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Drosophila melanogaster Protostome-specific GEF (PsGEF), transcript


LOCUS       NM_001169176            6858 bp    mRNA    linear   INV 26-DEC-2023
            variant C, mRNA.
ACCESSION   NM_001169176
VERSION     NM_001169176.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 6858)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6858)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6858)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 6858)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 6858)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 6858)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 6858)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 6858)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 6858)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 6858)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 6858)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 6858)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 6858)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 6858)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 6858)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 6858)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 6858)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 6858)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 6858)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 6858)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 6858)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 6858)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 6858)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_001169176.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..6858
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..6858
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="Protostome-specific GEF"
                     /map="3A2-3A2"
                     /db_xref="FLYBASE:FBgn0264598"
                     /db_xref="GeneID:31224"
     CDS             260..4741
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="CG43947 gene product from transcript CG43947-RC;
                     CG43947-PC; PsGEF-PC; protostome-specific GEF"
                     /codon_start=1
                     /product="Protostome-specific GEF, isoform C"
                     /protein_id="NP_001162647.1"
                     /db_xref="FLYBASE:FBpp0305708"
                     /db_xref="GeneID:31224"
                     /db_xref="FLYBASE:FBgn0264598"
                     /translation="MPTMTRMHRHSSSSAVVEESRGRRRGVGVPGVGDANKENFGVHF
                     MSSPFGNASLIALQDLSNVHGKSPQRRSFSEGSGPRQATPQLAALRCLPRTTGGAVAL
                     EDSQLSSSRMGDTTLDRMLDAIIESARKEVRCTKTLPGAGATTSTTILADNAEWSETS
                     VHEMEVRTPTHLKRQRVVRRKNPHKTTTINQTQSHQAKKLEPLQLVPSTKRCLSFSSS
                     SASSDLDEDEQQVAKRSSLASPTTTPPSHCTTTTSSISSSSSSNGGADMEASQRGSID
                     VSIAFDAKEQQLNVHVIRCRDLQRSHGSGNGSINAYVKVALSGGAQPPGYGGHSSGGS
                     MSSGYQRTAVHRHSGRPYFDQRFNFQISSGEETAGQYLQLAVWHRDRHLKRSEFLGCS
                     TFPLNELVHPDSGVSAGSYKLHAQACPPPTSRHSQPKANAGQDQKQETEAAKDQDKQQ
                     DDSPAEMAAAVTVTPQKPVATGSGSGSNSAAMALNDEVISISIDSMGKEDPLLPQQPQ
                     QPMKLSKKALHQRDADENLFLRFLELDPPADGNANSTTTQAQATGSQSSASKANESNA
                     NHLNNGTSGGRRQSTMPNSGGSSVGGAVRQQQGRTPFTMTKRLTRTEERGFGFSIVWT
                     HPPRVEKIEAGLSADRCGILPGDYVIFVDKHNVVTMPEADVLNLIRSQGSSLTLEIFR
                     RSGAGATTITSTDLGQNNVHISTRLGAAVGLGSEEHTLATTATGTTTVMSLQRTTSTR
                     IQPLANSMSRPATACSGTTSSIEAAKRRLHLPQVTFSKESIVPVTDNRRRFLLQLISR
