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LOCUS NM_001144683 4673 bp mRNA linear INV 26-DEC-2023 variant I, mRNA. ACCESSION NM_001144683 VERSION NM_001144683.1 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 4673) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 4673) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 4673) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 4673) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 4673) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 4673) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 4673) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 4673) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 4673) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 4673) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 4673) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 4673) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 4673) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 4673) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 4673) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 4673) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 4673) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 4673) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 4673) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 4673) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 4673) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 4673) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 4673) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..4673 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..4673 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 380..4108 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RI; CG34412-PI; Tlk-PI; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /product="Tousled-like kinase, isoform I" /protein_id="NP_001138155.1" /db_xref="FLYBASE:FBpp0288858" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MSPGAHLQMSPQNTSSLSQHHPHQQQQLQPPQQQQQHFPNHHSA QQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQLHQQQQQQLHQQQQQH FHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPGAAAAAIQQQHPAFAP TLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTPAERKRKRKMPPCATS ADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLGDRLGGSAGSGVGAGG AGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGVGVGVPGGAGGNTAGL RGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQVQVQTSSAYALYPPAS PQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVPPHVVVGLGGHPLSLA SIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLGSLGVVGMVGVGVGVG VGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQEREAEHESGKVKLDEMTR LSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKKEARQKCMQNRLRLGQ FVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQLMKKRPAESGRKRNN NSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDRVSVSVDSGLGGNNAG AIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLLHNGGGGSGGNVGNSG GVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQEYYEYDEILKLRQNA LKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVLNDRYLLLMLLGKGGF SEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYNIHKALDHPRVVKLYD VFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQVVSALKYLNEIKPPVI HYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMDLTSQGAGTYWYLPPE CFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATILEENTILKATEVQFS NKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKHGRGSLNQQQQAQQQQ QQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS" misc_feature <1985..>2395 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 3119..3922 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(3128..3130,3167..3169,3173..3175,3281..3283, 3332..3343,3353..3355,3359..3361,3476..3478,3482..3484, 3488..3493,3497..3499,3539..3541,3548..3550,3617..3628) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(3353..3355,3359..3361,3476..3478,3482..3484, 3488..3490,3548..3550,3617..3628) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(3536..3574,3587..3628) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 tggtgtcggt gtcgttttgg ttttgtcggc ggttgctaaa cacaatttaa gttcactcgg 61 ttagcagaca ttacacactg cctgctctca tacatattta cgcacttgta tatacatgca 121 atgtgcctgt gtgtgcgcaa gaaaccagaa aaaacgaaaa gtacaacatt cgttgagtcg 181 cgttcggctt aatttttttt tgtgttaccg tgtgtgtgtt tgtgctttgg atttgccaat 241 tttagccgac tggctctcag tgtcgaactt aaacttaaag agcgagcaac gtgacgtgtc 301 gcccagtgtc gcttaaaatt cgcgcacaca acttcctact acaaaaaaac gaaagaaaga 361 aggagaaaaa acgttaaaga tgtcccccgg cgcccatttg cagatgtccc cgcagaacac 421 ttcgtcccta agtcaacacc atccacatca acagcaacag ttacaacccc cacagcagca 481 acaacagcat ttccctaacc atcacagcgc ccagcaacag tcgcagcagc agcagcaaca 541 ggagcaacag aatccccagc agcaggcgca acagcagcag cagatactcc cacatcaaca 