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LOCUS NM_001144681 7243 bp mRNA linear INV 26-DEC-2023 variant G, mRNA. ACCESSION NM_001144681 VERSION NM_001144681.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 7243) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 7243) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 7243) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 7243) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 7243) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 7243) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 7243) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 7243) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 7243) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 7243) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 7243) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 7243) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 7243) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 7243) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 7243) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 7243) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 7243) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 7243) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 7243) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 7243) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 7243) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 7243) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 7243) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On May 8, 2012 this sequence version replaced NM_001144681.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..7243 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..7243 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 1201..5670 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RG; CG34412-PG; Tlk-PG; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /product="Tousled-like kinase, isoform G" /protein_id="NP_001138153.1" /db_xref="FLYBASE:FBpp0288856" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MSCTPSPLCGSFALAMLQQQQQQLEIREAQQRQQQKSRLQLNNY YKDIPRNQHHMQNCQDFLQVQQTVEINKLHFVQKTQQQECYMQQIHHHQQQQQKQIVD YQRVNERAHMQPTQILQSQQKISELQQIQRSARKPELLQIPEILQKQQFQTAQQKQTK KQGANTATITSFNSNSNSNNSSSSCKNYNTTSNSNKNNIDNNSSNSSGQIMLASASAS ASARKRSRSTSNGSKSNNKTASGRIFTKSMSPGAHLQMSPQNTSSLSQHHPHQQQQLQ PPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHLHKHPHQLQL HQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDMLSGGAATPG AAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSVLTVGKPRTP AERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMPKVNMSLNLG DRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKINDYFNKQQTGV GVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGSAGGSAGNQV QVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQQQTSNQMVP PHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASVVPTHPHQLG SLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEVSLHELQERE AEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLLKEKSSIEKK EARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAEREEIDRQKKQ LMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSGVVTGPGSDR VSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNSTQANQAQLL HNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPDPVSGAYTAQ EYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQSRFNNHPVL NDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANYIKHALREYN IHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPEREARSIIMQV VSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDENYNPDHGMD LTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPFGHNQSQATI LEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHEYIQPPIPKH GRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQSSSS" misc_feature 4681..5484 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(4690..4692,4729..4731,4735..4737,4843..4845, 4894..4905,4915..4917,4921..4923,5038..5040,5044..5046, 5050..5055,5059..5061,5101..5103,5110..5112,5179..5190) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(4915..4917,4921..4923,5038..5040,5044..5046, 5050..5052,5110..5112,5179..5190) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(5098..5136,5149..5190) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 gaactttgac attgtaatgt tttcactgag gatttgatag ggtattcaac ttttcgtctt 61 ttgctttcaa tccgtcattc gtgagttttt attttgtgcg aattttctgt tctgtcgcct 121 tttattatta ttactacagt tttatatatt tttttgtgtg aagcgtactc tgccgacgtc 181 gctgccactg ccagcgctgt cgctttgacg atttgcgctt tgcgttgcgc ttactcacaa 241 tcaaatctca cgccgcattt ttagtctcaa taataactga aacgaaaaac acgcgcagcc 301 gaaacgaagc gcaaaccaaa gagtaaagcg aaagaagcaa ggaaggcaaa cggcgaacaa 361 aaacgcaaaa cgaaaacgac gacacgtcgt caaacatata ccctgaataa aatgctgtgg 421 ataaggggat taaaaaaata tgtaattgca ttgcagttag cgaatgtgca agctttctaa 481 cgccgaagtc agcgtgggca gcgcagtcag cggtcttgcc aacaagaaca agcgcgaaac 541 atcgcgaagc aacgagagca tggcagagcc gcagagcagc agcgagagga gcaccgctga 601 gagcagagag cagaacgaca tttcggctgc agacggcggt ggtgtcggtg tcgttttggt 661 tttgtcggcg gttgctaaac acaatttaag ttcactcggt tagcagacat tacacactgc 721 ctgctctcat acatatttac gcacttgtat atacatgcaa tgtgcctgtg tgtgcgcaag 781 aaaccagaaa aaacgaaaag tacaacattc gttgagtcgc gttcggctta attttttttt 841 gtgttaccgt gtgtgtgttt gtgctttgga tttgccaatt ttagccgact ggctctcagt 901 gtcgaactta aacttaaaga gcgagcaacg tgacgtgtcg cccagtgtcg cttaaaattc 961 gcgcacacaa cttcctacta caaaaaaacg aaagaaagaa ggagaaaaaa cgttaaaggc 1021 gagacttgtt tttttttctt gtgcatctct gtgtgtttgt gcatgtgtga agagaaacaa 1081 agagagggag atagacggag agtcgcaaag cgagagagct agagcagctg attcagccgg 1141 caagtgtcag ctgtttcgtg cctgagcgag atagagctag tttagcgagg cgaacatgtt 1201 atgtcttgta cgccgtctcc tctttgcggt tcattcgctc tagcaatgct ccagcaacaa 1261 cagcaacaac tggaaataag agaagcacag caaaggcaac aacagaaatc gcgtttacaa 1321 ctaaataatt attataaaga tataccccga aatcaacatc atatgcaaaa ctgtcaggat 1381 tttctacaag ttcagcaaac cgtagaaata aacaagttgc attttgtaca aaaaacacag 1441 caacaagaat gttatatgca acaaattcac catcatcaac aacagcaaca aaagcaaatc 1501 gttgattatc agcgtgtcaa tgaaagggcg cacatgcaac ccacacaaat attgcaaagt 1561 cagcagaaaa tatcagaatt gcaacaaata caacgttcag caagaaaacc agaactgttg 1621 caaataccag aaatactaca aaaacagcaa tttcaaacag ctcaacaaaa gcaaacgaaa 1681 aagcaaggtg caaatacagc aacgataaca tcgtttaaca gcaatagcaa tagcaacaat 1741 agtagcagca gttgcaagaa ctacaatacc actagtaaca gcaacaaaaa taatatcgac 1801 aataatagca