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Drosophila melanogaster Calmodulin-binding protein related to a


LOCUS       NM_001169239            7001 bp    mRNA    linear   INV 26-DEC-2023
            Rab3 GDP/GTP exchange protein (Crag), transcript variant D, mRNA.
ACCESSION   NM_001169239
VERSION     NM_001169239.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 7001)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7001)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 7001)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 7001)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 7001)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 7001)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 7001)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 7001)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 7001)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 7001)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 7001)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 7001)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 7001)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 7001)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 7001)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 7001)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 7001)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 7001)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 7001)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 7001)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 7001)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 7001)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 7001)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001169239.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..7001
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..7001
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="Calmodulin-binding protein related to a Rab3
                     GDP/GTP exchange protein"
                     /map="7F7-7F8"
                     /db_xref="FLYBASE:FBgn0025864"
                     /db_xref="GeneID:31800"
     CDS             578..5593
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="CG12737 gene product from transcript CG12737-RD;
                     CG12737-PD; Crag-PD; Calmodulin-binding protein related to
                     a Rab3 GDP-GTP exchange protein"
                     /codon_start=1
                     /product="Calmodulin-binding protein related to a Rab3
                     GDP/GTP exchange protein, isoform D"
                     /protein_id="NP_001162710.2"
                     /db_xref="FLYBASE:FBpp0310013"
                     /db_xref="GeneID:31800"
                     /db_xref="FLYBASE:FBgn0025864"
                     /translation="MEEKRIADYFVVAGMPENPQLLQENSFNDSGRLRAATTIEPITD
                     IGVYFPLLGEEVPEGYEILSHTPTGLQANLNHGSVRTTDCYIYFRRGKDRPPLVDIGV
                     LYDGHERIMSDAEIVAETPGGRVANVNNSSAKTFLTYRRARADMPCNELVVTELCVIV
