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Drosophila melanogaster ruby (rb), transcript variant D, mRNA.


LOCUS       NM_001169193            4432 bp    mRNA    linear   INV 26-DEC-2023
ACCESSION   NM_001169193
VERSION     NM_001169193.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 4432)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4432)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4432)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 4432)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 4432)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 4432)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 4432)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 4432)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 4432)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 4432)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 4432)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 4432)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 4432)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 4432)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 4432)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 4432)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 4432)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 4432)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 4432)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 4432)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 4432)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 4432)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 4432)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jul 15, 2014 this sequence version replaced NM_001169193.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4432
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..4432
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="ruby"
                     /map="4C7-4C7"
                     /db_xref="FLYBASE:FBgn0003210"
                     /db_xref="GeneID:31381"
     CDS             322..3804
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="CG11427 gene product from transcript CG11427-RD;
                     CG11427-PD; rb-PD; adaptor protein complex 3, beta
                     subunit; ruby"
                     /codon_start=1
                     /product="ruby, isoform D"
                     /protein_id="NP_001162664.2"
                     /db_xref="FLYBASE:FBpp0310168"
                     /db_xref="GeneID:31381"
                     /db_xref="FLYBASE:FBgn0003210"
                     /translation="MQQNSASNPFAMSTYVERPQMGLDVEFGADPASGAAFFQSDGRK
                     HDDLKQMLDSNKDGLKLEAMKRIIGMIARGRDASDLFPAVVKNVVSKNIEVKKLVYVY
                     LVRYAEEQQDLALLSISTFQRALKDPNQLIRASALRVLSSIRVSMIVPIVMLAIRDSA
                     ADLSPYVRKTAAHAIPKLYSLDADQKDELVMVIEKLLSDRTTLVVGSAVMAFDEVCPE
                     RVDLIHKNYRKLCNFLLDVDEWGQVIIINMLTRYARTQFVDPNADDEDLVNDGLGETP
                     VSERFYDESSHSSSHSDDGSSDDEKNKSSTNNKNNGGGNGSRTPSSPSNSYHIDVDHR
                     LLLRQTKPLLQSRNASVVMAVAQLYHHVAPKNEVQLIAKALIRLLRSHKEVQSVVLNC
                     IASMSTKRKAIFEPHLKSFFVRTSDPTHIKLLKLDILTNLASAGSISLILREFQTYIS
                     SSDRSFVAATIQAIGRCASSIKEVTETCLSGLVHLLSNHDEHVVAESVVVIKRLLQTK
                     AAEHFEIITQMAKLIDYINVPAARAAIIWLIGEYNEKVPLIAPDVLRKMAKSFVDEQD
                     VVKLQVLNLGVKLYLTNPEQTSLLCQYVFTLARYDPNYDVRDRARFLRQIIFPASGTS
                     SVLSQHARQVFLASKPAPVPESKYRDGNNFQLGSLSHYLNMPAAGYKELPAFPVIPPD
                     SSVRNIAGFMQDKLPGEDSPSGHSKDKSGREGGKEKGAGGEKGFLSESDDKSSAYSES
