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Drosophila melanogaster ADAM metallopeptidase with thrombospondin


LOCUS       NM_001169207            3372 bp    mRNA    linear   INV 26-DEC-2023
            type 1 motif B (AdamTS-B), transcript variant C, mRNA.
ACCESSION   NM_001169207
VERSION     NM_001169207.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 3372)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3372)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3372)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 3372)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 3372)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 3372)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 3372)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 3372)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 3372)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 3372)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 3372)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 3372)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 3372)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 3372)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 3372)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 3372)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 3372)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 3372)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 3372)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 3372)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 3372)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 3372)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 3372)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..3372
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..3372
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="ADAM metallopeptidase with thrombospondin type 1
                     motif B"
                     /map="5B1-5B1"
                     /db_xref="FLYBASE:FBgn0029791"
                     /db_xref="GeneID:31490"
     CDS             186..2495
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /EC_number="3.4.24.-"
                     /note="CG4096 gene product from transcript CG4096-RC;
                     CG4096-PC; AdamTS-B-PC"
                     /codon_start=1
                     /product="ADAM metallopeptidase with thrombospondin type 1
                     motif B, isoform C"
                     /protein_id="NP_001162678.1"
                     /db_xref="FLYBASE:FBpp0290306"
                     /db_xref="GeneID:31490"
                     /db_xref="FLYBASE:FBgn0029791"
                     /translation="MTCSRMWIRSRWLGLLLHYWLVVVTQGGGVRPLYGLHSDELVAG
                     EGQLVVPRRVHPDGAFMTHQLEYAHELDHRRHRQRRSLNSEHDTQAADLHLLLPLANE
                     TLHLELMAHSYFLAPNLVVERHRRDLRTRSPLTTRHLNCHFHGKVRGQPATNVAISTC
                     AGLVGHIRTAGNEYFIEPSKEHEPHPVNGHPHVVFQRSSVKPKHSLRKRNKRKRGGKS
                     GSGAEVSNCGTREPRRRMETRLEWQARGKVKVQGGRQIRRHHHHHHHHHHKHKYRHHQ
                     QKISRVPHTKFKYETQFQTEPDHAEIPRRRRSISSPRHVETLIVADATMSAFHRDLNG
                     YLLTIMNMVSALYKDPSIGNSIEIVVVRIIQLDEEESQLQLNLTQNAQKNLDRFCSWQ
                     HKLNKGSEKDPHHHDVAILITRKNICANNCMTLGLANVGGMCKPKQSCSVNEDNGIML
                     SHTITHELGHNFGMFHDTAKIGCHPRVGPIVHIMTPTFGADTLQVCWSNCSRKYITHF
                     LDQGLGECLDDPPTPLDEYNYTGELPGMRYNARGQCRLQFNLTTDSEVGACSAPHEFC
                     STLWCKVNGECVTHMRPTAPGTLCGRNKWCQNGKCVRREELAAVNGGWGDWSEWSECS
                     RSCGGGVSTQQRECDNPVPANGGVFCIGERKRYKICRKRPCPAEEPSFRAQQCARFDN
                     VSYQGATYKWLPFFDKNNPCKLFCSDVDDTIIANWGATVLDGTPCTLGTNNMCIDGIC
                     KLVAIGSSTRRCRTIGAVSAAVLAISASR"
     misc_feature    324..770
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Reprolysin family propeptide; Region:
                     Pep_M12B_propep; pfam01562"
                     /db_xref="CDD:460254"
     misc_feature    1125..1739
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Zinc-dependent metalloprotease, ADAMTS_like
                     subgroup. ADAMs (A Disintegrin And Metalloprotease) are
                     glycoproteins, which play roles in cell signaling, cell
                     fusion, and cell-cell interactions. This particular
                     subfamily represents domain architectures that...; Region:
                     ZnMc_ADAMTS_like; cd04273"
                     /db_xref="CDD:239801"
     misc_feature    order(1551..1556,1563..1565,1581..1583)
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="active site"
                     /db_xref="CDD:239801"
     misc_feature    1785..1991
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="ADAMTS cysteine-rich domain 2; Region: ADAMTS_CR_2;
