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Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_001144697            5244 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant G, mRNA.
ACCESSION   NM_001144697
VERSION     NM_001144697.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5244)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5244)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5244)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5244)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5244)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5244)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5244)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5244)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5244)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5244)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5244)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5244)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5244)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5244)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5244)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5244)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5244)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5244)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5244)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5244)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5244)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5244)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5244)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_001144697.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5244
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5244
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             602..4306
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RG;
                     CG42328-PG; C3G-PG; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     G"
                     /protein_id="NP_001138169.1"
                     /db_xref="FLYBASE:FBpp0289073"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQTLETHVK
                     DISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQV
                     YQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQ
                     CAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTP
                     KERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRSQPSASAG
                     TVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDE
                     NSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSFVSMREFRTST
                     QTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCT
                     TTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVG
                     DELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIE
                     GPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHAC
                     NISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTP
                     PPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDG
                     QTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPA
                     NVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVA
                     DNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDL
                     TSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGA
                     GSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFA
                     KDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNY
                     NSYLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPY
                     IGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRF
                     FDNFKDFMGEEEMWQISEKIKPRGRRPVNY"
     misc_feature    3098..3508
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(3155..3157,3290..3292,3302..3307,3314..3316,
                     3323..3328,3425..3427,3434..3436)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    3593..4264
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(3692..3700,3722..3727,3731..3739,3743..3748,
                     3755..3760,3767..3769,3866..3868,3875..3880,3884..3892,
                     3896..3907,3911..3916,3968..3970,3983..3991,3998..4000,
                     4037..4045,4052..4060,4064..4072,4076..4087,4130..4132,
                     4142..4144,4244..4246,4253..4258)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 cgggaacgga cgaacgcccc ggtttacgac gcactccatc ggccaaaaac tatagaaccg
       61 aaaaaaaaga ggaaatatat atatatatac aagaataagt atcgaaactc aagtggccac
      121 atatatttag gtgcgccagc tgattgataa ttgggcggag aggccgacgg ttggagagca
      181 gcctcccggg tgaaaagagc cgcaaaccgc ggactgcact gcgagaaagg ggggtgtacc
      241 tgcaagtata aacaacggca gcatcagttc tccatccacg cccggcacct gttccagtgg
      301 catcggagtg ggcggtggcg gctgcagcag cagcagcaac aatagcatca acagcggcag
      361 ctactccacc gcctgcactc cgccaccacc cacgcatcag catcactcgc agcaccagca
      421 gctgcagggc acgccgggag gatctagtcg ggtaggggga gcaggagcag gcggaggtgg
      481 tggtgtacca ccggcaccac ccagtgccgg atcctcgggc cacaagaaca gtctcaaggg
      541 caccaagcta gcgcgccggg cgcgttcctt taaggacgac ctcatcgaga agatttccct
      601 gatgcgaacc accaacaata cactgggtcg ctcccactcg ccgcacagtc cgcgcaccaa
      661 gcacggcaca aaggcaccgc ccaccaccga ggaggtgcta cggtccaccc aaaccctgga
      721 gacgcacgtc aaggacattt cgaatgccct gaagcacttc cgggatgtta tactcaagaa
      781 gaagctggag gtgttgccgg gcaacggaac ggtcattctg gaaaccatag ccagcatgta
      841 ctccgtgatc caaacctata ccctgaatga aaacagtgcc atcatgagca gcgccacgct
      901 gcaggtttac cagagcctgg gcaagctcat caagctctgc gacgaggtga tgctctccga
      961 ggacagcggc gagtgcgcct ccctgagcaa cgagaatgtg cgggaagtca ttgatcttct
     1021 cgaggatgct gtgcggaatc tcgttacgct ggcgcagggc aagctgaagg agcaggatca
     1081 gtgcgccttt cgctacagtg gatctggctt gggcggcatt ggagcggcgg cggagatcat
     1141 gggtgcggtc accgcctcgc cgggagcgag tgttcccggt actggagtca tgcgcgtttc
     1201 ggccgccgaa tcagctgccc agcgtacttc gttgccggac atagcgctca cgcccaagga
     1261 gcgcgacata ctggagcagc acaatgtgaa cccgatgcgc ggctcccaca gcaccgaaag
     1321 tatcctgcgc gacacgagtc caccgccgaa gccaccgcta cccaataggg ccagtaatcc
     1381 gccgccgttg ccaccaaagc gacgcagcca gccgagcgca tcagctggta cagtgggcgt
     1441 aggctgctca tcgtcgacat ccacctccaa tcaggccagt ccactgccct acgcccagtc
     1501 ccataatatt agtctgaact cggacctgga ctgcagttcc aatatctcgc tgctgaatta
     1561 tggcgtggat cgcctatccg tgcgttcacg gtcaccggat gagaatagtc agtgctcctt
     1621 tgactcggcg ttgaatcact cacgcgagga ggaggaccag caacagcaac atcagcatct
     1681 gaggtcattt ccaaagttgg ctgcgatgat ggacgaagac atggacaaga tggtcagcta
     1741 cagtttcgtg tcgatgcgtg agtttcgcac ttccacacag acgacggact acagtgtcca
     1801 gtcctccacg aagtcgtcca gcagcaattc ggagattgcg ttcagcatca gtgagtcgac
     1861 ggcggtcggc agcagtagcg agtaccagca gattagccag ttggtgtcgc acagccagcg
     1921 tcatatatcc tcgagcagta gcagctgcac caccacgacc accagcagca gcacaaccac
     1981 cggctatggc agcagcgaag tggagcagct gcagcagcag cagcagcagc agacgacgac
     2041 gacgccggcc gatctggcgc ccgccttgcc gccaaagagc atccaacgga gcagcctaac
     2101 ccgccacgac tcgcccggag ttggcgatga gctggacgag gtgcagtcct cctccggctg
     2161 ggccagccat cggagcagcc agtcggaggt ggccgagctg cgtcagctgt cgccgctcca
     2221 tcacctcaat caccatccgc atactgcgtc cgccggtcaa ctgcagcagt ggcactccaa
     2281 gcaccacagc ctgatcgagg gaccccgcct ccagctggcg gggagtggca gctgcagtgc