                     EQNFTAALHFGVDRFVQPLGERKDLISPNDHRTLFQNIDELLRIAEDILEQLCSSDQQ
                     DQEPQMNFASRVYLSKTTAICAAYKKYCNGIKRADCVLVNKSRQTGSEFIAFITEPAV
                     PRKRPDLTMFIHRPLQHFREILKLMQLLAGNCHVDTEEHKNFSTVINELQAAYREITV
                     SSGLMEPLGEGRPLLTLQDLESRMVFTKCKPFTLAVQGRQWIFGGDLSRVEGRSVKPY
                     WTLLFSDIIVFAKVSRDRVLFITEEPIPIANVVDSCFHMRKKTTEFRLTVDPNGRLAE
                     SPTGYCAPDLTRTPKRGARRKSLILRAPSLELKAVWQNLLQRQIFLVNAALGSTPLSS
                     PLDSPDVLNTLVPLSDIGLTTASMGSMKLPSLDSIHLKQQQKQQVRLFRSKRLDSGDS
                     YENLQRLASAVRHHCASTTTSSATQTQSHPQPPLCTTSLPSRTNSPARNQRHPNGQGH
                     VGGSVPNGVGGVSFGGCNTNSSCLSSSASLTQTQTQVHTQTLNHSQTHSQTQTSVLSL
                     SSCKCLTVIPEVTSEPPVNQHASQKLLEFSLSSVGRSFIDESGGVVGGQVSLTTPETP
                     TPNISPTTSQPCNSDAFSNDFVATSTTGKGPNIPLAEFGGSWDLLELDLQLHEVNLDP
                     SYDTDVEECIFLGDEEDREGTEGHGHDEDSDEDDSVVVDDPFGMLPTRPTPPDSLDL"
     misc_feature    <494..886
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="Domain of unknown function (DUF4799); Region:
                     DUF4799; pfam16056"
                     /db_xref="CDD:318308"
     misc_feature    1115..1498
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="C2 domain; Region: C2; pfam00168"
                     /db_xref="CDD:425499"
     misc_feature    2084..2299
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="canonical PDZ domain; Region: PDZ_canonical;
                     cl49608"
                     /db_xref="CDD:483948"
     misc_feature    2654..3172
                     /gene="PsGEF"
                     /locus_tag="Dmel_CG43947"
                     /old_locus_tag="Dmel_CG14045"
                     /old_locus_tag="Dmel_CG14047"
                     /gene_synonym="CG14045; CG14047; CG43947; Dmel\CG43947;
                     DmPsGEF; EG:BACH48C10.4; EG:BACH7M4.1; EG:BACH7M4.2;
                     FBgn0264598; null; psGEF; PsGef"
                     /note="Guanine nucleotide exchange factor for
                     Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous
                     (DH) domain. It appears that PH domains invariably occur
                     C-terminal to RhoGEF/DH domains; Region: RhoGEF; cl02571"
                     /db_xref="CDD:470622"
ORIGIN      
        1 atttccgttt ctgagctcgt gctaagcaga cacgtgaact tcatagcaga aaagaacgaa
       61 aatacctttg gcttgaagaa attagttggc ttattttttt tttcgtgtaa aagatctatc
      121 aaaatttgtg tgccgccgac gcgcaaggat cacattttta aacaaaatca gtgctgttaa
      181 tcaagttgaa cctaagctaa atcgagttgc agttcgccag gcgacgtagt cgcaaaaaga
      241 tcaagttacc agtagggaca tgccaaccat gacacggatg catcgccact ccagttccag
      301 tgccgtggtg gaggagtcgc gtggccggcg ccgtggagtg ggcgtgccag gagtcggaga
      361 cgcgaacaag gagaatttcg gggtgcactt catgagcagt cccttcggca atgccagttt
      421 gattgccctg caggatttga gcaacgtgca cggaaagagt ccgcagcgca ggagtttcag
      481 cgagggcagt ggtccgcggc aggccacgcc acaattggcg gcactgcgct gcttgccacg
      541 caccaccggt ggtgcagttg ctctggagga ttctcagctc tcctcatcgc gaatgggcga
      601 taccacactg gaccgcatgc tggatgccat catagagtcg gccaggaagg aggtgaggtg
      661 tacgaagaca ctgccaggcg ccggcgccac cacttcgacc accattttgg cggataatgc
      721 cgagtggagc gagaccagtg tccacgaaat ggaggtgcgc acgcccaccc acttgaagcg
      781 gcagcgggtg gtgcggcgca agaacccaca caagactacc accattaacc aaacgcaaag
      841 tcaccaagcc aagaagttgg agccactgca gttggttccc agcaccaaac gctgcctgag
      901 cttctcatcc agttccgcct cgagtgattt ggacgaggat gagcagcagg tggccaagag
      961 gagttcgctg gcctccccca ccaccacacc tccctcccac tgcaccacca ccaccagcag
     1021 catcagcagc agcagcagca gtaatggtgg tgcggacatg gaggccagtc agcggggcag