                     QSKGERAPHAFCLIYKTLNKGYVGSDVYLCYKKSMYRPKHISYKPEILLRYPTFDHTD
                     FPLNLCPSVPLFCLPMGASLEAWPHVNGTEKRKPISPVFSTFVLTVSDGTYKVYGSAL
                     TFYEDYDESKLSAEQKELLGWDEEFGAQHSLHMIKAICLLSHHPFGDTFDKWLKYLHR
                     MVLYDVNIPIPVERYITQLLDEVPFPAPSIHLQLSSESNDRILLTQPEDSPLPRSGAG
                     FHILLQNLGTDNCLHVLLLALTEQKILIHSLRPATLTAVAEAIVSLLFPFKWQCPYIP
                     LCPLGLAEVLHAPLPYLIGVDSRFFDLYEPPTDVTCIDLDTNNISLCESQRHLSPKLL
                     PKRAARLLRQTLTELENAKPISYDSTNSLDRDIRKRKRELVLEQRIQEAFLLFMASIL
                     RGYRDFLVPISKAPSVGATDPSALFQLKAFLRSRDKSHQKFFELMMKTQMFIRFIEER
                     SFVSDGDHGLSFFDECAEKVGNYDETPAQLHLVDWDTGQNSERTKYIFPPDSVTPAGS
                     QPGGGGGGLAYNYENFTLQPELLQSTKKTALSKFLQLQLNASLSPGSPIARRTKHEIK
                     LSQKMASRCQQHPEAWSKYLLATCYSLYFLILPSMVLDPRHAGKEPEILRAAYDVLVR
                     ASRLKITCDEFCYRIMMQLCGIHNLPVLAVRLHYLMKRSGVQANALTYGFYNRCVLES
                     QWPQDSTTISQIRWNRIKNVVLGAAQFRKAGKQRAASKVNKSLSASQDQNLSTLETVD
                     GQSRTSLASSSGDGGGHGLLDFAAFDRLRNKLGSIVRQTVTGGNNETMGDAVNNTGLL
                     IPGELSAPNTPTYGGDTEILAKALQQQQPRKQIMSIGGGDDDDEDEDEDEYTAGSPST
                     PQKQLEAGADDLEYAGGGDYEADEEDEDEVDEHVAAQRARQRVQSPTKISPRTPVTQN
                     DPLGALNEEESAASATPTQETQQEQQHSQSQIDSSIYSDKPILFRGQRSATFDESTQI
                     GKSMHRSETMPVASSGVTNSLANIGSSLKFTFGRYSPARLSLKKDLKLPANIIENISS
                     ISPSLTGKKSNELIQGSLSSIKSAANSLTKKFDEIKGVISANSTPTKTNNGHHPHGLH
                     HGHHHPHHHHHHHSQHGNAEQEEHDAAVHEEGKLRRVSSDLDPWGRLSESRKSSYNNL
                     VPLGENSSTGALHMHAFPAVPDNLYSLTSENAADRDCDVLIQLTTCSQCHNCSVLVYD
                     EEIMSGWTAEDSNLNTTCHACNKLTVPFLSVQIERQVEESEQSDPLQDGKEQIANGNS
                     HKTSLTVPYLNPLVLRKELENILTQEGDIALIKPEFVDEHPIIYWNLLWLMERIESKT
                     HLPELCLPVPSDKEHIDPLSKVKTVHIQCLWDNLSLHTEASGPPMYLLYRETQPTSPL
                     IKALLTDQAQLNKNVIQQIISAIRCNDFATPLKRLANERHKLKSNGVERSHSFYRDIL
                     FLALTAIGRSNVDLATFHREYAAVFDKLTERECNMYYRNQDLPPSASTIFCRAYFRPL
                     LLP"
     misc_feature    1142..1414
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="Domain always found upstream of DENN domain, found
                     in a variety of signalling proteins; Region: uDENN;
                     smart00800"
                     /db_xref="CDD:214824"
     misc_feature    1499..2053
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="DENN (AEX-3) domain; Region: DENN; pfam02141"
                     /db_xref="CDD:460461"
     misc_feature    2228..2449
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="Domain always found downstream of DENN domain,
                     found in a variety of signalling proteins; Region: dDENN;
                     smart00801"
                     /db_xref="CDD:129037"
     misc_feature    2999..3088
                     /gene="Crag"
                     /locus_tag="Dmel_CG12737"
