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Drosophila melanogaster tomosyn, transcript variant F (Tomosyn),


LOCUS       NM_001169264            5290 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001169264
VERSION     NM_001169264.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5290)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5290)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5290)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5290)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5290)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5290)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5290)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5290)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5290)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5290)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5290)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5290)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5290)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5290)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5290)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5290)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5290)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5290)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5290)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5290)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5290)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5290)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5290)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001169264.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5290
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5290
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /map="11B6-11B7"
                     /db_xref="FLYBASE:FBgn0030412"
                     /db_xref="GeneID:32217"
     CDS             639..5051
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="CG17762 gene product from transcript CG17762-RF;
                     CG17762-PF; Tomosyn-PF; tomosyn ortholog"
                     /codon_start=1
                     /product="tomosyn, isoform F"
                     /protein_id="NP_001162735.1"
                     /db_xref="FLYBASE:FBpp0289604"
                     /db_xref="GeneID:32217"
                     /db_xref="FLYBASE:FBgn0030412"
                     /translation="MKKFTFKGVLDGFRQSVQPQATRQEQEIQEQLKADHFTLKKTFR
                     HGFPYSPTSFAFDPVQKLLAIGDKSGYIRILGRPGVDAHAKHEGESECAVLFAQFLVN
                     EGALVTVTADDTIHLWSIRQKTPRIVQSLKFQRERVTCIHLPVGSKWLYVGTEKGNIH
                     VVHIDTFALSGYIINWNKAIEVVRTSHPGAVIALCDNPLDANKLLIAFECGLLVLWDL
                     KAKCAELRWQAAEAVKSLAWHYEGKYFVSSHTDGSICSWPTKPQAKPQSQVCPHAKIN
                     KDGNAEKCKPIYKVDLKSSATGETFTIFSGGMPSEKGSKSNCITVMVGKATTVLEMEH
                     AVCDFITLCENPWPCETQEPYAIAVLLQYDLVLIDLLTPGFPCFESPYPMDLHESPVT
                     CCTYLTDCPSDLVPAFYSVGRTTTSKKSCFSEREWPISGGEWSPASCSYSEIVITGHQ
                     DGSLKFWDSGAGTLQILYKLKTAKMFEKPRSHVAHSHPESDNPLAVHLIFLCSESRRL
                     CVAGAMGQVMLFKFRKVESTSEVLVLEIPILYENFDDIYGTSPECDFLTGHQVQKAES
