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LOCUS NM_001144680 6513 bp mRNA linear INV 26-DEC-2023 variant F, mRNA. ACCESSION NM_001144680 VERSION NM_001144680.3 DBLINK BioProject: PRJNA164 BioSample: SAMN02803731 KEYWORDS RefSeq. SOURCE Drosophila melanogaster (fruit fly) ORGANISM Drosophila melanogaster Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora. REFERENCE 1 (bases 1 to 6513) AUTHORS Matthews,B.B., Dos Santos,G., Crosby,M.A., Emmert,D.B., St Pierre,S.E., Gramates,L.S., Zhou,P., Schroeder,A.J., Falls,K., Strelets,V., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: Impact of High-Throughput Data JOURNAL G3 (Bethesda) 5 (8), 1721-1736 (2015) PUBMED 26109357 REMARK Publication Status: Online-Only REFERENCE 2 (bases 1 to 6513) AUTHORS Crosby,M.A., Gramates,L.S., Dos Santos,G., Matthews,B.B., St Pierre,S.E., Zhou,P., Schroeder,A.J., Falls,K., Emmert,D.B., Russo,S.M. and Gelbart,W.M. CONSRTM FlyBase Consortium TITLE Gene Model Annotations for Drosophila melanogaster: The Rule-Benders JOURNAL G3 (Bethesda) 5 (8), 1737-1749 (2015) PUBMED 26109356 REMARK Publication Status: Online-Only REFERENCE 3 (bases 1 to 6513) AUTHORS Hoskins,R.A., Carlson,J.W., Wan,K.H., Park,S., Mendez,I., Galle,S.E., Booth,B.W., Pfeiffer,B.D., George,R.A., Svirskas,R., Krzywinski,M., Schein,J., Accardo,M.C., Damia,E., Messina,G., Mendez-Lago,M., de Pablos,B., Demakova,O.V., Andreyeva,E.N., Boldyreva,L.V., Marra,M., Carvalho,A.B., Dimitri,P., Villasante,A., Zhimulev,I.F., Rubin,G.M., Karpen,G.H. and Celniker,S.E. TITLE The Release 6 reference sequence of the Drosophila melanogaster genome JOURNAL Genome Res 25 (3), 445-458 (2015) PUBMED 25589440 REFERENCE 4 (bases 1 to 6513) AUTHORS Hoskins,R.A., Carlson,J.W., Kennedy,C., Acevedo,D., Evans-Holm,M., Frise,E., Wan,K.H., Park,S., Mendez-Lago,M., Rossi,F., Villasante,A., Dimitri,P., Karpen,G.H. and Celniker,S.E. TITLE Sequence finishing and mapping of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1625-1628 (2007) PUBMED 17569867 REFERENCE 5 (bases 1 to 6513) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. TITLE The Release 5.1 annotation of Drosophila melanogaster heterochromatin JOURNAL Science 316 (5831), 1586-1591 (2007) PUBMED 17569856 REMARK Erratum:[Science. 