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LOCUS NM_001169230 9866 bp mRNA linear INV 26-DEC-2023 (Trf2), transcript variant F, mRNA. ACCESSION NM_001169230 VERSION NM_001169230.2 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 9866) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 9866) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 9866) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 9866) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 9866) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 9866) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 9866) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 9866) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 9866) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 9866) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 9866) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 9866) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 9866) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 9866) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 9866) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 9866) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 9866) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 9866) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 9866) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 9866) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 9866) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 9866) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 9866) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_001169230.1. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..9866 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..9866 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TATA box binding protein-related factor 2" /map="7E7-7E9" /db_xref="FLYBASE:FBgn0261793" /db_xref="GeneID:31773" CDS 883..6030 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="CG18009 gene product from transcript CG18009-RF; CG18009-PF; Trf2-PF; lethal (1) G0295; lethal (1) G0425; TBP-related factor 2; lethal (1) G0039; TBP related factor 2; lethal (1) G0071; TATA box-binding protein related factor 2; TBP-like factor" /codon_start=1 /product="TATA box binding protein-related factor 2, isoform F" /protein_id="NP_001162701.1" /db_xref="FLYBASE:FBpp0289804" /db_xref="GeneID:31773" /db_xref="FLYBASE:FBgn0261793" /translation="MGSAVKKGDGSPTRILEEYQVARDLRNEDLFPEHPVEHPDEDSD KENQSPNQSPNPRAIGDCEQGPDIGKDTLNPNEADQFSSEEVEKNEANSSCNESGGDA RNSRDRLSSSHSEDEQLNQEYSTSSSGSTIGNREQGSDVGKDTSSRNEADQFSNEEVE KNEANSSGNESYGDACNSSDRLSSSNSEDEQLHQEYSTSSRGRTREYAQSDLNPGYQD LNIGNQDLNQVNREYQESNNEYQVSNQEYQHLNTEYQELNHGDQDSNDEYQELNHGNQ DSNDEYQESNHGNQDSNDEYQELNHSNQDSNDEYQELNHGDQDSSDEYQDLNHVNQDS NHEYQAWNHEYQDSNHEYQALNREYQYPESDEEEAARKRNIYTRLRSYACQVHLPRLG ESEVDSDDRRHNPINQPFNQPINRPNQKSDSSLESSSPERQDSESESRQASDEESSSG