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Drosophila melanogaster polyhomeotic proximal (ph-p), transcript


LOCUS       NM_001169173            5724 bp    mRNA    linear   INV 26-DEC-2023
            variant B, mRNA.
ACCESSION   NM_001169173
VERSION     NM_001169173.1
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5724)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5724)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5724)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5724)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5724)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5724)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5724)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5724)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5724)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5724)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5724)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5724)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5724)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5724)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5724)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5724)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5724)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5724)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5724)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5724)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5724)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5724)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5724)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5724
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5724
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="polyhomeotic proximal"
                     /map="2D2-2D3"
                     /db_xref="FLYBASE:FBgn0004861"
                     /db_xref="GeneID:31181"
     CDS             1085..5125
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="CG18412 gene product from transcript CG18412-RB;
                     CG18412-PB; ph-p-PB; polyhomeotic; polyhomeotic proxima;
                     Polyhomeotic-proximal; polyhomeotic proximal; ph-proximal"
                     /codon_start=1
                     /product="polyhomeotic proximal, isoform B"
                     /protein_id="NP_001162644.1"
                     /db_xref="FLYBASE:FBpp0290730"
                     /db_xref="GeneID:31181"
                     /db_xref="FLYBASE:FBgn0004861"
                     /translation="MEVQQQLQLQQQLSEANGGGAASAGAGGAASPANSQQSQQQQHS
                     TAISTMSPMQLAAATGGVGGDWTQGRTVQLMQPSTSFLYPQMIVSGNLLHPGGLGQQP
                     IQVITAGKPFQGNGPQMLTTTTQNAKQMIGGQAGFAGGNYATCIPTNHNQSPQTVLFS
                     PMNVISPQQQQNLLQSMAAAAQQQQLTQQQQQFNQQQQQQLTQQQQQLTAALAKVGVD
                     AQGKLAQKVVQKVTTTSSAVQAATGPGSTGSTQTQQVQQVQQQQQQTTQTTQQCVQVS
                     QSTLPVGVGGQSVQTAQLLNAGQAQQMQIPWFLQNAAGLQPFGPNQIILRNQPDGTQG
                     MFIQQQPATQTLQTQQNQIIQCNVTQTPTKARTQLDALAPKQQQQQQQVGTTNQTQQQ
                     QLAVATAQLQQQQQQLTAAALQRPGAPVMPHNGTQVRPASSVSTQTAQNQSLLKAKMR
                     NKQQPVRPALATLKTEIGQVAGQNKVVGHLTTVQQQQQATNLQQVVNAAGNKMVVMST
