataat tacctaaatt taatgttttt tttttttttg attttttttg
     4441 ctattttaat attgatttaa aaaacaaatg atgaacttat ctcaaaaggt taaattaaaa
     4501 caatgataac gactgccata tacctatgaa atatgaagtg aaatcccgaa agtgaagaat
     4561 gaaaaccgaa aatgaaaaat tcagttatca accttgaaaa tcgataatta tagaaagaac
     4621 caactttcat aaaacaaatg ttgattacgc tctttgctgg aagacctatt tttataatta
     4681 agtctgattt gaaaacttcc tttttatttg tttgagaatt ttaggtatat tttacaatta
     4741 aagcctaact aaatgttttg gcagtaaaat taagcttatt taattttggg tcaaaagaaa
     4801 accacgaaaa gaaattatta ttatacagtt aataatttat aaaaaaaaaa tacatattat
     4861 gtgtagctac gaatataatg aatatgcgag aaattccaaa agacttttga tttaaagaaa
     4921 atgcaattat tattttgttt atggtttaat catttttatt ttcaattata ttgaaggaac
     4981 gacgaacaca cacaaataaa gttgtaactg atgttattac tattattatt attattatta
     5041 ttattatgat atcgctatta ttatgcatac cctaaatgtt gatagttgtt atgtgtagcg
     5101 ttgtaaccta tttaccatgc cggaataaga aacacaaaag tgaaaatata agagaacaaa
     5161 cccacaacca aacaacattg aaaagtaacg actaagttta gtataccgat tgttataccc
     5221 acaaataaag atcaagatcg agagtactct gcatttgtat gcccaagccc aactatttat
     5281 gtataaacat caacaaatat tccaaccacg aattttgccc actcccatga atcgaactaa
     5341 ctgagaaact taaactataa agtttttttt tttttgttga tattagcttg gtaaatttta
     5401 aacaatttga ttgacatacg taatctatat gttcatagag tcgataaatg tgttaaacaa
     5461 tctcagagat tgcatattcc tcattaaatt aaatgttaaa gtcaagtcaa tgaacgacag
     5521 agatagcgtt agtaggtgca agtgagatgg agagagacag agaaagaaat agagagagag
     5581 agagagagag agagcgaaga gctcgcgctt aagaattgtt agtgttaaat gttatacacc
     5641 tatatataca ttatttatgt tatatatata caaacatata tctaacttta caatgaataa
     5701 aataaatgta tttttgatgt tcttattgcc caaagtgcag aaccgataaa ccaatgaaaa
     5761 tcccgaagag aactccctga actttgtaac cgaactgtca aacgtatcaa ttggcgaaat
     5821 aacgatccta atatccatat ccacactacc ccaaaacttg tccaaaatcc tcccaacgga
     5881 aacaatacta ttctgctcgt tatctctttt tatgtgaata aaaacgaaat cattg