                     /gene_synonym="CG12737; CJ; crag; CRAG; Dmel\CG12737"
                     /note="PPR repeat [structural motif]; Region: PPR repeat"
                     /db_xref="CDD:276811"
ORIGIN      
        1 aagctagtct tatctggcaa cgctgaaaat ggcctgaagc aaaggccaaa tagttattaa
       61 taatagtaaa tccgataata atagtcgcgt gtttcgtatt gcatgttaat tatatagttc
      121 gccaagcagc gcatacaggc gattggcaca ttccgccagt cacaccgagc cgcgcacacg
      181 gctggcaggc cagttaaatg aacattattc cttacttttc tgtccactgc actccacacg
      241 tatttgcgta gcttttaaag tagctaaatt cgtggatttc aacgcacttg gcgcgtctta
      301 gtcaaagtgg cccagttaag cagtccaatt ggaaaactgt gaaaatgatg taaaggaaaa
      361 ctctcaagta gtccaactgt gtgtgcgtgt gtgtgtgtgt gcgtgcggtg agtgttggtg
      421 tgtggaaatt aacgtagtgt gaagaagaaa agcgaaggaa aagcgacaat tgcagtccaa
      481 ggcgaacagc aaaagcaact gaaggttgcc cacgccccct tcgtccccgc gcccccttgg
      541 aggacaacta acgggagtgc aaggaaacgg cgccgccatg gaggaaaagc gcatcgccga
      601 ctactttgtg gtggccggaa tgccggagaa tccgcagctg ctgcaggaga acagcttcaa
      661 tgactcggga agattgagag cggccaccac catcgaaccg atcacggaca tcggcgtcta
      721 tttcccgctg ctgggcgagg aggtgcccga gggatacgag atcctctcgc acacgcccac
      781 gggtctacag gcgaacctca atcacggatc ggtccgcacc accgactgct acatctactt
      841 ccggcgtggc aaggatcgcc cgccgctggt ggacatagga gtcctgtacg atggccacga
      901 gcggatcatg tcggatgcgg aaatcgttgc ggagacgcct ggcggcaggg tggccaatgt
      961 gaacaactcg tccgcgaaga cgttcctcac gtaccgacgc gcccgagcgg acatgccctg
     1021 caacgagctg gtggtcaccg aactgtgcgt cattgtccag agcaagggtg agcgggctcc
     1081 gcacgccttt tgcctaatct acaagaccct gaacaagggc tatgttggca gcgacgtcta
     1141 cctgtgctac aagaagtcca tgtaccggcc taagcacatc agctacaagc cggagatcct
     1201 gctgcgctac cccaccttcg accacaccga cttcccgctg aatctgtgcc cgagcgtgcc
     1261 gctcttctgc ctgccaatgg gcgcctccct ggaggcctgg ccacacgtca acggcacgga
     1321 gaagcggaaa cccatcagtc cggtgttcag cacttttgtg ctcaccgtga gcgatggcac
     1381 ctacaaggtt tacggatcgg cgttaacttt ctacgaggat tacgatgagt caaagttgtc
     1441 ggctgagcag aaggagctgc tcggttggga cgaggagttc ggcgcccagc actcgctgca
     1501 catgatcaag gctatatgtc tgctgtcgca tcatcccttt ggcgacacct tcgacaaatg
     1561 gctgaagtac cttcatcgaa tggttctgta tgacgttaat atacccattc ccgtggagcg
     1621 ctacatcacc cagctgctgg acgaagtacc gtttccggcg cccagcattc acctgcagct
     1681 gtccagcgag tccaacgatc gcatactgct cacacagccg gaagattccc cgctgccgcg
     1741 aagtggcgcc ggtttccaca tactgctcca gaacctgggc accgacaact gtctgcatgt
     1801 gctgctgctg gccctcaccg aacagaagat actcatccac tcactcagac ctgccacgtt
     1861 gactgctgtg gccgaagcca ttgtctccct gctgtttccg ttcaagtggc agtgtccgta
     1921 catcccactt tgtccgctgg gcttggcgga ggtgctccat gccccattgc cttatctcat
     1981 tggcgtggac tcgcgcttct tcgatttgta cgagccgccc acggatgtca cctgcatcga
     2041 tttggacacc aacaacatta gcctatgtga gtcgcagcgt cacttgtcac ccaagctgct
     2101 gccgaaacgg gcagcccgcc tacttcgcca gacgctcacc gaactggaga atgccaagcc
     2161 cattagctat gactccacaa acagtttgga tcgcgatatt cgaaagcgga aacgagaact