                     SDSDKTAECSLKVRNGAQRKPPGFQSQLVCLTTGPNRRNVQVTSLCISSSYGLMAYGT
                     EYGLVIIDIIQKICLLSVACPDLYGAHDPYSRTPKSPKRIENKEEQSRSPSSDQLNDT
                     TSPDSPSLEFVPEAGETSAHDGVATATSSRPSSPDPVVNSARETLLSGSAAATAAAAA
                     SAAVMMAKSPQRDDAAPKELQDRRKSMSWKTFNLKRQLSKVNMKIGGLNVNTDMESLK
                     NSSIFYTPKEVSPEAATPPATEEEATPEGKEDESLDDGEMATNAGAAAAASPSPAVRG
                     KFRSSTTDSPDEGASSSIASGIRRVDFEQPAGVEVERPNNLPLADAPAPLKPARQKFK
                     EKSRDQRLLSVPNIKYQPRDSRGGARNLKNDVSPLMGGGGGGGGVVGASSGIGGSVAG
                     GKKIHKLDGTFSRSRSSSMSSIDMSSSESVTCLAFIESYAKRNDILTLVPTLWIGTSF
                     GSILTLFITMPERDVRKSQPVLITINGGPVVRLKGSITSMSFLDSYGSIIPYTFETWR
                     DEKRDNKDRTPTKSSSRTSPTFTPTTANTLSNTSVAGGASAGGGAGGGGGAGGGAASG
                     GAAAGGPAGGGAGAGSAAGAAGGVGSGVTSGGGMSSSSASSSGISGSVSTGLETLTDR
                     QYIVIASEKQTKVFDVANQCCINRIQLSEMDFAVKAETITMKDGSCLATYLSNGHLMV
                     HSLPSLKLLLDTDFLPLMELSFQTKCKQGIVDPMLSIWGQQIIVHEDTTQISKIFCFS
                     HKGHGLYMASPTEIQKFTISSEFCQFILEMMGELYTVHEMPEQPKEGFFKGLFGGGAK
                     LLDREELFGEQSGKPNRSVARHIPGPNLEQLGQRASTAASEISRAHQLAMERGEKLNL
                     LEERAERMANTAQDFSGTAHQLMLKYKDKKWYQL"
     misc_feature    <759..1409
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [General function prediction only];
                     Region: WD40; COG2319"
                     /db_xref="CDD:441893"
     misc_feature    921..1037
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1050..1190
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1212..1316
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="WD40 repeat [structural motif]; Region: WD40
                     repeat"
                     /db_xref="CDD:293791"
     misc_feature    1440..1766
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="LLGL2; Region: LLGL; pfam08366"
                     /db_xref="CDD:462446"
     misc_feature    4845..5027
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="SNARE domain of STXBP5, STXBP6 and related
                     proteins; Region: R-SNARE_STXBP5_6; cd15873"
                     /db_xref="CDD:277226"
     misc_feature    order(4854..4856,4863..4868,4872..4874,4884..4889,
                     4893..4901,4905..4910,4914..4919,4926..4931,4935..4952,
                     4956..4973,4977..4994,4998..5006,5010..5015,5022..5024)
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="heterotetramer interface [polypeptide binding];
                     other site"
                     /db_xref="CDD:277226"
     misc_feature    4926..4928
                     /gene="Tomosyn"
                     /locus_tag="Dmel_CG17762"
                     /gene_synonym="BcDNA:RH19475; CG11056; CG17762; CG2205;
                     Dmel\CG17762; tomosyn"
                     /note="zero layer; other site"
                     /db_xref="CDD:277226"
ORIGIN      
        1 gcccagtcgt cgaagttttc acagctctaa cagttgagac aacattttga gaaattgtcg
       61 tttgttttgt cgtgcttttt gtttaaacat tgcgttgtgt tttttgttta tcgcccccgt
      121 gtcgatctga tctgattcgg ttcgccaatc caattggatt gggcaagcgc cacaaacgtt
      181 caacagcgga gtgaatcgcc atgaaacagc aaatatttcg accactgtta acctagtttc