601 tttgcagcac ctgcacaagc atccgcatca gctgcaactg catcagcagc agcaacaaca 661 actccaccag caacagcagc aacacttcca ccagcagtcg ctgcaagggc tgcatcaggg 721 tagcagcaat ccggattcga atatgagcac tggctcctcg catagcgaga aggatgtcaa 781 tgatatgctg agtggcggtg cagcaacgcc aggagctgca gcagcagcga ttcaacagca 841 acatcccgcc tttgcgccca cactgggaat gcagcaacca ccgccgcccc cacctcaaca 901 ctccaataat ggaggcgaga tgggctactt gtcggcaggc acgaccacga cgacgtcggt 961 gttaacggta ggcaagcctc ggacgccagc ggagcggaaa cggaagcgaa aaatgcctcc 1021 atgtgccact agtgcggatg aggcggggag tggcggtggc tctggcggag caggagcaac 1081 cgttgttaac aacagcagcc tgaagggcaa atcattggcc tttcgtgata tgcccaaggt 1141 aaacatgagc ctgaatctgg gcgatcgtct gggaggatct gcaggaagcg gagtaggagc 1201 cggtggcgcc ggaagcgggg gaggtggcgc tggttccggt tctggaagcg gtggcggcaa 1261 aagcgcccgc ctgatgctgc cagtcagcga caacaagaag atcaacgact atttcaataa 1321 gcagcaaacg ggcgtgggcg tcggtgtgcc aggtggtgcg ggaggcaata ccgctggcct 1381 tcgaggatca catacgggag gtggcagcaa gtcaccctca tccgcccagc agcagcaaac 1441 ggcggcacag cagcagggaa gcggtgttgc gacgggaggc agtgcaggcg gttccgctgg 1501 caaccaggtg caagtgcaaa cgagcagcgc ttacgccctt tacccaccag ctagtcccca 1561 aacccagacg tcacagcaac agcagcagca gcaaccggga tcagactttc actatgtcaa 1621 ctccagcaag gcgcagcaac aacagcagcg tcaacagcaa cagacttcca atcaaatggt 1681 tcctccacac gtggtcgttg gccttggtgg tcatccactg agcctcgcgt ccattcagca 1741 gcagacgccc ttatcccagc agcaacagca gcaacaacag cagcagcaac agcagcaact 1801 gggaccaccg accacatcga cggcctccgt cgtgccaacg catccgcatc aactcggatc 1861 cctgggagtt gttgggatgg tcggtgtggg tgttggcgtg ggcgttggag taaatgtggg 1921 tgtgggacca ccactgccac caccaccgcc gatggccatg ccagcggcca ttatcactta 1981 tagtaaggcc actcaaacgg aggtgtcgct gcatgaattg caggagcgcg aagcggagca 2041 cgaatcgggc aaggtgaagc tagacgagat gacacggctg tccgatgaac aaaagtccca 2101 aattgttggc aaccagaaga cgattgacca gcacaagtgc cacatagcca agtgtattga 2161 tgtggtcaag aagctgttga aggagaagag cagcatcgag aagaaggagg cgcgacagaa 2221 gtgcatgcag aatcgcctca ggctcggaca gtttgttacc caacgagtgg gcgccacatt 2281 ccaggagaac tggacggacg gctatgcgtt ccaggagctg agtcggcggc aagaagaaat 2341 aaccgctgag cgtgaagaga tagatcggca gaaaaagcag ctgatgaaaa agcgtccggc 2401 ggagtccgga cgcaagcgca acaacaacag taaccagaac aaccagcagc agcagcaaca 2461 gcaacaccag caacagcagc agcaacaaaa ttccaactcg aacgattcca cgcagctgac 2521 gagcggagtt gttaccggtc caggcagtga tcgtgtgagc gtaagcgtcg acagcggatt 2581 gggtggcaat aatgcgggcg cgatcggtgg cggaaccgtt ggtggtggcg ttggaggtgg 2641 tggtgttgga ggcggtggtg tcggaggcgg cggtggacgt ggactttctc gcagcaattc 2701 gacgcaggcc aatcaggctc aattgctgca caacggcggt ggtggttcgg gcggcaatgt 2761 cggcaactcg ggcggcgttg gcgaccgctt gtcagatcga ggaggaggag gtggcggcat 2821 cggcggaaac gatagcggca gctgctcgga ctcgggcact ttcctgaagc cagaccccgt 2881 atcgggtgcc tacacagcgc aggagtatta cgagtacgat gagatcctca agttgcgaca 2941 aaatgccctc aaaaaggagg acgccgacct gcagctggag atggagaagc tggagcggga 3001 gcgcaatctg cacatccgag agctcaagcg gattcttaac gaggatcagt cccgctttaa 3061 caatcatccc gtgctgaatg atcgctatct tctgttgatg ctcctgggca agggcggctt 3121 ctcagaggtc cacaaggcct tcgacctgaa ggagcaacgc tatgtcgcat gtaaggtgca 3181 ccaattaaac aaggattgga aggaggataa gaaagctaat tatatcaaac acgctttgcg 3241 ggaatacaac attcacaagg cactggatca tccgcgggtc gtcaagctat acgatgtctt 3301 cgagatcgat gcgaattcct tttgcacagt gctcgaatac tgtgatggcc acgatctgga 3361 cttctatttg aagcaacata agactatacc cgagcgtgaa gcgcgctcga taataatgca 3421 ggttgtatct gcactcaagt atctaaatga gattaagcct ccagttatcc actacgatct 3481 gaagcccggc aacattctgc ttaccgaggg caacgtctgc ggcgagatta agatcaccga 3541 cttcggtctg tcaaaggtga tggacgacga gaattacaat cccgatcacg gcatggatct 3601 gacctctcag ggggcgggaa cctactggta tctgccaccc gagtgctttg tcgtgggcaa 3661 aaatccgccg aaaatctcct ccaaagtgga cgtatggagt gtgggtgtta tcttctacca 3721 gtgtctgtac ggcaaaaagc ccttcggtca caatcagtcg caggccacga ttctcgagga 3781 gaatacgatc ctgaaggcca ccgaagtgca gttctccaac aagccaaccg tttctaacga 3841 ggccaagagt ttcattcggg gatgcttggc ctatcgcaag gaggatcgca tggatgtgtt 3901 cgcactggcc aggcacgagt acattcagcc accgataccg aaacatgggc gcggttcgct 3961 caatcagcaa cagcaggcgc aacaacagca gcagcaacaa cagcaacagc agcagcaaca 4021 gtcgtcgacg tcacaggcca attctacagg ccagacatct ttctctgccc acatgtttgg 4081 caatatgaat cagtcgagtt cgtcctagct gccaaccaag cgcaattcga actcataatt 4141 cgccgccgcc gcagtagcag cagctacatt agctgccagt agtcaacagc aacttcaaca 4201 ccagcaacag caactccaaa tccagcaata ccagcagaat cagcaacttc atttgcaaaa 4261 cagcagtagc aattatgcgg ccacgcttct agatgcagcg gccttttgct acgaaaccgt 4321 gatggatgca gcccacttcc aaaacaacaa taataacagc accatcatca agaacaatat 4381 gcagacaatg ccggcaaacg ctgccaatgc tgctgcagct gcagggggag ggggaacacc 4441 gacctatcag gggaaataca agcgctggca gcagcaacag ttacaacagc aggcgcaact 4501 ccaacagcag cagcacaagc tgctgttgca gcaagagctg ctctaaaata tgaagggaat 4561 gatgacaagc gagtttaaga gaacgaggag ctgcctgcca cactgccgcc gtcagcaata 4621 acaacatccc aagaaaattc acagcgagtc gcaaaagcat caacaaacaa agc