     2341 gttcgatcag cgacacttgg atcaggagcc accgccgctg ccaataaaaa agaagcacat
     2401 tctggcgtac atggaaatct gttcggcgtc cacgcgatcc attgagcagc atcgtcacac
     2461 aatgcacgcc tgcaacataa gtcgcaacat ctcgcacagc cagaccatga acattatgcc
     2521 catgagcaag gaactgtcgc cggagctcga gatgccacct gccctgccgc caaagaacta
     2581 caagcagcgc aaggcgacaa gcatggtagc atcacccacg ctgcagcccg tcattgtgac
     2641 cacgccaccg ccgagtccga agccgacgct gggcgagaat gggtcgacgg gcaggccgga
     2701 cagccggatg gccaccgtat gcgaggagct gaacgatgca gtggccagcg aggatgcgat
     2761 gccggagccc cgttcgcccg tgctggacag caatgagaat gtgagcgccg tcgatgatgg
     2821 acagactttc tactgtcact cacatcagtt gcccgccgcc gaaatggaga tgagcgagga
     2881 tgcgagcagt gccgacaacc agccaataac cacgccccaa gtgctcgagg agcaggagga
     2941 gccaacggcg gagtcccgac cactggtcgc tgtgcacgag tcggttaagc cagcgaacgt
     3001 cgacgaggat gaggaggcgg agcgagcgga tatgctgatc aacatgctgg aagaggtcaa
     3061 catcacacgg tacctgatac tcaagaagag agaggaggac gggcccgagg tgaagggcgg
     3121 ctacatcgat gccctcatcg tgcacgccag ccgtgtccaa aaggtcgccg acaatgcatt
     3181 ctgcgaggcc ttcatcacca cctttcgcac cttcatccag ccgatcgacg tgatcgagaa
     3241 gctgacccat cgctacacat acttcttctg tcaagtgcag gacaacaagc agaaggccgc
     3301 taaggagacc tttgcgctgc tggtccgagt cgtcaacgat ctaacgtcga cggatctaac
     3361 cagccagctg ttgagcctgc tggtggagtt cgtctatcag ttggtttgct ctgggcaatt
     3421 gtacttggcc aagttgctgc gcaacaagtt cgtggagaag gtgacgctgt acaaggagcc
     3481 caaggtgtac ggctttgttg gggagttggg cggagccggt agtgtcggcg gagcaggaat
     3541 cgccggcagt ggtggatgca gtggtacagc tggtggtgga aaccagccta gtctgctcga
     3601 cctcaagtcg ctggagattg ccgaacagat gacgctgctg gatgcggagc tgttcacgaa
     3661 gatcgagata cccgaagtat tactatttgc caaagatcag tgcgaggaga agtcgcccaa
     3721 cctaaacaag ttcaccgagc acttcaacaa gatgtcctac tgggcgcgct ccaaaatcct
     3781 gcgcctgcag gatgccaagg agcgggagaa gcatgtgaac aagtttatca aaatcatgaa
     3841 gcatctacgc aagatgaaca actacaactc gtatctggcg ttgttgtcgg ccctcgattc
     3901 gggtcccata agaagattgg agtggcaaaa aggcatcacc gaggaggtgc gatcattctg
     3961 cgccctcatc gattccagct ccagttttcg cgcctatcga caggcgctgg ccgaaactaa
     4021 tccgccctgc ataccctaca tcggcctaat tctgcaggat ctaacgtttg tgcatgtggg
     4081 caaccaggac tacttgtcca agggcgtcat aaacttctcc aagcgctggc agcagtacaa
     4141 cataattgac aacatgaaac gttttaagaa atgtgcctat ccatttcgac gcaacgagcg
     4201 cattatacgc ttctttgata acttcaagga ctttatgggc gaggaggaga tgtggcagat
     4261 atcggagaag atcaagccgc gtggacgccg ccccgttaac tattagtctt caagcagcaa
     4321 cagcaaaaca ccaatattat atatgataaa gtatatacac cgtattaatt aaacagttca
     4381 aaacggttgc cacgtctagg aggaggatca gcatcgggag cagccaacaa ctattctaat
     4441 gggtctgagc aataatgttc gctattctct gtctatatat atacaattat acaagatatt
     4501 tagctgtaat taccagccga tgccgaatcg gaaatacata tacatactta cttaagatgt
     4561 agcgattcag atacggatac ggatacatgt agccgcgtac aaataacgag ccgatctgta
     4621 gtttaactat taagctctat gagtcattgg gtcgatggac ctaacctcag ctaactcccc
     4681 accaatattc gaatccgaat ccctgtctgc gagtcccaaa aactttttcc cggacttttg
     4741 ccagcactag aacaccaaac taactaacta acttacttac caccagagac aaccaatcaa
     4801 gaaatcagca attttcgctt ttgttttgag atctcttttt tacacaagaa cacaacgaat
     4861 tttgaaagca agctacgtga acgtagaggc caaccgacaa actatattcg acgatatatg
     4921 tagcgatatc tcggactata aatcgatgca atccacgagc agaacaccaa gcgaacccta
     4981 gcacaaagcg cgttatatgc aattctctct ccaaacaacc aatattaaat acccgtgtgt
     5041 gtgtatgtgt gttagaagtt attcaaattg aaattgaact caaaatcaaa atcagagatt
     5101 tcagagtgca cgaaacagaa aacagaaggc ggtatctatc gatcaaatca atcaatcaat
     5161 gaaatcaatc aaaaattcat tttgcgactc aattaattga agaaactttt aaagttacaa
     5221 aacaaaacaa aatacaaaaa atac