     2221 ggtgctggag cagcgcatcc aggaggcctt tctgctcttc atggccagca ttctgcgcgg
     2281 ctacagagac tttctggtgc ccatatccaa ggcaccatcg gtgggagcca ccgatccaag
     2341 tgccctcttc cagctgaagg cttttttgcg atcgcgtgat aagtcgcacc agaagttctt
     2401 cgagctgatg atgaagaccc agatgttcat ccgtttcatt gaggagcgtt cctttgtctc
     2461 cgatggcgat catggtctca gcttcttcga cgagtgtgcg gagaaggtgg gcaactacga
     2521 tgaaacgccc gcccagctgc atttggtgga ctgggacacg gggcagaaca gcgagcgcac
     2581 caagtacatc tttccgccgg acagcgtaac tccggcggga tctcagcctg gcggcggagg
     2641 aggaggatta gcctacaact acgagaactt tacgctgcaa ccggaactgt tgcagagcac
     2701 gaagaagacg gctttatcga aatttctgca gctgcagctg aacgcttccc tctcgccagg
     2761 atcacccatt gcccggcgaa ccaaacacga gattaagctg tcccagaaga tggccagccg
     2821 ttgtcagcag catccggagg cgtggtccaa atacttgttg gccacctgtt actcgctgta
     2881 cttcctcatc ctgccatcca tggtcttgga tccgcggcac gccggcaagg agccagagat
     2941 actgcgcgcc gcctacgatg tcctcgtgcg agccagtcgt ctaaagatca cctgtgacga
     3001 gttctgctac aggatcatga tgcagctatg cggtattcac aatctgcctg tgctggccgt
     3061 ccgtctgcac tacctgatga aacgctctgg cgtgcaggcc aatgcgctca cctatggctt
     3121 ctacaaccgc tgcgtccttg agtcgcagtg gccccaggac agtaccacga tcagccagat
     3181 ccgctggaat cgcattaaga acgtggtgtt gggagcggcg cagttccgca aggctggcaa
     3241 acaaagggcc gcctccaagg tgaacaagtc gctcagtgcg tcccaggacc agaacctcag
     3301 caccctggaa acggtggacg gacagtcgcg caccagtttg gcttcctcct ccggcgatgg
     3361 cggtggccat ggactgctcg attttgccgc cttcgatcgg ctcaggaaca agttgggcag
     3421 cattgtgcgg cagacggtga cgggcggcaa taacgagaca atgggcgatg cggtcaacaa
     3481 cactgggttg ctcatacccg gcgaactcag cgccccgaat acgccgacct atggcggtga
     3541 caccgaaatc ctggccaagg cacttcagca acagcagcca cgcaaacaga tcatgagcat
     3601 tggcggcggc gatgacgatg atgaggatga ggacgaagat gaatacacgg ccggatcgcc
     3661 gagcacgccg caaaagcaac tggaagcggg cgccgatgac ctggaatacg ccggtggagg
     3721 agactacgag gcggacgagg aggacgaaga tgaagtcgac gagcatgtgg ccgcacagcg
     3781 ggcacgtcag cgagtgcaga gtccaaccaa aatctcgcca cgcacgcccg tgacccaaaa
     3841 cgatccactg ggtgctctca acgaggagga gtccgccgcc agtgccacgc ccacgcagga
     3901 gacgcagcag gagcagcagc actcacagtc gcagatcgac agcagcatat acagcgacaa
     3961 gccgatcctg ttccggggcc agaggagcgc cactttcgac gagtcgacgc agatcgggaa
     4021 gagtatgcac cgttcggaaa cgatgccggt ggccagcagc ggtgtgacca acagcctggc
     4081 caacatcgga tcctcgctga agttcacgtt cggacgttat tcacccgcac gattgtccct
     4141 taagaaagac ttgaaattgc ccgccaatat tatagaaaat atatcgagca taagtcccag
     4201 cttgacgggc aagaagtcga acgagttgat ccagggcagt ctgagcagca tcaaatcggc
     4261 ggccaattcg ctgaccaaaa agttcgacga gatcaaaggc gtgatatcgg ccaattcaac
     4321 gccgacgaaa acgaacaatg gacaccatcc gcatggcctg catcatggtc accatcatcc
     4381 gcaccaccac catcatcatc attcgcagca cggcaatgcg gagcaggagg agcacgatgc
     4441 cgccgtccac gaggagggca agctgcgtcg cgtctcaagc gacctggatc catggggcag
     4501 gctcagcgag tcgcgtaaat ccagctacaa taacctcgtg ccgctcggcg agaacagctc
     4561 caccggcgcc cttcacatgc acgcctttcc cgctgtgccc gacaacctct atagtctaac
