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LOCUS NM_001169250 3159 bp mRNA linear INV 26-DEC-2023 transcript variant C (Evi5), mRNA. ACCESSION NM_001169250 VERSION NM_001169250.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 3159) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 3159) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 3159) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 3159) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 3159) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 3159) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 3159) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 3159) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 3159) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 3159) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 3159) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 3159) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 3159) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 3159) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 3159) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 3159) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 3159) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 3159) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 3159) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 3159) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 3159) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 3159) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 3159) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_001169250.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..3159 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..3159 /gene="Evi5" /locus_tag="Dmel_CG11727" /gene_synonym="BcDNA:GH08923; BcDNA:LD11130; CG11727; Dmel\CG11727; MRE21" /note="Ecotropic viral integration site 5" /map="10B11-10B14" /db_xref="FLYBASE:FBgn0262740" /db_xref="GeneID:32088" CDS 756..3077 /gene="Evi5" /locus_tag="Dmel_CG11727" /gene_synonym="BcDNA:GH08923; BcDNA:LD11130; CG11727; Dmel\CG11727; MRE21" /note="CG11727 gene product from transcript CG11727-RC; CG11727-PC; Evi5-PC; mRNA-like ncRNA in embryogenesis 21; ecotropic viral integration site 5 ortholog" /codon_start=1 /product="ecotropic viral integration site 5, isoform C" /protein_id="NP_001162721.1" /db_xref="FLYBASE:FBpp0289956" /db_xref="GeneID:32088" /db_xref="FLYBASE:FBgn0262740" /translation="MTLTTTTTASSAESQAKMDVKGGALPGEENLPTSEMDLLAKLEA ANKLIESDAKSLNSLHSTHSRKNSDTSQISLTSSGNSVAEEDIWTTWATILNDWEGAL KRKNPCVSELVRRGIPHHFRAIVWQQLSGASDGDKKQYAEYIKATSACEKVIRRDIAR TYPEVEFFKEKDGPGQEALFNVIKAYSLHDREVGYCQGSGFIVGLLLMQMPEEEAFAV LVQIMQQHRMRHMFKPSMSELGLCMYQLENLVQEQIPDMHIHFQQQGFQTTMYASSWF LTLYTTTLNVNLSCRIMDVFLSEGMEFIFKVALALLLTGKDTLLCLDMEAMLKFFQKE LPGRVEADVEGFFNLAYSIKLNTKRMKKMEKEYQDLKKKEQEEMAELRRLRRENCLLK QRNELLEAESAELADRLVRGQVSRAEEEETSYAIQTELMQLRRSYLEVSHQLENANEE VRGLSLRLQENNNSRQSSIDELCMKEEALKQRDEMVSCLLEELVKVRQGLAESEDQIR NLKAKVEELEEDKKTLRETTPDNSVAHLQDELIASKLREAEASLSLKDLKQRVQELSS QWQRQLAENQRSESERTTNAVDSTPKKLLTNFFDSSKSSEHTQKLEEELMTTRIREME TLTELKELRLKVMELETQVQVSTNQLRRQDEEHKKLKEELEMAVTREKDMSNKAREQQ HRYSDLESRMKDELMNVKIKFTEQSQTVAELKQEISRLETKNSEMLAEGELRANLDDS DKVRDLQDRLADMKAEYPTPITSPDTEPWKWIS" misc_feature 1092..1715 /gene="Evi5" /locus_tag="Dmel_CG11727" /gene_synonym="BcDNA:GH08923; BcDNA:LD11130; CG11727; Dmel\CG11727; MRE21" /note="Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Region: TBC; smart00164" /db_xref="CDD:214540" misc_feature <1827..