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Drosophila melanogaster nostrin, transcript variant E (Nost), mRNA.


LOCUS       NM_001169240            3916 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001169240
VERSION     NM_001169240.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3916)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3916)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3916)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3916)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3916)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3916)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3916)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3916)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3916)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3916)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3916)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3916)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3916)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3916)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3916)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3916)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3916)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3916)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 31, 2011 this sequence version replaced NM_001169240.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3916
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3916
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="Nostrin"
                     /map="8C3-8C4"
                     /db_xref="FLYBASE:FBgn0259734"
                     /db_xref="GeneID:8673992"
     CDS             197..3874
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="CG42388 gene product from transcript CG42388-RE;
                     CG42388-PE; Nost-PE; nostrin"
                     /codon_start=1
                     /product="nostrin, isoform E"
                     /protein_id="NP_001162711.1"
                     /db_xref="FLYBASE:FBpp0289277"
                     /db_xref="GeneID:8673992"
                     /db_xref="FLYBASE:FBgn0259734"
                     /translation="MNHLRVHKFKLGGKDNAAMADLPQSENTTNNNNNIGSNNNQKGG
                     AKGFLGRIKRYSVLGNKLGRRNLGSMNLNPPNNVVDNSVSPTKLHTGSYNMTGSHSDD
                     HRLEIGAPILISTTTLDTDRFDVTEARLKQIGGGIAQTSSIVRTLTPRSSDEEEFVDA
                     RSSPQQMERDEDLQIADDQVEKNDRDQYGHQFQLPKKQHREEEMGDLKYLDDLEEPEQ
                     FETPKHEVEEKLLTANQDVKRPITPITIAIDPPIRRPRIARQQRQSQSVQNLHRSELK
                     VYLHKSNSVALDMNVTAPAKLGLDLNLPELPELYGASELSLAASDNKENLPAVKPSAE
                     RSPIPNGGFMAQQPHFKSLDSFHLNTRSHSNQSSQQSSRQSLACSSSNGEYDFDLKSV
                     SYQSLNAQNLFVSIDELQELTRQINETEDFGKEIDLEYCAHRDQLRPSERRITLLKNK
                     NQTLINFNHNKEKLRKGWHGMKHWLGEEGSKIKEAVRQQTPLKRLAQSRSNLNQSTAD
                     ASRQSMSPERTQRDVTESCEDVTERTEMESSMSHRNSEEDLSPHAKRFKDEGQNGFEE
                     LRRYVKQGGDFSKELIFVLQERADSELIYSKSLSKLANKLNKAGREIPGSVADAWRGV
                     ATEMESRSDIHRQLAASLTDELVKPLKIVVEGHHKARKAVESNVDKAARVLGEWRASE
                     AKAKKASHTAARENEKLQDAMLDVRIQKSPSIALLHQGPNKQAAEKELKSAEKDCVKL
                     DNKRKKAEEAVKRADVEYYTLCVRSERARVDWEMAVLRGSAQLQSSEQQRLGNMHNFA
                     QQYARLISDMNPILGGLSTRLQPQLDACNVAKDMQVVRHIRRNSEGPSEQLLPDFYCE
                     HTTLAMNRERRKHALIKLLQLVKTDLERERRSRDGLRGLSQSLNHQEHQNITDKLYHI
                     RSMLTYLEGARLKLHSALLELDHKPRATHPLAQHIHITRDRTGLQQSILKVPNWLKNN