2007 Sep 7;317(5843):1325] REFERENCE 6 (bases 1 to 6513) AUTHORS Quesneville,H., Bergman,C.M., Andrieu,O., Autard,D., Nouaud,D., Ashburner,M. and Anxolabehere,D. TITLE Combined evidence annotation of transposable elements in genome sequences JOURNAL PLoS Comput Biol 1 (2), 166-175 (2005) PUBMED 16110336 REFERENCE 7 (bases 1 to 6513) AUTHORS Hoskins,R.A., Smith,C.D., Carlson,J.W., Carvalho,A.B., Halpern,A., Kaminker,J.S., Kennedy,C., Mungall,C.J., Sullivan,B.A., Sutton,G.G., Yasuhara,J.C., Wakimoto,B.T., Myers,E.W., Celniker,S.E., Rubin,G.M. and Karpen,G.H. TITLE Heterochromatic sequences in a Drosophila whole-genome shotgun assembly JOURNAL Genome Biol 3 (12), RESEARCH0085 (2002) PUBMED 12537574 REFERENCE 8 (bases 1 to 6513) AUTHORS Kaminker,J.S., Bergman,C.M., Kronmiller,B., Carlson,J., Svirskas,R., Patel,S., Frise,E., Wheeler,D.A., Lewis,S.E., Rubin,G.M., Ashburner,M. and Celniker,S.E. TITLE The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective JOURNAL Genome Biol 3 (12), RESEARCH0084 (2002) PUBMED 12537573 REFERENCE 9 (bases 1 to 6513) AUTHORS Misra,S., Crosby,M.A., Mungall,C.J., Matthews,B.B., Campbell,K.S., Hradecky,P., Huang,Y., Kaminker,J.S., Millburn,G.H., Prochnik,S.E., Smith,C.D., Tupy,J.L., Whitfied,E.J., Bayraktaroglu,L., Berman,B.P., Bettencourt,B.R., Celniker,S.E., de Grey,A.D., Drysdale,R.A., Harris,N.L., Richter,J., Russo,S., Schroeder,A.J., Shu,S.Q., Stapleton,M., Yamada,C., Ashburner,M., Gelbart,W.M., Rubin,G.M. and Lewis,S.E. TITLE Annotation of the Drosophila melanogaster euchromatic genome: a systematic review JOURNAL Genome Biol 3 (12), RESEARCH0083 (2002) PUBMED 12537572 REFERENCE 10 (bases 1 to 6513) AUTHORS Celniker,S.E., Wheeler,D.A., Kronmiller,B., Carlson,J.W., Halpern,A., Patel,S., Adams,M., Champe,M., Dugan,S.P., Frise,E., Hodgson,A., George,R.A., Hoskins,R.A., Laverty,T., Muzny,D.M., Nelson,C.R., Pacleb,J.M., Park,S., Pfeiffer,B.D., Richards,S., Sodergren,E.J., Svirskas,R., Tabor,P.E., Wan,K., Stapleton,M., Sutton,G.G., Venter,C., Weinstock,G., Scherer,S.E., Myers,E.W., Gibbs,R.A. and Rubin,G.M. TITLE Finishing a whole-genome shotgun: release 3 of the Drosophila melanogaster euchromatic genome sequence JOURNAL Genome Biol 3 (12), RESEARCH0079 (2002) PUBMED 12537568 REFERENCE 11 (bases 1 to 6513) AUTHORS Adams,M.D., Celniker,S.E., Holt,R.A., Evans,C.A., Gocayne,J.D., Amanatides,P.G., Scherer,S.E., Li,P.W., Hoskins,R.A., Galle,R.F., George,R.A., Lewis,S.E., Richards,S., Ashburner,M., Henderson,S.N., Sutton,G.G., Wortman,J.R., Yandell,M.D., Zhang,Q., Chen,L.X., Brandon,R.C., Rogers,Y.H., Blazej,R.G., Champe,M., Pfeiffer,B.D., Wan,K.H., Doyle,C., Baxter,E.G., Helt,G., Nelson,C.R., Gabor,G.L., Abril,J.F., Agbayani,A., An,H.J., Andrews-Pfannkoch,C., Baldwin,D., Ballew,R.M., Basu,A., Baxendale,J., Bayraktaroglu,L., Beasley,E.M., Beeson,K.Y., Benos,P.V., Berman,B.P., Bhandari,D., Bolshakov,S., Borkova,D., Botchan,M.R., Bouck,J., Brokstein,P., Brottier,P., Burtis,K.C., Busam,D.A., Butler,H., Cadieu,E., Center,A., Chandra,I., Cherry,J.M., Cawley,S., Dahlke,C., Davenport,L.B., Davies,P., de