     4621 aagcgagaac gccgcggatc gtgactgcga tgtgctgatc cagctgacga cctgctcgca
     4681 gtgccacaat tgctcggtgc tcgtctacga cgaggagatc atgagcggct ggacggcgga
     4741 ggactctaac ctgaacacca cctgccatgc ctgcaacaag ctcacggtgc ctttcctcag
     4801 cgtacagatc gaacggcagg tggaggagtc ggaacagtcg gatccgctgc aggacggcaa
     4861 ggagcaaata gccaacggca atagccacaa gaccagcctg accgtgccgt atctaaatcc
     4921 gctggtgctg cgcaaggagc tggagaacat actcacgcag gagggcgaca ttgcgctgat
     4981 aaaaccggaa tttgtcgatg agcacccgat catctattgg aacttgctct ggctgatgga
     5041 gcgcatcgag agcaagacgc acctgcccga gctctgtctg cccgtgccga gcgacaagga
     5101 gcacatcgat ccgctgagca aggtgaagac ggtgcacatc cagtgcctgt gggacaatct
     5161 gagcctgcat acggaggcca gtggtccacc catgtacttg ctgtacaggg agacccagcc
     5221 gacgagtccg ctcatcaagg cgctgctcac cgatcaggcg cagctcaaca agaatgtcat
     5281 tcagcaaatc atttcggcca tccggtgcaa tgacttcgcc actcctctca agcgcttggc
     5341 caatgagcga cacaagctga agagcaacgg cgtggagcga tcgcactcgt tctatcgcga
     5401 catactcttc ctggccctga ccgccatcgg taggtccaac gtggacctgg ccacattcca
     5461 tcgcgagtat gcagccgtgt tcgacaagct gacggagcgg gagtgcaaca tgtactatcg
     5521 caatcaggat ctgccgccct cggcatcgac gatcttctgt cgtgcttact tccgcccgct
     5581 tctgctgccc tgacgcagtg gctcccagct ggaggcagga gcagcttcaa gcgatgccga
     5641 agtggacaca tgagtggagc agccgaagcc taaaagacaa gacgaccaaa taacttgata
     5701 acaaaatgga aacgaaggga gagtttgacg acaacgaaac gcttatcaca caccttaggc
     5761 tgggtcgatt ttatagatgg gacaagtatg aattaatttt acttagatat cagagctctt
     5821 atttacgtta cggaaaagaa aaggacggta ttttggaact attcctagta ggctataaaa
     5881 atgtaattgt tttaaacgaa aaaaaaaaaa tacttgattc gaagtgttct taggttttca
     5941 aactaatagt tttttcccaa gcgaggaagc cttctgggca aacttcttta gaattgtcct
     6001 caatttactt gtacttgtac acaagccaga atatttaaat tcttaaacga actttcctaa
     6061 gtgaaagccc caacttgaca tgtgttgcat tgtgaaaaca tgcaaatgat tttgtaaatg
     6121 acttgatctt aacatttaag tacttaacga tttttcgctg tttaaaacta atcaaaaata
     6181 tacacacaca cacacgaatg actggtttct gtgacaatac atgaatgcgt tcaggcagtg
     6241 cgtttcatag gtgtaatagc agcaatggat tagtttaacg cccctcctaa tattttgtac
     6301 ttacgaccaa ctcacctagt ctaacgactg ccttttctga tgacgctaca ttttgcacta
     6361 cggttcaccg aacaacgagg ccttacacgg ccgaaacgca ctgcacttac cactatccat
     6421 aaaaacacga aaggaagcca cacttttgat tgcccctcgt cagatttgcc ttattatata
     6481 taatataacg atacatattc gtgtacatac aaagctatat gtgcgatcct gtaaatcagc
     6541 attgttagcg gaacccccag cctcttctcc tgcgcggctc catcctctcc accatccggt
     6601 tatttcaaaa ataatcgcct gtgtaaacgc actttttttt taacttgaga tttcctcaca
     6661 atgctcggct cttttagtta gcatagcaaa cttttgggaa cgtgggaagg aggataaacg
     6721 gggggcggcg gttaactaat atcgacggca gataacaatt aaacaacgat tacaatagca
     6781 ataattaatg gataatcgga taatcgtatt taaatgtaga tgggactcta actcttgcag
     6841 atctaatggt acgacacacg ttcacgtcca cgtttttaaa gacaacacat ccccaaacac
     6901 acacttctaa ttttttttgt cgggaatctt aactaaatgt atattaaata attcatttaa
     6961 ttgaaacgta aatcgtaaca aaaatggcaa aaagaataaa c