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Drosophila melanogaster twenty-four (tyf), transcript variant F,


LOCUS       NM_001169189            8145 bp    mRNA    linear   INV 26-DEC-2023
            mRNA.
ACCESSION   NM_001169189
VERSION     NM_001169189.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 8145)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8145)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8145)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 8145)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 8145)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 8145)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 8145)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 8145)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 8145)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 8145)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 8145)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 8145)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 8145)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 8145)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 8145)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 8145)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 8145)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 8145)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 8145)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 8145)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 8145)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 8145)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 8145)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Oct 19, 2015 this sequence version replaced NM_001169189.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..8145
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..8145
                     /gene="tyf"
                     /locus_tag="Dmel_CG4857"
                     /gene_synonym="CG485; CG4857; Dmel\CG4857; EG:EG0007.12;
                     EG:EG0007.4; TYF"
                     /note="twenty-four"
                     /map="4B1-4B1"
                     /db_xref="FLYBASE:FBgn0026083"
                     /db_xref="GeneID:31363"
     CDS             189..5192
                     /gene="tyf"
                     /locus_tag="Dmel_CG4857"
                     /gene_synonym="CG485; CG4857; Dmel\CG4857; EG:EG0007.12;
                     EG:EG0007.4; TYF"
                     /note="CG4857 gene product from transcript CG4857-RF;
                     CG4857-PF; tyf-PF; twenty four; TWENTY-FOUR"
                     /codon_start=1
                     /product="twenty-four, isoform F"
                     /protein_id="NP_001162660.1"
                     /db_xref="FLYBASE:FBpp0290346"
                     /db_xref="GeneID:31363"
                     /db_xref="FLYBASE:FBgn0026083"
                     /translation="MLKKAEYDEEISYRAIKSCLTINPSALTSSAATGSSGGSSSSAG
                     HNSSYNSTNHRSTDPGQRHKQGGSLQDLVEAAHRSELATTSAAAAAAATAAATQRFNC
                     DYQLSGRSNRRQQQQQQQHNQNATSSASASKKIKNLNVSGRQREGGSLPSSVNFEPAS