Pablos,B., Delcher,A., Deng,Z., Mays,A.D., Dew,I., Dietz,S.M., Dodson,K., Doup,L.E., Downes,M., Dugan-Rocha,S., Dunkov,B.C., Dunn,P., Durbin,K.J., Evangelista,C.C., Ferraz,C., Ferriera,S., Fleischmann,W., Fosler,C., Gabrielian,A.E., Garg,N.S., Gelbart,W.M., Glasser,K., Glodek,A., Gong,F., Gorrell,J.H., Gu,Z., Guan,P., Harris,M., Harris,N.L., Harvey,D., Heiman,T.J., Hernandez,J.R., Houck,J., Hostin,D., Houston,K.A., Howland,T.J., Wei,M.H., Ibegwam,C., Jalali,M., Kalush,F., Karpen,G.H., Ke,Z., Kennison,J.A., Ketchum,K.A., Kimmel,B.E., Kodira,C.D., Kraft,C., Kravitz,S., Kulp,D., Lai,Z., Lasko,P., Lei,Y., Levitsky,A.A., Li,J., Li,Z., Liang,Y., Lin,X., Liu,X., Mattei,B., McIntosh,T.C., McLeod,M.P., McPherson,D., Merkulov,G., Milshina,N.V., Mobarry,C., Morris,J., Moshrefi,A., Mount,S.M., Moy,M., Murphy,B., Murphy,L., Muzny,D.M., Nelson,D.L., Nelson,D.R., Nelson,K.A., Nixon,K., Nusskern,D.R., Pacleb,J.M., Palazzolo,M., Pittman,G.S., Pan,S., Pollard,J., Puri,V., Reese,M.G., Reinert,K., Remington,K., Saunders,R.D., Scheeler,F., Shen,H., Shue,B.C., Siden-Kiamos,I., Simpson,M., Skupski,M.P., Smith,T., Spier,E., Spradling,A.C., Stapleton,M., Strong,R., Sun,E., Svirskas,R., Tector,C., Turner,R., Venter,E., Wang,A.H., Wang,X., Wang,Z.Y., Wassarman,D.A., Weinstock,G.M., Weissenbach,J., Williams,S.M., WoodageT, Worley,K.C., Wu,D., Yang,S., Yao,Q.A., Ye,J., Yeh,R.F., Zaveri,J.S., Zhan,M., Zhang,G., Zhao,Q., Zheng,L., Zheng,X.H., Zhong,F.N., Zhong,W., Zhou,X., Zhu,S., Zhu,X., Smith,H.O., Gibbs,R.A., Myers,E.W., Rubin,G.M. and Venter,J.C. TITLE The genome sequence of Drosophila melanogaster JOURNAL Science 287 (5461), 2185-2195 (2000) PUBMED 10731132 REFERENCE 12 (bases 1 to 6513) AUTHORS Celniker,S., Carlson,J., Wan,K., Pfeiffer,B., Frise,E., George,R., Hoskins,R., Stapleton,M., Pacleb,J., Park,S., Svirskas,R., Smith,E., Yu,C. and Rubin,G. CONSRTM Berkeley Drosophila Genome Project TITLE Drosophila melanogaster release 4 sequence JOURNAL Unpublished REFERENCE 13 (bases 1 to 6513) CONSRTM NCBI Genome Project TITLE Direct Submission JOURNAL Submitted (20-DEC-2023) National Center for Biotechnology Information, NIH, Bethesda, MD 20894, USA REFERENCE 14 (bases 1 to 6513) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (13-DEC-2023) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 15 (bases 1 to 6513) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (19-OCT-2022) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 16 (bases 1 to 6513) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (20-APR-2020) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 