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Drosophila melanogaster C3G guanyl-nucleotide exchange factor


LOCUS       NM_001144694            5397 bp    mRNA    linear   INV 26-DEC-2023
            (C3G), transcript variant D, mRNA.
ACCESSION   NM_001144694
VERSION     NM_001144694.2
DBLINK      BioProject: PRJNA164
            BioSample: SAMN02803731
KEYWORDS    RefSeq.
SOURCE      Drosophila melanogaster (fruit fly)
  ORGANISM  Drosophila melanogaster
            Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
            Pterygota; Neoptera; Endopterygota; Diptera; Brachycera;
            Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora.
REFERENCE   1  (bases 1 to 5397)
  AUTHORS   Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St
            Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K.,
            Strelets,V., Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: Impact of
            High-Throughput Data
  JOURNAL   G3 (Bethesda) 5 (8), 1721-1736 (2015)
   PUBMED   26109357
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5397)
  AUTHORS   Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St
            Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B.,
            Russo,S.M. and Gelbart,W.M.
  CONSRTM   FlyBase Consortium
  TITLE     Gene Model Annotations for Drosophila melanogaster: The
            Rule-Benders
  JOURNAL   G3 (Bethesda) 5 (8), 1737-1749 (2015)
   PUBMED   26109356
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5397)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I.,
            Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R.,
            Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G.,
            Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N.,
            Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A.,
            Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E.
  TITLE     The Release 6 reference sequence of the Drosophila melanogaster
            genome
  JOURNAL   Genome Res 25 (3), 445-458 (2015)
   PUBMED   25589440
REFERENCE   4  (bases 1 to 5397)
  AUTHORS   Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M.,
            Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F.,
            Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E.
  TITLE     Sequence finishing and mapping of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1625-1628 (2007)
   PUBMED   17569867
REFERENCE   5  (bases 1 to 5397)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  TITLE     The Release 5.1 annotation of Drosophila melanogaster
            heterochromatin
  JOURNAL   Science 316 (5831), 1586-1591 (2007)
   PUBMED   17569856
  REMARK    Erratum:[Science. 2007 Sep 7;317(5843):1325]
REFERENCE   6  (bases 1 to 5397)
  AUTHORS   Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D.,
            Ashburner,M. and Anxolabehere,D.
  TITLE     Combined evidence annotation of transposable elements in genome
            sequences
  JOURNAL   PLoS Comput Biol 1 (2), 166-175 (2005)
   PUBMED   16110336
REFERENCE   7  (bases 1 to 5397)
  AUTHORS   Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A.,
            Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A.,
            Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W.,
            Celniker,S.E., Rubin,G.M. and Karpen,G.H.
  TITLE     Heterochromatic sequences in a Drosophila whole-genome shotgun
            assembly
  JOURNAL   Genome Biol 3 (12), RESEARCH0085 (2002)
   PUBMED   12537574
REFERENCE   8  (bases 1 to 5397)
  AUTHORS   Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J.,
            Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E.,
            Rubin,G.M., Ashburner,M. and Celniker,S.E.
  TITLE     The transposable elements of the Drosophila melanogaster
            euchromatin: a genomics perspective
  JOURNAL   Genome Biol 3 (12), RESEARCH0084 (2002)
   PUBMED   12537573
REFERENCE   9  (bases 1 to 5397)
  AUTHORS   Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S.,
            Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E.,
            Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L.,
            Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D.,
            Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J.,
            Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M.,
            Rubin,G.M. and Lewis,S.E.
  TITLE     Annotation of the Drosophila melanogaster euchromatic genome: a
            systematic review
  JOURNAL   Genome Biol 3 (12), RESEARCH0083 (2002)
   PUBMED   12537572
REFERENCE   10 (bases 1 to 5397)
  AUTHORS   Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W.,
            Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E.,
            Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M.,
            Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S.,
            Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M.,
            Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W.,
            Gibbs,R.A. and Rubin,G.M.