                     SAMEAKQNKQQAQPSTEAAGGSFSGSVGNKHHHRSSTGSCSSLITQSRDTEANNQFDL
                     DMDDATGVGASAVVGASGDQDDNMLEQLDPQNPSMKFLIDALNDTPLEARYTGAGKKF
                     LIDDRLHFSVLELSARRKLQQQAQYLAALTGQFGLGLEEEKRKVEAGYVSLNDNYTAC
                     SSVYGGGAGSPAAVEGSKPSTSSSAVSGGSNCGASSDALSSDLRPAKIGRMVPAAAAV
                     AAAPMGGKTTTRQLDENGNALGDGFGGSAASGSSGASGASAAASSSNGNGNANQFTAL
                     ITPTVGSSVPTSTVAHRQNSVSTLLSTGTNTTTTAMAAAAVAASYSQLQQAPVGGAAG
                     TVSGIGIGMQQPTKQKTKKKSQQERNTTTVDVESVAGYRGNDPVEQLVKYIENDVNGG
                     GNSAAGQRKKERKKQNKLKKSNSLEELRTCSKMEVDDLKRQSATTEMMRHKKGTNNAS
                     SGGSSSTASGSSNSGKHNSASVADINKNCNKEQQQQSTPTVQVRNSNNPGTQQRKGER
                     RSWGTEELQYLGDHQEISAAWSELETVGQKELPLALPALARMSELDALNTVLSETAEF
                     HVVTKKKKPKKQRAVTMDDAAVAAAAVTGGNLQRMQQITKSASSNIMSQRMHYYTPYN
                     SNNGGGSVNYKQQQQQSQQYQEHYQAPQGQHHHHHHHHHHHHHHHSGSAVSNQVDSSR
                     RKSTSSMPPSEKSDSSDLDSVHSLPIQTGKKKSLGGGNNKQRGAPSASQRQAKQNNNA
                     AAPISYADIARNKQEALNNATASDTELELGDKMQIKSGGKSKSRPDFPELPGAVTAVA
                     ASGGAANQATVVSSQNTPPSSSSSISYSQSLNATPPSSSSDAESTNSPELLAQVQIPA
                     YSMITPTLTASMISSVSSSVASTSSTSCSPPALQKSKSVEHDTSYSCNSSNLDQQYPA
                     LEKTVKRHSTNNVSVAVAASTSASASSSLYNFAAAAKQQLTENTHSAVSPPAAVTTTS
                     TAVAASAPAPTTVTVPAAVTVPCYSSSSTHGSTQTSTSTASSAIAALPSGKAKAKPKE
                     LSPSSSCSKKPTKPSQDVPSISLSISTTPRATTSTSTTTTQKTTAATQTEGAKKLIGG
                     IHKLPSSSCIAKGAGAVLEATAGRRAVIILNDDREAGRSNNEFIFGDFNEDELKLFDD
                     NLDDEEEGQHKQSSNKKQQTEGESDVTQDDTEDVDQDLDKELECLGRRPEKKQERQQD
                     ISASSDQHLNDSGAASDAVNSSASLDMLSISAEAAQSSPNAGATATSSSVASPINSST
                     PSGASSASASTSTSSSSVSISSSSGGNGAACLASVSGMLGGVANQSGDSGIYAAANTS
                     IKEHVNTFLSKASSSEETLPSPNSISMQQLETCNDIEAAIIAAARAAAAARSTSCSRS
                     NSQEQDALQPQVKTKATPNPEAKMVLPVFVTYNNNNNDDDDDEEDDESLQELSFMADL
                     KADAATEDIAMQPPPPSCPAMMTNTELIVDYIAKTWNAIANSKYVTYYNEQEQEQET"
ORIGIN      
        1 ctgactgact gggattgtgg ctttcgaaat agtgccgtta catttggtcc catcaaacaa
       61 aatacgatac ctgggaagat agcgatttta atgatctgga cgacgcatca ttgaagaaac
      121 ttctcgaaga ggcctactgg tatcgaaatc ctggcgacag gaagaacaag agcgagcgat
      181 ttctgcaaat gctcaaaaag gctgagtacg acgaagagat ctcttatcgt gccatcaaat
      241 cctgcctcac aatcaaccca tccgcactaa cgtccagtgc agcaacaggc tcgagcggcg
      301 ggagcagcag cagtgcaggg cacaacagca gctataattc caccaatcac cggtcaacgg
      361 atcccggcca gcggcacaag cagggcggct ccctgcagga tctcgttgag gcggcgcacc
      421 gcagcgaact ggccacaacc tcggcggcgg cggcagcagc agcgacagcg gcagcaaccc
      481 aacgtttcaa ctgtgattac cagctgagtg gtcgctccaa tcgccggcag cagcagcagc
      541 aacagcagca caaccaaaac gccacctcct ccgcatccgc atccaaaaag atcaagaact
      601 taaacgtctc gggccggcag cgcgaaggag gcagcctgcc cagcagtgtt aactttgagc
      661 cggcatcgtc tgccatggaa gccaagcaga ataagcaaca ggctcagcct tcgacagaag
      721 ctgcaggtgg ctcgttttcg gggtcggtcg gtaacaagca ccaccaccgc agcagcaccg