DSDYLIDPVTGWLSRRRETSTEREEKSDQSQQESSEEITDEQKEESDDVEQQSPAEHT SSDRRDHSPDKQQNKRKSLGTGNSSYSKKPLLDGDKGDPRSHLSSLGSRRSLKRKWPF DCTDSKKFKPNLQSEEDKSEEEKREDTESECSDEEDSDSSSFDTDSNSDSDSNLDLDS DSDSHSDFESSSSSEESAQDPAPEGETDQDPAPEGEADQDPAPEGGVDQDPAPEGGVD QDPAPEGEVDQDPAPEGESDQDLAPEGGVDQDPAPEFGTDQDPHPYYNDQDPAPYYDD QDPASYYDDHICDSEEDYKPFIFSKERKFLKFVTNPLGDDKSSLDLSIQLYKVFGAYK LEDVYSSIDEEGQPEQDLQLKQQQKHLKKYQKLQLVVFWHQEKFFSKEQLLLYEYLKL LLQKFFPQEQQEKRLQQEKLLQQEKLLQQEKRLQQEKRLQQEKRLQQEKRLQQEKRLQ QQKLLQQQKLLQQEKLLQQQKLLQQEKLLQQEKLLQQEKQLQQEKHLPQERQLQQDKV FLQLRQLQQKKELEEQRERKRHLFEQQKQFVLEKLRQQKEQHRRQQNRVKRERKLRQK KEKQRLEYERFLKEYREDCKRQLRLQREHYLIKIKQLEKASQRSLKGNRKHKLMQNDM VSIPVANLNGGLKAASSGSGVGVVTSGGVVSSAVLANAPRVYLTPSSTFMTNRQMAGV ASTGRMSGQVVGGSSGTASTAGTVRYFSQFSKMQTAGGPSLQRKLANGDTIVLATGSK NMFLTSSENKANLPTVASNGNGLITAKMDLLEEEVMQSITVIDDDDEEKKEVAEDEEE SSNNAKPIDLHQPIADNEHELDIVINNVVCSFSVGCHLKLREIALQGSNVEYRRENGM VTMKLRHPYTTASIWSSGRITCTGATSESMAKVAARRYARCLGKLGFPTRFLNFRIVN VLGTCSMPWAIKIVNFSERHRENASYEPELHPGVTYKMRDPDPKATLKIFSTGSVTVT AASVNHVESAIQHIYPLVFDFRKQRSAEELQHLRQKQRLQAGGDPHELEKNVLADNKT ASLDNIFVNTTAAHSKSSSNDQTSAPATILSSTVDSMPRLKQMVNYHQMMKQTQEERR HIMFNGEKANPASTSSAAAAPSTSSSSSSSGDNICANARRRATECWATKLQNKRPRYN DPGTTGTINAASSTASAATSSLASQATHLRNPLKTAALANARMLGAKVTTCTRNSIIV QQPQRIQMQQQQQQLQPQQQQTSFSPSEFDVDDLIEEEENNELDMPF" misc_feature <2812..3078 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="hypothetical E4 protein; Provisional; Region: PHA03418" /db_xref="CDD:177646" misc_feature <3553..>4146 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 4729..5250 /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="TBP-like factors (TLF; also called TLP, TRF, TRP), which are found in most metazoans. TLFs and TBPs have well-conserved core domains; however, they only share about 60% similarity. TLFs, like TBPs, interact with TFIIA and TFIIB, which are part of the...; Region: TLF; cd04517" /db_xref="CDD:239953" misc_feature order(4744..4749,4753..4755,4831..4836,4846..4848, 4852..4854,4873..4875,4879..4881,4891..4893,4897..4899, 4903..4905,4909..4911,4999..5001,5014..5016,5020..5022, 5107..5112,5125..5127,5164..5166,5170..5172,5176..5178, 5188..5190) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative DNA interaction surface [nucleotide binding]; other site" /db_xref="CDD:239953" misc_feature order(4789..4791,4810..4818,4822..4824,4834..4836, 4852..4854,4858..4860) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIA interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" misc_feature order(5050..5055,5089..5103,5110..5112,5125..5127) /gene="Trf2" /locus_tag="Dmel_CG18009" /gene_synonym="CG11195; CG18009; Dmel\CG18009; dTrf2; dTRF2; dTRF2L; dTRF2S; l(1)G0039; l(1)G0071; l(1)G0295; l(1)G0425; p79/TRF2; TLF; trf2; TRF2; TRF2S" /note="putative TFIIB interaction surface [polypeptide binding]; other site" /db_xref="CDD:239953" ORIGIN 1 gctcaaagtg aaacggccaa acgaagaaga cgtatcgtgt gtgctcagac ttgtgctctc 61 