17 (bases 1 to 6513) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (22-APR-2019) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 18 (bases 1 to 6513) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (24-MAY-2018) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 19 (bases 1 to 6513) CONSRTM FlyBase TITLE Direct Submission JOURNAL Submitted (07-DEC-2016) FlyBase, Harvard University, Biological Laboratories, 16 Divinity Ave, Cambridge, MA 02138, USA REFERENCE 20 (bases 1 to 6513) AUTHORS Celniker,S., Carlson,J., Kennedy,C., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Karpen,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One #Cyclotron RoadOne Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 21 (bases 1 to 6513) AUTHORS Celniker,S., Carlson,J., Wan,K., Frise,E., Hoskins,R., Park,S., Svirskas,R. and Rubin,G. TITLE Direct Submission JOURNAL Submitted (10-AUG-2006) Berkeley Drosophila Genome Project, Lawrence Berkeley National Laboratory, One Cyclotron Road, MS 64-121, Berkeley, CA 94720, USA REMARK Direct Submission REFERENCE 22 (bases 1 to 6513) AUTHORS Smith,C.D., Shu,S., Mungall,C.J. and Karpen,G.H. CONSRTM Drosophila Heterochromatin Genome Project TITLE Direct Submission JOURNAL Submitted (01-AUG-2006) Drosophila Heterochromatin Genome Project, Ernest Orlando Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Mailstop 64-121, Berkeley, CA 94720, USA REFERENCE 23 (bases 1 to 6513) AUTHORS Adams,M.D., Celniker,S.E., Gibbs,R.A., Rubin,G.M. and Venter,C.J. TITLE Direct Submission JOURNAL Submitted (21-MAR-2000) Celera Genomics, 45 West Gude Drive, Rockville, MD 20850, USA COMMENT REVIEWED REFSEQ: This record has been curated by FlyBase. This record is derived from an annotated genomic sequence (NC_004354). On Jan 16, 2013 this sequence version replaced NM_001144680.2. ##Genome-Annotation-Data-START## Annotation Provider :: FlyBase Annotation Status :: Full annotation Annotation Version :: Release 6.54 URL :: http://flybase.org ##Genome-Annotation-Data-END## FEATURES Location/Qualifiers source 1..6513 /organism="Drosophila melanogaster" /mol_type="mRNA" /db_xref="taxon:7227" /chromosome="X" /genotype="y[1]; Gr22b[1] Gr22d[1] cn[1] CG33964[R4.2] bw[1] sp[1]; LysC[1] MstProx[1] GstD5[1] Rh6[1]" gene 1..6513 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Tousled-like kinase" /map="3E6-3F1" /db_xref="FLYBASE:FBgn0283657" /db_xref="GeneID:318206" CDS 299..4099 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /EC_number="2.7.11.1" /note="CG34412 gene product from transcript CG34412-RF; CG34412-PF; Tlk-PF; BEST:GH17330; tousled-like