      781 gcagttgcag cagcctgata actcaatcgc gcgatacgga ggcaaacaat cagttcgact
      841 tggacatgga cgatgcgacg ggtgttggtg ccagcgccgt tgtcggtgcc agcggcgacc
      901 aagacgacaa catgttggag caattggatc ctcagaaccc ctcgatgaag tttctgattg
      961 acgccctaaa cgacacgcca ttggaggcca ggtacaccgg tgccggcaaa aagttcctaa
     1021 tcgacgaccg gttgcatttt tccgtcctgg agctgtctgc caggaggaag ctgcagcagc
     1081 aggcacaata cctggccgcc ctcaccggac aatttggtct cggcctggag gaggagaagc
     1141 gcaaggtaga ggccggctac gtgtcgctca acgacaacta cacggcgtgc tcctcagttt
     1201 acggcggcgg tgcaggttcg ccagctgccg tggagggcag caagccctct acctcctcct
     1261 cggccgtgtc tggcggtagc aactgcggtg cctcctctga cgcactgtct agcgatctgc
     1321 gacctgcgaa gattggacgc atggtccccg ccgcagcggc agtggcagct gcgccaatgg
     1381 gtggcaagac gactactcga cagctagacg agaatggaaa tgcattgggc gatggtttcg
     1441 ggggcagtgc agccagtggc tccagtggcg ccagtggcgc cagtgctgcc gccagcagta
     1501 gcaacggcaa cggtaacgca aaccagttca cagctctaat aacccccacg gtgggatcca
     1561 gtgtacccac ctctactgtc gctcaccgtc agaatagtgt ctccacgctg ctctccacgg
     1621 gcaccaacac tacaacaacg gccatggcag cggcggcggt ggctgcatcc tacagccagt
     1681 tgcaacaggc accggtcgga ggcgcggctg gaacggtttc tgggatcggc attggcatgc
     1741 agcagcccac caagcagaag acgaagaaga agtcgcagca ggagcgcaac accaccaccg
     1801 tcgatgtgga gtcggttgcc ggctataggg gcaatgatcc tgttgagcag ctcgtcaagt
     1861 acattgaaaa cgatgtcaac ggtggcggaa acagtgccgc tggacagcgc aagaaggagc
     1921 gcaagaagca aaacaagctc aagaagagca actcgttgga ggagctgcgc acctgctcaa
     1981 aaatggaggt ggacgatttg aagcgccagt cggcgaccac ggagatgatg cgacataaga
     2041 agggcacgaa caatgcatcc tcgggcggat cgtcgtcgac ggcctctggt tcctcaaaca
     2101 gtggcaagca caactcggca tccgtggcgg atattaacaa aaactgcaac aaggagcagc
     2161 aacagcaatc gacgccgacg gtgcaagtgc gcaacagcaa caatccagga acgcagcagc
     2221 ggaagggcga gcgtcggtcc tggggcaccg aggagttgca gtacctgggt gaccaccagg
     2281 aaatatccgc tgcctggtcg gagctggaga ctgtgggcca gaaggagctg ccgctggcgc
     2341 tgcccgcctt ggcgcgcatg tccgaactgg atgccctgaa taccgtcttg tcggagaccg
     2401 ctgagttcca tgtggttacc aagaagaaga aaccaaagaa gcagcgtgct gttaccatgg
     2461 acgatgcggc ggtggctgca gctgccgtca cgggcggcaa cttacagcgc atgcagcaga
     2521 tcaccaagtc cgcgtcctcc aacatcatgt cccagcggat gcactactat actccgtaca
     2581 acagcaacaa tggtggaggc agtgtcaact ataagcaaca gcagcaacag agccaacagt
     2641 accaggagca ctaccaggcg ccacaggggc agcaccacca tcaccaccat catcatcacc
     2701 accatcatca ccatcacagc ggctcggcgg tttcgaatca ggtggatagc tcacggcgca
     2761 agtccacgtc gtctatgccc ccatcggaga aatctgactc cagtgatctc gactcggtcc
     2821 actccctgcc catccagacg gggaagaaga agagcctagg cggtggcaac aacaaacaac
     2881 ggggggcgcc gtcagccagt caacgccagg ccaagcaaaa caacaatgct gcagccccca
     2941 tttcgtatgc ggatatcgcc cggaacaagc aggaggctct aaacaatgcc acggccagcg
     3001 acaccgagtt ggagctgggc gacaagatgc agatcaagag tggcggcaaa tccaagtcgc
     3061 gacccgattt cccggagctg ccaggtgctg ttacggcagt ggctgccagt ggaggtgcag
     3121 ccaatcaggc gacggttgtc agcagccaaa atacgccacc atcctcgtcc agttccatca
     3181 gttattcgca gagtctcaat gcaacgccgc ccagcagcag cagcgatgcg gagtccacca