                     GSSSGSGTSDSESDSDGSGSSDEEEEEVQKQQPTKVSSVKERLIDAGSNELAATSSPV
                     KATINNNNNARGSSGTSDSEDSSAYSGSSSDDSASGSDNEVKKNETKTDTGTKPEKLK
                     EKHEKQPEQTAVKSNLDLLLDLDDIPPIGPVMTPSLGGFLTPGTPMMAGQAAPLQPQH
                     ARNRVELVGPSHIEFKHKELLNKVSGHGLHLAYRFTRSPHLYSSSMCSIELQFQNRGE
                     KEITAIRLGQTTLPAGMQLNEFAPITVLQPQQTASGVLGVDFNDSTHAVDLELLSSAG
                     SSRLQLKPPVGELVRSVQIGESCHREERAKLRGMNEHQCELRGLRQDLIDVVALRQKV
                     FESINVAHTHSSSSGQLHCFAGQTLSSKSLVLLTLDWKTEDALTLLVNCEKMVIGSMV
                     LNELRNALQLSFAM"
     misc_feature    439..2184
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="Adaptin N terminal region; Region: Adaptin_N;
                     pfam01602"
                     /db_xref="CDD:396262"
     misc_feature    463..540
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    670..753
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    760..858
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    883..963
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="HEAT repeat [structural motif]; Region: HEAT
                     repeat"
                     /db_xref="CDD:293787"
     misc_feature    2962..3378
                     /gene="rb"
                     /locus_tag="Dmel_CG11427"
                     /gene_synonym="AP-3beta; apl6; beta3; cg11427; CG11427;
                     Dmel\CG11427; Rb"
                     /note="Clathrin-adaptor complex-3 beta-1 subunit
                     C-terminal; Region: AP3B1_C; pfam14796"
                     /db_xref="CDD:464319"
ORIGIN      
        1 gactatcgac agttgcccac cattaggaaa cagaaagcta aaaaaaaaaa tgcaaaaatt
       61 ggccagaatt tcggcataaa taatagtatc ccttgcaaaa cttgcaagct gcgtggcagg
      121 acgagcagct gaccaccaga tcgtcttgag gattcaacat caggaacaaa ggtttcacat
      181 tggacgcatt tgcaaaaacc gaaagggaaa actgccaact cccacacaca aaaaaaaagg
      241 aaaaaaaaaa tcatcagcac ggaaagtaaa aggtcaagtg gtcaaccgaa atctgggtaa
      301 tccgggggaa tctttgcaag aatgcagcag aactcggcca gcaatccctt cgccatgtcc
      361 acatatgtgg agcggcccca aatgggactg gacgtcgaat tcggagcgga tcctgccagc
      421 ggagcagctt tcttccaatc cgatggacgc aagcatgatg atctcaagca aatgttggac
      481 agcaacaagg atggactaaa gctggaggcc atgaagcgca tcattggcat gattgcccgc
      541 ggacgggatg ccagtgatct gttcccggca gtcgtcaaga atgtggtgtc caagaatatc
      601 gaggtcaaga agttggtcta cgtctatttg gtgcgatacg ccgaggagca gcaggacttg
      661 gccctgctat ccatttccac atttcagagg gcgctcaagg atcccaatca acttattcgc
      721 gcctcggctc tgcgagtgtt atcctccata agggtcagca tgattgtgcc aatcgtaatg
      781 ctggccattc gggatagcgc cgccgatttg agtccatatg tgcggaaaac agcggcacat
      841 gccatcccca agttgtattc tctggacgcg gatcaaaagg atgaactggt catggtcatt
      901 gagaagcttt tatcggatcg cactactcta gtggtgggat cagcggtgat ggccttcgac
      961 gaggtttgtc cggaacgtgt agatttgata cacaagaact accgcaagct gtgcaatttc
     1021 ctgctggatg tggacgaatg gggtcaggtg atcatcatta atatgttgac ccgctatgcg
     1081 cgcactcagt tcgttgatcc caatgcggat gatgaggatc tggtcaacga tggcctgggc
     1141 gaaacgcccg ttagtgaacg cttctacgac gaatcctcgc actcctcttc ccacagcgat
     1201 gatggcagta gcgatgacga aaaaaacaag tcgagtacga acaataaaaa caatggcgga
     1261 ggaaatggca gtagaacacc cagttctccg agcaacagct accacatcga tgtggatcac
     1321 cgcctgctgt tgaggcaaac gaaaccattg ctccaatcgc gaaatgcctc cgtggtgatg
     1381 gcagtggcgc agctctatca tcatgtggct cccaagaacg aagtgcaatt gattgccaag
     1441 gcgctgatac gactgctgcg atcgcataag gaggttcaga gcgtggtcct caattgcatt
     1501 gcctcgatgt ccaccaaacg aaaggcgatc tttgagccgc acctcaagtc gttctttgtg