      241 acatctcaaa aataaaacca aacaacaagg acgaactcag accagcactg gctcctctgt
      301 cttcaattac gcacagctct accagtatct agagaataac gagtaaaggc taccaaggac
      361 tcgagggaag agaatcgcct ggggcagagg aagaagccaa tccccatact tttcggttct
      421 cctcggacca gaatcatcac ctcccccatc ccgaccccgg cactaccttc ccgctgaacc
      481 acatacactc tgtccactat ccactattcg acaccaccac actctgtgca tccaactatt
      541 tggccaacca ttaatccttg ggcgagacca gagcagcccc atcgcataac tgtggatagc
      601 agagcagccg gagcacgagg acgactcatg ttacaaaaat gaaaaagttc acattcaaag
      661 gagttctaga tggatttcga caaagcgttc agccccaagc cacacgacag gagcaggaga
      721 ttcaggagca actcaaggcc gatcacttta cgttaaagaa aacctttcgc catggctttc
      781 catactcgcc cacatccttc gccttcgatc cagtacaaaa gctactagcg attggcgaca
      841 aatcgggcta cattcgcatt ttgggacgac ctggcgtcga tgcccatgcc aaacacgagg
      901 gcgaatccga gtgcgccgtg ctctttgccc agttcctggt caacgagggc gcattggtca
      961 ccgtcaccgc cgatgacacc attcacttgt ggagcattcg ccaaaagaca ccgcgcattg
     1021 tgcagagtct gaagtttcag agggagcgcg tgacttgcat acacctgcct gtgggcagca
     1081 aatggctgta cgtgggcacc gagaagggaa acatacacgt tgttcacata gatacatttg
     1141 cacttagtgg ttatattatt aactggaata aagcaattga agtggttaga actagtcatc
     1201 caggtgctgt gattgcgtta tgtgataatc cattggatgc aaacaagttg cttattgcat
     1261 ttgagtgcgg gctgcttgtg ctgtgggatc tgaaggcgaa atgcgctgag ctgcgatggc
     1321 aggcggccga ggccgtcaag tccctggcct ggcactacga gggcaaatat tttgtgtcct
     1381 cgcacacgga tggctccatt tgctcctggc ccacgaagcc gcaggctaag ccgcagtcgc
     1441 aggtctgtcc gcatgctaaa atcaacaagg atggcaatgc ggagaaatgc aagccgatat
     1501 ataaagttga cttgaagtcc agcgcaactg gggaaacctt cacaattttc tcgggcggca
     1561 tgccctcgga gaagggctcc aagtccaact gcatcacggt gatggtgggc aaggccacca
     1621 cggtgctgga gatggagcac gccgtttgcg atttcataac actctgcgag aatccctggc
     1681 cctgcgagac ccaggagccg tatgctattg ccgtgctgtt gcaatacgac ttagtattaa
     1741 tagacttatt aacacccggt tttccatgtt ttgaatcgcc ttatccaatg gacttacacg
     1801 aatcacctgt tacatgttgc acatatttaa ccgattgccc atcggatttg gttcctgctt
     1861 tctattcagt tggtcgcaca acgacaagta aaaagagctg cttctcggag cgcgaatggc
     1921 cgatatccgg tggcgagtgg tcgccggcgt cgtgcagcta ttcggagatc gtgatcaccg
     1981 gacaccagga cggcagcctc aagttctggg attccggtgc cggcacactg cagatcctct
     2041 ataagctgaa gacagccaag atgttcgaga agccgcgctc ccacgtcgcc cactcgcatc
     2101 cggaaagcga caatccgctg gcggtgcacc taatcttcct ttgctcggaa tcgcgacgcc
     2161 tgtgtgtggc cggcgccatg ggacaggtga tgctcttcaa gttccgcaaa gtggagtcca
     2221 cgtcggaggt actggtgctg gagataccca tactctatga gaattttgat gacatttatg
     2281 ggacaagtcc cgagtgcgat tttctaacgg gccatcaagt gcagaaggct gagtcgagtg
     2341 attcggataa gacggccgag tgttcgctaa aggtgcgcaa tggggcgcaa cgcaagccgc
     2401 cgggcttcca gtcgcagctg gtctgcctca ccaccggacc aaatcgccgg aacgtgcagg
     2461 tcacctcgct gtgcatcagc tccagttatg gcctaatggc ttatggtacc gaatatggac
     2521 ttgtcataat tgatataatc caaaaaattt gcctattgag tgttgcatgc cccgatctgt
     2581 atggcgcaca tgatccttac tcgcgaacac caaaaagtcc aaaacgtatt gaaaacaaag
     2641 aggagcaaag ccgatcgccc agctcagatc agctgaacga cacgaccagt ccggatagtc
     2701 cgtctctcga atttgtaccg gaggctggcg aaacatcggc ccacgatggc gtggcgacgg