     3241 actcgccgga gctgctggcg caggtgcaga taccggctta cagcatgatc acgccaactc
     3301 taacagcctc catgatcagc agtgtcagca gttctgtcgc cagcacctct tccacatcct
     3361 gctcaccgcc agctctgcag aaatccaaga gcgtggagca cgacaccagc tacagctgca
     3421 atagtagcaa cttggatcaa cagtatccgg cactagaaaa gaccgtcaag cggcatagca
     3481 ccaacaacgt gtctgtggcc gtcgcagcct ccacctcggc atcggcgtcc tcctcgttgt
     3541 acaactttgc agcggcagcc aagcagcagc tgacagagaa cacccattcg gccgtatcgc
     3601 cgccggcagc tgtaacaact acctcaaccg cagtcgcagc ctcagctcca gctccaacta
     3661 cagttacagt tccagctgca gttacagttc cttgttattc ctcatcctcc acacacggct
     3721 cgactcaaac ttcaacttct actgcatcgt ctgctatagc agctttaccc tcgggcaagg
     3781 ccaaggccaa gccaaaggag ctatctccca gcagcagttg cagcaagaag ccaacgaagc
     3841 ctagtcaaga tgtgccgtca atcagtctgt ccatttccac cacgccaagg gcgacgacca
     3901 gcaccagcac tactactaca caaaagacca cggctgccac gcagaccgag ggagccaaaa
     3961 agctaatcgg cgggatccac aagctgccca gtagcagttg tattgcgaag ggagccggag
     4021 ccgttttgga ggccaccgcc ggcaggcgtg ctgttatcat actcaacgat gatcgcgaag
     4081 caggcaggag caacaatgag ttcatattcg gtgatttcaa cgaggatgag ctaaaactct
     4141 tcgacgacaa cttggatgat gaggaggagg gccagcacaa gcagtcttca aacaagaaac
     4201 agcaaactga aggggaatct gatgtgaccc aagatgacac cgaagacgtg gaccaagatc
     4261 tggacaagga actggaatgc ctgggacgac gaccagagaa gaagcaagag cgacagcagg
     4321 atatcagcgc cagcagcgat cagcatctga atgattctgg tgcggcttcg gatgcagtca
     4381 acagctcagc cagccttgac atgctctcaa tttctgcaga ggcggcacaa tcgtcaccta
     4441 atgcgggggc aaccgctacc tcatccagcg tcgccagtcc cattaactcg tccacgccct
     4501 cgggtgcttc gtccgcatcg gcgagcacgt ccacctcatc gtcctcggtc tcgatttcat
     4561 catcgtcggg cggcaacggt gccgcttgtc ttgcatccgt ttccggtatg cttggtggag
     4621 tggccaatca gtccggggac agcggcatct atgctgccgc caacacgtct attaaggagc
     4681 acgttaacac tttcctaagc aaggccagca gcagcgagga gacgctgccg agtcccaact
     4741 ccatatcgat gcaacagctg gaaacatgca acgacatcga ggcggccatc atagccgcag
     4801 cccgtgctgc cgctgctgcc cggagcacca gctgcagtcg cagcaactct caggagcagg
     4861 atgccttgca gccgcaggtc aagaccaagg cgactcccaa tccggaggcg aagatggttc
     4921 tgcctgtgtt tgtgacctac aacaacaaca acaacgacga cgatgacgac gaggaggacg
     4981 acgagagcct gcaagaactg agcttcatgg ccgaccttaa ggcggatgca gccacggagg
     5041 atattgcaat gcagccgcca ccgccttcat gtccggcgat gatgaccaac acggaactaa
     5101 tcgtcgacta catcgccaaa acctggaatg ccattgccaa cagtaagtac gtaacgtact
     5161 acaacgagca agagcaggag caggagacct agaaaccaca caaacagcaa tcgctgcagc
     5221 gtcagcgaaa tcgaaatcag caacatcggc gtcaatcaca atagcaacgt cagcaatatc
     5281 ggcagcaatc taacgagagc atccaacgtc ggctgaaatc aggagagcag attggttgga
     5341 atagagtgtt ctaaaagtta aaattttttt tttttttgct gggctattgt ttatatatct
     5401 accgatatcg tacacacact atatattatt gcaataatga tacgctttaa tgctaattaa
     5461 tgtaacgagt cgatagccga actattgatt aacttttgca agcgcggcag ccgaggatca
     5521 gggtagacat ctaacccatg gggtcaccgt tgtcaagaag tatcttcagg tgtttccagt
     5581 gtgagtgcag gagtacagga tcgtgtcggc tagggttccg gtgccgcatg cctaataggt
     5641 taactgttgc agaaagaaaa ttttatagag aaggagagcg ttcagctgtg aataagaagg