                     TGTPITLQNGQTLHAATAAGVDKQQQQLQLFQKQQILQQQQMLQQQIAAIQMQQQQAA
                     VQAQQQQQQQVSQQQQVNAQQQQAVAQQQQAVAQAQQQQREQQQQVAQAQAQHQQALA
                     NATQQILQVAPNQFITSHQQQQQQQLHNQLIQQQLQQQAQAQVQAQVQAQAQQQQQQR
                     EQQQNIIQQIVVQQSGATSQQTSQQQQHHQSGQLQLSSVPFSVSSSTTPAGIATSSAL
                     QAALSASGAIFQTAKPGTCSSSSPTSSVVTITNQSSTPLVTSSTVASIQQAQTQSAQV
                     HQHQQLISATIAGGTQQQPQGPPSLTPTTNPILAMTSMMNATVGHLSTAPPVTVSVTS
                     TAVTSSPGQLVLLSTASSGGGGSIPATPTKETPSKGPTATLVPIGSPKTPVSGKDTCT
                     TPKSSTPATVSASVEASSSTGEALSNGDASDRSSTPSKGATTPTSKQSNAAVQPPSST
                     TPNSVSGKEEPKLATCGSLTSATSTSTTTTITNGIGVARTTASTAVSTASTTTTSSGT
                     FITSCTSTTTTTTSSISNGSKDLPKAMIKPNVLTHVIDGFIIQEANEPFPVTRQRYAD
                     KDVSDEPPKKKATMQEDIKLSGIASAPGSDMVACEQCGKMEHKAKLKRKRYCSPGCSR
                     QAKNGIGGVGSGETNGLGTGGIVGVDAMALVDRLDEAMAEEKMQTEATPKLSESFPIL
                     GASTEVPPMSLPVQAAISAPSPLAMPLGSPLSVALPTLAPLSVVTSGAAPKSSEVNGT
                     DRPPISSWSVDDVSNFIRELPGCQDYVDDFIQQEIDGQALLLLKEKHLVNAMGMKLGP
                     ALKIVAKVESIKEVPPPGEAKDPGAQ"
     misc_feature    3398..>4051
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="Family of unknown function (DUF5585); Region:
                     DUF5585; pfam17823"
                     /db_xref="CDD:465521"
     misc_feature    4877..5083
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="SAM domain of Ph (polyhomeotic) proteins of
                     Polycomb group; Region: SAM_Ph1,2,3; cd09577"
                     /db_xref="CDD:188976"
     misc_feature    order(4931..4936,5036..5041,5048..5053,5060..5062)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface EH [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
     misc_feature    order(4964..4978,4982..4987,4994..4999,5009..5011,
                     5024..5026)
                     /gene="ph-p"
                     /locus_tag="Dmel_CG18412"
                     /gene_synonym="CG18412; CG18414; Dmel\CG18412; dPh;
                     EG:87B1.5; ph; Ph; PH; ph-P; Ph-p; PH-p; ph-proximal; phm;
                     php; PhP; PHP; ph[p]; ph[P]"
                     /note="oligomer interface ML [polypeptide binding]; other
                     site"
                     /db_xref="CDD:188976"
ORIGIN      
        1 cttgcgctct gctctctctg cgttcgtgtt ggtgtggtgt cgtatgtgtc gcataccgca
       61 tcgcatgtgt attgaacgaa gaaaaaaccc gccgacgcga catactcact ggataccctg
      121 caaatttgtt aaattttttt caaaaagagc taacggtgct gttgattagc tagtgcagat
      181 gtgcagacat aaaaagtgat gccgcgccac agtggagccc ctagctggcg aatcgtcgct
      241 ggcgacgtag gcagtgcagt taaaacaagt acttagtgct gtgactgtgg cttaatttta
      301 tgtaagatcg cgtgcacagg tgcttagtcg ttacactgag aaaaagaaaa gtgcctgcag
      361 ccagcgggga gaagttgaag tggagtgact agcggacaca gaaagcgata cgaccacacc
      421 cgtgagcacc acagcatccc aggggatttc agcatcagcg attctagcag gaggcactct
      481 tcccttgaag gacaactcga acatccgcga gaagcccctc caccataact acaaccacaa
      541 taacaacaac agctcccagc actcacactc gcaccagcag cagcaacaac agcaggtggg
      601 tggcaagcag ctcgagcggc cactaaagtg cctggaaacg ctcgcccaga aggcgggaat