kinase; tousled like kinase" /codon_start=1 /product="Tousled-like kinase, isoform F" /protein_id="NP_001138152.1" /db_xref="FLYBASE:FBpp0288855" /db_xref="GeneID:318206" /db_xref="FLYBASE:FBgn0283657" /translation="MDQFQTSLNPRKLELLESRITGVRMSPGAHLQMSPQNTSSLSQH HPHQQQQLQPPQQQQQHFPNHHSAQQQSQQQQQQEQQNPQQQAQQQQQILPHQHLQHL HKHPHQLQLHQQQQQQLHQQQQQHFHQQSLQGLHQGSSNPDSNMSTGSSHSEKDVNDM LSGGAATPGAAAAAIQQQHPAFAPTLGMQQPPPPPPQHSNNGGEMGYLSAGTTTTTSV LTVGKPRTPAERKRKRKMPPCATSADEAGSGGGSGGAGATVVNNSSLKGKSLAFRDMP KVNMSLNLGDRLGGSAGSGVGAGGAGSGGGGAGSGSGSGGGKSARLMLPVSDNKKIND YFNKQQTGVGVGVPGGAGGNTAGLRGSHTGGGSKSPSSAQQQQTAAQQQGSGVATGGS AGGSAGNQVQVQTSSAYALYPPASPQTQTSQQQQQQQPGSDFHYVNSSKAQQQQQRQQ QQTSNQMVPPHVVVGLGGHPLSLASIQQQTPLSQQQQQQQQQQQQQQLGPPTTSTASV VPTHPHQLGSLGVVGMVGVGVGVGVGVNVGVGPPLPPPPPMAMPAAIITYSKATQTEV SLHELQEREAEHESGKVKLDEMTRLSDEQKSQIVGNQKTIDQHKCHIAKCIDVVKKLL KEKSSIEKKEARQKCMQNRLRLGQFVTQRVGATFQENWTDGYAFQELSRRQEEITAER EEIDRQKKQLMKKRPAESGRKRNNNSNQNNQQQQQQQHQQQQQQQNSNSNDSTQLTSG VVTGPGSDRVSVSVDSGLGGNNAGAIGGGTVGGGVGGGGVGGGGVGGGGGRGLSRSNS TQANQAQLLHNGGGGSGGNVGNSGGVGDRLSDRGGGGGGIGGNDSGSCSDSGTFLKPD PVSGAYTAQEYYEYDEILKLRQNALKKEDADLQLEMEKLERERNLHIRELKRILNEDQ SRFNNHPVLNDRYLLLMLLGKGGFSEVHKAFDLKEQRYVACKVHQLNKDWKEDKKANY IKHALREYNIHKALDHPRVVKLYDVFEIDANSFCTVLEYCDGHDLDFYLKQHKTIPER EARSIIMQVVSALKYLNEIKPPVIHYDLKPGNILLTEGNVCGEIKITDFGLSKVMDDE NYNPDHGMDLTSQGAGTYWYLPPECFVVGKNPPKISSKVDVWSVGVIFYQCLYGKKPF GHNQSQATILEENTILKATEVQFSNKPTVSNEAKSFIRGCLAYRKEDRMDVFALARHE YIQPPIPKHGRGSLNQQQQAQQQQQQQQQQQQQQSSTSQANSTGQTSFSAHMFGNMNQ SSSS" misc_feature <1976..>2386 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Family of unknown function (DUF5401); Region: DUF5401; pfam17380" /db_xref="CDD:375164" misc_feature 3110..3913 /gene="Tlk" /locus_tag="Dmel_CG34412" /old_locus_tag="CG32781" /old_locus_tag="CG32782" /old_locus_tag="Dmel_CG32781" /old_locus_tag="Dmel_CG32782" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; Region: STKc_TLK; cd13990" /db_xref="CDD:270892" misc_feature order(3119..3121,3158..3160,3164..3166,3272..3274, 3323..3334,3344..3346,3350..3352,3467..3469,3473..3475, 3479..3484,3488..3490,3530..3532,3539..3541,3608..3619) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="active site" /db_xref="CDD:270892" misc_feature order(3344..3346,3350..3352,3467..3469,3473..3475, 3479..3481,3539..3541,3608..3619) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="polypeptide substrate binding site [polypeptide binding]; other site" /db_xref="CDD:270892" misc_feature order(3527..3565,3578..3619) /gene="Tlk" /locus_tag="Dmel_CG34412" /gene_synonym="anon-WO03040301.114; anon-WO03040301.116; BcDNA:GH07910; BEST:GH17330; CG12462; CG2829; CG32781; CG32782; CG33219; CG34412; Dmel\CG34412; dtlk; EP(X)1408; EP(X)1413; EP1408; EP1413; GH17330; l(1)G0054; tlk; TLK" /note="activation