                     DKSQTQQSTSMLAHDITDITTNHEDELPDENCSHLHSSSHSNNNSNGSCTDVSSVVKP
                     FNRSKSNIETNFTSQPKIISTTNAAIAVSVKSKTLANLQDGHHNNQQHHHHHHNHHSD
                     RGQADGGSNQQDSDFDEFSSQDEDDEPQQPQQQPQPLQSQQQQQQPLLQNPTINGQVQ
                     TQHFYQNAQELQKGQKNGSVPILGRCKALYSYTPKLYDELELSPGDIIEVHAKQDDGW
                     WLGALRNHIGIFPATYVEECA"
     misc_feature    1868..2605
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="The F-BAR (FES-CIP4 Homology and
                     Bin/Amphiphysin/Rvs) domain of Nitric Oxide Synthase
                     TRaffic INducer (NOSTRIN); Region: F-BAR_NOSTRIN; cd07658"
                     /db_xref="CDD:153342"
     misc_feature    order(1883..1885,1892..1894,1913..1915,1922..1927,
                     1934..1936,1943..1948,1955..1960,1967..1969,1979..1981,
                     1988..1990,2000..2002,2075..2077,2084..2086,2405..2407,
                     2417..2419,2492..2494,2504..2506,2513..2515,2522..2527,
                     2534..2536,2546..2548,2555..2557,2567..2569,2579..2581,
                     2588..2593,2600..2602)
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="dimer interface [polypeptide binding]; other site"
                     /db_xref="CDD:153342"
     misc_feature    3707..3865
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /old_locus_tag="CG4040"
                     /old_locus_tag="Dmel_CG15364"
                     /old_locus_tag="Dmel_CG33224"
                     /old_locus_tag="Dmel_CG4040"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="Src homology 3 domain of Nitric Oxide Synthase
                     TRaffic INducer; Region: SH3_Nostrin; cd11823"
                     /db_xref="CDD:212757"
     misc_feature    order(3722..3724,3728..3730,3737..3739,3749..3751,
                     3803..3808,3845..3847,3851..3856)
                     /gene="Nost"
                     /locus_tag="Dmel_CG42388"
                     /gene_synonym="CG15364; CG33224; CG4040; CG42388;
                     Dmel\CG42388; nost; NOSTRIN"
                     /note="peptide ligand binding site [polypeptide binding];
                     other site"
                     /db_xref="CDD:212757"
ORIGIN      
        1 cgttgttgac gtcgcatcgt cgacgacgtt gctcccccgt cgctgttcta aatttagtca
       61 ccgacgcgtt tctgtaaatg tcgccgctgc cgccgtctac aaataacaat aatattagca
      121 acaataatta cagttttatt tattttcggt aaattttgca ccagatcgta cacacattgt
      181 ataaccgccg tcaaagatga accacctgcg ggtgcacaaa ttcaagctgg gcggcaaaga
      241 taatgccgcc atggccgatt tgccccaatc ggaaaacacc accaacaata acaataatat
      301 cggaagcaat aataatcaaa aaggcggtgc aaaaggattt ctgggaagga ttaagcgcta
      361 ctcagtgttg ggaaataaac tgggacgtcg taatctcggc agtatgaatt tgaatccgcc
      421 gaataatgtc gttgataatt ccgtttcgcc cactaaactc catactggaa gctacaatat
      481 gaccggtagc cattccgatg atcatcgcct ggaaatcgga gctccgattt taatatcgac
      541 tacaacattg gacaccgacc gtttcgatgt cacggaggcg agactcaaac agattggcgg
      601 cggcatagcc cagacctcca gtatagtaag aaccctgacg cccaggagtt cggatgagga
      661 ggagtttgtg gacgccagga gtagtccgca acaaatggaa agggatgagg atctgcaaat
      721 cgctgatgat caggtcgaaa agaacgatcg cgatcagtat ggtcatcaat ttcagcttcc
      781 taagaaacaa catcgtgaag aagagatggg ggacttaaaa tatctagacg atctggagga
      841 accagaacaa tttgagacgc ccaaacacga ggtggaggaa aagctcctga ctgccaacca
      901 ggatgtgaag cgccccataa cgcccataac cattgccata gatcccccaa tcagacgacc
      961 acgtattgcc cgccagcaaa ggcaatcgca atccgttcag aatctgcatc gcagcgaact
     1021 gaaggtatac ctgcacaagt ccaactccgt ggcgctggac atgaatgtca cggctccggc