gcaatagcag cggccaaata atgttagcct ctgccagcgc ctctgcctcc 1861 gctcggaaac gcagtcgcag cacgagtaac ggcagcaaaa gcaacaacaa aactgccagt 1921 ggccgcatat ttacaaaaag catgtccccc ggcgcccatt tgcagatgtc cccgcagaac 1981 acttcgtccc taagtcaaca ccatccacat caacagcaac agttacaacc cccacagcag 2041 caacaacagc atttccctaa ccatcacagc gcccagcaac agtcgcagca gcagcagcaa 2101 caggagcaac agaatcccca gcagcaggcg caacagcagc agcagatact cccacatcaa 2161 catttgcagc acctgcacaa gcatccgcat cagctgcaac tgcatcagca gcagcaacaa 2221 caactccacc agcaacagca gcaacacttc caccagcagt cgctgcaagg gctgcatcag 2281 ggtagcagca atccggattc gaatatgagc actggctcct cgcatagcga gaaggatgtc 2341 aatgatatgc tgagtggcgg tgcagcaacg ccaggagctg cagcagcagc gattcaacag 2401 caacatcccg cctttgcgcc cacactggga atgcagcaac caccgccgcc cccacctcaa 2461 cactccaata atggaggcga gatgggctac ttgtcggcag gcacgaccac gacgacgtcg 2521 gtgttaacgg taggcaagcc tcggacgcca gcggagcgga aacggaagcg aaaaatgcct 2581 ccatgtgcca ctagtgcgga tgaggcgggg agtggcggtg gctctggcgg agcaggagca 2641 accgttgtta acaacagcag cctgaagggc aaatcattgg cctttcgtga tatgcccaag 2701 gtaaacatga gcctgaatct gggcgatcgt ctgggaggat ctgcaggaag cggagtagga 2761 gccggtggcg ccggaagcgg gggaggtggc gctggttccg gttctggaag cggtggcggc 2821 aaaagcgccc gcctgatgct gccagtcagc gacaacaaga agatcaacga ctatttcaat 2881 aagcagcaaa cgggcgtggg cgtcggtgtg ccaggtggtg cgggaggcaa taccgctggc 2941 cttcgaggat cacatacggg aggtggcagc aagtcaccct catccgccca gcagcagcaa 3001 acggcggcac agcagcaggg aagcggtgtt gcgacgggag gcagtgcagg cggttccgct 3061 ggcaaccagg tgcaagtgca aacgagcagc gcttacgccc tttacccacc agctagtccc 3121 caaacccaga cgtcacagca acagcagcag cagcaaccgg gatcagactt tcactatgtc 3181 aactccagca aggcgcagca acaacagcag cgtcaacagc aacagacttc caatcaaatg 3241 gttcctccac acgtggtcgt tggccttggt ggtcatccac tgagcctcgc gtccattcag 3301 cagcagacgc ccttatccca gcagcaacag cagcaacaac agcagcagca acagcagcaa 3361 ctgggaccac cgaccacatc gacggcctcc gtcgtgccaa cgcatccgca tcaactcgga 3421 tccctgggag ttgttgggat ggtcggtgtg ggtgttggcg tgggcgttgg agtaaatgtg 3481 ggtgtgggac caccactgcc accaccaccg ccgatggcca tgccagcggc cattatcact 3541 tatagtaagg ccactcaaac ggaggtgtcg ctgcatgaat tgcaggagcg cgaagcggag 3601 cacgaatcgg gcaaggtgaa gctagacgag atgacacggc tgtccgatga acaaaagtcc 3661 caaattgttg gcaaccagaa gacgattgac cagcacaagt gccacatagc caagtgtatt 3721 gatgtggtca agaagctgtt gaaggagaag agcagcatcg agaagaagga ggcgcgacag 3781 aagtgcatgc agaatcgcct caggctcgga cagtttgtta cccaacgagt gggcgccaca 3841 ttccaggaga actggacgga cggctatgcg ttccaggagc tgagtcggcg gcaagaagaa 3901 ataaccgctg agcgtgaaga gatagatcgg cagaaaaagc agctgatgaa aaagcgtccg 3961 gcggagtccg gacgcaagcg caacaacaac agtaaccaga acaaccagca gcagcagcaa 4021 cagcaacacc agcaacagca gcagcaacaa aattccaact cgaacgattc cacgcagctg 4081 acgagcggag ttgttaccgg tccaggcagt gatcgtgtga gcgtaagcgt cgacagcgga 4141 ttgggtggca ataatgcggg cgcgatcggt ggcggaaccg ttggtggtgg cgttggaggt 4201 ggtggtgttg gaggcggtgg tgtcggaggc ggcggtggac gtggactttc tcgcagcaat 4261 tcgacgcagg ccaatcaggc tcaattgctg cacaacggcg gtggtggttc gggcggcaat 4321 gtcggcaact cgggcggcgt tggcgaccgc ttgtcagatc gaggaggagg aggtggcggc 4381 atcggcggaa acgatagcgg cagctgctcg gactcgggca ctttcctgaa gccagacccc 4441 gtatcgggtg cctacacagc gcaggagtat tacgagtacg atgagatcct caagttgcga 4501 caaaatgccc tcaaaaagga ggacgccgac