aaaatttttg gtcaactaca ttattcagct ctgagtttta actaaaaaag atcacaagcc 121 aaaaaaaaaa aaaacaaaga gaaacctaaa gaaatatcaa ccaaaagtgt gcaaaatcca 181 aaagattcta caatccgaat cgaaaacaaa aacataagaa ccacaaaagc agcagcagaa 241 agagacacag agagcagcga aaacttaact gcgaattcag cggctgaagc aaagcagcgg 301 agcccaagtg caagcgagac ggcagcagag ctccgctgca aggcaacggg atagaaagag 361 agataaatag agagacagcg cagcagcgat atagagtgag agcaggcggg agagcgagta 421 gcggcagcga cagcaacaca gccacaaaag agatcgtgag agggagggag agctagacga 481 cgacctacta cacaaaaaaa gactgctaaa cggaacaact aaaaactaca agcaaattta 541 accaggagaa aagaacggaa gactagacat aatcataaac atagtagata gaattagaga 601 accagcaaac ccaacaacta gaacactaag aaaacattaa ttctaataca aaatcacaca 661 taaaaaagta ttttttggcc ttaagtgcaa acatactcac atacaaacac atacatacac 721 atccacatga acgaaacaat ggaaagaatg taatacaaca ccaaggaaga atcaccttta 781 gccttatata caattaaata taattaagaa gctagcaaga aaacgcagag caagagtcct 841 atcaagaaac ccaaaaagat aacaagaaat atttttttaa cgatgggcag tgccgtcaaa 901 aagggggatg gttccccgac tcgaatactt gaagaatacc aagtagctag agacttaagg 961 aacgaggatt tgtttccgga acatccggtt gaacatccgg acgaagattc ggataaggag 1021 aaccaatcgc cgaatcaatc ccccaatcca agagccatcg gtgattgtga gcaaggacct 1081 gacattggta aagatactct aaatcccaac gaagctgacc agttttcgag cgaagaagtt 1141 gagaagaacg aagccaacag cagctgtaac gagtcgggcg gggatgctcg caattctaga 1201 gatcgtttaa gttcctctca tagcgaggac gaacagctta accaagaata ttcaacttca 1261 tcaagcggaa gcaccatcgg aaatcgtgag caaggctctg acgttggtaa agatacttca 1321 agtcgcaacg aagctgacca gttttcgaac gaagaagttg agaagaacga agccaacagc 1381 agcggtaacg agtcgtacgg ggatgcctgc aattctagtg atcgcttaag ttcttctaat 1441 agcgaggacg aacagctgca ccaagaatat tcaacttcat caagaggaag aacaagggaa 1501 tatgcacaat ctgacttgaa tcccgggtac caggacttga atatcggtaa ccaggacttg 1561 aatcaagtta atcgcgagta ccaggagtct aataacgagt accaggtttc aaaccaagag 1621 taccagcact tgaataccga gtaccaggag ttgaatcacg gcgatcagga ctcaaatgac 1681 gagtaccagg agttgaatca cggcaaccag gactcaaatg acgagtacca ggaatcaaat 1741 cacggcaacc aggactcaaa tgacgagtac caggagttga atcacagcaa ccaggactca 1801 aatgacgagt accaggagtt gaatcacggc gatcaggact caagtgacga gtaccaggat 1861 ttgaatcacg tcaaccaaga ctcaaatcac gagtaccagg cttggaatca cgaataccag 1921 gactcaaatc acgagtatca ggccttgaat cgagagtacc aatatcctga atctgatgag 1981 gaagaggccg ctagaaaaag aaacatatat acccgtttac gatcctacgc ttgtcaggta 2041 catctccctc gtttaggaga atcagaagtt gatagcgacg atcgtcgcca taacccaatc 2101 aatcagccat tcaatcagcc aatcaatagg ccaaatcaaa aatcggattc atctttagag 2161 tcatcttcgc cggagagaca agactctgaa agcgagtcgc gacaagcttc agatgaggaa 2221 tcgtcttctg gggactcgga ctacttaatc gatccagtta ctgggtggct atcgcgccgg 2281 cgagaaactt ctaccgaacg cgaggaaaaa agcgaccaaa gccaacagga gtcgtcagag 2341 gaaattacag acgaacagaa ggaagaaagc gacgacgtcg aacaacagtc gccggctgaa 2401 catacttctt ctgatagacg cgatcattcg ccagacaagc aacagaataa gcgaaaatcg 2461 ttaggcactg ggaattcttc gtattcgaag aaaccattat tggacggtga caaaggagac 2521 