      661 caccttcgac gagaaatacg atgtggccag ccccccgcat cccggcattg cccagcagca
      721 ggcgacttca ggaacaggcc cagcaacggg atcaggctca gtcaccccca caagccatcg
      781 gcacggaact ccgcccacgg gccgcaggca aacccacacc ccaagcactc cgaacaggcc
      841 cagtgctccc agcacaccca acactaactg caactcaatt gcccgccaca ccagcctcac
      901 gctggagaag gcgcagaatc ccggccagca ggtggccgcc accaccacgg tgccactgca
      961 gatatcccct gagcagctgc agcagttcta tgcgagcaat ccctacgcca ttcaggtgaa
     1021 gcaagagttt cccacgcaca cgaccagtgg cagtggaact gaactaaagc atgcaaccaa
     1081 cattatggaa gttcagcagc agttgcagct gcagcagcag ctgtcggaag ccaacggtgg
     1141 aggagcagcc tcggccggag ccggaggagc agctagtccg gccaactcgc agcaaagcca
     1201 gcaacagcag cactccacag ccatcagcac catgtcgccg atgcaattgg cagcggccac
     1261 tggaggagtt ggcggggatt ggacacaggg aaggacggtg cagctaatgc aaccctccac
     1321 cagtttcctg tatccccaaa tgattgtgtc gggaaatctg ttgcatccag gaggcctcgg
     1381 tcagcagcca atccaggtga tcaccgccgg caagccattc caaggcaacg gcccccagat
     1441 gcttaccacc acgactcaaa acgccaagca aatgatcggt ggccaagcgg gattcgctgg
     1501 cggaaattac gcgacctgca ttcccacaaa ccacaatcaa tcgccccaga cggtgctctt
     1561 ctcaccgatg aacgtcattt cgccacagca gcaacagaac ctgctgcaat caatggccgc
     1621 tgcagctcag cagcagcaac tcacccaaca gcagcaacag tttaaccagc agcaacaaca
     1681 gcagcttact cagcagcaac agcagttgac agctgctctg gccaaggtgg gagtggatgc
     1741 gcagggcaag ctggcccaga aagtggttca gaaagtgact accaccagta gcgcggtcca
     1801 ggcggcgacg ggtcctggat ctactgggtc aacacagacc cagcaggtgc agcaggttca
     1861 gcaacagcag cagcagacca cccaaaccac tcagcagtgc gtgcaggttt cacagtcgac
     1921 tttgccagtc ggtgtgggtg gacagtctgt tcagactgcc caacttctga acgctggcca
     1981 agcgcaacaa atgcagattc cctggttctt acagaatgct gcaggactgc agccgtttgg
     2041 gccaaaccag atcatcctgc gaaaccagcc agacggaacc caaggcatgt tcattcaaca
     2101 gcaaccggcg acgcagactt tgcagaccca gcaaaaccag attattcaat gcaacgtgac
     2161 gcagacgccc actaaggcac gcactcaact ggatgcactt gctcccaagc agcaacagca
     2221 gcagcagcag gttggcacta ccaaccagac gcagcagcag caactagcgg tggctactgc
     2281 ccagttgcag caacagcagc agcaactcac tgcagcagct ctgcagcgac caggagcccc
     2341 tgtcatgccc cacaatggaa ctcaagtgcg tccggccagt tccgtatcca cacagactgc
     2401 ccagaaccag agcctgctga aggccaaaat gcgcaacaag cagcagccgg tgcgccccgc
     2461 tttagccaca ttgaaaaccg aaatcggtca agtcgcagga caaaataagg tagtaggcca
     2521 cctgaccacc gtgcagcagc agcaacaggc gacgaatctc cagcaggtgg ttaatgcggc
     2581 gggcaacaaa atggttgtga tgagcacaac gggcactccg atcaccctgc agaatggaca
     2641 gacccttcat gcagccactg cggcaggagt cgacaagcag caacagcagc tacaactgtt
     2701 tcagaaacag caaatcctgc aacaacaaca aatgttgcaa cagcagattg ctgccattca
     2761 aatgcagcag cagcaagcgg ctgttcaggc ccagcaacaa cagcagcaac aggtctctca
     2821 gcagcagcag gttaacgccc agcaacagca agcggtggcg caacaacaac aggcagtcgc
     2881 gcaggctcag caacagcaga gggagcaaca gcagcaagtt gcccaagccc aggcgcagca
     2941 tcaacaggct ctcgcgaatg ccactcagca aatccttcag gtggcgccaa atcaattcat
     3001 cacgtcccac cagcaacagc agcagcagca acttcacaac caactgatac agcagcagct
     3061 acagcaacag gcgcaggcac aagttcaagc ccaagtgcag gctcaagcgc aacagcaaca
     3121 acagcagcga gagcagcagc agaatattat ccagcagatt gtggtgcaac agtctggagc