     1561 cgcaccagcg atcccacgca cataaagctt ctcaagctgg atattctcac caatctggcc
     1621 tcggcgggca gtatttcgct cattctgcgc gaatttcaaa cctacatctc cagcagcgat
     1681 cgttcgtttg tggcggccac gattcaggcc attggacgat gtgcatctag cattaaggag
     1741 gttaccgaga cctgcttgag tggcctggtt catctgctgt ccaatcatga cgaacacgtg
     1801 gtggccgaga gcgtggtggt gattaagcgt cttctgcaaa cgaaagccgc cgagcacttt
     1861 gagattatca cccaaatggc caaactgatc gattatatca atgtgcccgc agctagggca
     1921 gccatcattt ggcttatagg cgaatacaac gagaaggtgc cgctgattgc cccggatgtg
     1981 ctgcgcaaaa tggccaaatc gtttgtcgat gagcaggatg tggtgaagct gcaggtccta
     2041 aacttaggcg ttaagctcta tctgaccaat ccggagcaga catcgttgct gtgtcagtac
     2101 gtctttacgc tggctcgcta tgatcccaac tacgatgtac gcgatcgtgc ccgttttctg
     2161 cggcaaatca tctttccggc gagcggaacg agctcggtgc tcagccagca tgcccgccaa
     2221 gtatttctcg ccagcaaacc ggctccggtg ccggagagta aataccggga tggcaataac
     2281 ttccagttag gatcgttgtc tcactacctg aacatgccag cggctggcta caaggaactg
     2341 cccgcctttc cggtgattcc accggattca tcggtacgca atatagctgg atttatgcag
     2401 gacaagctgc cgggtgaaga ctcgccatcc ggacattcaa aggataaatc cggccgtgaa
     2461 ggcggtaagg aaaagggtgc tggtggcgag aagggcttcc tctctgagtc ggacgacaag
     2521 tcttccgctt actcggaatc aggcagcagc agtggcagtg gcaccagcga cagtgaatcc
     2581 gatagcgatg gcagcgggag cagcgatgag gaggaggagg aggtgcaaaa gcagcagccg
     2641 accaaggttt cctcggtgaa ggagcggctt atcgatgctg gaagcaatga gctggccgct
     2701 acttcttcgc ctgtaaaagc aactataaac aacaataaca atgcgagagg ttcgtcagga
     2761 acatcggaca gcgaggattc atcagcgtac agtggcagta gtagtgatga cagcgcttcc
     2821 ggtagcgata atgaagtgaa aaagaacgaa acgaaaacgg acacaggcac aaagccggag
     2881 aagttgaaag agaagcacga gaaacagccg gagcaaacgg ctgtcaagag caatctggac
     2941 ctgctactcg atctggatga cattccgccc attggtcccg tgatgacgcc ctcgttggga
     3001 ggattcctga cgcctggcac accaatgatg gctggacagg cggcgccact gcagccgcag
     3061 cacgcccgca atcgggtgga attggtgggt ccctcgcaca tcgagttcaa gcacaaggag
     3121 ctgcttaaca aggtcagtgg ccatggactg catttggcct accgtttcac ccgctccccg
     3181 catctgtact cctcgagcat gtgctccatt gagctgcagt tccagaatcg tggcgaaaaa
     3241 gagattacgg ccattcgtct cgggcaaaca actctgccgg cgggcatgca attgaatgag
     3301 tttgcgccaa tcactgttct ccagccccaa caaacagcga gtggtgtgct gggcgtcgat
     3361 ttcaatgatt cgacgcatgc tgtagacctg gagcttctgt caagtgcggg cagttcacga
     3421 ctgcaattga aaccgccggt gggcgagctg gtgagatccg tccagatcgg cgagagctgt
     3481 catcgcgagg agcgggccaa gctgcgtgga atgaatgagc atcagtgcga gttgcgtggc
     3541 ctgaggcagg acctaatcga tgtggtcgca ttgcggcaaa aggttttcga gtccatcaac
     3601 gtggcgcata cgcacagctc ttccagcggt cagctacact gtttcgccgg ccaaaccctg
     3661 agctccaaaa gcctcgtgct actcaccctc gattggaaaa cagaggatgc cctcacgctg
     3721 ctggtaaact gcgagaaaat ggtcattgga tccatggtgc tcaacgagct gcgcaatgct
     3781 ctgcagctca gtttcgccat gtgagcgatg gacacgaaag cgaacaagac gaaagcgagc
     3841 agcgaactaa cttgaggagt ggaatcccct ggagcagggc tactcaactg agaataaggc
     3901 aaagccgcct cactacgtaa acatagcatt catatttagc tatacacttg taaacgggcg
     3961 gggagaacgt aatctttgaa attagctgat aacattagct gagattacag gtgttttaaa
     4021 ttccattttc gagagattat atgtaaatgt gcagtgtaac agatgcaact taagtgttca
     4081 agtgggatcg aaatccaaaa ctaatttaaa ttgcaatttc aactgtaatt attacatatt
     4141 ctttaacttg ttgaaaactg aatgaaaagt gatgcaaact attgtgtaaa tgctacaaaa
     4201 ctatatttat tgttatacac attcgcaaat tcttaatgaa acttattgaa atgggaaaca
     4261 cacaacttcc tatatatttg tatccgctta tactgagata ttttgcataa aagagtcacc
     4321 atttcctttt atgaatggat gaacacaaca tgagattagt gtagctttca tatccaaatc
     4381 gaaaattatt caaggattac caaccgcccc gcccaaatat aaatgaaaca tg