ccacgttcac atttatcgtc tctgggaagt cgcagatcct taaagcgtaa atggcctttt 2581 gattgtacag actctaagaa atttaaacca aacttgcaga gtgaggaaga caaatctgag 2641 gaggaaaaac gtgaagatac ggaaagcgaa tgctctgacg aagaagactc agatagttca 2701 agtttcgata cagattcaaa ttcagattca gattcaaatt tagatttaga ttccgattcc 2761 gattcccatt ccgatttcga atcatcttca agttctgagg aatctgccca ggatccagct 2821 cctgaaggcg aaaccgatca agatccagct cctgaaggcg aagccgatca agatccagct 2881 cctgaaggcg gagtcgatca agatccagct cctgaaggcg gagtcgatca agatccagct 2941 cctgaaggcg aagtcgatca agatccagct cctgaaggcg aatccgatca agatctagct 3001 cctgaaggcg gagtcgatca agatccagct cctgaattcg gaaccgatca agatccacat 3061 ccttattaca acgatcagga tccagctcct tattacgacg atcaggatcc agcttcttat 3121 tacgacgatc acatttgtga ttctgaggag gattataaac catttatctt ctcaaaggaa 3181 aggaagttct tgaaattcgt aacaaatcct ttaggggatg ataaatctag tttggacctt 3241 agcatacagc tctataaggt atttggagct tacaaactgg aagacgtata cagcagtatt 3301 gatgaggaag gccaaccaga acaggacctg caactgaagc agcaacagaa acatttaaaa 3361 aaatatcaaa agttgcaact ggtggtattc tggcaccagg agaaattctt ttcaaaggag 3421 caactgttgc tatatgagta tctgaaacta cttttgcaga aattctttcc acaagagcaa 3481 caggagaaac ggttgcaaca ggagaaactt ttgcaacagg agaaactctt gcaacaggag 3541 aaacggttgc aacaggagaa acggttgcaa caggagaaac ggttgcaaca ggagaaacgg 3601 ttgcaacagg agaaacggtt gcaacagcag aaactcttgc aacagcagaa actcttgcaa 3661 caggagaaac tcttgcaaca gcagaaactc ttgcaacagg agaaactctt gcaacaggag 3721 aaactcttgc aacaggagaa acaattgcaa caggagaaac acttgccaca ggagcgacag 3781 ttgcaacagg ataaagtctt cctacagcta cgacagttgc aacagaagaa agaactggag 3841 gagcagcgag agcgaaagcg ccacctcttt gagcaacaga aacagtttgt cctagaaaaa 3901 ttgcgccaac agaaggagca gcatcgtcgt cagcaaaatc gcgtaaaacg cgaacgtaaa 3961 ttgcgccaga aaaaggagaa acagcgcttg gaatacgaac gattcttgaa ggaatatagg 4021 gaggactgta aacgtcagtt gcgtttgcag cgcgagcatt atctgatcaa gattaagcag 4081 ctggagaagg ccagtcagcg ctcgttgaag gggaatcgaa agcacaagct gatgcaaaac 4141 gatatggtca gcataccggt ggccaatttg aacggcggcc ttaaagcggc cagcagcggt 4201 tccggagttg gtgtagtgac ctccggcggc gtcgtatcct cggcggtgct ggccaatgcc 4261 ccacgtgtat acctaacgcc ctcctccaca ttcatgacca atcgccaaat ggcgggagtg 4321 gcgtccaccg gaagaatgag cggacaagtc gtcggtggtt catctggcac agcctcaaca 4381 gccggtaccg ttcgctattt ttcgcaattc agcaaaatgc aaacggccgg cggacccagt 4441 ttgcaaagga aacttgccaa cggggatacc attgttctgg caaccggcag taaaaatatg 4501 ttccttacta gcagcgaaaa taaggctaat ctgccgaccg tcgccagcaa tggcaatggt 4561 ctgatcacag ccaaaatgga tctattggag gaggaggtca tgcagtcgat aactgtgatt 4621 gatgacgatg acgaggagaa aaaggaagtc gctgaagacg aagaagagag cagcaataat 4681 gccaaaccca ttgaccttca ccagccaatt gctgataatg agcacgagct ggacattgtg 4741 ataaacaatg tggtctgctc gtttagcgtc ggctgtcacc tgaagctgcg cgaaattgcg 4801 ctgcagggat caaatgtgga gtaccgtcgc gagaacggaa tggtgacaat gaagctccgc 4861 catccataca ccactgcctc gatttggtcg tcggggagga ttacctgcac tggtgccact 4921 tccgagtcaa tggccaaggt cgctgcacgc cgctatgcca gatgccttgg