     1081 catcgatgtg agcatcgcat tcgatgccaa ggagcagcaa cttaatgtac atgtgattcg
     1141 ctgtcgcgac ttgcagcgct cccatggcag tggaaacggc agcatcaacg cctacgtcaa
     1201 ggtggccctg tccggaggag cccagccacc cggatacggt ggccactcgt cggggggaag
     1261 catgagttcc gggtaccaac gcaccgccgt ccatcggcac tcgggccgcc cgtacttcga
     1321 tcagcgattc aacttccaga tttccagtgg cgaggagacc gctggacagt atcttcagtt
     1381 ggccgtgtgg catcgggatc gccatttaaa acgcagcgag ttcctgggct gcagcacttt
     1441 tccactgaat gagttagtgc atccggattc gggcgtctcg gcaggatcct acaagctgca
     1501 tgcacaggca tgtcctccgc ctactagccg ccatagccaa ccaaaagcca acgcaggcca
     1561 ggatcaaaag caggaaacgg aagcggcgaa ggatcaggat aaacagcagg acgattcccc
     1621 cgcagaaatg gcagcagccg tcacagtcac gccccaaaaa ccggttgcca ctggatccgg
     1681 ttcgggatcg aattccgcag cgatggcact gaacgacgag gtgatcagca ttagcatcga
     1741 tagcatgggc aaagaggatc ctctgctacc ccagcagccc cagcagccca tgaagctcag
     1801 caagaaggca ctccaccagc gagatgccga cgagaatctc tttttaagat tcctggagct
     1861 ggatccgcca gcggatggca atgcaaacag taccaccacc caggcacaag cgacgggctc
     1921 ccagtcctcg gcgtcgaagg ccaacgaaag caatgccaac cacttgaaca atgggacatc
     1981 cggtggacgc agacagtcca ccatgccaaa tagcggagga tctagcgtag gaggcgctgt
     2041 ccgccagcag cagggacgta ccccattcac catgacgaaa agacttacgc gaaccgagga
     2101 acggggcttt ggattctcta ttgtctggac gcatccgcca cgggtggaga aaatcgaggc
     2161 gggactctcg gccgatcggt gtggcatttt gcccggcgac tatgtgatct ttgtggacaa
     2221 gcataacgtc gtcacgatgc ccgaggctga tgttctgaat ttgatacgat cgcagggctc
     2281 gtccttgacg ttggagatat tcagaaggtc aggcgcgggc gccacaacaa tcacgtcgac
     2341 ggacttgggc cagaacaatg tacacataag caccagattg ggcgcggcag tgggcttggg
     2401 cagcgaggag cacaccctgg ccaccaccgc aacaggaacg accaccgtaa tgagtctgca
     2461 aaggaccacc agtacgagga tccagccatt ggcaaatagc atgagccggc cggctaccgc
     2521 atgctcggga accacctcct ccatcgaggc ggccaaaagg aggcttcacc tgccacaggt
     2581 caccttcagc aaggagtcga ttgtgcctgt cacggacaac cgtaggcgct tcctgctcca
     2641 gctgattagt cgggagcaga acttcacggc tgccctgcac ttcggagtgg accgctttgt
     2701 gcagccgctt ggcgaacgaa aggatctgat ctcgccgaac gatcatcgca ctttgttcca
     2761 gaacatcgac gagctgctca ggattgccga ggacatcctg gagcagttgt gcagcagcga
     2821 tcagcaggac caggagccac aaatgaactt tgcctcgcgg gtctacctat caaaaactac
     2881 agcgatctgt gcggcataca agaagtactg caatggaatt aagcgggccg actgtgtttt
     2941 ggtcaataag tcccgacaga ctggctccga gtttatagcc ttcattacgg aaccggccgt
     3001 tccacgtaaa agacccgatc tcaccatgtt catccatcga ccactgcagc attttcgtga
     3061 aatccttaaa ctgatgcagt tgctcgctgg aaattgccat gtggatacgg aggagcacaa
     3121 gaactttagc acggttatca acgaactgca ggctgcctat cgggagatca ctgtgagcag
     3181 tggtctgatg gaaccactgg gagaaggtcg ccccctgctc accctccagg atctggagtc
     3241 ccggatggtc tttaccaaat gcaagccttt tacgttggcc gttcaggggc gccagtggat
     3301 ctttggcggc gatttgtccc gggtcgaagg tcgctccgtt aagccctatt ggacactact
     3361 attcagtgat atcatcgttt ttgccaaggt cagccgtgat cgagtcctgt ttatcacaga
     3421 ggagcccatt cccatcgcca atgtggttga ctcttgtttc catatgcgca agaaaaccac
     3481 cgagtttcgt ctcacagtgg atcccaatgg acgcctggcg gagagtccga cgggttactg
     3541 tgctcccgat ctcacccgca ctccaaagcg aggagcccgc cgcaagagcc ttattttaag
     3601 ggcaccttcg ctggaactta aggccgtttg gcagaatctt ctccagcggc agatctttct
     3661 agttaacgcc gcccttggct ccacgccctt gtccagtccc ttggactcgc cggatgttct
     3721 caacaccctg gtgccgctga gtgatattgg tctgaccacc gcctccatgg ggtcgatgaa
     3781 gttaccatcg ctggacagca tccacctgaa gcagcagcag aaacagcagg tgcgtctctt
     3841 tcgcagcaag cgtttggaca gcggtgattc ctacgagaat cttcagcgtc tggccagtgc
     3901 ggttcgacac cactgtgcca gcaccaccac gagcagcgcc acccagacgc agtcccatcc