loop (A-loop); other site" /db_xref="CDD:270892" ORIGIN 1 atatttttag gccatttctg cgtgtgtgcg ttcgtgtgaa tattgtgaat atttttttta 61 ctgtgaaaat agacaaaaat cggctgtgga aaaccgaaat gaatttgtca ctttattatt 121 gccatggctc tgacaaatct tgtcgcactc gttgccgaca tttgcaatcg atcaatatta 181 aaatattgaa taactaaacc aaccacgagc taaaagaaaa atttcagaaa aacttttgta 241 tctgaatcga aaacaaaaaa aaaaacaaat tcctatcggc gcttataatc acaaagtaat 301 ggatcaattt caaacttcac taaatccgcg gaaactcgag cttctggagt ctcgaattac 361 tggagtgcgg atgtcccccg gcgcccattt gcagatgtcc ccgcagaaca cttcgtccct 421 aagtcaacac catccacatc aacagcaaca gttacaaccc ccacagcagc aacaacagca 481 tttccctaac catcacagcg cccagcaaca gtcgcagcag cagcagcaac aggagcaaca 541 gaatccccag cagcaggcgc aacagcagca gcagatactc ccacatcaac atttgcagca 601 cctgcacaag catccgcatc agctgcaact gcatcagcag cagcaacaac aactccacca 661 gcaacagcag caacacttcc accagcagtc gctgcaaggg ctgcatcagg gtagcagcaa 721 tccggattcg aatatgagca ctggctcctc gcatagcgag aaggatgtca atgatatgct 781 gagtggcggt gcagcaacgc caggagctgc agcagcagcg attcaacagc aacatcccgc 841 ctttgcgccc acactgggaa tgcagcaacc accgccgccc ccacctcaac actccaataa 901 tggaggcgag atgggctact tgtcggcagg cacgaccacg acgacgtcgg tgttaacggt 961 aggcaagcct cggacgccag cggagcggaa acggaagcga aaaatgcctc catgtgccac 1021 tagtgcggat gaggcgggga gtggcggtgg ctctggcgga gcaggagcaa ccgttgttaa 1081 caacagcagc ctgaagggca aatcattggc ctttcgtgat atgcccaagg taaacatgag 1141 cctgaatctg ggcgatcgtc tgggaggatc tgcaggaagc ggagtaggag ccggtggcgc 1201 cggaagcggg ggaggtggcg ctggttccgg ttctggaagc ggtggcggca aaagcgcccg 1261 cctgatgctg ccagtcagcg acaacaagaa gatcaacgac tatttcaata agcagcaaac 1321 gggcgtgggc gtcggtgtgc caggtggtgc gggaggcaat accgctggcc ttcgaggatc 1381 acatacggga ggtggcagca agtcaccctc atccgcccag cagcagcaaa cggcggcaca 1441 gcagcaggga agcggtgttg cgacgggagg cagtgcaggc ggttccgctg gcaaccaggt 1501 gcaagtgcaa acgagcagcg cttacgccct ttacccacca gctagtcccc aaacccagac 1561 gtcacagcaa cagcagcagc agcaaccggg atcagacttt cactatgtca actccagcaa 1621 ggcgcagcaa caacagcagc gtcaacagca acagacttcc aatcaaatgg ttcctccaca 1681 cgtggtcgtt ggccttggtg gtcatccact gagcctcgcg tccattcagc agcagacgcc 1741 cttatcccag cagcaacagc agcaacaaca gcagcagcaa cagcagcaac tgggaccacc 1801 gaccacatcg acggcctccg tcgtgccaac gcatccgcat caactcggat ccctgggagt 1861 tgttgggatg gtcggtgtgg gtgttggcgt gggcgttgga gtaaatgtgg gtgtgggacc 1921 accactgcca ccaccaccgc cgatggccat gccagcggcc attatcactt atagtaaggc 1981 cactcaaacg gaggtgtcgc tgcatgaatt gcaggagcgc gaagcggagc acgaatcggg 2041 caaggtgaag ctagacgaga