     1081 aaagctgggc ttggacttga atctgcccga gttgccggaa ctctatggag ccagcgagct
     1141 cagtttggcg gccagtgata ataaggaaaa tctgccagcg gtgaagccat ccgctgagcg
     1201 atcgcccata ccaaatggtg gcttcatggc ccagcagcca catttcaaga gcctagactc
     1261 gttccacctg aacacccgct cccattcgaa tcagagctcc caacagagtt cccgccaaag
     1321 cttggcctgc agcagcagca atggggaata cgactttgat ctgaagtcgg tgagctatca
     1381 gagcctgaat gcccagaatc tgttcgtttc gattgacgaa ctgcaggagc taacgcgtca
     1441 gatcaacgaa acggaggatt ttggcaagga gatcgatctg gagtactgcg cgcatcgcga
     1501 tcaattgaga cccagtgaac gcaggatcac cctgctgaag aacaaaaacc aaacgttgat
     1561 caacttcaat cacaacaagg agaagctgcg taagggctgg cacggcatga agcactggct
     1621 gggcgaggag ggctccaaga ttaaggaggc agtgcgtcaa cagacgcccc tcaaacgtct
     1681 ggcccaatca cggagcaatc ttaaccagtc aactgcggat gccagtcgcc agtcaatgtc
     1741 gccggaacgc actcaacgcg atgtaaccga gagctgtgag gatgtcaccg aacgcaccga
     1801 aatggagtcg tccatgtcgc accgaaacag cgaggaggat ctgtcgccgc atgccaagcg
     1861 gttcaaggat gagggacaga acggcttcga ggaactccgg cgatatgtga agcagggcgg
     1921 tgattttagc aaggagctca tctttgtcct gcaggagaga gccgattcgg agctgatcta
     1981 ctccaagtcg ctatcgaaac tggccaacaa gctgaacaaa gcgggcaggg aaattcccgg
     2041 gagcgtggcc gacgcctggc gtggagtggc tacggagatg gagagccgca gcgacatcca
     2101 tcgccagttg gcagcctcgc taacggatga gctggtcaag ccgctcaaga tcgtcgtcga
     2161 aggacatcac aaggcgcgca aggcggtgga aagcaacgtg gacaaggcgg cgcgagtact
     2221 gggcgaatgg cgagccagcg aggcgaaagc caagaaggcc tcccatacgg cggcgcgcga
     2281 gaacgagaag ctgcaggacg caatgctgga cgtgcgcatc cagaagtcac catcgattgc
     2341 cctgctccac cagggaccca acaagcaggc cgcagaaaag gagctcaagt cagcggagaa
     2401 ggattgcgtc aagctggata acaagcgcaa gaaggccgag gaggcggtga agcgtgcgga
     2461 tgtggaatac tacaccctgt gcgtgcgttc ggagcgagca cgcgtagact gggagatggc
     2521 cgtgctccgg ggaagtgccc aactgcagag cagcgaacag cagcggctgg gcaatatgca
     2581 caactttgcc cagcagtatg cacgcctcat ctcggacatg aatccgatac tcggtggcct
     2641 gagcacacgc ctgcagccgc aactcgatgc ttgcaatgtg gctaaggata tgcaagtggt
     2701 gcgccacatc cgccgcaatt cggagggacc cagtgagcaa ctcctaccgg acttttactg
     2761 cgaacacacc acgctggcca tgaatcggga gcgtcgcaag cacgctctga tcaagctgct
     2821 gcagctggtc aagacggatc tggagcggga gcgacgatcc cgcgacggat tgaggggact
     2881 gtcgcaatcg cttaaccatc aggagcatca gaacatcacc gataagctgt accacattcg
     2941 ttccatgctg acctatttgg agggcgcccg tctcaagctg cactctgccc tcttggagct
     3001 ggaccacaag cccagagcca ctcacccact ggcccagcac attcatatca cccgtgaccg
     3061 cactggtttg cagcagagca tcctgaaggt gcccaactgg ctgaagaaca acgacaagtc
     3121 gcagacgcag caatcgacca gtatgctggc ccacgacatc accgacataa ccactaacca
     3181 cgaggatgag cttcccgacg agaactgctc ccacctgcac agcagtagcc atagcaacaa
     3241 taatagcaac ggctcctgca cagatgtcag ttcggtggtg aagcctttta accgaagcaa
     3301 aagcaacatc gagaccaatt tcaccagtca accaaagata atctcgacga caaatgccgc
     3361 gattgccgtg tccgttaagt ccaaaaccct ggccaatctg caggatggcc atcacaataa
     3421 ccaacagcac catcatcatc atcataatca tcacagcgat cgcggccagg cggatggtgg
     3481 atccaatcag caggactctg atttcgatga gttcagctcg caggacgagg acgacgagcc
     3541 gcagcagccg cagcaacaac cgcagccgtt gcaatcgcag cagcagcaac agcagccgtt
     3601 gctgcaaaat ccaaccatca atggccaagt gcagacgcag catttctatc agaatgcgca
     3661 ggaactgcag aagggccaaa agaacggatc cgttccgata ctgggacgct gcaaggcact
     3721 gtatagctac accccgaagc tctacgacga gctggaactg agtcccggcg acatcatcga
     3781 ggtgcatgcc aaacaggacg acggctggtg gctgggcgcc ctgcgcaatc acatcggcat
     3841 ctttccggcc acctatgtgg aggagtgcgc ctagttctag ttgggaaacg ccctgccagc
     3901 ttccctccat agctat