caagctggga 4981 tttcccactc gtttcctcaa ctttcgcatt gtcaacgtac tgggcacctg cagcatgccg 5041 tgggccatca agatcgtcaa cttttcggag cgccatcgcg agaacgccag ctacgagccc 5101 gagctgcatc ctggagtgac ttacaagatg cgcgatcccg atccaaaggc caccctgaag 5161 atcttctcca ccggcagcgt aacagtcacc gcggctagcg taaaccacgt tgaatcggct 5221 atccagcaca tatacccgct ggtctttgat ttccgcaagc aacgttcggc ggaggagctg 5281 cagcatctgc gtcaaaagca gcgtctgcaa gccggcggtg atccccacga actggagaaa 5341 aatgtcttgg ccgataacaa gactgcttcc cttgataata tctttgttaa tacaacagcg 5401 gcgcactcta aatcatcgtc gaatgaccaa acatcagcac ccgcgaccat cttgtccagc 5461 acagttgata gtatgcctcg tctgaaacag atggtcaact atcaccagat gatgaagcaa 5521 acccaggaag agcgccgcca tataatgttt aatggggaga aggccaatcc ggcctccacc 5581 tcatcggcgg cagcagctcc ctccacctcc tcctcatcgt cctcatccgg ggataatatc 5641 tgtgccaatg cccgtcgccg ggccaccgaa tgctgggcaa ccaagctgca gaataagcgt 5701 ccacgttaca atgatcccgg taccacgggc acaattaacg ccgcatcgtc cacagcatca 5761 gccgccacat cttcgttagc ctcccaggcg acacatctgc gtaatcctct caagacggcc 5821 gcgttggcca atgcacgtat gttaggcgcc aaggtgacaa catgcacacg caacagcata 5881 atcgtgcagc agccgcaacg tatccaaatg cagcagcagc agcaacagct gcaaccgcag 5941 cagcaacaga ccagcttctc gcccagcgaa ttcgatgttg atgacttgat cgaggaggag 6001 gagaacaacg aattggatat gcccttctaa gctagcgctg cccgtgccaa aaaaaaattt 6061 caactaaaat ggttcaaatc gatgatgaaa cactacaaca ctaaacacgc cacactcaca 6121 aatagccacg agcttctttt cgaatttgtt ggttattcgt tcaagtcatt tttcatcaca 6181 tttattttcg tgtgcttgcc gcatttaaac taaactcgag aaagcctgga caccgaagcg 6241 aaaagcaccc acagcgaagc aacaacaaca aacaacaaac aaaacaccgc agcaacaaca 6301 aaatcaagag ccaaatattt aaaatataag atttacgttt aaactacttt gtaagttaag 6361 cgagcacacc agaaacaaac aagcagagat agcgaataga tgatttcgat cccgaagtat 6421 cccagaaacc tcaataacat ctagatggta agcaagggag cttaccacac ggtaaacata 6481 agtttagact taaagaaaat acgtatgcga cagcgtttta cgtatataac cgaaatctgt 6541 ggatagcctg gatgagtcac catcaatcat cgcaattgca atcaattgtg gtgaaagtaa 6601 gagaacacac atgtagaact aatcaccagg acaggaagag gacgatacga gcaaggtgcc 6661 caggcggatc ggatctcgca gcttcctatc ttattttaaa tttttttttg aagctgaact 6721 ccaattcagt tctggccaag caaactacaa ttctcaagta aaaatccgtg gagaggaggt 6781 ggggccagag aaaagcccac taggatagtt atcaattatc tgaagaacaa ctgattaatt 6841 tcttgtatat tcataggaaa ttttttttgt tttcgctata agtcctacat aataaatgct 6901 atacataagt gctgcgtgtg ggcgcataac aaacgaaacg aaatgcgttt gaatgcgatt 6961 ataatattaa tattattatg catatataca acacacacaa atacctatat ctggtcactt 7021 ctaaccaatt ataaacaaaa ctggaaaagc agaaagtaat tatgtatgtt ttaatttgtg 7081 ctggcagttt ttgtgttgcg cagaaactcg aatcgaatta agaatgaact cctgtaagat 7141 gatgacaaaa ataaaaaaaa cattgtaata ggatagaggg aagaggagtc gattaatgcg 7201 cgacttatta acaataagct gaaacacata tatatatata tatatattgt aatgtttttt 7261 ttttttgtat ttcgcttaag tgtagattta caaacttgtt cctgtgttgt taaaatcaga 7321 aagtaaatat tttagttaac ttaacgaagc atacgcatac acaaacacac tcacacacac 7381 acacacacat acgtatacat atacataata ttaaggcatc