  TITLE     Finishing a whole-genome shotgun: release 3 of the Drosophila
            melanogaster euchromatic genome sequence
  JOURNAL   Genome Biol 3 (12), RESEARCH0079 (2002)
   PUBMED   12537568
REFERENCE   11 (bases 1 to 5397)
  AUTHORS   Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D.,
            Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F.,
            George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N.,
            Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X.,
            Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D.,
            Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L.,
            Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D.,
            Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M.,
            Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S.,
            Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P.,
            Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A.,
            Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B.,
            Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I.,
            Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S.,
            Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C.,
            Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S.,
            Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z.,
            Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J.,
            Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J.,
            Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z.,
            Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C.,
            Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A.,
            Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C.,
            McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C.,
            Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L.,
            Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K.,
            Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S.,
            Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K.,
            Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I.,
            Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C.,
            Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R.,
            Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A.,
            Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT,
            Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F.,
            Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H.,
            Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O.,
            Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C.
  TITLE     The genome sequence of Drosophila melanogaster
  JOURNAL   Science 287 (5461), 2185-2195 (2000)
   PUBMED   10731132
REFERENCE   12 (bases 1 to 5397)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R.,
            Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R.,
            Smith,E., Yu,C. and Rubin,G.
  CONSRTM   Berkeley Drosophila Genome Project
  TITLE     Drosophila melanogaster release 4 sequence
  JOURNAL   Unpublished
REFERENCE   13 (bases 1 to 5397)
  CONSRTM   NCBI Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (20-DEC-2023) National Center for Biotechnology
            Information, NIH, Bethesda, MD 20894, USA
REFERENCE   14 (bases 1 to 5397)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (13-DEC-2023) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   15 (bases 1 to 5397)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (19-OCT-2022) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   16 (bases 1 to 5397)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (20-APR-2020) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   17 (bases 1 to 5397)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (22-APR-2019) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   18 (bases 1 to 5397)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (24-MAY-2018) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   19 (bases 1 to 5397)
  CONSRTM   FlyBase
  TITLE     Direct Submission
  JOURNAL   Submitted (07-DEC-2016) FlyBase, Harvard University, Biological
            Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA
REFERENCE   20 (bases 1 to 5397)
  AUTHORS   Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R.,
            Park,S., Svirskas,R. and Karpen,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne
            Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   21 (bases 1 to 5397)
  AUTHORS   Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S.,
            Svirskas,R. and Rubin,G.
  TITLE     Direct Submission
  JOURNAL   Submitted (10-AUG-2006) Berkeley Drosophila Genome Project,
            Lawrence Berkeley National Laboratory, One Cyclotron Road, MS
            64-121, Berkeley, CA 94720, USA
  REMARK    Direct Submission
REFERENCE   22 (bases 1 to 5397)
  AUTHORS   Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H.
  CONSRTM   Drosophila Heterochromatin Genome Project
  TITLE     Direct Submission
  JOURNAL   Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project,
            Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron
            Road, Mailstop 64-121, Berkeley, CA 94720, USA
REFERENCE   23 (bases 1 to 5397)
  AUTHORS   Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J.
  TITLE     Direct Submission
  JOURNAL   Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive,
            Rockville, MD 20850, USA
COMMENT     REVIEWED REFSEQ: This record has been curated by FlyBase. This
            record is derived from an annotated genomic sequence (NC_004354).
            
            On Dec 17, 2009 this sequence version replaced NM_001144694.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider :: FlyBase
            Annotation Status   :: Full annotation
            Annotation Version  :: Release 6.54
            URL                 :: http://flybase.org
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5397
                     /organism="Drosophila melanogaster"
                     /mol_type="mRNA"
                     /db_xref="taxon:7227"
                     /chromosome="X"
                     /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2]
                     bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]"
     gene            1..5397
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="C3G guanyl-nucleotide exchange factor"
                     /map="6D1-6D2"
                     /db_xref="FLYBASE:FBgn0259228"
                     /db_xref="GeneID:31618"
     CDS             602..4459
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="CG42328 gene product from transcript CG42328-RD;
                     CG42328-PD; C3G-PD; C3G ortholog"
                     /codon_start=1
                     /product="C3G guanyl-nucleotide exchange factor, isoform
                     D"
                     /protein_id="NP_001138166.1"
                     /db_xref="FLYBASE:FBpp0289070"
                     /db_xref="GeneID:31618"
                     /db_xref="FLYBASE:FBgn0259228"
                     /translation="MRTTNNTLGRSHSPHSPRTKHGTKAPPTTEEVLRSTQTLETHVK
                     DISNALKHFRDVILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQV
                     YQSLGKLIKLCDEVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQ
                     CAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTP
                     KERDILEQHNVNPMRGSHSTESILRDTSPPPKPPLPNRASNPPPLPPKRRSQPSASAG
                     TVGVGCSSSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDE
                     NSQCSFDSALNHSREEEDQQQQHQHLRSFPKLAAMMDEDMDKMVSYSAAIDDKTQTPL
                     STGGGIAGVAGGTGGAGEGVAAAASGDGETNSNRHSNESGFVSMREFRTSTQTTDYSV
                     QSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCTTTTTSSS
                     TTTGYGSSEVEQLQQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQ
                     SSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIEGPRLQLA
                     GSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISRNIS
                     HSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPT
                     LGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHS
                     HQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEE
                     AERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEA
                     FITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTS
                     QLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAG
                     IAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEK
                     SPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALL
                     SALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQD
                     LTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDF
                     MGEEEMWQISEKIKPRGRRPVNY"
     misc_feature    3251..3661
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Guanine nucleotide exchange factor for Ras-like
                     GTPases; N-terminal motif; Region: RasGEFN; smart00229"
                     /db_xref="CDD:214571"
     misc_feature    order(3308..3310,3443..3445,3455..3460,3467..3469,
                     3476..3481,3578..3580,3587..3589)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="GTPase interaction site [polypeptide binding];
                     other site"
                     /db_xref="CDD:100121"
     misc_feature    3767..4282
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /old_locus_tag="Dmel_CG14436"
                     /old_locus_tag="Dmel_CG3126"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="RasGEF domain; Region: RasGEF; pfam00617"
                     /db_xref="CDD:459872"
     misc_feature    order(3845..3853,3875..3880,3884..3892,3896..3901,
                     3908..3913,3920..3922,4019..4021,4028..4033,4037..4045,
                     4049..4060,4064..4069,4121..4123,4136..4144,4151..4153,
                     4190..4198,4205..4213,4217..4225,4229..4240,4283..4285,
                     4295..4297,4397..4399,4406..4411)
                     /gene="C3G"
                     /locus_tag="Dmel_CG42328"
                     /gene_synonym="c(3)G; C(3)G; CG14436; CG3126; CG42328;
                     DC3-G; DC3G; Dmel\CG42328"
                     /note="Ras interaction site [polypeptide binding]; other
                     site"
                     /db_xref="CDD:238087"
ORIGIN      
        1 cgggaacgga cgaacgcccc ggtttacgac gcactccatc ggccaaaaac tatagaaccg
       61 aaaaaaaaga ggaaatatat atatatatac aagaataagt atcgaaactc aagtggccac
      121 atatatttag gtgcgccagc tgattgataa ttgggcggag aggccgacgg ttggagagca
      181 gcctcccggg tgaaaagagc cgcaaaccgc ggactgcact gcgagaaagg ggggtgtacc
      241 tgcaagtata aacaacggca gcatcagttc tccatccacg cccggcacct gttccagtgg
      301 catcggagtg ggcggtggcg gctgcagcag cagcagcaac aatagcatca acagcggcag
      361 ctactccacc gcctgcactc cgccaccacc cacgcatcag catcactcgc agcaccagca
      421 gctgcagggc acgccgggag gatctagtcg ggtaggggga gcaggagcag gcggaggtgg
      481 tggtgtacca ccggcaccac ccagtgccgg atcctcgggc cacaagaaca gtctcaaggg
      541 caccaagcta gcgcgccggg cgcgttcctt taaggacgac ctcatcgaga agatttccct
      601 gatgcgaacc accaacaata cactgggtcg ctcccactcg ccgcacagtc cgcgcaccaa
      661 gcacggcaca aaggcaccgc ccaccaccga ggaggtgcta cggtccaccc aaaccctgga
      721 gacgcacgtc aaggacattt cgaatgccct gaagcacttc cgggatgtta tactcaagaa
      781 gaagctggag gtgttgccgg gcaacggaac ggtcattctg gaaaccatag ccagcatgta
      841 ctccgtgatc caaacctata ccctgaatga aaacagtgcc atcatgagca gcgccacgct
      901 gcaggtttac cagagcctgg gcaagctcat caagctctgc gacgaggtga tgctctccga
      961 ggacagcggc gagtgcgcct ccctgagcaa cgagaatgtg cgggaagtca ttgatcttct
     1021 cgaggatgct gtgcggaatc tcgttacgct ggcgcagggc aagctgaagg agcaggatca
     1081 gtgcgccttt cgctacagtg gatctggctt gggcggcatt ggagcggcgg cggagatcat
     1141 gggtgcggtc accgcctcgc cgggagcgag tgttcccggt actggagtca tgcgcgtttc
     1201 ggccgccgaa tcagctgccc agcgtacttc gttgccggac atagcgctca cgcccaagga
     1261 gcgcgacata ctggagcagc acaatgtgaa cccgatgcgc ggctcccaca gcaccgaaag
     1321 tatcctgcgc gacacgagtc caccgccgaa gccaccgcta cccaataggg ccagtaatcc
     1381 gccgccgttg ccaccaaagc gacgcagcca gccgagcgca tcagctggta cagtgggcgt
     1441 aggctgctca tcgtcgacat ccacctccaa tcaggccagt ccactgccct acgcccagtc
     1501 ccataatatt agtctgaact cggacctgga ctgcagttcc aatatctcgc tgctgaatta
     1561 tggcgtggat cgcctatccg tgcgttcacg gtcaccggat gagaatagtc agtgctcctt
     1621 tgactcggcg ttgaatcact cacgcgagga ggaggaccag caacagcaac atcagcatct
     1681 gaggtcattt ccaaagttgg ctgcgatgat ggacgaagac atggacaaga tggtcagcta
     1741 cagcgccgca atcgacgaca aaacgcagac accactttcg actggtggtg gtatagctgg
     1801 tgttgctggt ggaactggag gagcaggcga aggtgtagct gctgcagcgt ctggtgacgg
     1861 ggaaactaac agcaatcgcc actcaaacga atcgggtttc gtgtcgatgc gtgagtttcg