tgacacggct gtccgatgaa caaaagtccc aaattgttgg 2101 caaccagaag acgattgacc agcacaagtg ccacatagcc aagtgtattg atgtggtcaa 2161 gaagctgttg aaggagaaga gcagcatcga gaagaaggag gcgcgacaga agtgcatgca 2221 gaatcgcctc aggctcggac agtttgttac ccaacgagtg ggcgccacat tccaggagaa 2281 ctggacggac ggctatgcgt tccaggagct gagtcggcgg caagaagaaa taaccgctga 2341 gcgtgaagag atagatcggc agaaaaagca gctgatgaaa aagcgtccgg cggagtccgg 2401 acgcaagcgc aacaacaaca gtaaccagaa caaccagcag cagcagcaac agcaacacca 2461 gcaacagcag cagcaacaaa attccaactc gaacgattcc acgcagctga cgagcggagt 2521 tgttaccggt ccaggcagtg atcgtgtgag cgtaagcgtc gacagcggat tgggtggcaa 2581 taatgcgggc gcgatcggtg gcggaaccgt tggtggtggc gttggaggtg gtggtgttgg 2641 aggcggtggt gtcggaggcg gcggtggacg tggactttct cgcagcaatt cgacgcaggc 2701 caatcaggct caattgctgc acaacggcgg tggtggttcg ggcggcaatg tcggcaactc 2761 gggcggcgtt ggcgaccgct tgtcagatcg aggaggagga ggtggcggca tcggcggaaa 2821 cgatagcggc agctgctcgg actcgggcac tttcctgaag ccagaccccg tatcgggtgc 2881 ctacacagcg caggagtatt acgagtacga tgagatcctc aagttgcgac aaaatgccct 2941 caaaaaggag gacgccgacc tgcagctgga gatggagaag ctggagcggg agcgcaatct 3001 gcacatccga gagctcaagc ggattcttaa cgaggatcag tcccgcttta acaatcatcc 3061 cgtgctgaat gatcgctatc ttctgttgat gctcctgggc aagggcggct tctcagaggt 3121 ccacaaggcc ttcgacctga aggagcaacg ctatgtcgca tgtaaggtgc accaattaaa 3181 caaggattgg aaggaggata agaaagctaa ttatatcaaa cacgctttgc gggaatacaa 3241 cattcacaag gcactggatc atccgcgggt cgtcaagcta tacgatgtct tcgagatcga 3301 tgcgaattcc ttttgcacag tgctcgaata ctgtgatggc cacgatctgg acttctattt 3361 gaagcaacat aagactatac ccgagcgtga agcgcgctcg ataataatgc aggttgtatc 3421 tgcactcaag tatctaaatg agattaagcc tccagttatc cactacgatc tgaagcccgg 3481 caacattctg cttaccgagg gcaacgtctg cggcgagatt aagatcaccg acttcggtct 3541 gtcaaaggtg atggacgacg agaattacaa tcccgatcac ggcatggatc tgacctctca 3601 gggggcggga acctactggt atctgccacc cgagtgcttt gtcgtgggca aaaatccgcc 3661 gaaaatctcc tccaaagtgg acgtatggag tgtgggtgtt atcttctacc agtgtctgta 3721 cggcaaaaag cccttcggtc acaatcagtc gcaggccacg attctcgagg agaatacgat 3781 cctgaaggcc accgaagtgc agttctccaa caagccaacc gtttctaacg aggccaagag 3841 tttcattcgg ggatgcttgg cctatcgcaa ggaggatcgc atggatgtgt tcgcactggc 3901 caggcacgag tacattcagc caccgatacc gaaacatggg cgcggttcgc tcaatcagca 3961 acagcaggcg caacaacagc agcagcaaca acagcaacag cagcagcaac agtcgtcgac 4021 gtcacaggcc aattctacag gccagacatc tttctctgcc cacatgtttg gcaatatgaa 4081 tcagtcgagt tcgtcctagc tgccaaccaa gcgcaattcg aactcataat tcgccgccgc 4141 cgcagtagca gcagctacat tagctgccag tagtcaacag caacttcaac accagcaaca 4201 gcaactccaa atccagcaat accagcagaa tcagcaactt catttgcaaa acagcagtag 4261 caattatgcg gccacgcttc tagatgcagc