     3961 gcagccacct ctctgcacca cctcgctgcc ctcgcgcacc aactcgcccg cccggaacca
     4021 acgccatccg aatggccaag gacatgtggg tgggtcggtg ccgaacggag tgggtggtgt
     4081 gagtttcggt ggctgcaata caaacagctc ttgcttgagc agcagcgcta gcttgactca
     4141 aacccagacg caggtccaca cccagactct aaaccattca cagacccact cgcagaccca
     4201 aacctctgtg ctgtccctct ccagttgcaa gtgcttaacc gtcattccgg aggttactag
     4261 tgaaccgcca gtcaatcaac atgcctcgca gaaactcttg gagtttagct tgagctcagt
     4321 gggtcgatcg ttcatcgatg agtctggcgg tgtggttggt ggtcaggtct ccctgactac
     4381 gccagagaca cccacaccca acatttcacc caccacttcg cagccctgca actcggacgc
     4441 cttttccaat gacttcgtgg caacatccac gaccgggaaa ggaccgaata taccgctagc
     4501 tgaatttggt ggctcctggg atctattgga gctcgatctc cagctgcacg aggtcaattt
     4561 agatcccagc tacgacacgg atgtggagga gtgcatcttt ttgggcgacg aggaggacag
     4621 agagggcact gagggacacg gacacgacga ggacagtgac gaggacgata gcgtggtagt
     4681 ggacgatccc ttcggcatgc taccaaccag accaacgcca ccggactcgc tggacctgtg
     4741 atttgacttc tggctgcagt cagaccccgc taacagcccc ttgccgcaca atctttgaat
     4801 ctcgacgagc ttactcaact atgttaccac tgaactaccc agaaacctct gctctatatc
     4861 tctaaatatt tagctcaatc gccgttttgc tctgcttttg tgtcagcttt ggccaagttt
     4921 tccatcactc acaatcaaaa ctttgtagtg tagtggcagc ctgtctttgg aagattgggg
     4981 attgactttg ccaggatatc agaatcagga accgaacagt gagattaaaa cgagtgacac
     5041 ccgaataaga tactagaaac aacatttaag aacctatcac ctggatatga gccattttaa
     5101 aaatccgctg tgtttcacag atttcttttc caatttgcat cgtaagatag ctagctgact
     5161 tcacatgtat attcaactgt tatataatag ctctagtgat ttcttaaggc agaaacactt
     5221 aaagggccaa agattttaag atccaggtga aaagcatatg tgtttagctg actctaattt
     5281 cgagtgagaa gtgacaatta tccgtggaaa attgtacata gacatatatt attcatcgct
     5341 ctctaagtgt atgtatctct gttgtgcatt gtatatactc gtgtattgac atccgtacca
     5401 tatatcccat tgagtaaccc tccctttata tggtattcgt tccatccaag tcgattttga
     5461 atcgggtgta aatagcaata aacagttgaa cgagggcaga gattaacgtt cgatgatgat
     5521 tgtatgtgtt taacgctagt atttagctgt ttttagtaat gtatgtgagt atacatagta
     5581 tacccacctt agatatagcc atatatatat gtatattagc tagtcaaata tacaccaaac
     5641 agatgcacaa tctgctacgc gaaaccccaa cggggtttac gttttacaag agtttttagc
     5701 ttatggatat atacatatat ctacatagaa tatgcatata tatatatcac actctattcg
     5761 tactaaccat tcgattgaaa cttttttgcc aatccaacaa aaacaaaaaa caaagaaaca
     5821 agataaccta cttgaaatta tactaatgtt aataatgctt ccattttgta gccaaattga
     5881 aaacctattg attactgtta ttgctgttgt tatcctacat tagcctagtc ctagtttctc
     5941 ctaacttccc cgaaattctc gcctcggatc ggatcctcct cgtatgctaa gttgacccat
     6001 tagccaaatt tcttgtagaa tcgctcgatt aatcgactaa cttagttaag tttacctcga
     6061 ttggccagtt caaattttaa tcaaaatcga aatcaaaatc ttagttgtat atatactact
     6121 ttcctattaa catgattcag tatgcgtttt tatcatctgt aataaaatgt tgctcagtcg
     6181 aatgactttt ggctggatgg caaaatacac gtgctatata catatatgta tctgatctag
     6241 ccatcgatgt caattagcta tgacaagcaa tttgttgcct taaaaatata tcttcacgct
     6301 aaccacttac ataaatgtat tacccagcac tagtctgcct ttgcacagtg gtacaaaatt
     6361 ctaaaggaag ttaaattgat taaatgctaa acttctaaga tttggtccct cagtgcggat
     6421 tcagtttggt caaatttcca cccagccaga agtttaaaca gacagtttag catacaaaca
     6481 gacacacaca caccaataaa cacccactca ctctacgcac acagacaact attgcaaatt
     6541 gaaactgatt gtgaaatatc aagcatacgc cgctttgtct tttgcggttc ggttttgagt
     6601 gtgccttgag cagtaaacaa gaaacttcta tacacagtat atatatatac atacaaacta
     6661 tttagattca tattcatatt ctgtaaactt tatgtacgtc tagatatttt ccatttatgg
     6721 tttttcgaca ttttacataa aacgagagga tcgagaatcg actatcgata tatcgatcga
     6781 gtcgattgcg attgagatta agaatgcgaa gagaaacgat gaattcaaat aataataaaa
     6841 ccaaatgatt ctttgact