     3181 gacttctcaa cagacttccc agcagcaaca gcaccaccaa tccgggcaac tacagctaag
     3241 tagcgtgccc ttctcagttt cttcgtcaac gacgccagcc ggaatagcta cctctagtgc
     3301 tctgcaggca gccctctccg cctctggcgc catctttcag acagctaagc cgggtacttg
     3361 cagttcctcc tcccccacaa gcagtgtggt cacaattacc aaccagagca gcactccttt
     3421 ggtcaccagc agtacggtgg ccagtataca gcaggctcag acgcaatctg ctcaggtcca
     3481 ccaacatcag cagctaatca gcgccacaat tgccggaggg actcaacaac agccacaggg
     3541 accgccatca cttacaccca ccacaaatcc aattttggcc atgacctcga tgatgaatgc
     3601 tacagtgggt cacctttcca ctgctccgcc tgtaactgtt tctgtgacaa gcaccgctgt
     3661 tacttcgtcg ccgggtcagc tggttctctt aagcacggct agtagcggtg gaggaggtag
     3721 cataccagcc acgcccacca aagagacacc ttcgaaaggg cccaccgcaa ccctggtgcc
     3781 cattggttcg cccaagactc ctgtatcagg aaaggacacc tgcactaccc ccaaatcatc
     3841 tactcctgcc actgtcagcg catccgtaga ggccagtagt tccacaggcg aagccctgtc
     3901 caatggagat gcctcagata ggtcttccac gccgtcaaag ggcgctacca ctcccaccag
     3961 caagcaaagc aatgcagcag tgcagccacc gagtagcacc actcccaaca gtgtcagtgg
     4021 gaaagaagag ccgaagctgg caacctgcgg cagtttaacg tccgcaacat caacttcaac
     4081 cacgacaacg atcaccaatg ggattggagt agccagaacg acagccagca cggctgtctc
     4141 aaccgctagc acaaccacta ccagttctgg cacctttatc acaagttgca ccagcacaac
     4201 cacaaccacc acgtcgagta tcagtaatgg atcgaaggat ctccccaagg cgatgattaa
     4261 gccgaacgtc ttaactcacg tcatcgatgg cttcatcatc caggaggcca acgagccatt
     4321 tcccgtcacc agacagcgat atgcagacaa agacgtcagc gatgagccgc caaagaaaaa
     4381 ggcaaccatg caggaggaca tcaagctaag tggaatagca tcagctccag gctcggatat
     4441 ggttgcttgc gagcagtgtg gaaagatgga gcacaaagca aagctgaaac ggaagcgcta
     4501 ctgttcgcca ggatgctcga ggcaggcaaa gaacggcatc ggtggagttg gatcaggaga
     4561 gacgaacggc ctggggacag gtggtatagt tggggtggac gccatggcat tggtggacag
     4621 gctggatgaa gccatggctg aggagaagat gcagacagag gccaccccaa agctttcaga
     4681 atcgtttcct attttgggag cctcaacaga agtacctcca atgtcactgc cagtccaagc
     4741 ggcgatttct gcgccctcgc ctcttgcaat gcctctagga tcgccattgt cagttgcact
     4801 tccaactctt gcaccactgt ctgtagtcac ttctggcgcg gcgcccaagt cttcggaagt
     4861 gaatggaaca gatcgtccgc caatcagcag ctggagtgtg gacgatgtca gcaacttcat
     4921 tcgagaactg cctggttgtc aggactacgt ggacgacttt atacagcagg agatcgacgg
     4981 ccaagcgctt ctgttgctca aggagaagca tttggtgaac gctatgggca tgaagctggg
     5041 tccagctctt aaaattgtgg ccaaggtgga gtccattaag gaggtcccgc cacctggcga
     5101 ggccaaggat ccaggagcgc agtagggcag ctagagcacg aaaagccgaa aaagatgatc
     5161 tcctaaccga gcagtggacc tggttcaacc aagtctgtcg tgccaggtga ttctgattca
     5221 atcgggcagg cgaaaaggac gcgaatccat ttgcaaaata ttattagcat caggccatca
     5281 ggtcttaaac ccattgactt tgtacatact cccaagatca cttataagca tattcattta
     5341 taaattaaac taacagtcaa cagtcaaaaa cgaatggaat tacttaaact aaggaaaagc
     5401 tatgaattaa ttgccagcca agtaaatgaa taaagtacat tttataaata agcataagtt
     5461 tatagtctaa gtagcatatt aataactccc aacgtcatgg atagtttgta caagtatttt
     5521 aatcttagga atcaaatgta gcactatgat tgttctaaca actaagaatt ttaagcctat
     5581 gaataataat tgatatctaa atgtgaattt gaacttttta ctaaataata tttgaatgcc
     5641 tagacctaag cttttttttc aagatttttt ttttgcaatt gctgaagaaa ttaaaatggc
     5701 actgaatagt gtttaataaa tgtg