     5701 aaatcataac taaatgaagt gatcttacga aagcttcaag tgaatattta tttaacataa
     5761 gttgaccgag atttaaacgt tttttttttt ttcgcctcaa gaagcgatgg tcagatagtg
     5821 atgttcaatc aagcatttgg atctgctttt gttaatttac aaccttctgg atcccgaaaa
     5881 cgcaacgttt taccattact attactatta ttgtacttta ataattatta tgcaaacgtt
     5941 ttttcgtcat tgtttcatat gcccaatttt tgggcgcgtt gtttggagga aatcctaatc
     6001 ctagatatta aaccgagtca acgtcgcgtg tacatagtgg accagaagtc gtgtgggcag
     6061 ttcgatctct gtgttatgga ttagtggaaa cagaacaaat cagaacagga tagaacagag
     6121 caaaacagaa agccccacgg aagatatttg atatgtgtgt atgataacga ctatttaaag
     6181 taaactatgt aaggccgctt ctttgctccg gctagccata aataagcctc aagaggagag
     6241 tatgttaaac cgaataaccg aatgcaaaca gagaaccaca aaataccggc aaaaacacta
     6301 ttatgcactt acgaaaaatg ccgccgttta gctgggagag cctcagatgg tctctccgag
     6361 ggtatagaag tatagatatc gtaactattt aaacaagaat taatttaaaa gtaacaaaca
     6421 cgaaaaagtt cggcagtgaa gaaatgaatt ggagtcaaag gcggatacgg agaaacaaac
     6481 aaacaataag cgttaagtaa actcgtaagt ataaagagcg caactaaatt gctatcaata
     6541 ggaatataca ttatatacgt gcatctatta acgtaacttt ttttttttta aatgcaaacg
     6601 ttaaccgttt aaaatcgagt atgtaacagc aggtagcagt taggtgaaca aaagtcggaa
     6661 taaaattacg gaaataaatc attaatttaa agtatctaaa gtgcgaatcg agaaagccta
     6721 tttaaagcta atcattaaaa catttaaaag tcccatttgg aatgcccaga ggaagtgggc
     6781 atgtccgaat aaacagaaca aacagtgcga aatgtttttt agatatatgt gaaactgttt
     6841 tgcttcaatc gctgtatatt ttgaaaataa aagttaagta atatgccgta aagcgggaca
     6901 tgtattcaac accactcaac accccgagtc ctgacccttg aaccttgacc cttgaccctc
     6961 taaaactccg catgcaacac tcggccagag ctgttgctgt gctgctctaa accatgttag
     7021 ccatccgcag cagaatcaaa agtcagagca ggagaatttt aactgagttg ctaggaggac
     7081 gataatatgg aatatatgaa atatttgtat ctgtaccaca cacattaagc aaacattaag
     7141 gaaacacaca ctagtttaca aatttggcct tttggcggtt accttaagga gcgttatatt
     7201 ttctaattaa aattctaaag cgaatgagtg tatccgaacc cagctaactg taggtttatc
     7261 atacgaatat taataccaac ctgcgaatgg aataaacctg tcaaaatatt gtttagtgaa
     7321 ttgtatttca aacaaattat ttaaatacta cgtgttttat agtcgactgg ttattatacc
     7381 cgttactcgt agagtaaaag ggtatactag atacattgaa aagtatgtaa caggcagaag
     7441 gaagactttc cgaccatata aagtatatat atattcttga tcagcatcaa tagccacgtc
     7501 cgtctgtccg tatgaacgtc gagatctcag gaactataaa aggtagatgg ttgagattca
     7561 gcataaagat tctagagaca tagacgcagt ataagtttgt tgacccatgt tgccacgccc
     7621 actctaacgc ccacaaaccg cacaaaaatg tcacgcccac acttttgaag aatttttaaa
     7681 tgaaaaatga taaaatttcg cgttcgcatt cacattagct gagtaacggg tatgtgatag
     7741 ttggggaact cgactatagc attccctctt gtttttcgcc agtaaacatt acttcctttt
     7801 acatccaacg ctcttttcga aaatatcaaa acagtttttc cgttctattt agaaaacaca
     7861 tgtttaattt cagcaaactc aaattagtct aagaaacgtg ttttaaagac gtacatcttt
     7921 cgtgtaaact agtgttatat atgtacaacc actaagtcaa actaagccaa tgtacactgc
     7981 aacaatttta gacaattgag aactaacgag aaacagaaac aagatacaca aaaccgaata
     8041 tataagggta tggaaaagaa catgaaatta aattatacga taggccagta attaaacata
     8101 atactgaaat attattaatt acttataaac aaacggaaaa aacac