                     pfam17771"
                     /db_xref="CDD:465496"
     misc_feature    2025..2183
                     /gene="AdamTS-B"
                     /locus_tag="Dmel_CG4096"
                     /gene_synonym="CG4096; CT13580; Dmel\CG4096"
                     /note="Thrombospondin type 1 repeats; Region: TSP1;
                     smart00209"
                     /db_xref="CDD:214559"
ORIGIN      
        1 ccgaagtatg cgaagtatct tcgatccagc gatggtatct gatagtcgaa tgactgttgc
       61 gatatcgaga tacgagcgct gatctcctga ccagcccaag atccgtatta tgcgaccgct
      121 gccatgctgc tgagacaacg cctggataac ggctagggct gtggactagg atcgggttga
      181 ggagcatgac gtgcagcagg atgtggatca ggagtcgctg gctgggcctg ctgctccact
      241 attggctggt cgtggttacg caaggcggtg gcgtacgtcc gctttacgga ctccattccg
      301 acgaactggt ggcgggtgag gggcagttgg tggtgccacg acgcgttcat cccgatggtg
      361 cgtttatgac ccaccaattg gagtacgcac acgaactgga tcatcggcgg catcggcaga
      421 ggcgcagcct gaactcggaa cacgataccc aggcggcgga cctgcatctg ctgttgccgc
      481 tggcgaacga gacactgcat ctggagctta tggcgcacag ctactttctg gccccgaatc
      541 tggtggtgga gcgccaccgg cgggatctgc gcactcggtc accgttgaca acgcggcacc
      601 tcaactgtca cttccatgga aaggtgcgcg gccaaccggc caccaatgtg gccatctcca
      661 catgcgccgg actggtgggt cacatccgga cggcaggcaa tgagtacttc attgagccct
      721 cgaaggagca cgagccgcat ccggtcaacg ggcatccgca cgtggtcttc cagcgctcct
      781 ccgtcaaacc gaagcattcg ttgcgaaagc gaaacaagcg caagcggggc ggcaaatcgg
      841 gatccggagc cgaggtcagc aattgcggca cgcgggagcc acgccgtcga atggagacga
      901 gactggagtg gcaggccagg ggcaaggtga aggtccaggg aggccgtcaa attaggcgcc
      961 accatcacca ccaccaccat catcatcaca agcacaagta ccgccatcat cagcagaaaa
     1021 tcagcagagt tccgcacacc aagttcaagt acgagacgca gttccaaacg gagccggatc
     1081 acgcagagat tccccggcgc aggcgatcca tcagcagtcc acggcatgtg gagacgctca
     1141 tcgtggccga tgccaccatg tcggcgtttc acagggacct caacggctat ctgctgacca
     1201 tcatgaacat ggtgtccgca ttgtacaagg atcccagcat tggcaactcc atcgagatcg
     1261 ttgtggtgcg cattatccaa ctggacgagg aggagtccca gctccagctg aatctcacgc
     1321 agaatgcgca gaagaacttg gatcggttct gcagttggca gcacaaactg aacaagggca
     1381 gcgaaaagga tccgcatcac catgacgtgg ccattctcat cacgcggaag aacatctgcg
     1441 ccaacaactg catgactctc ggcctggcca acgtgggtgg catgtgcaag ccgaagcaat
     1501 cgtgcagcgt gaacgaggac aatggcatca tgctctcgca caccatcacc catgaactgg
     1561 gccacaactt cgggatgttc cacgatacgg cgaagatcgg ctgccatccg cgcgtgggtc
     1621 ccattgtgca catcatgacg cccacttttg gggcggacac cctgcaggtt tgctggtcga
     1681 actgcagccg caagtatatc acacatttcc tggatcaggg attgggcgag tgcctggacg
     1741 atccgccgac gcccttggat gagtacaact acacgggcga gctgccgggc atgcgataca
     1801 atgcgagggg ccagtgccgc ctgcagttca acttgaccac ggacagcgag gtgggcgcct
     1861 gttccgcccc ccacgaattc tgctcgacgc tgtggtgcaa ggtcaacggc gagtgcgtca
     1921 cccacatgcg gcccacagcg ccgggcacat tgtgcggtcg gaacaagtgg tgccagaacg
     1981 gcaagtgcgt ccgacgcgag gagctggcgg cggtcaacgg gggatggggc gattggagcg
     2041 agtggagcga gtgctcgcga agctgcggcg gcggcgtgtc cacgcagcag cgggaatgcg
     2101 acaatccggt gccggccaat ggcggtgtct tctgcattgg cgaacggaag cggtacaaga
     2161 tttgccggaa gcggccgtgt ccggcggagg agcccagttt ccgggcgcag caatgcgctc
     2221 ggttcgataa tgtcagctac cagggtgcca cctacaagtg gctgcccttc ttcgataaga
     2281 ataatccctg caagctgttc tgcagcgatg tggacgacac gataatcgcc aactggggcg
     2341 ccacggtgct ggacgggaca ccctgcacct tgggcacgaa caacatgtgc atcgacggca
     2401 tctgcaagtt ggttgcgatt ggatcgtcga ctcggaggtg caggacgatc ggtgcggtgt
     2461 ctgcggcggt tctggcgatc agtgccagcc ggtgagggag acctacacgg atccgtttgc
     2521 cgccaaggat ggcgcctatg tggaaatcgt caccataccg gcacgggcgc ggcacattct
     2581 catccgcgag ctggccaatt cgccgcactt tcttgccatt gccacgggcg acggcgggga
     2641 tcgattctat ttgaacgggg atagcctcat ctccatgccc ggcgagtttg agatcgctgg
     2701 cgccgagagc ctctacgatc gcgtcgacga gcaggagacc atcacaatac ctcagcccat
     2761 ccagcattcc atatcgttat atgcgattgt gcgcggcaat gagagcaacg ctggcatttt
     2821 ctacgagttc accctgcccg cactgaatgt gaccgctggc aggcagttcc agtggcgcct
     2881 gagcaactgg accgcctgct ccgccagctg cggcggtggc gtgcagcacc gtgagcccat
     2941 ctgccaggag aacggcaagg ccttgggtga tacgctgccc tgctggacgc acgccaagaa
     3001 caagagaccg gcccggcaat cgcgaggatg tggcgaccag ccatgtcctg cccactggtg
     3061 gccaggtcct tggcaatttt gtccggtcac ctgtcgtcca gttggatttg tggcgccacc
     3121 tcagcgccgg cgatccgtcg tctgtctgga cgaacacgat gtggtggtgg ccgatgccga
     3181 atgtggtcac ctgcagaagc cggcggaaat ggagccctgc gaatcctcgc tgccgatctg
     3241 caggaccaag tagcacagga cacactccct atttattgac gccaccgaag gatcagtgcg
     3301 ttgttatgga acatatttat tcagcgagta agcgatcatc ccagatgtac ttaactaact
     3361 atacgcacgc ac