ggccttttgc tacgaaaccg tgatggatgc 4321 agcccacttc caaaacaaca ataataacag caccatcatc aagaacaata tgcagacaat 4381 gccggcaaac gctgccaatg ctgctgcagc tgcaggggga gggggaacac cgacctatca 4441 ggggaaatac aagcgctggc agcagcaaca gttacaacag caggcgcaac tccaacagca 4501 gcagcacaag ctgctgttgc agcaagagct gctctaaaat atgaagggaa tgatgacaag 4561 cgagtttaag agaacgagga gctgcctgcc acactgccgc cgtcagcaat aacaacatcc 4621 caagaaaatt cacagcgagt cgcaaaagca tcaacaaaca aagcaaaaaa cgcaaaaaag 4681 gattacaaag acgcagagaa taggggacat ttgcaatggg aaataacaaa ttattgcatt 4741 atctgctgga ttgtgattgt ggttcaaaca ttaaaaatac acttactcat acacacaagg 4801 tagacactgc agactaattt tgccttaaaa gaaacaaaac gaataatgtt aactgtaaat 4861 tttcactttg tgtccatgca tagttactag taatgatgat ataaatatat aaatatatat 4921 aaaatataaa aattatataa atgtataaat ttatatttat atatatatat atatatatat 4981 atatatatct gcataaacat tgaagcatac tagtaaatct ttataaatat atttatatat 5041 atatttatct cttcctttta acgcttttaa tcggaaaaaa catcccaatt atattttaat 5101 tcaatttgaa atataaaagt catttttgtt tgttttgtat caaaatccaa aaaaaattga 5161 tttaaatata aaaataccat aaacattaac accacacaca cacacacaca cacatatata 5221 tatatatata tatatatata tatatataca tatatatata catttgtata tagtcgtatc 5281 tgaaccacaa acaaatccac agataaaaaa aactgaaaaa ttcatagaat caaaccattt 5341 ttttatatgc cacaaagaaa agaaaataag tagaaatgca agaaaaatcg agaaaaagcg 5401 taattcatga gatcagatcg gatcagaaaa atcaacagaa aataaaccta tttgaagtaa 5461 aatacttcta aatacatagt aaactaatgt aatagttttt attaaaatta cacatatatg 5521 tatcgatata tatacatgtt tttttttttt taattttaaa attataattg taatgcacta 5581 tgcgtaaatt gtattaaata ttaatatcca aggcatatta atagaaatat atatacatat 5641 ataaaacctg caaaaaaaaa acatgaacta ccaagctaaa tgtttcaata atatatagat 5701 ctatatgtat gtaaaaccga tatgaaatct gcctacagcc agacaaaaaa aaccttaaag 5761 agaaagatca gaagaggaac agaagagtat gagcggggag tgaaagatgc aagattcatc 5821 caaaagcgaa aaacattttt ttcttaagtc tacgcaaaac aaaatgaatg aaaagtaacc 5881 cgaaattagt ttttagagta taagtataaa aaatggaaaa tatcgcgata gaaagaaaca 5941 aaaatggacg cagataagga cggcaagcag aacaagagta ataaagcagc ggcaagaact 6001 ccctaaaaat agcaaagagc attgtaaata tttatataaa taatttatgc ctaattaaag 6061 tttaaattaa tgaagaaaac cagcaaaaaa acataaaaaa ccagaagaac catttcagat 6121 ttgtatgcaa atttgtatat gtacgtactt tcctttaatt ttagccaatc agtttgtaag 6181 attaaatttt ttttttgcat ctctataaag aataatgata tgaggataat gattccgatt 6241 tttttttccg tttaatgtaa ccgttagaat tagcccataa tggtcgatat ctaaatgtgt 6301 gtgtatatcg atgtgatgtc atcgattgtc gataacgatt ggatgcgagt gtgtgttaat 6361 ttaatttgat aaaagataaa ggaaagcaag gaatgtgaag ataatgaaag gagatgcata 6421 gagaatgaga gcgaatctat ctattatata attatgtaaa atgcacatct ttaaattata 6481 aattatacat atttaaaagg aaactattat tat