     1921 cacttccaca cagacgacgg actacagtgt ccagtcctcc acgaagtcgt ccagcagcaa
     1981 ttcggagatt gcgttcagca tcagtgagtc gacggcggtc ggcagcagta gcgagtacca
     2041 gcagattagc cagttggtgt cgcacagcca gcgtcatata tcctcgagca gtagcagctg
     2101 caccaccacg accaccagca gcagcacaac caccggctat ggcagcagcg aagtggagca
     2161 gctgcagcag cagcagcagc agcagacgac gacgacgccg gccgatctgg cgcccgcctt
     2221 gccgccaaag agcatccaac ggagcagcct aacccgccac gactcgcccg gagttggcga
     2281 tgagctggac gaggtgcagt cctcctccgg ctgggccagc catcggagca gccagtcgga
     2341 ggtggccgag ctgcgtcagc tgtcgccgct ccatcacctc aatcaccatc cgcatactgc
     2401 gtccgccggt caactgcagc agtggcactc caagcaccac agcctgatcg agggaccccg
     2461 cctccagctg gcggggagtg gcagctgcag tgcgttcgat cagcgacact tggatcagga
     2521 gccaccgccg ctgccaataa aaaagaagca cattctggcg tacatggaaa tctgttcggc
     2581 gtccacgcga tccattgagc agcatcgtca cacaatgcac gcctgcaaca taagtcgcaa
     2641 catctcgcac agccagacca tgaacattat gcccatgagc aaggaactgt cgccggagct
     2701 cgagatgcca cctgccctgc cgccaaagaa ctacaagcag cgcaaggcga caagcatggt
     2761 agcatcaccc acgctgcagc ccgtcattgt gaccacgcca ccgccgagtc cgaagccgac
     2821 gctgggcgag aatgggtcga cgggcaggcc ggacagccgg atggccaccg tatgcgagga
     2881 gctgaacgat gcagtggcca gcgaggatgc gatgccggag ccccgttcgc ccgtgctgga
     2941 cagcaatgag aatgtgagcg ccgtcgatga tggacagact ttctactgtc actcacatca
     3001 gttgcccgcc gccgaaatgg agatgagcga ggatgcgagc agtgccgaca accagccaat
     3061 aaccacgccc caagtgctcg aggagcagga ggagccaacg gcggagtccc gaccactggt
     3121 cgctgtgcac gagtcggtta agccagcgaa cgtcgacgag gatgaggagg cggagcgagc
     3181 ggatatgctg atcaacatgc tggaagaggt caacatcaca cggtacctga tactcaagaa
     3241 gagagaggag gacgggcccg aggtgaaggg cggctacatc gatgccctca tcgtgcacgc
     3301 cagccgtgtc caaaaggtcg ccgacaatgc attctgcgag gccttcatca ccacctttcg
     3361 caccttcatc cagccgatcg acgtgatcga gaagctgacc catcgctaca catacttctt
     3421 ctgtcaagtg caggacaaca agcagaaggc cgctaaggag acctttgcgc tgctggtccg
     3481 agtcgtcaac gatctaacgt cgacggatct aaccagccag ctgttgagcc tgctggtgga
     3541 gttcgtctat cagttggttt gctctgggca attgtacttg gccaagttgc tgcgcaacaa
     3601 gttcgtggag aaggtgacgc tgtacaagga gcccaaggtg tacggctttg ttggggagtt
     3661 gggcggagcc ggtagtgtcg gcggagcagg aatcgccggc agtggtggat gcagtggtac
     3721 agctggtggt ggaaaccagc ctagtctgct cgacctcaag tcgctggaga ttgccgaaca
     3781 gatgacgctg ctggatgcgg agctgttcac gaagatcgag atacccgaag tattactatt
     3841 tgccaaagat cagtgcgagg agaagtcgcc caacctaaac aagttcaccg agcacttcaa
     3901 caagatgtcc tactgggcgc gctccaaaat cctgcgcctg caggatgcca aggagcggga
     3961 gaagcatgtg aacaagttta tcaaaatcat gaagcatcta cgcaagatga acaactacaa
     4021 ctcgtatctg gcgttgttgt cggccctcga ttcgggtccc ataagaagat tggagtggca
     4081 aaaaggcatc accgaggagg tgcgatcatt ctgcgccctc atcgattcca gctccagttt
     4141 tcgcgcctat cgacaggcgc tggccgaaac taatccgccc tgcataccct acatcggcct
     4201 aattctgcag gatctaacgt ttgtgcatgt gggcaaccag gactacttgt ccaagggcgt
     4261 cataaacttc tccaagcgct ggcagcagta caacataatt gacaacatga aacgttttaa
     4321 gaaatgtgcc tatccatttc gacgcaacga gcgcattata cgcttctttg ataacttcaa
     4381 ggactttatg ggcgaggagg agatgtggca gatatcggag aagatcaagc cgcgtggacg
     4441 ccgccccgtt aactattagt cttcaagcag caacagcaaa acaccaatat tatatatgat
     4501 aaagtatata caccgtatta attaaacagt tcaaaacggt tgccacgtct aggaggagga
     4561 tcagcatcgg gagcagccaa caactattct aatgggtctg agcaataatg ttcgctattc
     4621 tctgtctata tatatacaat tatacaagat atttagctgt aattaccagc cgatgccgaa
     4681 tcggaaatac atatacatac ttacttaaga tgtagcgatt cagatacgga tacggataca
     4741 tgtagccgcg tacaaataac gagccgatct gtagtttaac tattaagctc tatgagtcat
     4801 tgggtcgatg gacctaacct cagctaactc cccaccaata ttcgaatccg aatccctgtc
     4861 tgcgagtccc aaaaactttt tcccggactt ttgccagcac tagaacacca aactaactaa
     4921 ctaacttact taccaccaga gacaaccaat caagaaatca gcaattttcg cttttgtttt
     4981 gagatctctt ttttacacaa gaacacaacg aattttgaaa gcaagctacg tgaacgtaga
     5041 ggccaaccga caaactatat tcgacgatat atgtagcgat atctcggact ataaatcgat
     5101 gcaatccacg agcagaacac caagcgaacc ctagcacaaa gcgcgttata tgcaattctc
     5161 tctccaaaca accaatatta aatacccgtg tgtgtgtatg tgtgttagaa gttattcaaa
     5221 ttgaaattga actcaaaatc aaaatcagag atttcagagt gcacgaaaca gaaaacagaa
     5281 ggcggtatct atcgatcaaa tcaatcaatc aatgaaatca atcaaaaatt cattttgcga
     5341 ctcaattaat tgaagaaact tttaaagtta caaaacaaaa caaaatacaa aaaatac