caaacaaaca accaaacaaa 7441 caaacaaaca aacgaacgaa cgaatcataa gcaataatag aatgttttcg ttgtaaaaga 7501 ggtaaaaata aaaacaaaaa ctaatgaaag aaatactcac gttaaacata aaataacaaa 7561 ctctagatgt tttggcgtgc cttcacccat aaataggaaa acgaaatgag atacgatagc 7621 caattgtaca atcattgaag aaatagtact tccagaccac aacagaaccc aaaatcattg 7681 tacatacgca aacaaaattg atgttttcca attaaacgtg aattgcctca ttcgtacatc 7741 aagttcaatt ttcatttgtg cttaaaaaca tgaaaccaac tttcatatcg ttcaacttgt 7801 gcataatcaa aatagctaaa acgaaagtaa aagggaaatt acatataatt agtgagaaat 7861 atcaaacttt tctttccctc gattatttat acacattttt ggtatacaat tttttttttg 7921 tttatttttt tttttttaat gttttaattt gcataaacaa aatcgagaaa tgaaaatgcc 7981 tttagggaac aaataactag cgcggaaagg aaagagatag gtttaggtat aaaaaaaaaa 8041 aaaatgaaag atattgaaca gatcggagcc gaaatgtatt ttttgtgtat gcgaatatgt 8101 gaataggtcg acgatggccg aagaacgtgt tacaattgca aaattaactt agccactaag 8161 cattagtctt aagttagctg acaaactgaa tactaaattg taagccacaa tgcatatagc 8221 aatgtaaaaa agaaaatgaa acaaaaaaaa aacaaacaac aaatcaaatc taatggaacc 8281 taacgagaac atttaagtgt aatttaagtg taaataaaat agttgttaac aaatcacaaa 8341 acaaacgaaa gcaagaaacc aacaatagtg taatgtcttc acgtctaact gccttcgaaa 8401 gattcaagaa ttattgaaat ttaagcaagc ccacattttg aatgcgaagt tagtattctc 8461 ttaaaacacg actgcaaatt gcttcacttc aaccttgtac tttcaacaca tttttttttt 8521 tttgttagag caacaacaac aacagcaacc aacaattaac aattaacaat taacagacgg 8581 acggagaact ggacaaacgg acaagccgac aaacggacag acacaacgga caaatagatc 8641 gaaaagccta aataagtgta tttggtttca agaactttga aaaagcaaaa cttaatatta 8701 atatagtata cagatatatt tttgattatt atgtatttaa tgagaaacaa tgaaacgatt 8761 aatgataatg atgcaagtat cgatgataac taagtgaaaa caaattgaga aatcaaatag 8821 cataattctg tttttgtttt gccgtaaaga ctgcattata ccaacaatta attatataca 8881 aacataataa ataattaact gataaatggg gcgagtaagc tttgcaacta agctgagaac 8941 aaaacggatg gataaacatt taaagcaagc atacaaaaaa agaaaaacaa acaaaaaaaa 9001 aaagaagaag caaaccatgg aaaataaaac caagaaacat ttatttatta gatcctaagt 9061 gaagactacg atttgctagc ggagatcaag tcaggccaga gcggaccttc aaggtaccgc 9121 atccaagtac gaaaagcaag atgaaattac cttaccaaaa tgtgctagcc ctcgaaaatc 9181 caccattatc tccatggtgg taatcaaatg attattcgcg agggcgagtc tacaagaaaa 9241 aagtccataa tagggcgagt aatcggagta attagtaaca ctatctatcg tatgataaat 9301 caattaccaa ctaaactggg ctaacaaaac acgtatatcc actaagattt atagttttcc 9361 cctaatcccc tgaaactaat tctaagtaca taagttgcaa gcaaaacgct aagaaaaaaa 9421 aaaaaagaac ctaaaagtta gttatataca cacaaaagag gatatatgaa tgagtgaatg 9481 gcggtaagaa ggaaggatgt gcgtttactt tggttttgag attgtttgcc gcagcttcac 9541 atctcgagcg aaactgtgcg gtttttttga aaacgtcagt tttgaaaaaa aaaaaccaga 9601 actggcgatt tcaagcaccg agcgtcgttt gtctttcaat atttatcaaa aaaaaaacac 9661 acacacacac aaatacacac agaaagaact catttgatgt atttagttta acgtttagcc 9721 actagtttcg aggaacgtta aaaaatgcct ttcctgaact gcagtcaaca ctcaaataag 9781 cgacaaacaa acaaaatgag aaaagaaaaa aaggaaacca accaaccaaa tgaaagcaaa 9841 ttgtttgaat aaaaatcaaa ttacat