ctgcagctgg agatggagaa gctggagcgg 4561 gagcgcaatc tgcacatccg agagctcaag cggattctta acgaggatca gtcccgcttt 4621 aacaatcatc ccgtgctgaa tgatcgctat cttctgttga tgctcctggg caagggcggc 4681 ttctcagagg tccacaaggc cttcgacctg aaggagcaac gctatgtcgc atgtaaggtg 4741 caccaattaa acaaggattg gaaggaggat aagaaagcta attatatcaa acacgctttg 4801 cgggaataca acattcacaa ggcactggat catccgcggg tcgtcaagct atacgatgtc 4861 ttcgagatcg atgcgaattc cttttgcaca gtgctcgaat actgtgatgg ccacgatctg 4921 gacttctatt tgaagcaaca taagactata cccgagcgtg aagcgcgctc gataataatg 4981 caggttgtat ctgcactcaa gtatctaaat gagattaagc ctccagttat ccactacgat 5041 ctgaagcccg gcaacattct gcttaccgag ggcaacgtct gcggcgagat taagatcacc 5101 gacttcggtc tgtcaaaggt gatggacgac gagaattaca atcccgatca cggcatggat 5161 ctgacctctc agggggcggg aacctactgg tatctgccac ccgagtgctt tgtcgtgggc 5221 aaaaatccgc cgaaaatctc ctccaaagtg gacgtatgga gtgtgggtgt tatcttctac 5281 cagtgtctgt acggcaaaaa gcccttcggt cacaatcagt cgcaggccac gattctcgag 5341 gagaatacga tcctgaaggc caccgaagtg cagttctcca acaagccaac cgtttctaac 5401 gaggccaaga gtttcattcg gggatgcttg gcctatcgca aggaggatcg catggatgtg 5461 ttcgcactgg ccaggcacga gtacattcag ccaccgatac cgaaacatgg gcgcggttcg 5521 ctcaatcagc aacagcaggc gcaacaacag cagcagcaac aacagcaaca gcagcagcaa 5581 cagtcgtcga cgtcacaggc caattctaca ggccagacat ctttctctgc ccacatgttt 5641 ggcaatatga atcagtcgag ttcgtcctag ctgccaacca agcgcaattc gaactcataa 5701 ttcgccgccg ccgcagtagc agcagctaca ttagctgcca gtagtcaaca gcaacttcaa 5761 caccagcaac agcaactcca aatccagcaa taccagcaga atcagcaact tcatttgcaa 5821 aacagcagta gcaattatgc ggccacgctt ctagatgcag cggccttttg ctacgaaacc 5881 gtgatggatg cagcccactt ccaaaacaac aataataaca gcaccatcat caagaacaat 5941 atgcagacaa tgccggcaaa cgctgccaat gctgctgcag ctgcaggggg agggggaaca 6001 ccgacctatc aggggaaata caagcgctgg cagcagcaac agttacaaca gcaggcgcaa 6061 ctccaacagc agcagcacaa gctgctgttg cagcaagagc tgctctaaaa tatgaaggga 6121 atgatgacaa gcgagtttaa gagaacgagg agctgcctgc cacactgccg ccgtcagcaa 6181 taacaacatc ccaagaaaat tcacagcgag tcgcaaaagc atcaacaaac aaagcaaaaa 6241 acgcaaaaaa ggattacaaa gacgcagaga ataggggaca tttgcaatgg gaaataacaa 6301 attattgcat tatctgctgg attgtgattg tggttcaaac attaaaaata cacttactca 6361 tacacacaag gtagacactg cagactaatt ttgccttaaa agaaacaaaa cgaataatgt 6421 taactgtaaa ttttcacttt gtgtccatgc atagttacta gtaatgatga tataaatata 6481 taaatatata taaaatataa aaattatata aatgtataaa tttatattta tatatatata 6541 tatatatata tatatatatc tgcataaaca ttgaagcata ctagtaaatc tttataaata 6601 tatttatata tatatttatc tcttcctttt aacgctttta atcggaaaaa acatcccaat 6661 tatattttaa ttcaatttga aatataaaag tcatttttgt ttgttttgta tcaaaatcca 6721 aaaaaaattg atttaaatat aaaaatacca taaacattaa caccacacac acacacacac 6781 acacatatat atatatatat atatatatat atatatatac atatatatat acatttgtat 6841 atagtcgtat ctgaaccaca aacaaatcca cagataaaaa aaactgaaaa attcatagaa 6901 tcaaaccatt tttttatatg ccacaaagaa aagaaaataa gtagaaatgc aagaaaaatc 6961 gagaaaaagc gtaattcatg agatcagatc ggatcagaaa aatcaacaga aaataaacct 7021 atttgaagta aaatacttct aaatacatag taaactaatg taatagtttt tattaaaatt 7081 acacatatat gtatcgatat atatacatgt tttttttttt ttaattttaa aattataatt 7141 gtaatgcact atgcgtaaat tgtattaaat attaatatcc aaggcatatt aatagaaata 7201 tatatacata tataaaacct gcaaaaaaaa aacatgaact acc