     2761 caactagctc acgtcccagt tcaccggacc cggtggtgaa cagtgctcgt gaaacgctgc
     2821 tcagcggatc ggcagcggca acggcggctg cggcagcatc ggcggctgtc atgatggcca
     2881 agagtcccca gcgggatgat gcagctccca aggagctgca ggacagacga aagtccatgt
     2941 cctggaaaac gttcaatttg aagcgtcaat tatcgaaagt caatatgaag atcggcggcc
     3001 tgaatgtcaa taccgatatg gagtcgctaa agaatagctc cattttctac acgcccaagg
     3061 aggtgtcacc ggaggctgct acgccaccgg caacagaaga ggaggcaacg ccggagggca
     3121 aggaggacga gtccctggat gatggcgaaa tggcgaccaa cgcgggagca gcagcagctg
     3181 catcaccatc gccggcagtt cgtggcaaat ttcgctcatc caccacggat tcacctgatg
     3241 agggcgccag cagtagcatt gccagcggca ttcgtcgtgt ggactttgaa cagccggctg
     3301 gggtcgaggt ggagcgacca aacaacctgc cactggcgga tgcaccagct ccactgaagc
     3361 ccgcccgtca aaagttcaag gaaaagtcgc gcgatcagcg acttttatcc gttccgaaca
     3421 ttaagtatca gccgcgagat tcgcgtggcg gtgctcggaa cctcaagaat gatgtctcac
     3481 cgctgatggg cggtggtggc ggtggaggag gcgttgttgg tgccagcagc ggcattggtg
     3541 gaagcgtcgc tggaggcaag aagatacata aattggatgg aactttctca agatccagat
     3601 catcgtcaat gtccagcatt gatatgtctt cctctgaatc tgttacctgt ttagctttta
     3661 tcgagagtta tgcaaaacga aatgatattt tgacacttgt tcctactttg tggattggaa
     3721 ctagtttcgg ttcgatactg acattgttca tcaccatgcc cgagcgagat gtgcgcaaat
     3781 ctcagccagt attgataaca ataaatggtg gccccgtggt acgactcaaa ggatccataa
     3841 cttccatgtc ttttttagac tcatacggtt cgatcatacc ctatacgttt gagacctggc
     3901 gtgacgagaa gagggacaac aaagatcgca caccaacaaa gagcagcagc cgcaccagtc
     3961 ccacattcac accgacaact gccaatacat tatcaaacac ttcggtcgcg ggtggtgcgt
     4021 ccgcaggcgg aggagctggc ggcggtggtg gtgccggcgg tggtgcggcc agcggtggcg
     4081 cagccgcagg agggccagcc ggcggtggtg ccggagcagg atcggcggct ggagcggccg
     4141 gcggcgttgg aagcggtgta accagcggcg gggggatgag cagcagcagc gccagcagca
     4201 gcggcatcag cggaagtgtg agcaccggcc tggaaactct caccgatcga caatacatcg
     4261 ttatcgcaag cgagaagcaa acaaaagtct tcgatgtcgc caaccagtgc tgcatcaacc
     4321 gcatacaatt atcggaaatg gattttgcag tcaaggcaga aactatcacg atgaaagatg
     4381 gctcttgctt agcaacctat ctttcgaatg gccatctaat ggtacatagt cttcctagtc
     4441 taaaactgtt attggatact gatttcttac cacttatgga actaagtttt caaacaaaat
     4501 gtaaacaggg aattgtggat ccaatgcttt cgatatgggg tcaacagatc attgttcatg
     4561 aagatacaac tcaaatatca aaaatatttt gctttagtca taaaggtcat ggattgtaca
     4621 tggcatcgcc caccgaaatt caaaaattca cgatatcatc ggaattttgt caatttattt
     4681 tggagatgat gggtgaacta tatacggtac acgaaatgcc cgaacagccg aaggagggtt
     4741 tcttcaaggg tctatttggt ggtggcgcca aactcctgga tcgcgaggag ctatttggcg
     4801 agcagagcgg gaaaccgaat cgatcggtgg cacggcacat acccggcccc aatttggagc
     4861 agctcggcca gagggcttcc accgccgcat cggagatcag ccgggcgcac cagctggcca
     4921 tggagcgcgg cgagaagcta aatttgctgg aggagcgcgc cgagcgcatg gccaacactg
     4981 ctcaagattt cagcggcact gcgcatcaat taatgcttaa atataaagac aagaagtggt
     5041 atcagttgta aaatatctat tttaggagcc aattctacca cagttattgt aatattgctt
     5101 ttataacact ttctactaca ttacgagtaa agtacactta tttaatttct gttttcaagt
     5161 cgtcacgtta tttacaaaaa ccgaaaacca acaaaaaaaa acaacaaaaa ccgaaaattc
     5221 acaaaaacaa aaaaactgaa agagaaaacc caaccaaaaa aaaactgttt ttaataaaaa
     5281 tatatagacc