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Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_001144695            5651 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant E, mRNA.
ACCESSION   NM_001144695
VERSION     NM_001144695.3
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5651)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5651)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5651)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5651)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5651)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5651)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5651)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5651)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5651)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5651)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5651)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5651)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5651)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5651)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5651)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5651)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5651)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5651)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5651)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5651)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5651)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5651)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5651)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Jan 16, 2013 this sequence version replaced NM_001144695.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5651
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5651
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             460..4713
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RE;
                     CG42328-PE; C3G-PE; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     E"
                     /protein_id="NP_001138167.1"
                     /db_xref="FLYBASE:FBpp0289071"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MRVLNTELRLRFKNRKPRPFNRAASADDAMDLGSGVGVGTGIAN
                     GAGIGVGATIMPLDQRLNGATSMNGSISSPSTPGTCSSGIGVGGGGCSSSSNNSINSG
                     SYSTACTPPPPTHQHHSQHQQLQGTPGGSSRVGGAGAGGGGGVPPAPPSAGSSGHKNS
                     LKGTKLARRARSFKDDLIEKISLMRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRS
                     TQTLETHVKDISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSA
                     IMSSATLQVYQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLA
                     QGKLKEQDQCAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRT
                     SLPDIALTPKERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKR
                     RSQPSASAGTVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRL
                     SVRSRSPDENSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSFV
                     SMREFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRH
                     ISSSSSSCTTTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSL
                     TRHDSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQW
                     HSKHHSLIEGPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIE
                     QHRHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPT
                     LQPVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSN
                     ENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLV
                     AVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIV
                     HASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFA
                     LLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVY
                     GFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKI
                     EIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIM
                     KHLRKMNNYNSYLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALA
                     ETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPF
                     RRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRPVNY"
     misc_feature    3505..3915
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(3562..3564,3697..3699,3709..3714,3721..3723,
                     3730..3735,3832..3834,3841..3843)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    4000..4671
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     small GTPases. Small GTP-binding proteins of the Ras
                     superfamily function as molecular switches in fundamental
                     events such as signal transduction, cytoskeleton dynamics
                     and intracellular trafficking; Region: RasGEF; cd00155"
                     /db_xref="CDD:238087"
     misc_feature    order(4099..4107,4129..4134,4138..4146,4150..4155,
                     4162..4167,4174..4176,4273..4275,4282..4287,4291..4299,
                     4303..4314,4318..4323,4375..4377,4390..4398,4405..4407,
                     4444..4452,4459..4467,4471..4479,4483..4494,4537..4539,
                     4549..4551,4651..4653,4660..4665)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 agtcgcacgc gaaattttca caacaacggt gttgtttgcc atccgtctcc gtttaccgca
       61 cggcaacaca tcgcacaaat cgagccaagt tgaatataaa tgctcaagtt gagaataaat
      121 acgcgttgtt gaatagctcg tgatttgcag gcagtgtgtg tgatatcata tagaggggcg
      181 atccccgaaa tcattttcct atttaagttc tattttcgtt tgtgttcgat tttttttttt
      241 tgttttcggg taccagtgat cggggatcga agagcaatcg atgcggggca caaattgagt
      301 tggagtcgtt gatgcgtttg ctccaattcc cgcgccccaa acaaatcagc taaacaatag
      361 caaaaggccg tcgtttgttt ttttttgttt atatatacgt agtggttata tagtgtgtat
      421 atatatatat attcccatcg atttccgccc atcgacataa tgcgcgttct caacacggag
      481 ctgcgcctgc gcttcaaaaa tcgcaaaccg cgacccttta atcgcgctgc cagtgccgat
      541 gatgcgatgg atttgggatc gggagtggga gtgggcactg gcatcgcgaa tggagccggt
      601 atcggtgtgg gggccacgat aatgcccctc gatcagcgac tgaatggagc caccagtatg
      661 aacggcagca tcagttctcc atccacgccc ggcacctgtt ccagtggcat cggagtgggc
      721 ggtggcggct gcagcagcag cagcaacaat agcatcaaca gcggcagcta ctccaccgcc
      781 tgcactccgc caccacccac gcatcagcat cactcgcagc accagcagct gcagggcacg
      841 ccgggaggat ctagtcgggt agggggagca ggagcaggcg gaggtggtgg tgtaccaccg
      901 gcaccaccca gtgccggatc ctcgggccac aagaacagtc tcaagggcac caagctagcg
      961 cgccgggcgc gttcctttaa ggacgacctc atcgagaaga tttccctgat gcgaaccacc
     1021 aacaatacac tgggtcgctc ccactcgccg cacagtccgc gcaccaagca cggcacaaag
     1081 gcaccgccca ccaccgagga ggtgctacgg tccacccaaa ccctggagac gcacgtcaag
     1141 gacatttcga atgccctgaa gcacttccgg gatgttatac tcaagaagaa gctggaggtg
     1201 ttgccgggca acggaacggt cattctggaa accatagcca gcatgtactc cgtgatccaa
     1261 acctataccc tgaatgaaaa cagtgccatc atgagcagcg ccacgctgca ggtttaccag
     1321 agcctgggca agctcatcaa gctctgcgac gaggtgatgc tctccgagga cagcggcgag
     1381 tgcgcctccc tgagcaacga gaatgtgcgg gaagtcattg atcttctcga ggatgctgtg
     1441 cggaatctcg ttacgctggc gcagggcaag ctgaaggagc aggatcagtg cgcctttcgc
     1501 tacagtggat ctggcttggg cggcattgga gcggcggcgg agatcatggg tgcggtcacc
     1561 gcctcgccgg gagcgagtgt tcccggtact ggagtcatgc gcgtttcggc cgccgaatca
     1621 gctgcccagc gtacttcgtt gccggacata gcgctcacgc ccaaggagcg cgacatactg
     1681 gagcagcaca atgtgaaccc gatgcgcggc tcccacagca ccgaaagtat cctgcgcgac
     1741 acgagtccac cgccgaagcc accgctaccc aatagggcca gtaatccgcc gccgttgcca
     1801 ccaaagcgac gcagccagcc gagcgcatca gctggtacag tgggcgtagg ctgctcatcg
     1861 tcgacatcca cctccaatca ggccagtcca ctgccctacg cccagtccca taatattagt
     1921 ctgaactcgg acctggactg cagttccaat atctcgctgc tgaattatgg cgtggatcgc
     1981 ctatccgtgc gttcacggtc accggatgag aatagtcagt gctcctttga ctcggcgttg
     2041 aatcactcac gcgaggagga ggaccagcaa cagcaacatc agcatctgag gtcatttcca
     2101 aagttggctg cgatgatgga cgaagacatg gacaagatgg tcagctacag tttcgtgtcg
     2161 atgcgtgagt ttcgcacttc cacacagacg acggactaca gtgtccagtc ctccacgaag
     2221 tcgtccagca gcaattcgga gattgcgttc agcatcagtg agtcgacggc ggtcggcagc
     2281 agtagcgagt accagcagat tagccagttg gtgtcgcaca gccagcgtca tatatcctcg
     2341 agcagtagca gctgcaccac cacgaccacc agcagcagca caaccaccgg ctatggcagc