>3020 /gene="Evi5" /locus_tag="Dmel_CG11727" /gene_synonym="BcDNA:GH08923; BcDNA:LD11130; CG11727; Dmel\CG11727; MRE21" /note="Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; Region: Smc; COG1196" /db_xref="CDD:440809" ORIGIN 1 gccagtgggc gaaaaaaaac attcgtgaat tcaccgtcgt cgaacgaacg ctgtattttt 61 ttccagtgca atattcggtc gatgtataac gagtgattga attaaagtag tccttttaaa 121 aaaagtacta gtatttaaat aaaaataaag tcatacagaa cagcataggg agagagggcg 181 agagaaaaaa ttgctgctgc tgaggtgtgt gcaattgcct gtgcgtgtgt gtgtgtgtgt 241 gtttgtgtga cgtttacagc agcaaaaagt tcggtagtgt cgtcaaaata atcgtgtatt 301 ataaagttaa tgcaaacgat tctcgatcgg atacgagttg atcgcgacat attgagttcg 361 tcgaatgtgg aaaagtctag ctgattgaaa acgaaacgcg gataaaaaaa aaacgataaa 421 caacggcaat ttgttgctgc cgcaacagca acaacaacag cagcagcgca ctaacgcaac 481 caccaccacc ccctgttcca gcctaacggt tcatttacag tggccgaaga agcagcagca 541 aagtatgcga aactaggagc accatgtggc ggttttagag aagcagcaaa gtattattaa 601 ccacgattcg ggattaggat caggatcagg atcaggagca ctacagattg aagcaatcga 661 attcgaggaa aacggtagtc cagggacgca agattcggaa agaggggagt atagactgag 721 atcaaagatc ggagaacgtc gttctgtgtc agaagatgac cctgaccaca acgaccactg 781 cctcatcagc cgagagccaa gcgaaaatgg acgtaaaggg cggcgcactt cccggcgaag 841 agaacctgcc cacatccgaa atggatctgc tggccaaact ggaggcggcc aataagctca 901 tcgagagcga tgccaagtcc ctcaactctc tgcattccac gcacagtcgc aagaactcgg 961 atacgagtca aatcagtctt acgtcgagtg gaaattcggt ggccgaagag gacatctgga 1021 cgacgtgggc caccatcctc aatgactggg agggagcact gaaacgaaag aatccctgcg 1081 tcagtgagct ggtgcgccgt ggaattccac accacttccg agcgatcgta tggcagcagc 1141 taagtggagc gtccgacggc gacaaaaaac agtatgcgga gtacatcaag gcgaccagtg 1201 cctgcgagaa ggtcatacgg cgtgacattg cccgcaccta tcccgaggtg gagttcttca 1261 aggagaagga tggacccgga caggaggccc tgttcaatgt gatcaaggca tattctctgc 1321 acgatcgcga ggtcggctac tgccagggct cgggattcat tgtgggcctg ctgctgatgc 1381 aaatgcccga ggaggaggca ttcgctgtgc tcgtgcagat catgcagcag catcggatgc 1441 ggcacatgtt taagccctcc atgtcggagt tgggcttgtg catgtaccag ctggagaatc 1501 tggtgcagga gcaaataccc gacatgcaca ttcacttcca gcagcagggc ttccagacga 1561 ccatgtacgc ctccagttgg ttcctcaccc tatacacgac cactctgaat gtcaatctaa 1621 gttgtcgcat catggacgtc ttcctcagcg agggcatgga gttcatcttt aaggtggcct 1681 tggccctgct gctcaccggc aaggatacgt tgctctgcct ggacatggag gccatgctta 1741 agttcttcca aaaggagctg cccggtcgcg tggaggcgga tgtcgagggc ttcttcaatc 1801 tagcctactc cataaagctg aatactaagc gtatgaagaa gatggaaaag gagtaccagg 1861 acctcaagaa gaaggagcag gaggagatgg ccgagctgcg gcgactgaga cgcgagaact 1921 gcctgctgaa gcagcgcaac gagctgctgg aggccgagag tgccgaactg gccgatcgcc 1981 tggtccgtgg tcaggtctcc cgagctgagg aggaggaaac tagctatgcc attcagacgg 2041 agctaatgca gctgcgccga tcatacttgg aggtctcgca tcagctggaa aacgccaacg 2101 aggaggtgcg cggcctgagt ctacggctgc aggagaataa taactcccgg caatcgtcca 2161 ttgacgagct ctgcatgaag gaggaggcgc tgaagcagcg cgacgagatg gtctcctgtt 2221 tgctggagga actggtgaag gtgcgtcagg gactggccga aagcgaggat cagatcagga 2281 acctcaaggc caaggtcgag gagctggagg aggataagaa gacgctgcgg gaaacgacgc 2341 cagacaattc ggtggctcat ctgcaggatg aactgattgc tagtaaactt cgcgaggctg 2401 aggcctcact ttcgctaaag gatctcaagc agagggtgca ggagctgagc agccagtggc 2461 agcgtcaatt ggccgagaat cagcgcagcg aaagcgaacg caccaccaac gctgtggact 2521 ctacgcccaa aaagctgttg accaacttct ttgacagctc caagagtagc gagcacacgc 2581 agaagctcga ggaggagctg atgaccacgc gcatacgcga gatggagacg cttaccgagc 2641 tcaaggagct gcgacttaag gtcatggagc tggagacgca ggtccaggtg tccaccaatc 2701 agctgaggcg gcaggacgag gagcacaaga agctcaagga ggagctcgaa atggccgtga 2761 cccgggagaa ggacatgtcc aacaaggcgc gtgaacagca acacagatac tcggatctgg 2821 aatctcgcat gaaggatgag ctgatgaatg tgaaaatcaa attcaccgag caaagccaaa 2881 cggtggctga actgaaacag gaaatttccc gtcttgagac caagaactcg gaaatgctcg 2941 ccgagggcga actgcgcgcg aatctggatg attcggacaa ggtgcgcgac ctgcaggaca 3001 ggctggccga catgaaggcg gagtatccca cgccaataac cagccccgac actgagccgt 3061 ggaaatggat aagctaaact aattttaaca ccgcccccga atacgaaaac acacgaaatt 3121 gattgataac gaaacaaaac gatcaaaatt atgaaaatt