     2401 agcgaagtgg agcagctgca gcagcagcag cagcagcaga cgacgacgac gccggccgat
     2461 ctggcgcccg ccttgccgcc aaagagcatc caacggagca gcctaacccg ccacgactcg
     2521 cccggagttg gcgatgagct ggacgaggtg cagtcctcct ccggctgggc cagccatcgg
     2581 agcagccagt cggaggtggc cgagctgcgt cagctgtcgc cgctccatca cctcaatcac
     2641 catccgcata ctgcgtccgc cggtcaactg cagcagtggc actccaagca ccacagcctg
     2701 atcgagggac cccgcctcca gctggcgggg agtggcagct gcagtgcgtt cgatcagcga
     2761 cacttggatc aggagccacc gccgctgcca ataaaaaaga agcacattct ggcgtacatg
     2821 gaaatctgtt cggcgtccac gcgatccatt gagcagcatc gtcacacaat gcacgcctgc
     2881 aacataagtc gcaacatctc gcacagccag accatgaaca ttatgcccat gagcaaggaa
     2941 ctgtcgccgg agctcgagat gccacctgcc ctgccgccaa agaactacaa gcagcgcaag
     3001 gcgacaagca tggtagcatc acccacgctg cagcccgtca ttgtgaccac gccaccgccg
     3061 agtccgaagc cgacgctggg cgagaatggg tcgacgggca ggccggacag ccggatggcc
     3121 accgtatgcg aggagctgaa cgatgcagtg gccagcgagg atgcgatgcc ggagccccgt
     3181 tcgcccgtgc tggacagcaa tgagaatgtg agcgccgtcg atgatggaca gactttctac
     3241 tgtcactcac atcagttgcc cgccgccgaa atggagatga gcgaggatgc gagcagtgcc
     3301 gacaaccagc caataaccac gccccaagtg ctcgaggagc aggaggagcc aacggcggag
     3361 tcccgaccac tggtcgctgt gcacgagtcg gttaagccag cgaacgtcga cgaggatgag
     3421 gaggcggagc gagcggatat gctgatcaac atgctggaag aggtcaacat cacacggtac
     3481 ctgatactca agaagagaga ggaggacggg cccgaggtga agggcggcta catcgatgcc
     3541 ctcatcgtgc acgccagccg tgtccaaaag gtcgccgaca atgcattctg cgaggccttc
     3601 atcaccacct ttcgcacctt catccagccg atcgacgtga tcgagaagct gacccatcgc
     3661 tacacatact tcttctgtca agtgcaggac aacaagcaga aggccgctaa ggagaccttt
     3721 gcgctgctgg tccgagtcgt caacgatcta acgtcgacgg atctaaccag ccagctgttg
     3781 agcctgctgg tggagttcgt ctatcagttg gtttgctctg ggcaattgta cttggccaag
     3841 ttgctgcgca acaagttcgt ggagaaggtg acgctgtaca aggagcccaa ggtgtacggc
     3901 tttgttgggg agttgggcgg agccggtagt gtcggcggag caggaatcgc cggcagtggt
     3961 ggatgcagtg gtacagctgg tggtggaaac cagcctagtc tgctcgacct caagtcgctg
     4021 gagattgccg aacagatgac gctgctggat gcggagctgt tcacgaagat cgagataccc
     4081 gaagtattac tatttgccaa agatcagtgc gaggagaagt cgcccaacct aaacaagttc
     4141 accgagcact tcaacaagat gtcctactgg gcgcgctcca aaatcctgcg cctgcaggat
     4201 gccaaggagc gggagaagca tgtgaacaag tttatcaaaa tcatgaagca tctacgcaag
     4261 atgaacaact acaactcgta tctggcgttg ttgtcggccc tcgattcggg tcccataaga
     4321 agattggagt ggcaaaaagg catcaccgag gaggtgcgat cattctgcgc cctcatcgat
     4381 tccagctcca gttttcgcgc ctatcgacag gcgctggccg aaactaatcc gccctgcata
     4441 ccctacatcg gcctaattct gcaggatcta acgtttgtgc atgtgggcaa ccaggactac
     4501 ttgtccaagg gcgtcataaa cttctccaag cgctggcagc agtacaacat aattgacaac
     4561 atgaaacgtt ttaagaaatg tgcctatcca tttcgacgca acgagcgcat tatacgcttc
     4621 tttgataact tcaaggactt tatgggcgag gaggagatgt ggcagatatc ggagaagatc
     4681 aagccgcgtg gacgccgccc cgttaactat tagtcttcaa gcagcaacag caaaacacca
     4741 atattatata tgataaagta tatacaccgt attaattaaa cagttcaaaa cggttgccac
     4801 gtctaggagg aggatcagca tcgggagcag ccaacaacta ttctaatggg tctgagcaat
     4861 aatgttcgct attctctgtc tatatatata caattataca agatatttag ctgtaattac
     4921 cagccgatgc cgaatcggaa atacatatac atacttactt aagatgtagc gattcagata
     4981 cggatacgga tacatgtagc cgcgtacaaa taacgagccg atctgtagtt taactattaa
     5041 gctctatgag tcattgggtc gatggaccta acctcagcta actccccacc aatattcgaa
     5101 tccgaatccc tgtctgcgag tcccaaaaac tttttcccgg acttttgcca gcactagaac
     5161 accaaactaa ctaactaact tacttaccac cagagacaac caatcaagaa atcagcaatt
     5221 ttcgcttttg ttttgagatc tcttttttac acaagaacac aacgaatttt gaaagcaagc
     5281 tacgtgaacg tagaggccaa ccgacaaact atattcgacg atatatgtag cgatatctcg
     5341 gactataaat cgatgcaatc cacgagcaga acaccaagcg aaccctagca caaagcgcgt
     5401 tatatgcaat tctctctcca aacaaccaat attaaatacc cgtgtgtgtg tatgtgtgtt
     5461 agaagttatt caaattgaaa ttgaactcaa aatcaaaatc agagatttca gagtgcacga
     5521 aacagaaaac agaaggcggt atctatcgat caaatcaatc aatcaatgaa atcaatcaaa
     5581 aattcatttt gcgactcaat taattgaaga aacttttaaa gttacaaaac aaaacaaaat
     5641 acaaaaaata c